JP2008502683A5 - - Google Patents

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Publication number
JP2008502683A5
JP2008502683A5 JP2007516542A JP2007516542A JP2008502683A5 JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5 JP 2007516542 A JP2007516542 A JP 2007516542A JP 2007516542 A JP2007516542 A JP 2007516542A JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
optionally substituted
nitrogen
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007516542A
Other languages
English (en)
Japanese (ja)
Other versions
JP5000492B2 (ja
JP2008502683A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/019901 external-priority patent/WO2005123668A1/en
Publication of JP2008502683A publication Critical patent/JP2008502683A/ja
Publication of JP2008502683A5 publication Critical patent/JP2008502683A5/ja
Application granted granted Critical
Publication of JP5000492B2 publication Critical patent/JP5000492B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007516542A 2004-06-14 2005-06-08 グルカゴン受容体拮抗物質及びその調製並びに治療的使用 Expired - Lifetime JP5000492B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57936204P 2004-06-14 2004-06-14
US60/579,362 2004-06-14
PCT/US2005/019901 WO2005123668A1 (en) 2004-06-14 2005-06-08 Glucagon receptor antagonists, preparation and therapeutic uses

Publications (3)

Publication Number Publication Date
JP2008502683A JP2008502683A (ja) 2008-01-31
JP2008502683A5 true JP2008502683A5 (https=) 2012-05-10
JP5000492B2 JP5000492B2 (ja) 2012-08-15

Family

ID=35219490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007516542A Expired - Lifetime JP5000492B2 (ja) 2004-06-14 2005-06-08 グルカゴン受容体拮抗物質及びその調製並びに治療的使用

Country Status (28)

Country Link
US (3) US7816557B2 (https=)
EP (2) EP1758853B1 (https=)
JP (1) JP5000492B2 (https=)
KR (1) KR100835496B1 (https=)
CN (1) CN1968921B (https=)
AT (1) ATE455756T1 (https=)
AU (2) AU2005254950B2 (https=)
BR (1) BRPI0512058A (https=)
CA (1) CA2569459C (https=)
CY (1) CY1109787T1 (https=)
DE (1) DE602005019043D1 (https=)
DK (1) DK1758853T3 (https=)
EA (1) EA013003B1 (https=)
EC (1) ECSP067082A (https=)
ES (1) ES2337596T3 (https=)
HR (1) HRP20100148T1 (https=)
IL (1) IL179599A (https=)
MA (1) MA28706B1 (https=)
MX (1) MXPA06014426A (https=)
NO (1) NO341028B1 (https=)
NZ (1) NZ551015A (https=)
PL (1) PL1758853T3 (https=)
PT (1) PT1758853E (https=)
RS (1) RS51202B (https=)
SI (1) SI1758853T1 (https=)
UA (1) UA86621C2 (https=)
WO (1) WO2005123668A1 (https=)
ZA (1) ZA200610298B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1968921B (zh) * 2004-06-14 2011-11-23 伊莱利利公司 胰高血糖素受体拮抗剂、制备和治疗用途
US7524870B2 (en) * 2004-12-03 2009-04-28 Hoffmann-La Roche Inc. Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
SI1856090T1 (sl) 2005-02-11 2010-02-26 Lilly Co Eli Substituirani derivati tiofena kot antagonisti glukagonskega receptorja, priprava in terapevtske uporabe
US8318760B2 (en) * 2005-03-21 2012-11-27 Merck Sharp & Dohme Corp. Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use
BRPI0618140A2 (pt) * 2005-11-22 2011-08-16 Lilly Co Eli composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto ou um sal do mesmo
WO2007136577A2 (en) 2006-05-16 2007-11-29 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
KR20190126460A (ko) 2007-02-09 2019-11-11 메타베이시스 테라퓨틱스, 인크. 글루카곤 수용체의 길항제
CA2770298C (en) 2008-08-13 2017-06-20 Metabasis Therapeutics, Inc. Glucagon antagonists
US8809579B2 (en) 2009-02-13 2014-08-19 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8039495B2 (en) * 2009-11-16 2011-10-18 Hoffman-La Roche Inc. Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators
MX2013006768A (es) 2010-12-23 2013-07-22 Pfizer Moduladores de receptor de glucagon.
HRP20161177T1 (hr) 2011-02-08 2016-11-04 Pfizer Inc. Modulator glukagonskog receptora
AU2012288493B2 (en) 2011-07-22 2015-08-06 Pfizer Inc. Quinolinyl glucagon receptor modulators
US9453073B2 (en) 2011-12-02 2016-09-27 Eli Lilly And Company Anti-glucagon antibodies and uses thereof
US20140210770A1 (en) * 2012-10-04 2014-07-31 Corning Incorporated Pressure sensing touch systems and methods
TW201427658A (zh) 2012-12-10 2014-07-16 Merck Sharp & Dohme 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
EP3065736B1 (en) 2013-11-04 2018-11-14 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions thereof, and methods of use
WO2015191900A1 (en) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
CN108290840A (zh) 2015-12-01 2018-07-17 巴斯夫欧洲公司 作为杀真菌剂的吡啶化合物
EP3383848B1 (en) 2015-12-01 2020-01-08 Basf Se Pyridine compounds as fungicides
EA201992764A1 (ru) 2017-05-30 2020-04-29 Басф Се Пиридиновые и пиразиновые соединения
WO2019160940A1 (en) 2018-02-13 2019-08-22 Ligand Pharmaceuticals Incorporated Glucagon receptor antagonists
CN111184706B (zh) * 2020-03-05 2020-11-17 牡丹江医学院 一种防治胆囊炎的活性药物及其用途
KR102606541B1 (ko) * 2021-04-23 2023-11-29 가천대학교 산학협력단 바이페닐설폰아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 글루카곤 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973731A (en) 1987-04-23 1990-11-27 Riker Laboratories, Inc. Di-t-butylphenyl alkyl and benzyl ether nitriles
GB9420557D0 (en) * 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
CA2333927A1 (en) * 1998-04-01 1999-10-07 Dupont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
WO2000069810A1 (en) * 1999-05-17 2000-11-23 Novo Nordisk A/S Glucagon antagonists/inverse agonists
PL359619A1 (en) * 2000-06-23 2004-08-23 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6706744B2 (en) * 2000-11-17 2004-03-16 Novo Nordisk A/S Glucagon antagonists/inverse agonists
EP1463715A1 (en) * 2001-12-03 2004-10-06 Novo Nordisk A/S Novel glucagon antagonists
AU2003233780A1 (en) * 2002-06-27 2004-01-19 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
AU2003291959A1 (en) 2002-12-20 2004-07-14 Novo Nordisk A/S Novel glucagon antagonists
WO2005102067A1 (en) 2004-04-26 2005-11-03 Ipn Ip B.V. Packaged flowable ice product, such as a milk shake
EP1758859B1 (en) * 2004-05-28 2013-07-17 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
CN1968921B (zh) * 2004-06-14 2011-11-23 伊莱利利公司 胰高血糖素受体拮抗剂、制备和治疗用途
SI1856090T1 (sl) * 2005-02-11 2010-02-26 Lilly Co Eli Substituirani derivati tiofena kot antagonisti glukagonskega receptorja, priprava in terapevtske uporabe
US8318760B2 (en) 2005-03-21 2012-11-27 Merck Sharp & Dohme Corp. Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use
ES2393757T3 (es) * 2005-11-17 2012-12-27 Eli Lilly & Company Antagonistas de receptor de glucagón, preparación y usos terapéuticos
BRPI0618349A2 (pt) * 2005-11-17 2011-08-23 Lilly Co Eli composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e , uso de um composto ou um sal do mesmo
PT1951659E (pt) * 2005-11-18 2010-09-10 Lilly Co Eli Antagonistas do receptor do glucagon, preparação e utilizações terapêuticas
BRPI0618140A2 (pt) * 2005-11-22 2011-08-16 Lilly Co Eli composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto ou um sal do mesmo
PL1957484T3 (pl) * 2005-11-23 2010-07-30 Lilly Co Eli Antagoniści receptora glukagonu, wytwarzanie i zastosowanie w lecznictwie

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