JP2008088100A - 皮膚外用組成物 - Google Patents
皮膚外用組成物 Download PDFInfo
- Publication number
- JP2008088100A JP2008088100A JP2006270076A JP2006270076A JP2008088100A JP 2008088100 A JP2008088100 A JP 2008088100A JP 2006270076 A JP2006270076 A JP 2006270076A JP 2006270076 A JP2006270076 A JP 2006270076A JP 2008088100 A JP2008088100 A JP 2008088100A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- bht
- external
- present
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
【解決手段】固体状態のブチルヒドロキシトルエンを含有することを特徴とする皮膚外用組成物。
【選択図】なし
Description
項1.固体状態のブチルヒドロキシトルエン(以下、BHTと示す)を含有することを特徴とする皮膚外用組成物。
項2.BHTの粒子径が1000μm以下であることを特徴とする項1に記載の皮膚外用組成物。
項3.粒子径350μm未満のBHT、粒子径350〜500μmのBHT、粒子径501〜1000μmのBHTを1種又は2種以上組み合わせて配合することを特徴とする項1又は2に記載の皮膚外用組成物。
項4.BHTの含有量が10〜40重量%である項1〜3のいずれかに記載の皮膚外用組成物。
項5.さらに水溶性高分子を含有する、項1〜4のいずれかに記載の皮膚外用組成物。
(1)ブチルヒドロキシトルエン(BHT)
本発明の鎮痒剤は、BHTを必須の成分として含有する。ブチルヒドロキシトルエンは、白色結晶の形状を有する化合物であり、ジブチルヒドロキシトルエンとも呼ばれるが、両者は同じ化合物([(CH3)3C]2C6H2(CH3)OH)を指す。BHTは、従来、化粧料、医薬品、食品等の酸化防止剤、安定化剤等の用途で配合されている。
本発明の皮膚外用組成物には、前記BHTの他、アルコールが含有されることが好ましい。アルコールを配合することで、固体状態のBHTを好適に分散させることができ、皮膚を満遍なく、かつ適度に刺激することが可能となる。本発明において使用されるアルコールとしては、化粧料、医薬品の分野において一般的に使用されているものであれば特に限定されないが、例えば、メタノール、エタノール、プロパノール、イソプロパノール、ブタノール、イソブタノール等の炭素数1〜6、好ましくは炭素数1〜3の低級アルコール;プロピレングリコール、ジプロピレングリコール、グリセリン、1,3−ブチレングリコール、ブチレングリコール、濃グリセリン、ポリエチレングリコール、マルチトール、マンニトール、ソルビトール等の多価アルコールなどが例示される。これらを1種単独で使用してもよく、2種以上を組み合わせて用いてもよい。また、低級アルコールは、無水、含水の別を問わない。本発明においては、(含水)エタノール、無水エタノール、イソプロパノールを用いることが好ましい。
Claims (5)
- 固体状態のブチルヒドロキシトルエン(以下、BHTと示す)を含有することを特徴とする皮膚外用組成物。
- BHTの粒子径が1000μm以下であることを特徴とする請求項1に記載の皮膚外用組成物。
- 粒子径350μm未満のBHT、粒子径350〜500μmのBHT、粒子径501〜1000μmのBHTを1種又は2種以上組み合わせて配合することを特徴とする請求項1又は2に記載の皮膚外用組成物。
- BHTの含有量が10〜40重量%である請求項1〜3のいずれかに記載の皮膚外用組成物。
- さらに水溶性高分子を含有する、請求項1〜4のいずれかに記載の皮膚外用組成物。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006270076A JP5063072B2 (ja) | 2006-09-29 | 2006-09-29 | 皮膚外用組成物 |
PCT/JP2007/069111 WO2008038807A1 (en) | 2006-09-29 | 2007-09-28 | External composition for skin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006270076A JP5063072B2 (ja) | 2006-09-29 | 2006-09-29 | 皮膚外用組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008088100A true JP2008088100A (ja) | 2008-04-17 |
JP5063072B2 JP5063072B2 (ja) | 2012-10-31 |
Family
ID=39230237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006270076A Active JP5063072B2 (ja) | 2006-09-29 | 2006-09-29 | 皮膚外用組成物 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5063072B2 (ja) |
WO (1) | WO2008038807A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2493955A (en) * | 2011-08-25 | 2013-02-27 | Hds Ltd | Methods and compositions for reducing allergic reactions to fragranced products and perfumes |
WO2021204568A1 (en) | 2020-04-07 | 2021-10-14 | Universität Basel | A topical composition for treatment of pruritus |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07126158A (ja) * | 1993-10-27 | 1995-05-16 | Taisho Pharmaceut Co Ltd | クロタミトン配合外用剤 |
JPH07173078A (ja) * | 1993-12-21 | 1995-07-11 | Taisho Pharmaceut Co Ltd | 鎮痒剤組成物 |
JPH1036883A (ja) * | 1996-07-16 | 1998-02-10 | Asahi Chem Ind Co Ltd | 皮膚および頭髪洗浄剤組成物 |
JPH10330217A (ja) * | 1997-05-29 | 1998-12-15 | Kose Corp | 美白用皮膚外用剤 |
JPH11106307A (ja) * | 1997-09-30 | 1999-04-20 | Pola Chem Ind Inc | 亜硫酸塩含有石鹸 |
JP2004256805A (ja) * | 2003-02-07 | 2004-09-16 | Kao Corp | 枠練り石鹸組成物 |
WO2004078157A2 (en) * | 2003-03-04 | 2004-09-16 | The Procter & Gamble Company | Regulation of mammalian hair growth |
WO2005018320A1 (en) * | 2003-08-12 | 2005-03-03 | The William M. Yarbrough Foundation | Composition for treatment of biting and penetrating organisms and parasites, and urticaria and method of use |
-
2006
- 2006-09-29 JP JP2006270076A patent/JP5063072B2/ja active Active
-
2007
- 2007-09-28 WO PCT/JP2007/069111 patent/WO2008038807A1/ja active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07126158A (ja) * | 1993-10-27 | 1995-05-16 | Taisho Pharmaceut Co Ltd | クロタミトン配合外用剤 |
JPH07173078A (ja) * | 1993-12-21 | 1995-07-11 | Taisho Pharmaceut Co Ltd | 鎮痒剤組成物 |
JPH1036883A (ja) * | 1996-07-16 | 1998-02-10 | Asahi Chem Ind Co Ltd | 皮膚および頭髪洗浄剤組成物 |
JPH10330217A (ja) * | 1997-05-29 | 1998-12-15 | Kose Corp | 美白用皮膚外用剤 |
JPH11106307A (ja) * | 1997-09-30 | 1999-04-20 | Pola Chem Ind Inc | 亜硫酸塩含有石鹸 |
JP2004256805A (ja) * | 2003-02-07 | 2004-09-16 | Kao Corp | 枠練り石鹸組成物 |
WO2004078157A2 (en) * | 2003-03-04 | 2004-09-16 | The Procter & Gamble Company | Regulation of mammalian hair growth |
WO2005018320A1 (en) * | 2003-08-12 | 2005-03-03 | The William M. Yarbrough Foundation | Composition for treatment of biting and penetrating organisms and parasites, and urticaria and method of use |
Also Published As
Publication number | Publication date |
---|---|
WO2008038807A1 (en) | 2008-04-03 |
JP5063072B2 (ja) | 2012-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2009184951A (ja) | 皮膚外用剤組成物 | |
EP3131531B1 (en) | Topical compositions for pain relief, manufacture and use | |
US11007241B2 (en) | Compositions for relieving pain with malkangni oil and cypriol oil as active ingredients and method of topical administration of the same | |
JP6921493B2 (ja) | 水中油型乳化組成物 | |
WO2005000287A1 (ja) | 水虫治療用外用剤 | |
JP2010184903A (ja) | 外用医薬組成物 | |
JP6753312B2 (ja) | 医療用皮膚外用剤 | |
TWI766912B (zh) | 水性製劑 | |
JP2002212107A (ja) | 局所適用組成物 | |
JP5063072B2 (ja) | 皮膚外用組成物 | |
JP5170973B2 (ja) | 皮膚外用剤 | |
JP6903411B2 (ja) | 外用組成物 | |
JP7313111B2 (ja) | 皮脂分泌促進剤及び外用組成物 | |
JP2012092067A (ja) | 非ステロイド性消炎鎮痛外用剤 | |
JP5565995B2 (ja) | 鎮痒剤 | |
JP6512599B2 (ja) | 外用医薬組成物 | |
JP2018193319A (ja) | 乳化組成物 | |
JP2020100576A (ja) | 皮膚外用組成物 | |
JP7329910B2 (ja) | 皮膚外用組成物 | |
JP2007262031A (ja) | 知覚過敏型肌掻痒感改善剤 | |
JP7299683B2 (ja) | 皮膚外用組成物 | |
JP7312527B2 (ja) | 乳化組成物 | |
JP7299682B2 (ja) | 皮膚外用組成物 | |
JP6929339B2 (ja) | 外用組成物 | |
WO2015151991A1 (ja) | 外用医薬組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090826 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120424 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120625 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120717 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120807 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5063072 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150817 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |