JP2008504233A5 - - Google Patents
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- Publication number
- JP2008504233A5 JP2008504233A5 JP2007509742A JP2007509742A JP2008504233A5 JP 2008504233 A5 JP2008504233 A5 JP 2008504233A5 JP 2007509742 A JP2007509742 A JP 2007509742A JP 2007509742 A JP2007509742 A JP 2007509742A JP 2008504233 A5 JP2008504233 A5 JP 2008504233A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- heteroaryl
- group
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56504704P | 2004-04-23 | 2004-04-23 | |
| US56903204P | 2004-05-07 | 2004-05-07 | |
| US62325104P | 2004-10-28 | 2004-10-28 | |
| PCT/US2005/014345 WO2006076009A2 (en) | 2004-04-23 | 2005-04-25 | Transcription factor modulating compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504233A JP2008504233A (ja) | 2008-02-14 |
| JP2008504233A5 true JP2008504233A5 (https=) | 2008-06-19 |
Family
ID=36678027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007509742A Ceased JP2008504233A (ja) | 2004-04-23 | 2005-04-25 | 転写因子調節化合物およびその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060160799A1 (https=) |
| EP (1) | EP1742637A4 (https=) |
| JP (1) | JP2008504233A (https=) |
| AU (1) | AU2005324492B2 (https=) |
| CA (1) | CA2562763A1 (https=) |
| IL (3) | IL178600A0 (https=) |
| WO (1) | WO2006076009A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| US20040106553A1 (en) * | 2002-06-24 | 2004-06-03 | Alekshun Michael N. | Methods for preventing and treating microbial infections by modulating transcription factors |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| KR20060087386A (ko) * | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US20090175805A1 (en) * | 2006-03-13 | 2009-07-09 | The Trustees Of Columbia University In The City Of New York | Neuraminidase Inhibitors and uses thereof |
| CA2656157A1 (en) * | 2006-06-23 | 2008-10-30 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| WO2008014307A2 (en) * | 2006-07-26 | 2008-01-31 | Novartis Ag | Inhibitors of undecaprenyl pyrophosphate synthase |
| EP2089383B1 (en) * | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| CA2681813A1 (en) * | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| EP2000140A1 (en) * | 2007-06-05 | 2008-12-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of derivatives of 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine or of 3-oxo-2,3-dihydro-5H-imidazolo[3,2-a]pyrimidine for the preparation of pharmaceutical compositions intended for the treatment of cancer |
| TWI580356B (zh) | 2007-08-13 | 2017-05-01 | 孟山都科技有限責任公司 | 控制植物寄生性線蟲的化合物及方法以及被覆有該化合物之種子 |
| WO2009026657A1 (en) * | 2007-08-29 | 2009-03-05 | The University Of Sydney | Flavonoid ppar agonists |
| US8716283B2 (en) | 2007-11-07 | 2014-05-06 | University Of Massachusetts | Type III secretion inhibitors, analogs and uses thereof |
| WO2009061491A2 (en) * | 2007-11-07 | 2009-05-14 | University Of Massachusetts | Type iii secretion inhibitors and uses thereof |
| EP2732819B1 (en) * | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
| WO2010027762A1 (en) * | 2008-09-04 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Indolizine inhibitors of leukotriene production |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| US20110059962A1 (en) * | 2009-04-22 | 2011-03-10 | Alekshun Michael N | Transcription factor modulating compounds and methods of use thereof |
| ITPI20090140A1 (it) * | 2009-11-09 | 2011-05-10 | Univ Pisa | Composto inibitore dell'enzima lattato deidrogenasi (ldh) e composizione farmaceutica che comprende tale composto |
| MX2012012531A (es) * | 2010-04-27 | 2013-04-03 | Astellas Pharma Inc | Derivado de imidazo [1, 2-a] piridina. |
| WO2011151617A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151620A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| ES2568455T3 (es) | 2010-06-01 | 2016-04-29 | Summit Therapeutics Plc | Compuestos para el tratamiento de enfermedad asociada a Clostridium difficile |
| WO2011151618A2 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| WO2011151619A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| CN103402988B (zh) | 2010-10-25 | 2015-11-25 | 范德比尔特大学 | 用于抑制昆虫宿主感觉的组合物 |
| FR2967353B1 (fr) * | 2010-11-16 | 2013-08-16 | Centre Nat Rech Scient | Derives de quinolinone |
| EP3653054A1 (en) * | 2011-05-06 | 2020-05-20 | Vanderbilt University | Composition for inhibition of insect sensing |
| CN102887859B (zh) * | 2011-07-21 | 2014-10-29 | 首都医科大学 | 一种具有镇痛和抗炎活性的化合物,其制备方法及应用 |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| WO2016127102A2 (en) | 2015-02-06 | 2016-08-11 | Ernesto Abel-Santos | Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis |
| US10791739B2 (en) | 2015-03-25 | 2020-10-06 | Vanderbilt University | Binary compositions as disruptors of orco-mediated odorant sensing |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11576892B2 (en) | 2015-08-18 | 2023-02-14 | Novation Pharmaceuticals Inc. | Benzopyran derivatives and uses thereof |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| MX2020002869A (es) | 2017-09-15 | 2020-07-24 | Aduro Biotech Inc | Compuestos de pirazolopirimidinona y usos de los mismos. |
| KR102737283B1 (ko) | 2019-07-17 | 2024-12-03 | 서밋 (옥스포드) 리미티드 | 리디닐라졸 및 이의 결정 형태의 제조방법 |
| CA3184471A1 (en) * | 2020-05-27 | 2021-12-02 | The Penn State Research Foundation | Antibacterial compounds |
| CN116075510A (zh) * | 2020-08-19 | 2023-05-05 | 百时美施贵宝公司 | 1H-苯并[d]咪唑衍生物作为TLR9抑制剂用于治疗纤维化 |
| GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
| GB202100470D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Solid tablet dosage for of ridinilazole |
| EP4398890A4 (en) | 2021-09-09 | 2025-07-30 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Univ Of Nevada Las Ve | C. Difficile Spore Germination Inhibitors |
| US11975009B2 (en) * | 2022-05-02 | 2024-05-07 | Znable Llc | Use of zinc porphyrin as an antimicrobial |
| CN119033788B (zh) * | 2024-08-27 | 2025-10-31 | 南京中医药大学 | 分枝杆菌硫醇二硫还原酶抑制剂在制备抗分枝杆菌药物中的应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300505A (en) | 1964-12-07 | 1967-01-24 | Ciba Geigy Corp | Ether-2-r-substituted benzimidazoles and derivatives and acid addition salts thereof |
| US3429890A (en) | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
| US3325356A (en) | 1965-08-20 | 1967-06-13 | Merck & Co Inc | Compositions and method for treating helminthiasis |
| US3449498A (en) | 1965-11-18 | 1969-06-10 | Ciba Geigy Corp | Analgesic compositions of a 4-aminoal-kylamino-quinazoline and 1-amino-alkoxybenzimidazole |
| GB1141936A (en) | 1966-03-26 | 1969-02-05 | Shionogi & Co | Improvements in or relating to benzimidazole derivatives |
| US3549754A (en) | 1969-04-21 | 1970-12-22 | Merck & Co Inc | Combination of 2-substituted benzimidazoles and substituted phenothiazines in the treatment of helminthiasis |
| DE1923481A1 (de) | 1969-05-08 | 1970-11-12 | Hoechst Ag | Verfahren zur Herstellung von Amiden und Estern der 1-Hydroxy-benzimidazol-2-carbonsaeure |
| US3686110A (en) | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
| US3646049A (en) | 1970-03-05 | 1972-02-29 | Merck & Co Inc | Acylaminobenzimidazole derivatives |
| CA953726A (en) | 1970-03-05 | 1974-08-27 | Richard J. Bochis | Process for preparing 1,5-substituted or 1,6-substituted benzimidazoles |
| US3873558A (en) | 1970-03-05 | 1975-03-25 | Merck & Co Inc | Process for preparing 1,5-substituted or 1,6-substituted benzimidazoles |
| GB1507059A (en) | 1974-09-18 | 1978-04-12 | Univ Australian | Purines |
| US4269846A (en) * | 1979-10-29 | 1981-05-26 | Usv Pharmaceutical Corporation | Heterocyclic compounds useful as anti-allergy agents |
| JPH0784462B2 (ja) * | 1986-07-25 | 1995-09-13 | 日清製粉株式会社 | ベンゾイミダゾ−ル誘導体 |
| US4859684A (en) | 1986-09-15 | 1989-08-22 | Janssen Pharmaceutica N.V. | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders |
| NZ221729A (en) | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| DE3828537A1 (de) * | 1988-08-23 | 1990-03-01 | Basf Ag | Neue n-substituierte benzimidazol-2-carbonsaeureanilide, deren verwendung als lichtschutzmittel, insbesondere polymere und diese anilide enthaltendes organisches material |
| DE3828535A1 (de) * | 1988-08-23 | 1990-03-08 | Basf Ag | Benzimidazol-2-carbonsaeureanilide, ihre verwendung als lichtschutzmittel fuer organisches material und mit diesen aniliden stabilisiertes organisches material |
| DE3828536A1 (de) * | 1988-08-23 | 1990-03-01 | Basf Ag | 2,6-polyalkylpiperidinsubstituierte benzimidazol-2-carbonsaeureanilide und deren verwendung zum stabilisieren von organischem material |
| DE3830697A1 (de) | 1988-09-09 | 1990-03-22 | Knoll Ag | Substituierte phenylacetonitrile zur verwendung als resistenzbrecher |
| US5342957A (en) | 1988-11-29 | 1994-08-30 | Janssen Pharmaceutica N.V. | Benzimidazoles useful in treating epithelial disorders |
| CA2002859C (en) | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
| JPH0525140A (ja) | 1991-07-22 | 1993-02-02 | Sankyo Co Ltd | ベンズイミダゾール誘導体 |
| WO1994005810A1 (en) | 1992-08-28 | 1994-03-17 | Trustees Of Tufts College | Multiple antibiotic resistance operon assays |
| NZ270985A (en) | 1994-04-29 | 1997-06-24 | Lilly Co Eli | Substituted benzimidazole derivatives; medicaments and preparation of medicaments |
| US5552426A (en) | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| JP2915802B2 (ja) | 1994-07-14 | 1999-07-05 | 呉羽化学工業株式会社 | 抗生物質耐性微生物の薬剤感受性増感剤 |
| TW381092B (en) * | 1995-07-07 | 2000-02-01 | Otsuka Pharma Co Ltd | Novel benzimidazole derivatives for use in treating arteriosclerotic diseases |
| JP2000516611A (ja) * | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Mcp―1アンタゴニストとしての2―フェニルベンズイミダゾール誘導体 |
| US5976874A (en) | 1996-08-16 | 1999-11-02 | Yale University | Phenotypic conversion of drug-resistant bacteria to drug-sensitivity |
| WO1998017267A1 (en) | 1996-10-23 | 1998-04-30 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
| AU6328498A (en) | 1997-02-21 | 1998-09-09 | Hybridon, Inc. | Oligonucleotides specific for the (marorab) operon |
| US5942532A (en) | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| WO2000012089A1 (en) | 1998-08-31 | 2000-03-09 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| AU4803597A (en) | 1997-10-02 | 1999-04-27 | Trustees Of Tufts College | Methods and compositions for reducing bacterial tolerance of disinfectants and organic solvents |
| US5972995A (en) | 1997-10-16 | 1999-10-26 | Children's Hospital Medical Center Of Northern California | Compositions and methods for cystic fibrosis therapy |
| NZ505002A (en) * | 1997-12-10 | 2001-11-30 | Dainippon Ink & Chemicals | 1,2,5-oxadiazolyl, 1,2,5-thiadiazolyl or 1,2,3-thiadiazolyl oxime derivatives substituted by another heterocyclic group useful as agricultural chemicals |
| AU4196199A (en) | 1998-05-22 | 1999-12-13 | Tufts University | Mara family helix-turn-helix domains and their methods of use |
| US6162393A (en) | 1998-08-06 | 2000-12-19 | Ndt, Inc. | Contact lens and ophthalmic solutions |
| US6204264B1 (en) * | 1998-09-21 | 2001-03-20 | Shiseido Co., Ltd. | Benzimidazole derivative, hair growth promoter and external composition for skin using the same |
| AU782306B2 (en) | 1999-03-03 | 2005-07-21 | Board Of Regents, The University Of Texas System | Genetic and epigenetic manipulation of ABC transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors |
| SI1194425T1 (sl) | 1999-06-23 | 2005-12-31 | Sanofi Aventis Deutschland | Substituirani benzimidazoli |
| WO2004001058A2 (en) * | 2001-05-04 | 2003-12-31 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| US7405235B2 (en) | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| DE10238002A1 (de) | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
| WO2004041209A2 (en) * | 2002-11-01 | 2004-05-21 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| EP1479676A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Benzimidazole-derivatives as factor xa inhibitors |
-
2005
- 2005-04-25 EP EP05856651A patent/EP1742637A4/en not_active Withdrawn
- 2005-04-25 AU AU2005324492A patent/AU2005324492B2/en not_active Ceased
- 2005-04-25 JP JP2007509742A patent/JP2008504233A/ja not_active Ceased
- 2005-04-25 US US11/115,024 patent/US20060160799A1/en not_active Abandoned
- 2005-04-25 WO PCT/US2005/014345 patent/WO2006076009A2/en not_active Ceased
- 2005-04-25 CA CA002562763A patent/CA2562763A1/en not_active Abandoned
-
2006
- 2006-10-15 IL IL178600A patent/IL178600A0/en unknown
-
2009
- 2009-08-03 US US12/462,405 patent/US8436031B2/en not_active Expired - Fee Related
-
2011
- 2011-01-16 IL IL210693A patent/IL210693A0/en unknown
- 2011-01-16 IL IL210694A patent/IL210694A0/en unknown
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