JP2008007417A5 - - Google Patents
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- JP2008007417A5 JP2008007417A5 JP2006176355A JP2006176355A JP2008007417A5 JP 2008007417 A5 JP2008007417 A5 JP 2008007417A5 JP 2006176355 A JP2006176355 A JP 2006176355A JP 2006176355 A JP2006176355 A JP 2006176355A JP 2008007417 A5 JP2008007417 A5 JP 2008007417A5
- Authority
- JP
- Japan
- Prior art keywords
- fraction
- eyes
- fatigue
- ethyl acetate
- pdeia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000013399 edible fruits Nutrition 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 21
- 240000007842 Glycine max Species 0.000 claims description 11
- 235000010469 Glycine max Nutrition 0.000 claims description 11
- 240000008536 Vaccinium myrtillus Species 0.000 claims description 8
- 150000003648 triterpenes Chemical class 0.000 claims description 8
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 7
- 235000013824 polyphenols Nutrition 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 235000015725 bilberry Nutrition 0.000 claims description 6
- 240000000249 Morus alba Species 0.000 claims description 5
- 240000001890 Ribes hudsonianum Species 0.000 claims description 5
- 235000016954 Ribes hudsonianum Nutrition 0.000 claims description 5
- 235000001466 Ribes nigrum Nutrition 0.000 claims description 5
- 240000006365 Vitis vinifera Species 0.000 claims description 5
- 241000735234 Ligustrum Species 0.000 claims description 2
- 241001093501 Rutaceae Species 0.000 claims description 2
- 235000021374 legumes Nutrition 0.000 claims description 2
- 241000245165 Rhododendron ponticum Species 0.000 claims 1
- 150000002212 flavone derivatives Chemical class 0.000 claims 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 40
- 239000000727 fraction Substances 0.000 description 36
- 208000003464 Asthenopia Diseases 0.000 description 33
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 101710031992 pRL90232 Proteins 0.000 description 19
- 101710035540 plaa2 Proteins 0.000 description 19
- 210000003205 Muscles Anatomy 0.000 description 18
- 230000001886 ciliary Effects 0.000 description 17
- 230000002401 inhibitory effect Effects 0.000 description 17
- 239000002038 ethyl acetate fraction Substances 0.000 description 16
- 239000000284 extract Substances 0.000 description 14
- 239000003826 tablet Substances 0.000 description 14
- 239000012223 aqueous fraction Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 235000013305 food Nutrition 0.000 description 10
- 238000000622 liquid--liquid extraction Methods 0.000 description 10
- 238000000638 solvent extraction Methods 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 8
- 230000002265 prevention Effects 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- 102000015375 Endothelin-Converting Enzymes Human genes 0.000 description 6
- 108010025223 Endothelin-Converting Enzymes Proteins 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 241000208422 Rhododendron Species 0.000 description 5
- 150000002213 flavones Chemical class 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 206010048653 Enzyme inhibition Diseases 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Tris Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 239000007983 Tris buffer Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 230000002829 reduced Effects 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 241000207199 Citrus Species 0.000 description 3
- WCGUUGGRBIKTOS-RRHGHHQTSA-N Ursolic acid Natural products O=C(O)[C@@]12[C@@H]([C@@H](C)[C@@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@]4(C)[C@H](C(C)(C)[C@@H](O)CC4)CC3)CC=1)CC2 WCGUUGGRBIKTOS-RRHGHHQTSA-N 0.000 description 3
- 235000010208 anthocyanin Nutrition 0.000 description 3
- 239000004410 anthocyanin Substances 0.000 description 3
- 150000004636 anthocyanins Chemical class 0.000 description 3
- 229930002877 anthocyanins Natural products 0.000 description 3
- 235000020971 citrus fruits Nutrition 0.000 description 3
- 229920002770 condensed tannin Polymers 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 102100018545 MYLK Human genes 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L MgCl2 Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 108010074596 Myosin-Light-Chain Kinase Proteins 0.000 description 2
- 229940100243 Oleanolic Acid Drugs 0.000 description 2
- MIJYXULNPSFWEK-LXLHWSNGSA-N Oleanolic acid Natural products C1C[C@H](O)C(C)(C)[C@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@@H]5C4=CC[C@H]3[C@]21C MIJYXULNPSFWEK-LXLHWSNGSA-N 0.000 description 2
- 102000001253 Protein Kinases Human genes 0.000 description 2
- 108060006633 Protein Kinases Proteins 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N Xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 235000021028 berry Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 230000004059 degradation Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 230000000376 effect on fatigue Effects 0.000 description 2
- 239000002857 endothelin converting enzyme inhibitor Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N methylene dichloride Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000001737 promoting Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229940096998 ursolic acid Drugs 0.000 description 2
- -1 ursolic acid glycosides Chemical class 0.000 description 2
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3β-hydroxy-Olean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N Adenosine monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 229940102480 Bilberry extract Drugs 0.000 description 1
- 229940098773 Bovine Serum Albumin Drugs 0.000 description 1
- 108091003117 Bovine Serum Albumin Proteins 0.000 description 1
- 229960001681 Croscarmellose Sodium Drugs 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 229940087603 Grape Seed Extract Drugs 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 1
- MQYXUWHLBZFQQO-CWFQSGEHSA-N Lupenol Natural products C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@H](C(=C)C)[C@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-CWFQSGEHSA-N 0.000 description 1
- MQYXUWHLBZFQQO-QGTGJCAVSA-N Lupeol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-QGTGJCAVSA-N 0.000 description 1
- TZIHFWKZFHZASV-UHFFFAOYSA-N Methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 210000002464 Muscle, Smooth, Vascular Anatomy 0.000 description 1
- XAPRFLSJBSXESP-UHFFFAOYSA-N Oxycinchophen Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=C(O)C=1C1=CC=CC=C1 XAPRFLSJBSXESP-UHFFFAOYSA-N 0.000 description 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 229940073490 Sodium Glutamate Drugs 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229940032147 Starch Drugs 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 235000019209 bilberry extract Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated Effects 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- AANLCWYVVNBGEE-IDIVVRGQSA-L disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 AANLCWYVVNBGEE-IDIVVRGQSA-L 0.000 description 1
- 235000013890 disodium inosinate Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000002919 epithelial cells Anatomy 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- HBFXVTVOSLPOEY-UHFFFAOYSA-N ethoxyethane;2-propan-2-yloxypropane Chemical compound CCOCC.CC(C)OC(C)C HBFXVTVOSLPOEY-UHFFFAOYSA-N 0.000 description 1
- 230000004634 feeding behavior Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavones Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 229930003935 flavonoids Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 235000009754 grape Nutrition 0.000 description 1
- 235000012333 grape Nutrition 0.000 description 1
- 235000002532 grape seed extract Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- NNQSGBRGJHSRFN-UHFFFAOYSA-N isoflavan Chemical class C1OC2=CC=CC=C2CC1C1=CC=CC=C1 NNQSGBRGJHSRFN-UHFFFAOYSA-N 0.000 description 1
- 150000002516 isoflavones Chemical class 0.000 description 1
- 229930012948 isoflavones Natural products 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 230000003340 mental Effects 0.000 description 1
- LPUQAYUQRXPFSQ-UHFFFAOYSA-M monosodium glutamate Chemical compound [Na+].[O-]C(=O)C(N)CCC(O)=O LPUQAYUQRXPFSQ-UHFFFAOYSA-M 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 230000036640 muscle relaxation Effects 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 230000001575 pathological Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000284 resting Effects 0.000 description 1
- 230000036578 sleeping time Effects 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
- 230000002618 waking Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006176355A JP5281234B2 (ja) | 2006-06-27 | 2006-06-27 | 毛様体過緊張による疲れ目の改善・予防のための経口投与組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006176355A JP5281234B2 (ja) | 2006-06-27 | 2006-06-27 | 毛様体過緊張による疲れ目の改善・予防のための経口投与組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008007417A JP2008007417A (ja) | 2008-01-17 |
| JP2008007417A5 true JP2008007417A5 (zh) | 2009-07-30 |
| JP5281234B2 JP5281234B2 (ja) | 2013-09-04 |
Family
ID=39065939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006176355A Expired - Fee Related JP5281234B2 (ja) | 2006-06-27 | 2006-06-27 | 毛様体過緊張による疲れ目の改善・予防のための経口投与組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5281234B2 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5475958B2 (ja) * | 2008-04-01 | 2014-04-16 | 杏林製薬株式会社 | 視機能障害の予防または治療剤 |
| JP5689117B2 (ja) * | 2009-06-12 | 2015-03-25 | ジェネレックス ファーマシューティカルズ インコーポレイテッド | 心不全を防止及び治療するための組成物及び方法 |
| JP5848042B2 (ja) * | 2011-06-29 | 2016-01-27 | 株式会社ロッテ | 眼疲労抑制組成物及びそれを含む飲食品 |
| CA2918111A1 (en) * | 2013-07-14 | 2015-01-22 | Asiros A/S | Novel bioactive alkaloids and alkaloid fractions derivable from ribes species |
| JP6293559B2 (ja) * | 2014-04-02 | 2018-03-14 | 備前化成株式会社 | 眼精疲労及び／又はドライアイの予防及び／又は治療用組成物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61178924A (ja) * | 1985-02-04 | 1986-08-11 | Kesaichi Shibata | 養毛効果を有する健康食品 |
| IT1219732B (it) * | 1988-06-28 | 1990-05-24 | Tecnofarmaci Spa | Frazioni oligomeriche procianidoliche,loro procedimento di preparazione e composizioni farmaceutiche che le contengono |
| JPH0597798A (ja) * | 1991-10-09 | 1993-04-20 | Orion Mach Co Ltd | 血圧降下作用を有する新規物質、血圧降下剤、並びに健康食品及びその製法 |
| IT1255029B (it) * | 1992-05-11 | 1995-10-13 | Paolo Morazzoni | Formulazioni farmaceutiche orali contenenti antocianosidi |
| JP2795812B2 (ja) * | 1994-09-13 | 1998-09-10 | 敷島製パン株式会社 | 抗う蝕性剤の製造方法及び該製造方法により得られる抗う蝕剤 |
| GEP20022709B (en) * | 1997-04-15 | 2002-06-25 | Csir Za | Pharmaceutical Compositions Having Appetite Suppressant Activity |
| JP3510526B2 (ja) * | 1999-05-24 | 2004-03-29 | キッコーマン株式会社 | 抗動脈硬化症食品 |
| KR100547497B1 (ko) * | 1999-07-02 | 2006-02-01 | 메이지 세이까 가부시끼가이샤 | 식품 조성물, 그의 제조법 및 그것을 함유하는 기능성음식품 |
| JP2001178408A (ja) * | 1999-12-22 | 2001-07-03 | Gunze Ltd | 桑実を素材とする機能性食品 |
| JP3310649B2 (ja) * | 2000-03-16 | 2002-08-05 | 株式会社ファンケル | 食品組成物 |
| GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| EP1372412A2 (en) * | 2001-03-09 | 2004-01-02 | Societe Des Produits Nestle S.A. | Composition improving age-related physiological deficits and increasing longevity |
| WO2002078724A1 (en) * | 2001-03-29 | 2002-10-10 | Council Of Scientific And Industrial Research | Biologically active aqueous fraction of an extract obtained from a mangrove plant salvadora persica l. |
| JP4581082B2 (ja) * | 2003-03-31 | 2010-11-17 | 独立行政法人産業技術総合研究所 | 自己免疫増強剤、その製造方法及びそれを用いた化粧料 |
| JP4247833B2 (ja) * | 2004-03-16 | 2009-04-02 | 株式会社ケーツーコミュニケーションズ | 視機能改善剤 |
| JP2005328761A (ja) * | 2004-05-20 | 2005-12-02 | Wakasa Seikatsu:Kk | 健康食品 |
-
2006
- 2006-06-27 JP JP2006176355A patent/JP5281234B2/ja not_active Expired - Fee Related
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