JP2007537243A5 - - Google Patents
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- Publication number
- JP2007537243A5 JP2007537243A5 JP2007512729A JP2007512729A JP2007537243A5 JP 2007537243 A5 JP2007537243 A5 JP 2007537243A5 JP 2007512729 A JP2007512729 A JP 2007512729A JP 2007512729 A JP2007512729 A JP 2007512729A JP 2007537243 A5 JP2007537243 A5 JP 2007537243A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- branched
- group
- linear
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000013256 coordination polymer Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- -1 4- carboxybenzyl Chemical group 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 101710183280 Topoisomerase Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- UIVFUQKYVFCEKJ-OPTOVBNMSA-N gimatecan Chemical compound C1=CC=C2C(\C=N\OC(C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UIVFUQKYVFCEKJ-OPTOVBNMSA-N 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000008904 kidney osteogenic sarcoma Diseases 0.000 claims 1
- 201000000062 kidney sarcoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000242A ITRM20040242A1 (it) | 2004-05-13 | 2004-05-13 | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| PCT/IT2005/000245 WO2005110486A2 (en) | 2004-05-13 | 2005-04-28 | 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007537243A JP2007537243A (ja) | 2007-12-20 |
| JP2007537243A5 true JP2007537243A5 (enExample) | 2008-06-26 |
Family
ID=35124315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007512729A Withdrawn JP2007537243A (ja) | 2004-05-13 | 2005-04-28 | ２０位にてインテグリンアンタゴニストと接合した７−ｔ−ブトキシイミノメチルカンプトテシン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7589099B2 (enExample) |
| EP (1) | EP1747020A2 (enExample) |
| JP (1) | JP2007537243A (enExample) |
| CN (1) | CN101065150A (enExample) |
| AR (1) | AR049337A1 (enExample) |
| AU (1) | AU2005243883A1 (enExample) |
| BR (1) | BRPI0511077A (enExample) |
| CA (1) | CA2562569A1 (enExample) |
| IT (1) | ITRM20040242A1 (enExample) |
| MX (1) | MXPA06012885A (enExample) |
| TW (1) | TW200538123A (enExample) |
| WO (1) | WO2005110486A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040239A1 (it) * | 2004-05-13 | 2004-08-13 | Sigma Tau Ind Farmaceuti | Derivati ciclopeptidici ad attivita' antintegrine. |
| WO2011086553A1 (en) * | 2010-01-13 | 2011-07-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Cyclic peptides, compositions comprising them and uses thereof as nucleases of nucleotidic macromolecules |
| CN103275094B (zh) * | 2013-05-08 | 2015-07-08 | 中国农业科学院植物保护研究所 | (20s)-喜树碱的衍生物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19815812A1 (de) * | 1998-04-08 | 1999-10-14 | Bayer Ag | Modifizierte Cytostatika |
| ATE216998T1 (de) * | 1999-03-09 | 2002-05-15 | Sigma Tau Ind Farmaceuti | Camptothecin-derivate mit antitumor-wirkung |
| ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
-
2004
- 2004-05-13 IT IT000242A patent/ITRM20040242A1/it unknown
-
2005
- 2005-04-28 JP JP2007512729A patent/JP2007537243A/ja not_active Withdrawn
- 2005-04-28 CA CA002562569A patent/CA2562569A1/en not_active Abandoned
- 2005-04-28 CN CNA2005800152130A patent/CN101065150A/zh active Pending
- 2005-04-28 MX MXPA06012885A patent/MXPA06012885A/es not_active Application Discontinuation
- 2005-04-28 BR BRPI0511077-7A patent/BRPI0511077A/pt not_active IP Right Cessation
- 2005-04-28 WO PCT/IT2005/000245 patent/WO2005110486A2/en not_active Ceased
- 2005-04-28 US US11/596,016 patent/US7589099B2/en not_active Expired - Fee Related
- 2005-04-28 AU AU2005243883A patent/AU2005243883A1/en not_active Abandoned
- 2005-04-28 EP EP05743414A patent/EP1747020A2/en not_active Withdrawn
- 2005-05-04 TW TW094114400A patent/TW200538123A/zh unknown
- 2005-05-12 AR ARP050101934A patent/AR049337A1/es not_active Application Discontinuation
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