AU2005243883A1 - 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists - Google Patents

7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists Download PDF

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Publication number
AU2005243883A1
AU2005243883A1 AU2005243883A AU2005243883A AU2005243883A1 AU 2005243883 A1 AU2005243883 A1 AU 2005243883A1 AU 2005243883 A AU2005243883 A AU 2005243883A AU 2005243883 A AU2005243883 A AU 2005243883A AU 2005243883 A1 AU2005243883 A1 AU 2005243883A1
Authority
AU
Australia
Prior art keywords
group
phe
branched
carcinoma
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2005243883A
Other languages
English (en)
Inventor
Domenico Alloatti
Alma Dal Pozzo
Sabrina Dallavalle
Giuseppe Giannini
Lucio Merlini
Ming Hong Ni
Sergio Penco
Claudio Pisano
Maria Ornella Tinti
Loredana Vesci
Franco Zunino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of AU2005243883A1 publication Critical patent/AU2005243883A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2005243883A 2004-05-13 2005-04-28 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists Abandoned AU2005243883A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM2004A000242 2004-05-13
IT000242A ITRM20040242A1 (it) 2004-05-13 2004-05-13 "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
PCT/IT2005/000245 WO2005110486A2 (en) 2004-05-13 2005-04-28 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists

Publications (1)

Publication Number Publication Date
AU2005243883A1 true AU2005243883A1 (en) 2005-11-24

Family

ID=35124315

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005243883A Abandoned AU2005243883A1 (en) 2004-05-13 2005-04-28 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists

Country Status (12)

Country Link
US (1) US7589099B2 (enExample)
EP (1) EP1747020A2 (enExample)
JP (1) JP2007537243A (enExample)
CN (1) CN101065150A (enExample)
AR (1) AR049337A1 (enExample)
AU (1) AU2005243883A1 (enExample)
BR (1) BRPI0511077A (enExample)
CA (1) CA2562569A1 (enExample)
IT (1) ITRM20040242A1 (enExample)
MX (1) MXPA06012885A (enExample)
TW (1) TW200538123A (enExample)
WO (1) WO2005110486A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040239A1 (it) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti Derivati ciclopeptidici ad attivita' antintegrine.
WO2011086553A1 (en) * 2010-01-13 2011-07-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Cyclic peptides, compositions comprising them and uses thereof as nucleases of nucleotidic macromolecules
CN103275094B (zh) * 2013-05-08 2015-07-08 中国农业科学院植物保护研究所 (20s)-喜树碱的衍生物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.

Also Published As

Publication number Publication date
MXPA06012885A (es) 2007-08-14
US7589099B2 (en) 2009-09-15
CA2562569A1 (en) 2005-11-24
TW200538123A (en) 2005-12-01
WO2005110486A2 (en) 2005-11-24
ITRM20040242A1 (it) 2004-08-13
US20070225311A1 (en) 2007-09-27
BRPI0511077A (pt) 2007-12-26
CN101065150A (zh) 2007-10-31
AR049337A1 (es) 2006-07-19
WO2005110486A3 (en) 2007-03-08
EP1747020A2 (en) 2007-01-31
JP2007537243A (ja) 2007-12-20

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application