JP2008500148A5 - - Google Patents
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- JP2008500148A5 JP2008500148A5 JP2007527550A JP2007527550A JP2008500148A5 JP 2008500148 A5 JP2008500148 A5 JP 2008500148A5 JP 2007527550 A JP2007527550 A JP 2007527550A JP 2007527550 A JP2007527550 A JP 2007527550A JP 2008500148 A5 JP2008500148 A5 JP 2008500148A5
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- 239000000835 fiber Substances 0.000 claims 19
- 239000011248 coating agent Substances 0.000 claims 15
- 238000000576 coating method Methods 0.000 claims 15
- 230000000975 bioactive Effects 0.000 claims 13
- 229910052751 metal Inorganic materials 0.000 claims 10
- 239000002184 metal Substances 0.000 claims 10
- -1 di-saccharides Polymers 0.000 claims 8
- 239000004621 biodegradable polymer Substances 0.000 claims 6
- 229920002988 biodegradable polymer Polymers 0.000 claims 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 229960005188 collagen Drugs 0.000 claims 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 3
- 235000014655 lactic acid Nutrition 0.000 claims 3
- 239000004310 lactic acid Substances 0.000 claims 3
- 206010002329 Aneurysm Diseases 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 229920000272 Oligonucleotide Polymers 0.000 claims 2
- WUAPFZMCVAUBPE-UHFFFAOYSA-N Rhenium Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 claims 2
- 206010053648 Vascular occlusion Diseases 0.000 claims 2
- 239000000956 alloy Substances 0.000 claims 2
- 229910045601 alloy Inorganic materials 0.000 claims 2
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical class [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 claims 2
- 229920001222 biopolymer Polymers 0.000 claims 2
- 150000004676 glycans Polymers 0.000 claims 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
- 229910052737 gold Inorganic materials 0.000 claims 2
- 239000010931 gold Substances 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims 2
- 229910052741 iridium Inorganic materials 0.000 claims 2
- 150000002739 metals Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000002772 monosaccharides Chemical class 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 150000004804 polysaccharides Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 229910052702 rhenium Inorganic materials 0.000 claims 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 2
- 229910052703 rhodium Inorganic materials 0.000 claims 2
- 239000010948 rhodium Substances 0.000 claims 2
- 229910052709 silver Inorganic materials 0.000 claims 2
- 239000004332 silver Substances 0.000 claims 2
- BQCADISMDOOEFD-UHFFFAOYSA-N silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims 2
- 229910052715 tantalum Inorganic materials 0.000 claims 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 2
- 229910052721 tungsten Inorganic materials 0.000 claims 2
- 239000010937 tungsten Substances 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 238000004804 winding Methods 0.000 claims 2
- 229920002301 Cellulose acetate Polymers 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 claims 1
- 229940012952 Fibrinogen Drugs 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 229940019698 Fibrinogen containing hemostatics Drugs 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004698 Polyethylene (PE) Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920001299 Polypropylene fumarate Polymers 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 102100015249 VEGFA Human genes 0.000 claims 1
- 102100009661 VTN Human genes 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 230000002209 hydrophobic Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 229920000117 poly(dioxanone) Polymers 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 229920000747 poly(lactic acid) polymer Polymers 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920001888 polyacrylic acid Polymers 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 239000011528 polyamide (building material) Substances 0.000 claims 1
- 229920001707 polybutylene terephthalate Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000002040 relaxant effect Effects 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical compound CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
Claims (38)
- a)腔(lumen)並びに第1及び第2の端部を備え、患者の血管ネットワーク中の使用部位に挿入される大きさのコイルと、
b)前記コイルの前記第1の端部に固定して取り付けられる第1の端部と前記コイルの前記第2の端部に固定して取り付けられる第2の端部とを有する非伸縮性部材と、
c)その各々が前記非伸縮性部材の回りに少なくとも2回巻かれた(wrapped)複数の繊維と、
を備える、患者の血流を閉塞するための血管閉塞装置。 - 前記非伸縮性部材は、前記コイルの前記腔(lumen)を軸方向に横切ることを特徴とする請求項1記載の装置。
- 前記非伸縮性部材は、金属ワイヤで構成されることを特徴とする請求項1記載の装置。
- 前記金属ワイヤは、白金、パラジウム、ロジウム、レニウム、イリジウム、金、銀、タングステン、タンタル、又は、これら金属のうちの2つ以上の合金、又は、超弾性金属から選択される金属から構成されることを特徴とする請求項3記載の装置。
- 前記非伸縮性部材は重合体から構成されることを特徴とする請求項1記載の装置。
- 前記重合体は、非生物分解性重合体及び生物分解性重合体のうちの一つであることを特徴とする請求項5記載の装置。
- 前記非伸縮性部材は、生物活性コーティングをさらに備えることを特徴とする請求項1記載の装置。
- 前記生物活性コーティングは、成長因子、遺伝子、オリゴヌクレオチド、ペプチド、海洋生物由来高分子(marine biopolymer)、モノ−サッカライド、ジ−サッカライド、ポリ−サッカライド、コラーゲン及びこれらの組み合わせから選択されることを特徴とする請求項7記載の装置。
- 前記生物活性コーティングは重合体を備えることを特徴とする請求項7記載の装置。
- 前記コイルは金属ワイヤで構成されることを特徴とする請求項1記載の装置。
- 前記金属ワイヤは、白金、パラジウム、ロジウム、レニウム、イリジウム、金、銀、タングステン、タンタル、又は、これら金属のうちの2つ以上の合金、又は、超弾性金属から選択される金属から構成されることを特徴とする請求項10記載の装置。
- 前記コイルは、それ自体巻かれて(wound)二次的な形状となっている一次螺旋から構成されることを特徴とする請求項1記載の装置。
- 前記二次的な形状は螺旋であることを特徴とする請求項12記載の装置。
- 前記繊維は、生物活性材料及び生物不活性材料のうちの一つであることを特徴とする請求項1記載の装置。
- 前記繊維は、グリコール酸と乳酸との共重合体から構成されることを特徴とする請求項1記載の装置。
- 前記繊維は、生物活性コーティングをさらに備えることを特徴とする請求項1記載の装置。
- 前記生物活性コーティングは、潤滑性の親水性コーティング及び疎水性コーティングのうちの一つであることを特徴とする請求項16記載の装置。
- 前記生物活性コーティングは共重合体を備えることを特徴とする請求項16記載の装置。
- 前記共重合体は乳酸とグリコール酸とから構成されることを特徴とする請求項18記載の装置。
- 前記繊維は、非生物分解性重合体から構成されることを特徴とする請求項1記載の装置。
- 前記非生物分解性重合体は、ポリエチレン、ポリアクリル酸(polyacrylic)、ポリプロピレン、ポリ塩化ビニル、ポリアミド、ポリウレタン、ポリビニルピロリドン、ポリビニルアルコール、ポリ酢酸ビニル、酢酸セルロース、ポリスチレン、ポリテトラフルオロエチレン、ポリエステル、絹、ナイロン、ポリエチレンテレフタレート又は綿から選択されることを特徴とする請求項20記載の装置。
- 前記繊維は、生物分解性重合体から構成されることを特徴とする請求項1記載の装置。
- 前記生物分解性重合体は、ポリグリコール酸、ポリカプロラクトン、ポリヒドロキシブチレートバレレート(Polyhydroxybutyrate valerate)、ポリオルトエステル(Polyorthoester)、ポリ乳酸、ポリ−p−ジオキサノン(poly(p-dioxanone))、ポリバレトラクトン(Poly (valetolactone))、ポリタルトロン酸、ポリ−β−マロン酸、ポリプロピレンフマレート、チロシンを基にしたポリカーボネート(tyrosine based polycarbonate)、及び、ポリエチレンオキサイドとポリブチレンテレフタレートとの共重合体から選択されることを特徴とする請求項22記載の装置。
- グリコール酸の乳酸に対する比は、99:1、1:99、95:5、5:95、50:50、90:10及び10:90のうちの一つに選択されることを特徴とする請求項19記載の装置。
- 前記コーティング材料は、成長因子、遺伝子、オリゴヌクレオチド、ペプチド、海洋生物由来高分子(marine biopolymer)、モノ−サッカライド、ジ−サッカライド、ポリ−サッカライド、コラーゲン及びこれらの組み合わせから選択されることを特徴とする請求項16記載の装置。
- 前記生物活性コーティングは、前記コイル及び前記非伸縮性部材に適用されることを特徴とする請求項16記載の装置。
- 前記生物活性コーティングは前記繊維に単一層として適用されることを特徴とする請求項16記載の装置。
- 前記生物活性コーティングは、前記コイル及び前記非伸縮性部材に単一層として適用されることを特徴とする請求項26記載の装置。
- 前記生物活性コーティングは、前記繊維全体にわたって分散されていることを特徴とする請求項16記載の装置。
- 前記生物活性コーティングは、細胞接着を促進し、血栓形成を促進するものであることを特徴とする請求項16記載の装置。
- 前記生物活性コーティング材料は、コラーゲン、フィブリノーゲン、ビトロネクチン、血管内皮増殖因子、及び、アルギニン−グリシン−アスパラギン酸(RGD)配列を備えるペプチドから選択されることを特徴とする請求項16記載の装置。
- 前記繊維のそれぞれは第1及び第2の端部を備え、前記第1及び第2の繊維端部のそれぞれは前記コイルから自由に延びていることを特徴とする請求項1記載の装置。
- a)腔(lumen)、第1及び第2の端部、並びに、張力がかかっていないもとで隣接するワインディング(winding)間で繊維を掴む間隔を備える螺旋状に巻かれたワイヤ芯を得る工程と、
b)前記ワイヤ芯を延伸された状態まで延伸する工程と、
c)前記螺旋状に巻かれたワイヤの前記腔(lumen)の中へ非伸縮性部材を挿入し、前記非伸縮性部材の第1の端部を前記螺旋状に巻かれたワイヤの少なくとも一つの端部に固定して取り付ける工程と、
d)前記非伸縮性部材の回りに複数の繊維を少なくとも2回巻く(wrap)工程と、
e)前記コイルを緩和し、それにより前記コイルの前記隣接するワインディング(winding)に前記繊維を掴まえさせる工程と、
を備える、血管閉塞装置を製造する方法。 - 前記非伸縮性部材の第2の端部を前記螺旋状に巻かれたワイヤの第2の端部に固定して取り付ける工程をさらに備えることを特徴とする請求項33記載の方法。
- 前記巻く工程は前記コイルの複数のワインディング(winding)を通して行われることを特徴とする請求項33記載の方法。
- 前記繊維のそれぞれは第1及び第2の端部を備え、
前記方法は、前記繊維のそれぞれの前記第1及び第2の端部を前記コイルから自由に延ばすよう構成する工程をさらに備えることを特徴とする請求項33記載の方法。 - 患者の動脈瘤を治療する方法であって、血管閉塞装置を前記患者の体内に導入する工程と、それにより前記動脈瘤を治療する工程とを備え、
前記血管閉塞装置は、
a)前記患者の血管ネットワーク中の使用部位に挿入される大きさであって、第1及び第2の端部を備え、第1の表面領域から構成されるコイルと、
b)前記コイルの前記第1及び第2の端部にそれぞれ固定して取り付けられる第1の端部と第2の端部とを有する非伸縮性部材と、
c)複数の繊維であって、その各々が第1及び第2の端部を有し、巻き付けられる(enlaced)繊維のそれぞれが前記非伸縮性部材の回りに少なくとも2回巻き付けられ(wrapped)、前記第1及び第2の繊維端部のそれぞれが前記コイルから自由に延びる繊維と、
を備えることを特徴とする方法。 - 前記コイルは螺旋であることを特徴とする請求項37に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57371004P | 2004-05-21 | 2004-05-21 | |
US60/573,710 | 2004-05-21 | ||
PCT/US2005/018087 WO2005113035A2 (en) | 2004-05-21 | 2005-05-23 | Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011037486A Division JP5052682B2 (ja) | 2004-05-21 | 2011-02-23 | 生物学的、生物分解性若しくは合成重合体又は繊維が巻き付けられた体腔を閉塞するための金属製コイル |
Publications (3)
Publication Number | Publication Date |
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JP2008500148A JP2008500148A (ja) | 2008-01-10 |
JP2008500148A5 true JP2008500148A5 (ja) | 2008-07-03 |
JP4723584B2 JP4723584B2 (ja) | 2011-07-13 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2007527550A Expired - Fee Related JP4723584B2 (ja) | 2004-05-21 | 2005-05-23 | 生物学的、生物分解性若しくは合成重合体又は繊維が巻き付けられた体腔を閉塞するための金属製コイル |
JP2011037486A Expired - Fee Related JP5052682B2 (ja) | 2004-05-21 | 2011-02-23 | 生物学的、生物分解性若しくは合成重合体又は繊維が巻き付けられた体腔を閉塞するための金属製コイル |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2011037486A Expired - Fee Related JP5052682B2 (ja) | 2004-05-21 | 2011-02-23 | 生物学的、生物分解性若しくは合成重合体又は繊維が巻き付けられた体腔を閉塞するための金属製コイル |
Country Status (8)
Country | Link |
---|---|
US (2) | US7896899B2 (ja) |
EP (2) | EP2316355B1 (ja) |
JP (2) | JP4723584B2 (ja) |
AT (1) | ATE490736T1 (ja) |
CA (1) | CA2567331C (ja) |
DE (1) | DE602005025215D1 (ja) |
ES (2) | ES2440650T3 (ja) |
WO (1) | WO2005113035A2 (ja) |
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US20070093889A1 (en) * | 1999-01-27 | 2007-04-26 | Wu Benjamin M | Non-Fragmenting Low Friction Bioactive Absorbable Coils for Brain Aneurysm Therapy |
US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US8048104B2 (en) | 2000-10-30 | 2011-11-01 | Dendron Gmbh | Device for the implantation of occlusion spirals |
US7727221B2 (en) | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
JP4351405B2 (ja) * | 2001-08-29 | 2009-10-28 | インターナショナル・ビジネス・マシーンズ・コーポレーション | トランスコーディングシステム及びアノテーション管理装置 |
US8425549B2 (en) | 2002-07-23 | 2013-04-23 | Reverse Medical Corporation | Systems and methods for removing obstructive matter from body lumens and treating vascular defects |
JP2004261234A (ja) * | 2003-02-20 | 2004-09-24 | Kaneka Medix Corp | 塞栓形成用体内留置具 |
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DE102005019782A1 (de) | 2005-04-28 | 2006-11-09 | Dendron Gmbh | Vorrichtung zur Implantation von Okklusionswendeln mit innenliegendem Sicherungsmittel |
US8864790B2 (en) | 2006-04-17 | 2014-10-21 | Covidien Lp | System and method for mechanically positioning intravascular implants |
US7689889B2 (en) * | 2006-08-24 | 2010-03-30 | Cisco Technology, Inc. | Content addressable memory entry coding for error detection and correction |
CN101677821B (zh) | 2007-03-13 | 2014-05-14 | 泰科保健集团有限合伙公司 | 植入物和轴柄 |
JP5249249B2 (ja) | 2007-03-13 | 2013-07-31 | コヴィディエン リミテッド パートナーシップ | コイルと耐伸張性部材とが含まれているインプラント |
RU2011102994A (ru) | 2008-07-22 | 2012-08-27 | Микро Терапьютикс, Инк. (Us) | Устройство для реконструкции сосудов |
EP2349431B1 (en) | 2008-08-19 | 2015-01-21 | Covidien LP | Detachable tip microcatheter |
-
2005
- 2005-05-23 US US11/134,998 patent/US7896899B2/en active Active
- 2005-05-23 WO PCT/US2005/018087 patent/WO2005113035A2/en active Application Filing
- 2005-05-23 EP EP10194009.6A patent/EP2316355B1/en active Active
- 2005-05-23 DE DE602005025215T patent/DE602005025215D1/de active Active
- 2005-05-23 ES ES10194009.6T patent/ES2440650T3/es active Active
- 2005-05-23 CA CA2567331A patent/CA2567331C/en not_active Expired - Fee Related
- 2005-05-23 AT AT05756033T patent/ATE490736T1/de not_active IP Right Cessation
- 2005-05-23 EP EP05756033A patent/EP1761178B1/en active Active
- 2005-05-23 ES ES05756033T patent/ES2357243T3/es active Active
- 2005-05-23 JP JP2007527550A patent/JP4723584B2/ja not_active Expired - Fee Related
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2011
- 2011-01-20 US US13/010,671 patent/US8267955B2/en active Active
- 2011-02-23 JP JP2011037486A patent/JP5052682B2/ja not_active Expired - Fee Related
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