BRPI0511077A - 7-t-butoximinometilcamptotecina conjugada na posição 20 com antagonistas de integrina - Google Patents
7-t-butoximinometilcamptotecina conjugada na posição 20 com antagonistas de integrinaInfo
- Publication number
- BRPI0511077A BRPI0511077A BRPI0511077-7A BRPI0511077A BRPI0511077A BR PI0511077 A BRPI0511077 A BR PI0511077A BR PI0511077 A BRPI0511077 A BR PI0511077A BR PI0511077 A BRPI0511077 A BR PI0511077A
- Authority
- BR
- Brazil
- Prior art keywords
- butoxyiminomethylcamptothecin
- conjugated
- integrin antagonists
- compounds
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- UIVFUQKYVFCEKJ-OPTOVBNMSA-N gimatecan Chemical compound C1=CC=C2C(\C=N\OC(C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UIVFUQKYVFCEKJ-OPTOVBNMSA-N 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000242A ITRM20040242A1 (it) | 2004-05-13 | 2004-05-13 | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| PCT/IT2005/000245 WO2005110486A2 (en) | 2004-05-13 | 2005-04-28 | 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511077A true BRPI0511077A (pt) | 2007-12-26 |
Family
ID=35124315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511077-7A BRPI0511077A (pt) | 2004-05-13 | 2005-04-28 | 7-t-butoximinometilcamptotecina conjugada na posição 20 com antagonistas de integrina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7589099B2 (enExample) |
| EP (1) | EP1747020A2 (enExample) |
| JP (1) | JP2007537243A (enExample) |
| CN (1) | CN101065150A (enExample) |
| AR (1) | AR049337A1 (enExample) |
| AU (1) | AU2005243883A1 (enExample) |
| BR (1) | BRPI0511077A (enExample) |
| CA (1) | CA2562569A1 (enExample) |
| IT (1) | ITRM20040242A1 (enExample) |
| MX (1) | MXPA06012885A (enExample) |
| TW (1) | TW200538123A (enExample) |
| WO (1) | WO2005110486A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040239A1 (it) * | 2004-05-13 | 2004-08-13 | Sigma Tau Ind Farmaceuti | Derivati ciclopeptidici ad attivita' antintegrine. |
| WO2011086553A1 (en) * | 2010-01-13 | 2011-07-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Cyclic peptides, compositions comprising them and uses thereof as nucleases of nucleotidic macromolecules |
| CN103275094B (zh) * | 2013-05-08 | 2015-07-08 | 中国农业科学院植物保护研究所 | (20s)-喜树碱的衍生物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19815812A1 (de) * | 1998-04-08 | 1999-10-14 | Bayer Ag | Modifizierte Cytostatika |
| ATE216998T1 (de) * | 1999-03-09 | 2002-05-15 | Sigma Tau Ind Farmaceuti | Camptothecin-derivate mit antitumor-wirkung |
| ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
-
2004
- 2004-05-13 IT IT000242A patent/ITRM20040242A1/it unknown
-
2005
- 2005-04-28 JP JP2007512729A patent/JP2007537243A/ja not_active Withdrawn
- 2005-04-28 CA CA002562569A patent/CA2562569A1/en not_active Abandoned
- 2005-04-28 CN CNA2005800152130A patent/CN101065150A/zh active Pending
- 2005-04-28 MX MXPA06012885A patent/MXPA06012885A/es not_active Application Discontinuation
- 2005-04-28 BR BRPI0511077-7A patent/BRPI0511077A/pt not_active IP Right Cessation
- 2005-04-28 WO PCT/IT2005/000245 patent/WO2005110486A2/en not_active Ceased
- 2005-04-28 US US11/596,016 patent/US7589099B2/en not_active Expired - Fee Related
- 2005-04-28 AU AU2005243883A patent/AU2005243883A1/en not_active Abandoned
- 2005-04-28 EP EP05743414A patent/EP1747020A2/en not_active Withdrawn
- 2005-05-04 TW TW094114400A patent/TW200538123A/zh unknown
- 2005-05-12 AR ARP050101934A patent/AR049337A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06012885A (es) | 2007-08-14 |
| US7589099B2 (en) | 2009-09-15 |
| CA2562569A1 (en) | 2005-11-24 |
| TW200538123A (en) | 2005-12-01 |
| AU2005243883A1 (en) | 2005-11-24 |
| WO2005110486A2 (en) | 2005-11-24 |
| ITRM20040242A1 (it) | 2004-08-13 |
| US20070225311A1 (en) | 2007-09-27 |
| CN101065150A (zh) | 2007-10-31 |
| AR049337A1 (es) | 2006-07-19 |
| WO2005110486A3 (en) | 2007-03-08 |
| EP1747020A2 (en) | 2007-01-31 |
| JP2007537243A (ja) | 2007-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/64 (2017.01), A61P 35/00 (2006.01), A61P 3 |