JP2008069177A - 抗鬱薬投薬形態 - Google Patents
抗鬱薬投薬形態 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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Abstract
【解決手段】使用環境に薬を経口的に送達するための投薬用製剤であって、該投薬用製剤は、(a)少なくとも一部が流体の通路に浸透性の組成物を含む壁であって、(b)区画;(c)ベンラファクシン及び(d)ポリマーと浸透剤を含む区画中の置換物を囲む壁、及び、(e)投薬用製剤から薬組成物を送達するための投薬用製剤中の出口通路を含む、前記投薬用製剤である。
【選択図】なし
Description
描かれている図面では、尺度が記載されていないが、本発明の様々な実施態様を説明するために示されており、描かれている図面は以下の通りである。
図2は、投薬用製剤の構造及び投薬用製剤の中に含有される組成部材を描くための、描かれている図1の投薬用製剤の開かれた図である。;及び、
図3は、投薬用製剤の外表面にコーティングされた構造式の薬の外面での即座の放出を描く、投薬用製剤の図である。
図面の詳細な説明
ところで詳細に図面を参照すると、その描かれている図面は本発明で提供される投薬用製剤の例であり、その例は制限として解釈されるべきではなく、投薬用製剤の1実施例は、描かれている図1に見られる。描かれている図1では、投薬用製剤10は本体部分11からなるのが見られ、その本体部分11は描かれている図1には見られないが、取り囲んで内域を形成する壁部12からなる。投薬用製剤10は、投薬用製剤10の内部と外部をつなぐための少なくとも1つの出口13からなる。
本発明の実施例の詳細な開示
以下の実施例は単なる本発明の例示であり、これらの実施例及びそれらの他の均等物は、本発明の開示、図面及び添付の特許請求の範囲に照らして当該技術に精通した人々に明らかになるであろうから、いかなる方法でもそれらは本発明の範囲を制限するものとして考えられるべきではない
実施例1
治療範囲の薬を行き渡らせるのに適合した投薬用製剤を以下の通りに製造した。:初めに置換層又は押し出し層を、重合度が約3200で置換度が無水グルコース単位当たり0.7カルボキシメチル基である、ナトリウムカルボキシメチルセルロース587.5g、粉末状の塩化ナトリウム300g、分子量が約60000g/molのヒドロキシプロピルセルロース50g、並びに、平均メトキシル含量が29重量%、平均ヒドロキシプロピル含量が10重量%及び平均分子量が約11300g/molのヒドロキシプロピルメチルセルロース50gを混合して、420μmのメッシュ開口を有するステンレス鋼のサイジング篩を通すことによって調製した。次いで、酸化鉄(III)10gを約250μm(0.250mm)の開口を有するサイジング篩を通した。得られた粉末を単一な混合物になるまで遊星形ミキサー中で混合した。得られた混合物を、凝集性の固まりが形成されるまで無水エチルアルコールを攪拌しながら添加することによって、湿潤造粒した。この固まりを約840μm(0.840mm)の開口を有するサイジング篩を通して、コーティングされた置換粒子を形成し、それを周囲温度及び周囲湿度下で一夜乾燥させた。次いで、乾燥した粒子を再度840μm(0.840mm)のサイジング篩を通した。次に、予め180μmの開口を有する篩を通して分粒しておいた、ステアリン酸マグネシウム2.5gをコーティングされた粒子に回転式混合機で混合した。
実施例2
実施例1の手順を、薬組成物がベンラファクシン(venlafaxine)塩酸塩890g、ヒドロキシプロピルセルロース100g、及び、ステアリン酸マグネシウム10gからなる以外は、上記に述べた通りの製造手順で従った。得られた投薬用製剤は、疑似腸内流体中で、0次速度で16時間の長時間に渡ってベンラファクシン(venlafaxine)塩酸塩77mgを放出した。
実施例3
実施例1の手順を、薬組成物がベンラファクシン(venlafaxine)塩酸塩650.0g、平均分子量が約1800g/molで平均重合度が11.1のマルトデキストリン240.0g、ヒドロキシプロピルセルロース80.0g、ポリビニルピロリドン20.0g、及び、ステアリン酸マグネシウム10.0gからなる以外は、上記に記載した通りの全ての製造工程に従った。得られた投薬用製剤を人工の腸内流体中で試験したところ、投薬用製剤は0次速度で15時間に渡ってベンラファクシン(venlafaxine)塩酸塩57mgの投与量を送達した。
実施例4
実施例1の手順を、薬組成物がベンラファクシン(venlafaxine)塩酸塩840.0g、平均分子量が約100000g/molのポリエチレンオキサイド150.0g、及び、ステアリン酸マグネシウム10.0gからなる以外は、これまでに上記に述べた通りの製造で繰り返した。壁重量は約25mgであった。得られた投薬用製剤を疑似腸内流体中で試験したところ、それらは制御された速度で20時間の長時間に渡ってベンラファクシン(venlafaxine)塩酸塩73mgの投与量を放出した。
実施例5
組成物を実施例1と同様に製造した。製造方法は、製造された押し出し層を流動床水性ベースの造粒方法で調製した以外は同様であった。これは、ナトリウムカルボキシメシルセルロース、塩化ナトリウム、ヒドロキシプロピルセルロース及び酸化鉄(III)を420μm(0.420mm)の開口を有する篩を通して分粒することによって成し遂げられた。得られた粉体を流動床の造粒カラム中に詰めて、固形分濃度5%のヒドロキシプロピルメチルセルロースからなるバインダー水溶液をスプレーし、それによって押し出し層のための小粒を形成した。
実施例6
この実施例で従った組成及び方法は、押し出し層が平均分子量約5百万g/molのポリエチレンオキサイド740g、塩化ナトリウム200.0g、平均分子量が約11300g/molのヒドロキシプロピルメチルセルロース、酸化鉄(III)5.0g、及び、ステアリン酸マグネシウム5.0gからなる以外は、実施例1と同様であった。
本発明の実施方法の詳細
本発明の更なる実施態様は、本発明の構造式で含まれる薬をその意図された治療のために送達する方法に関する。1つの実施態様は、長時間に渡って治療的に反応する投薬量で、持続させられた放出及び制御された放出の投薬用製剤から選択される投薬用製剤から薬0.5mg〜750mgからなる投薬用製剤を投与することによって、一般式の薬を送達する方法に関する。本発明の他の実施態様は、本発明に開示された一般式の薬を、この治療を必要とする人間の胃腸系に送達する方法に関するものであり、この方法は以下の工程からなる。:(A)人間の胃腸系に以下からなる投薬用製剤を経口投与する工程:(1)壁を通して投薬用製剤中に外部の水性流体を吸収するための手段からなる非毒性の壁組成物、その壁は以下を囲んでおり、画定している;(2)内部区画;(3)投薬単位量の該薬からなる区画中の一般式の薬からなる薬組成物;(4)区画から薬組成物を押し出すための区画中の押し出し組成物;(5)投薬用製剤から薬を送達するための壁に設けられた少なくとも1つの出口手段;(B)壁を通して区画内に流体を吸収し、それによって組成物を送達し得る投薬用製剤に変えて、付随して押し出し組成物を膨張させて、薬組成物を出口手段を通して投薬用製剤から押し出す工程;及び(C)この治療を必要とする患者に長時間に渡って制御された速度で治療的に効果的な量の治療薬を送達する工程。この方法はまた、即座の抗鬱薬治療を与えるために、即座の放出外層投薬量の薬から患者に投薬量のこの薬を投薬することからなる。
(a)少なくとも一部が流体の通路に浸透性の組成物からなる壁であり、その壁は以下を囲んでおり:
(b)区画;
(c)下記式の薬からなる区画中の薬組成物:
(d)浸透性的に活性な化合物からなる組成物からなる区画中の置換物、及び、
(e)投薬用製剤から薬組成物を送達するための投薬用製剤中の出口通路
からなる、前記投薬用製剤。
(a)少なくとも一部が流体の通路に浸透性の組成物からなる壁であり、その壁は以下を囲んでおり:
(b)区画;
(c)下記式の薬からなる区画中の薬組成物:
(d)浸透性的に活性な化合物からなる組成物からなる区画中の置換物、及び、
(e)投薬用製剤から薬組成物を行き渡らせるための投薬用製剤中の出口通路からなる、前記投薬用製剤。
(a)少なくとも一部が流体の通路に浸透性の組成物からなる壁であり、その壁は以下を囲んでおり:
(b)区画;
(c)下記式の薬からなる区画中の薬組成物:
(d)ポリマーと浸透剤とからなる区画中の置換物、及び、
(e)投薬用製剤から薬組成物を送達するための投薬用製剤中の出口通路からなる、前記投薬用製剤。
11 本体部分
12 壁部
13 出口通路
14 内部の区画
15 薬の層
16 薬
Claims (5)
- 使用環境に薬を経口的に送達するための投薬用製剤であって、該投薬用製剤が以下、:
(a)少なくとも一部が流体の通路に浸透性の組成物からなる壁であり、その壁は以下を囲んでおり:
(b)区画;
(c)下記式の薬からなる区画中の薬組成物:
(式中、点線は不飽和又はシクロアルケニル基からなる群から選ばれる部分を表す。;R1は水素及び炭素原子1〜6のアルキルからなる群から選ばれる部分である。;R2は水素及び炭素原子1〜6のアルキルからなる群から選ばれる部分である。;R4は水素及び炭素原子1〜6のアルキル、ホルミル及び炭素原子2〜7のアルカノイルからなる群から選ばれる部分である。;R5及びR6は独立に、水素、ヒドロキシル、炭素原子1〜6のアルキル、炭素原子1〜6のアルコキシ、炭素原子2〜7のアルカノイロキシ、ニトロ、炭素原子1〜6のアルキルメルカプト、アミノ、炭素原子1〜6のアルキルアミノ、炭素原子2〜7のアルカンアミド、ハロ及びトリフルオロエチルからなる群から選ばれる部分であり、R7は水素及び炭素原子1〜6のアルキルからなる群から選ばれる部分であり、nは整数0〜4である。)、及び、
(d)ポリマーと浸透剤とからなる区画中の置換組成物、並びに、
(e)投薬用製剤から薬組成物を送達するための投薬用製剤の壁にある出口通路からなる、前記投薬用製剤。 - 薬が1−〔2−(ジメチルアミノ)−1−(4−メトキシフェニル)エチル〕シクロヘキサノールである、請求項1に記載の使用環境に薬を経口的に送達するための投薬用製剤。
- 薬組成物がヒドロキシアルキルセルロースを含む請求項1または2に記載の使用環境に薬を経口的に送達するための投薬用製剤。
- ヒドロキシアルキルセルロースがヒドロキシプロピルセルロース及びヒドロキシエチルセルロースから成る群から選択される少なくとも1種である請求項3に記載の使用環境に薬を経口的に送達するための投薬用製剤。
- 1日1回投与用の請求項1から4のいずれかに記載の投薬用製剤。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/068,480 US6440457B1 (en) | 1993-05-27 | 1993-05-27 | Method of administering antidepressant dosage form |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7501005A Division JPH08510755A (ja) | 1993-05-27 | 1994-05-27 | 抗鬱薬投薬形態 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010173633A Division JP2010248259A (ja) | 1993-05-27 | 2010-08-02 | 抗鬱薬投薬形態 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008069177A true JP2008069177A (ja) | 2008-03-27 |
Family
ID=22082852
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7501005A Withdrawn JPH08510755A (ja) | 1993-05-27 | 1994-05-27 | 抗鬱薬投薬形態 |
JP2007301927A Withdrawn JP2008069177A (ja) | 1993-05-27 | 2007-11-21 | 抗鬱薬投薬形態 |
JP2010173633A Withdrawn JP2010248259A (ja) | 1993-05-27 | 2010-08-02 | 抗鬱薬投薬形態 |
JP2011244253A Pending JP2012031208A (ja) | 1993-05-27 | 2011-11-08 | 抗鬱薬投薬形態 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7501005A Withdrawn JPH08510755A (ja) | 1993-05-27 | 1994-05-27 | 抗鬱薬投薬形態 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010173633A Withdrawn JP2010248259A (ja) | 1993-05-27 | 2010-08-02 | 抗鬱薬投薬形態 |
JP2011244253A Pending JP2012031208A (ja) | 1993-05-27 | 2011-11-08 | 抗鬱薬投薬形態 |
Country Status (11)
Country | Link |
---|---|
US (7) | US6440457B1 (ja) |
EP (1) | EP0700289A1 (ja) |
JP (4) | JPH08510755A (ja) |
KR (1) | KR960702303A (ja) |
AU (1) | AU677080B2 (ja) |
CA (1) | CA2157186A1 (ja) |
FI (1) | FI955681A (ja) |
NO (1) | NO954694L (ja) |
NZ (1) | NZ267841A (ja) |
WO (1) | WO1994027589A2 (ja) |
ZA (1) | ZA943743B (ja) |
Families Citing this family (47)
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US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
ATE213407T1 (de) * | 1993-06-28 | 2002-03-15 | American Home Prod | Neue behandlungsmethoden durch verwendung von phenethylderivaten |
EP1331003B1 (en) * | 1996-03-25 | 2015-08-26 | Wyeth LLC | Extended release formulation containing venlafaxine |
US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
PE57198A1 (es) * | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
GB9609094D0 (en) * | 1996-05-01 | 1996-07-03 | Univ Strathclyde | Delivery device |
EP0999830A1 (en) | 1997-07-01 | 2000-05-17 | Pfizer Inc. | Sertraline salts and sustained-release dosage forms of sertraline |
UA77145C2 (en) * | 1997-11-05 | 2006-11-15 | Wyeth Corp | Extended release dosage formulation |
KR100620935B1 (ko) | 1998-03-19 | 2006-09-13 | 브리스톨-마이어스스퀴브컴파니 | 용해도가 높은 약물에 대한 2상 서방성 전달 시스템과 방법 |
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US6572890B2 (en) * | 2000-01-13 | 2003-06-03 | Osmotica Corp. | Osmotic device containing venlafaxine and an anti-psychotic agent |
IL146462A (en) | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
KR20050044673A (ko) | 2001-12-05 | 2005-05-12 | 와이어쓰 | 벤라팍신 하이드로클로라이드의 신규한 결정 다형체 및이의 제조방법 |
WO2003055475A1 (en) * | 2002-01-03 | 2003-07-10 | Lek Pharmaceutical And Chemical Company D.D. | Controlled release pharmaceutical formulation containing venlafaxine |
AU2003229408A1 (en) * | 2002-06-10 | 2003-12-22 | Philippe Kriwin | Oral antidepressant formulation comprising a selective serotonin_reuptake inhibitor |
GB2392385A (en) * | 2002-09-02 | 2004-03-03 | Cipla Ltd | Pharmaceutical preparations comprising a 5HT uptake inhibitor and a homopolymer or copolymer of N-vinyl pyrrolidone |
WO2004047718A2 (en) * | 2002-11-28 | 2004-06-10 | Themis Laboratories Private Limited | Process for manufacturing sustained release microbeads containing venlafaxine hci |
US8293799B2 (en) * | 2003-12-29 | 2012-10-23 | Osmotica Keresleedelmo és Szolgáltató KFT | Osmotic device containing a venlafaxine salt and a salt having an ion in common |
US20070077301A1 (en) * | 2002-12-23 | 2007-04-05 | Meyer Glenn A | Venlafaxine osmotic device formulation |
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1994
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- 1994-05-27 NZ NZ267841A patent/NZ267841A/en unknown
- 1994-05-27 EP EP94919286A patent/EP0700289A1/en not_active Withdrawn
- 1994-05-27 ZA ZA943743A patent/ZA943743B/xx unknown
- 1994-05-27 JP JP7501005A patent/JPH08510755A/ja not_active Withdrawn
- 1994-05-27 AU AU70482/94A patent/AU677080B2/en not_active Ceased
- 1994-05-27 CA CA002157186A patent/CA2157186A1/en not_active Abandoned
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1995
- 1995-11-21 NO NO954694A patent/NO954694L/no unknown
- 1995-11-24 FI FI955681A patent/FI955681A/fi unknown
- 1995-11-27 KR KR1019950705306A patent/KR960702303A/ko not_active Application Discontinuation
-
2003
- 2003-10-28 US US10/696,370 patent/US20040086570A1/en not_active Abandoned
- 2003-10-28 US US10/696,217 patent/US20040092601A1/en not_active Abandoned
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2005
- 2005-12-22 US US11/315,434 patent/US20060099263A1/en not_active Abandoned
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2006
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2007
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2010
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- 2010-08-02 JP JP2010173633A patent/JP2010248259A/ja not_active Withdrawn
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2011
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Also Published As
Publication number | Publication date |
---|---|
EP0700289A1 (en) | 1996-03-13 |
JPH08510755A (ja) | 1996-11-12 |
US20070009600A1 (en) | 2007-01-11 |
CA2157186A1 (en) | 1994-12-08 |
JP2010248259A (ja) | 2010-11-04 |
AU7048294A (en) | 1994-12-20 |
US8084059B2 (en) | 2011-12-27 |
FI955681A0 (fi) | 1995-11-24 |
US20120070496A1 (en) | 2012-03-22 |
US20100260810A1 (en) | 2010-10-14 |
KR960702303A (ko) | 1996-04-27 |
WO1994027589A3 (en) | 1995-01-26 |
US6440457B1 (en) | 2002-08-27 |
NO954694D0 (no) | 1995-11-21 |
NO954694L (no) | 1995-11-24 |
FI955681A (fi) | 1995-11-24 |
JP2012031208A (ja) | 2012-02-16 |
US20060099263A1 (en) | 2006-05-11 |
US20040086570A1 (en) | 2004-05-06 |
US20040092601A1 (en) | 2004-05-13 |
WO1994027589A2 (en) | 1994-12-08 |
ZA943743B (en) | 1995-01-24 |
NZ267841A (en) | 1996-11-26 |
AU677080B2 (en) | 1997-04-10 |
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