JP2008502683A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008502683A5 JP2008502683A5 JP2007516542A JP2007516542A JP2008502683A5 JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5 JP 2007516542 A JP2007516542 A JP 2007516542A JP 2007516542 A JP2007516542 A JP 2007516542A JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- nitrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57936204P | 2004-06-14 | 2004-06-14 | |
| US60/579,362 | 2004-06-14 | ||
| PCT/US2005/019901 WO2005123668A1 (en) | 2004-06-14 | 2005-06-08 | Glucagon receptor antagonists, preparation and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008502683A JP2008502683A (ja) | 2008-01-31 |
| JP2008502683A5 true JP2008502683A5 (https=) | 2012-05-10 |
| JP5000492B2 JP5000492B2 (ja) | 2012-08-15 |
Family
ID=35219490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516542A Expired - Lifetime JP5000492B2 (ja) | 2004-06-14 | 2005-06-08 | グルカゴン受容体拮抗物質及びその調製並びに治療的使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7816557B2 (https=) |
| EP (2) | EP2159221A1 (https=) |
| JP (1) | JP5000492B2 (https=) |
| KR (1) | KR100835496B1 (https=) |
| CN (1) | CN1968921B (https=) |
| AT (1) | ATE455756T1 (https=) |
| AU (2) | AU2005254950B2 (https=) |
| BR (1) | BRPI0512058A (https=) |
| CA (1) | CA2569459C (https=) |
| CY (1) | CY1109787T1 (https=) |
| DE (1) | DE602005019043D1 (https=) |
| DK (1) | DK1758853T3 (https=) |
| EA (1) | EA013003B1 (https=) |
| EC (1) | ECSP067082A (https=) |
| ES (1) | ES2337596T3 (https=) |
| HR (1) | HRP20100148T1 (https=) |
| IL (1) | IL179599A (https=) |
| MA (1) | MA28706B1 (https=) |
| MX (1) | MXPA06014426A (https=) |
| NO (1) | NO341028B1 (https=) |
| NZ (1) | NZ551015A (https=) |
| PL (1) | PL1758853T3 (https=) |
| PT (1) | PT1758853E (https=) |
| RS (1) | RS51202B (https=) |
| SI (1) | SI1758853T1 (https=) |
| UA (1) | UA86621C2 (https=) |
| WO (1) | WO2005123668A1 (https=) |
| ZA (1) | ZA200610298B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1968921B (zh) * | 2004-06-14 | 2011-11-23 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| ES2332470T3 (es) * | 2005-02-11 | 2010-02-05 | Eli Lilly And Company | Derivados de tiofeno sustituidos como antagonistas del receptor de glucagon, preparacion y usos terapeuticos. |
| US8318760B2 (en) * | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| CN101312723B (zh) * | 2005-11-22 | 2012-01-11 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| US7935713B2 (en) | 2006-05-16 | 2011-05-03 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| KR20200123866A (ko) | 2007-02-09 | 2020-10-30 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
| PT2799428T (pt) | 2008-08-13 | 2017-02-17 | Metabasis Therapeutics Inc | Antagonistas de glicagina |
| WO2010098948A1 (en) * | 2009-02-13 | 2010-09-02 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containin such compounds and methods of use |
| US8039495B2 (en) * | 2009-11-16 | 2011-10-18 | Hoffman-La Roche Inc. | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators |
| NZ611529A (en) * | 2010-12-23 | 2015-06-26 | Pfizer | Glucagon receptor modulators |
| WO2012107850A1 (en) | 2011-02-08 | 2012-08-16 | Pfizer Inc. | Glucagon receptor modulator |
| US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
| EP2785740A1 (en) | 2011-12-02 | 2014-10-08 | Eli Lilly and Company | Anti-glucagon antibodies and uses thereof |
| US20140210770A1 (en) * | 2012-10-04 | 2014-07-31 | Corning Incorporated | Pressure sensing touch systems and methods |
| TW201427658A (zh) * | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
| EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
| WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| WO2017093120A1 (en) | 2015-12-01 | 2017-06-08 | Basf Se | Pyridine compounds as fungicides |
| EP3383849B1 (en) | 2015-12-01 | 2020-01-08 | Basf Se | Pyridine compounds as fungicides |
| CR20190580A (es) | 2017-05-30 | 2020-02-10 | Basf Se | Compuestos de piridina y pirazina |
| WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
| CN111184706B (zh) * | 2020-03-05 | 2020-11-17 | 牡丹江医学院 | 一种防治胆囊炎的活性药物及其用途 |
| KR102606541B1 (ko) * | 2021-04-23 | 2023-11-29 | 가천대학교 산학협력단 | 바이페닐설폰아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 글루카곤 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973731A (en) | 1987-04-23 | 1990-11-27 | Riker Laboratories, Inc. | Di-t-butylphenyl alkyl and benzyl ether nitriles |
| GB9420557D0 (en) | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| JP2003504301A (ja) * | 1998-04-01 | 2003-02-04 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | インテグリンアンタゴニスト |
| DE60023492T2 (de) * | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
| HUP0301501A2 (hu) * | 2000-06-23 | 2003-08-28 | Novo Nordisk A/S | Glükagon antaagonista/inverz agonista vegyületek, ezeket tartalmazó gyógyászati készítmények, valamint a vegyületek alkalmazása gyógyászati készítmények előállítására |
| US6706744B2 (en) | 2000-11-17 | 2004-03-16 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| JP2005511683A (ja) * | 2001-12-03 | 2005-04-28 | ノボ ノルディスク アクティーゼルスカブ | 新規なグルカゴンアンタゴニスト |
| EP1519723A1 (en) * | 2002-06-27 | 2005-04-06 | Novo Nordisk A/S | Novel glucagon antagonists/inverse agonists |
| WO2004056763A2 (en) | 2002-12-20 | 2004-07-08 | Novo Nordisk A/S | Novel glucagon antagonists |
| WO2005102067A1 (en) | 2004-04-26 | 2005-11-03 | Ipn Ip B.V. | Packaged flowable ice product, such as a milk shake |
| US7989457B2 (en) | 2004-05-28 | 2011-08-02 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| CN1968921B (zh) | 2004-06-14 | 2011-11-23 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| ES2332470T3 (es) * | 2005-02-11 | 2010-02-05 | Eli Lilly And Company | Derivados de tiofeno sustituidos como antagonistas del receptor de glucagon, preparacion y usos terapeuticos. |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| WO2007106181A2 (en) | 2005-11-17 | 2007-09-20 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| ES2393757T3 (es) | 2005-11-17 | 2012-12-27 | Eli Lilly & Company | Antagonistas de receptor de glucagón, preparación y usos terapéuticos |
| WO2007114855A2 (en) | 2005-11-18 | 2007-10-11 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| CN101312723B (zh) | 2005-11-22 | 2012-01-11 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| ATE459619T1 (de) | 2005-11-23 | 2010-03-15 | Lilly Co Eli | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung |
-
2005
- 2005-06-08 CN CN2005800194966A patent/CN1968921B/zh not_active Expired - Lifetime
- 2005-06-08 SI SI200530975T patent/SI1758853T1/sl unknown
- 2005-06-08 KR KR1020067026229A patent/KR100835496B1/ko not_active Expired - Fee Related
- 2005-06-08 AU AU2005254950A patent/AU2005254950B2/en not_active Ceased
- 2005-06-08 DE DE602005019043T patent/DE602005019043D1/de not_active Expired - Lifetime
- 2005-06-08 PL PL05757998T patent/PL1758853T3/pl unknown
- 2005-06-08 AT AT05757998T patent/ATE455756T1/de active
- 2005-06-08 CA CA2569459A patent/CA2569459C/en not_active Expired - Fee Related
- 2005-06-08 RS RSP-2010/0134A patent/RS51202B/sr unknown
- 2005-06-08 WO PCT/US2005/019901 patent/WO2005123668A1/en not_active Ceased
- 2005-06-08 NZ NZ551015A patent/NZ551015A/en not_active IP Right Cessation
- 2005-06-08 DK DK05757998.9T patent/DK1758853T3/da active
- 2005-06-08 UA UAA200612965A patent/UA86621C2/ru unknown
- 2005-06-08 EA EA200700027A patent/EA013003B1/ru not_active IP Right Cessation
- 2005-06-08 JP JP2007516542A patent/JP5000492B2/ja not_active Expired - Lifetime
- 2005-06-08 US US11/570,449 patent/US7816557B2/en active Active
- 2005-06-08 ES ES05757998T patent/ES2337596T3/es not_active Expired - Lifetime
- 2005-06-08 MX MXPA06014426A patent/MXPA06014426A/es active IP Right Grant
- 2005-06-08 EP EP08170258A patent/EP2159221A1/en not_active Withdrawn
- 2005-06-08 HR HR20100148T patent/HRP20100148T1/hr unknown
- 2005-06-08 BR BRPI0512058-6A patent/BRPI0512058A/pt not_active IP Right Cessation
- 2005-06-08 EP EP05757998A patent/EP1758853B1/en not_active Expired - Lifetime
- 2005-06-08 PT PT05757998T patent/PT1758853E/pt unknown
-
2006
- 2006-11-27 IL IL179599A patent/IL179599A/en not_active IP Right Cessation
- 2006-12-08 ZA ZA200610298A patent/ZA200610298B/en unknown
- 2006-12-13 EC EC2006007082A patent/ECSP067082A/es unknown
- 2006-12-29 MA MA29594A patent/MA28706B1/fr unknown
-
2007
- 2007-01-12 NO NO20070213A patent/NO341028B1/no not_active IP Right Cessation
-
2010
- 2010-02-11 CY CY20101100144T patent/CY1109787T1/el unknown
- 2010-08-26 US US12/868,773 patent/US20100324140A1/en not_active Abandoned
- 2010-11-19 AU AU2010246329A patent/AU2010246329A1/en not_active Abandoned
-
2011
- 2011-01-25 US US13/013,280 patent/US8609892B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008502683A5 (https=) | ||
| JP2008530102A5 (https=) | ||
| JP2013504593A5 (https=) | ||
| AR066120A1 (es) | Derivados de pirimidinona y sus metodos de uso | |
| JP2013536188A5 (https=) | ||
| JP2012532135A5 (https=) | ||
| JP2011519854A5 (https=) | ||
| JP2009533410A5 (https=) | ||
| EA200602058A1 (ru) | Производные адамантилпирролидин-2-она в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы | |
| RU2009105669A (ru) | Способ получения 3-замещенных 2-амино-5-галогенбензамидов | |
| JP2009511490A5 (https=) | ||
| JP2009519903A5 (https=) | ||
| RU2014128826A (ru) | Дисоли малоновой кислоты и способ получения малонилдигалогенидов | |
| WO2009156861A8 (en) | Substituted pyrimidone derivatives | |
| HRP20100148T1 (hr) | Antagonisti glukagonskog receptora, priprema i terapijska primjena | |
| JP2012504608A5 (https=) | ||
| WO2008078678A1 (ja) | オキシムエステル化合物及び該化合物を含有する光重合開始剤 | |
| JP2014507464A5 (https=) | ||
| MY169179A (en) | Novel piperidine compound or salt thereof | |
| CA2415532A1 (en) | Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof | |
| JP2006509842A5 (https=) | ||
| EA201071012A1 (ru) | Производные азетидинов, способ их получения и применение их в терапии | |
| JP2008540454A5 (https=) | ||
| JP2010535706A5 (https=) | ||
| JP2009519227A5 (https=) |