JP2008503523A5 - - Google Patents
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- Publication number
- JP2008503523A5 JP2008503523A5 JP2007517174A JP2007517174A JP2008503523A5 JP 2008503523 A5 JP2008503523 A5 JP 2008503523A5 JP 2007517174 A JP2007517174 A JP 2007517174A JP 2007517174 A JP2007517174 A JP 2007517174A JP 2008503523 A5 JP2008503523 A5 JP 2008503523A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- corresponding hydrochloride
- dimethylaminomethyl
- amine
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 30
- 208000002193 Pain Diseases 0.000 claims description 28
- 238000011282 treatment Methods 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 10
- 208000019901 Anxiety disease Diseases 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- 206010013663 drug dependence Diseases 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 208000017520 skin disease Diseases 0.000 claims description 6
- 208000011117 substance-related disease Diseases 0.000 claims description 6
- 208000024827 Alzheimer disease Diseases 0.000 claims description 5
- 208000032841 Bulimia Diseases 0.000 claims description 5
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 5
- 208000030814 Eating disease Diseases 0.000 claims description 5
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 5
- 208000001640 Fibromyalgia Diseases 0.000 claims description 5
- 208000019695 Migraine disease Diseases 0.000 claims description 5
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims description 5
- 208000003251 Pruritus Diseases 0.000 claims description 5
- 208000028017 Psychotic disease Diseases 0.000 claims description 5
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 5
- 208000016620 Tourette disease Diseases 0.000 claims description 5
- 206010046543 Urinary incontinence Diseases 0.000 claims description 5
- 208000010877 cognitive disease Diseases 0.000 claims description 5
- 235000014632 disordered eating Nutrition 0.000 claims description 5
- 206010027599 migraine Diseases 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 3
- 208000013403 hyperactivity Diseases 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 208000026139 Memory disease Diseases 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000012458 free base Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 29
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- CYHKDODPXAVVJY-UHFFFAOYSA-N 1-(5-methoxy-1-pyridin-3-yl-3,4-dihydronaphthalen-2-yl)-n,n-dimethylmethanamine Chemical compound CN(C)CC=1CCC=2C(OC)=CC=CC=2C=1C1=CC=CN=C1 CYHKDODPXAVVJY-UHFFFAOYSA-N 0.000 claims 2
- JKUVGEXRZZWOFY-UHFFFAOYSA-N 1-(6-fluoro-3-pyridin-3-yl-1h-inden-2-yl)-n,n-dimethylmethanamine Chemical compound C12=CC=C(F)C=C2CC(CN(C)C)=C1C1=CC=CN=C1 JKUVGEXRZZWOFY-UHFFFAOYSA-N 0.000 claims 2
- GQPGBYGEQXBPQQ-UHFFFAOYSA-N 1-(6-methoxy-3-pyridin-3-yl-1h-inden-2-yl)-n,n-dimethylmethanamine Chemical compound CN(C)CC=1CC2=CC(OC)=CC=C2C=1C1=CC=CN=C1 GQPGBYGEQXBPQQ-UHFFFAOYSA-N 0.000 claims 2
- AYIMCOMVIZKFTL-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-pyridin-3-yl-2,3-dihydroinden-1-ol Chemical compound CN(C)CC1CC2=CC=CC=C2C1(O)C1=CC=CN=C1 AYIMCOMVIZKFTL-UHFFFAOYSA-N 0.000 claims 2
- CJZGNRDVLLHEER-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-pyridin-3-yl-3h-inden-5-ol Chemical compound C12=CC=C(O)C=C2CC(CN(C)C)=C1C1=CC=CN=C1 CJZGNRDVLLHEER-UHFFFAOYSA-N 0.000 claims 2
- QRKAPEZZSALFQR-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-5-methoxy-1-pyridin-3-yl-3,4-dihydro-2h-naphthalen-1-ol Chemical compound COC1=CC=CC2=C1CCC(CN(C)C)C2(O)C1=CC=CN=C1 QRKAPEZZSALFQR-UHFFFAOYSA-N 0.000 claims 2
- JRQUDCPZCIGPEF-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-6-methoxy-1-pyridin-3-yl-2,3-dihydroinden-1-ol Chemical compound C12=CC(OC)=CC=C2CC(CN(C)C)C1(O)C1=CC=CN=C1 JRQUDCPZCIGPEF-UHFFFAOYSA-N 0.000 claims 2
- GDMQXYMWMGHHKE-UHFFFAOYSA-N 3-[(dimethylamino)methyl]-4-pyridin-3-yl-2,3-dihydrochromen-4-ol Chemical compound CN(C)CC1COC2=CC=CC=C2C1(O)C1=CC=CN=C1 GDMQXYMWMGHHKE-UHFFFAOYSA-N 0.000 claims 2
- AHCCCKGSLZERRE-UHFFFAOYSA-N 4-[(dimethylamino)methyl]-5-pyridin-3-yl-3,4-dihydro-2h-1-benzoxepin-5-ol Chemical compound CN(C)CC1CCOC2=CC=CC=C2C1(O)C1=CC=CN=C1 AHCCCKGSLZERRE-UHFFFAOYSA-N 0.000 claims 2
- AZFNLAWLWJOLDL-UHFFFAOYSA-N 6-[(dimethylamino)methyl]-5-pyridin-3-yl-6,7,8,9-tetrahydrobenzo[7]annulen-5-ol Chemical compound CN(C)CC1CCCC2=CC=CC=C2C1(O)C1=CC=CN=C1 AZFNLAWLWJOLDL-UHFFFAOYSA-N 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- YGCWTLJXPQFPEQ-UHFFFAOYSA-N n,n-dimethyl-1-(3-pyridin-3-yl-1h-inden-2-yl)methanamine Chemical compound C12=CC=CC=C2CC(CN(C)C)=C1C1=CC=CN=C1 YGCWTLJXPQFPEQ-UHFFFAOYSA-N 0.000 claims 2
- LAHZKUNEQKCMJZ-UHFFFAOYSA-N n,n-dimethyl-1-(5-pyridin-3-yl-8,9-dihydro-7h-benzo[7]annulen-6-yl)methanamine Chemical compound C12=CC=CC=C2CCCC(CN(C)C)=C1C1=CC=CN=C1 LAHZKUNEQKCMJZ-UHFFFAOYSA-N 0.000 claims 2
- VQEYEIUTACZWBP-UHFFFAOYSA-N n,n-dimethyl-1-[3-pyridin-3-yl-6-(trifluoromethoxy)-1h-inden-2-yl]methanamine Chemical compound C12=CC=C(OC(F)(F)F)C=C2CC(CN(C)C)=C1C1=CC=CN=C1 VQEYEIUTACZWBP-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- VSNLINZDYNIUSB-UHFFFAOYSA-N 1-(5-methoxy-3-pyridin-3-yl-1h-inden-2-yl)-n,n-dimethylmethanamine Chemical compound C12=CC(OC)=CC=C2CC(CN(C)C)=C1C1=CC=CN=C1 VSNLINZDYNIUSB-UHFFFAOYSA-N 0.000 claims 1
- PWFIDZRWWJSWEM-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-pyridin-3-yl-3,4-dihydro-2h-naphthalen-1-ol Chemical compound CN(C)CC1CCC2=CC=CC=C2C1(O)C1=CC=CN=C1 PWFIDZRWWJSWEM-UHFFFAOYSA-N 0.000 claims 1
- PRPULZAHTDWDFW-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-pyridin-3-yl-5-(trifluoromethoxy)-2,3-dihydroinden-1-ol Chemical compound CN(C)CC1CC2=CC(OC(F)(F)F)=CC=C2C1(O)C1=CC=CN=C1 PRPULZAHTDWDFW-UHFFFAOYSA-N 0.000 claims 1
- INBQRBCPBDIRFT-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-pyridin-3-yl-5-(trifluoromethyl)-2,3-dihydroinden-1-ol Chemical compound CN(C)CC1CC2=CC(C(F)(F)F)=CC=C2C1(O)C1=CC=CN=C1 INBQRBCPBDIRFT-UHFFFAOYSA-N 0.000 claims 1
- YEENLRKTQJLHGC-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-5-fluoro-1-pyridin-3-yl-2,3-dihydroinden-1-ol Chemical compound CN(C)CC1CC2=CC(F)=CC=C2C1(O)C1=CC=CN=C1 YEENLRKTQJLHGC-UHFFFAOYSA-N 0.000 claims 1
- HSQDHZQNMRYXIH-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-5-methoxy-1-pyridin-3-yl-2,3-dihydroinden-1-ol Chemical compound C=1C(OC)=CC=C2C=1CC(CN(C)C)C2(O)C1=CC=CN=C1 HSQDHZQNMRYXIH-UHFFFAOYSA-N 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 229930040373 Paraformaldehyde Natural products 0.000 claims 1
- KMKLUVYHNKQOSE-UHFFFAOYSA-N [Ce+2] Chemical compound [Ce+2] KMKLUVYHNKQOSE-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000002366 halogen compounds Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- ZIKZSXHMGBOHMR-UHFFFAOYSA-N n,n-dimethyl-1-(1-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-yl)methanamine Chemical compound CN(C)CC1CCC2=CC=CC=C2C1C1=CC=CN=C1 ZIKZSXHMGBOHMR-UHFFFAOYSA-N 0.000 claims 1
- AAMBJVCFOBUEQZ-UHFFFAOYSA-N n,n-dimethyl-1-(1-pyridin-3-yl-2,3-dihydro-1h-inden-2-yl)methanamine Chemical compound CN(C)CC1CC2=CC=CC=C2C1C1=CC=CN=C1 AAMBJVCFOBUEQZ-UHFFFAOYSA-N 0.000 claims 1
- QVNAEAOVUDUJDB-UHFFFAOYSA-N n,n-dimethyl-1-(1-pyridin-3-yl-3,4-dihydronaphthalen-2-yl)methanamine Chemical compound C12=CC=CC=C2CCC(CN(C)C)=C1C1=CC=CN=C1 QVNAEAOVUDUJDB-UHFFFAOYSA-N 0.000 claims 1
- MVFSHUNZGXRRAO-UHFFFAOYSA-N n,n-dimethyl-1-(4-pyridin-3-yl-2h-chromen-3-yl)methanamine Chemical compound C12=CC=CC=C2OCC(CN(C)C)=C1C1=CC=CN=C1 MVFSHUNZGXRRAO-UHFFFAOYSA-N 0.000 claims 1
- CRILCMHJXQMVLZ-UHFFFAOYSA-N n,n-dimethyl-1-(5-pyridin-3-yl-2,3-dihydro-1-benzoxepin-4-yl)methanamine Chemical compound C12=CC=CC=C2OCCC(CN(C)C)=C1C1=CC=CN=C1 CRILCMHJXQMVLZ-UHFFFAOYSA-N 0.000 claims 1
- CPRVRYUDZUPTAT-UHFFFAOYSA-N n,n-dimethyl-1-[3-pyridin-3-yl-6-(trifluoromethyl)-1h-inden-2-yl]methanamine Chemical compound C12=CC=C(C(F)(F)F)C=C2CC(CN(C)C)=C1C1=CC=CN=C1 CPRVRYUDZUPTAT-UHFFFAOYSA-N 0.000 claims 1
- 150000002902 organometallic compounds Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229920002866 paraformaldehyde Polymers 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- AEVWRTLZSNHCLK-UHFFFAOYSA-N thiepin-4-ol Chemical compound OC1=CC=CSC=C1 AEVWRTLZSNHCLK-UHFFFAOYSA-N 0.000 claims 1
- 208000002271 trichotillomania Diseases 0.000 claims 1
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 4
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- 208000005298 acute pain Diseases 0.000 description 4
- 229960002748 norepinephrine Drugs 0.000 description 4
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000407 monoamine reuptake Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
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- 239000002767 noradrenalin uptake inhibitor Substances 0.000 description 2
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- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 208000017194 Affective disease Diseases 0.000 description 1
- 208000008811 Agoraphobia Diseases 0.000 description 1
- 101001122476 Homo sapiens Mu-type opioid receptor Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 206010027940 Mood altered Diseases 0.000 description 1
- 102100028647 Mu-type opioid receptor Human genes 0.000 description 1
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- 230000001430 anti-depressive effect Effects 0.000 description 1
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- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004030099.2 | 2004-06-22 | ||
| DE102004030099A DE102004030099A1 (de) | 2004-06-22 | 2004-06-22 | Gesättigte und ungesättigte 3-Pyridyl-benzocycloalkylmethyl-amine als Serotonin- und/oder Noradrenalin-Reuptake-Hemmer und/oder µ-Opioidrezeptor-Modulatoren |
| PCT/EP2005/006624 WO2005123681A1 (de) | 2004-06-22 | 2005-06-20 | Gesättigte und ungesättigte 3-pyridyl-benzocycloalkylmethyl-amine zur behandlung von schmerzen, depressionen und angstzuständen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008503523A JP2008503523A (ja) | 2008-02-07 |
| JP2008503523A5 true JP2008503523A5 (OSRAM) | 2011-12-22 |
| JP4918486B2 JP4918486B2 (ja) | 2012-04-18 |
Family
ID=35106829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007517174A Expired - Fee Related JP4918486B2 (ja) | 2004-06-22 | 2005-06-20 | 苦痛、うつ病及び（又は）不安障害の治療に使用するための飽和及び不飽和３−ピリジル−ベンゾシクロアルキルメチル−アミン類 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8278338B2 (OSRAM) |
| EP (1) | EP1758860B1 (OSRAM) |
| JP (1) | JP4918486B2 (OSRAM) |
| AT (1) | ATE441632T1 (OSRAM) |
| CA (1) | CA2568897C (OSRAM) |
| CY (1) | CY1109519T1 (OSRAM) |
| DE (2) | DE102004030099A1 (OSRAM) |
| DK (1) | DK1758860T3 (OSRAM) |
| ES (1) | ES2333976T3 (OSRAM) |
| PL (1) | PL1758860T3 (OSRAM) |
| PT (1) | PT1758860E (OSRAM) |
| SI (1) | SI1758860T1 (OSRAM) |
| WO (1) | WO2005123681A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| EP1871355A1 (en) | 2005-04-22 | 2008-01-02 | Wyeth | New therapeutic combianations for the treatment or prevention of depression |
| ES2566479T3 (es) * | 2006-01-06 | 2016-04-13 | Sunovion Pharmaceuticals Inc. | Inhibidores de reabsorción de monoamina con base en tetralona |
| EP2271625B1 (en) | 2008-04-01 | 2012-09-12 | Abbott GmbH & Co. KG | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2013020930A1 (en) * | 2011-08-05 | 2013-02-14 | Abbott Gmbh & Co. Kg | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846741B2 (en) | 2011-11-18 | 2014-09-30 | Abbvie Inc. | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
| CA2924689A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN105764895A (zh) | 2013-10-17 | 2016-07-13 | 艾伯维德国有限责任两合公司 | 氨基四氢化萘及氨基二氢化茚衍生物，包含其的药物组合物及其在治疗中的用途 |
| CN104844471B (zh) * | 2015-04-21 | 2017-05-03 | 苏州远智医药科技有限公司 | 一种作为dor受体拮抗剂的化合物 |
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| US3444176A (en) * | 1967-04-28 | 1969-05-13 | Mcneilab Inc | Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof |
| US4845221A (en) * | 1988-04-15 | 1989-07-04 | American Home Products Corporation | Serotonergic substituted piperazinyl tetralins |
| AU648359B2 (en) * | 1990-11-22 | 1994-04-21 | Janssen Pharmaceutica N.V. | Isonicotinic acid derivatives |
| US5668141A (en) * | 1996-04-02 | 1997-09-16 | Abbott Laboratories | Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| AU4037699A (en) * | 1998-05-08 | 1999-11-29 | Akzo Nobel N.V. | Novel aryl-hydro naphthalenal kanamines |
| TW555757B (en) * | 1998-07-31 | 2003-10-01 | Akzo Nobel Nv | Aminomethylcarboxylic acid derivatives |
| CO5271697A1 (es) * | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona |
| BR0205829A (pt) * | 2001-03-16 | 2005-03-08 | Abbott Lab | Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticas |
| EP1411052B1 (en) * | 2001-07-05 | 2011-10-05 | Takeda Pharmaceutical Company Limited | Benzo-fused 5-membered hetrocycle compounds,process for preparation of the same, and use thereof |
| JP2004149429A (ja) * | 2002-10-29 | 2004-05-27 | Takeda Chem Ind Ltd | インドール化合物およびその用途 |
-
2004
- 2004-06-22 DE DE102004030099A patent/DE102004030099A1/de not_active Withdrawn
-
2005
- 2005-06-20 SI SI200530854T patent/SI1758860T1/sl unknown
- 2005-06-20 DK DK05766092T patent/DK1758860T3/da active
- 2005-06-20 ES ES05766092T patent/ES2333976T3/es not_active Expired - Lifetime
- 2005-06-20 JP JP2007517174A patent/JP4918486B2/ja not_active Expired - Fee Related
- 2005-06-20 WO PCT/EP2005/006624 patent/WO2005123681A1/de not_active Ceased
- 2005-06-20 EP EP05766092A patent/EP1758860B1/de not_active Expired - Lifetime
- 2005-06-20 PT PT05766092T patent/PT1758860E/pt unknown
- 2005-06-20 CA CA2568897A patent/CA2568897C/en not_active Expired - Fee Related
- 2005-06-20 AT AT05766092T patent/ATE441632T1/de active
- 2005-06-20 PL PL05766092T patent/PL1758860T3/pl unknown
- 2005-06-20 DE DE502005008058T patent/DE502005008058D1/de not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/643,792 patent/US8278338B2/en not_active Expired - Fee Related
-
2009
- 2009-11-30 CY CY20091101251T patent/CY1109519T1/el unknown
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