CN101065150A - 在20位与整联蛋白拮抗剂缀合的7－叔丁氧基亚氨基甲基喜树碱 - Google Patents

在20位与整联蛋白拮抗剂缀合的7－叔丁氧基亚氨基甲基喜树碱 Download PDF

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Publication number
CN101065150A
CN101065150A CNA2005800152130A CN200580015213A CN101065150A CN 101065150 A CN101065150 A CN 101065150A CN A2005800152130 A CNA2005800152130 A CN A2005800152130A CN 200580015213 A CN200580015213 A CN 200580015213A CN 101065150 A CN101065150 A CN 101065150A
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CN
China
Prior art keywords
group
phe
branched
chemical compound
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800152130A
Other languages
English (en)
Chinese (zh)
Inventor
A·达尔波佐
S·潘克
L·莫里尼
G·加尼尼
M·O·廷蒂
C·皮萨诺
F·祖尼诺
D·阿洛阿蒂
L·维西
S·德拉瓦勒
倪明红
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of CN101065150A publication Critical patent/CN101065150A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2005800152130A 2004-05-13 2005-04-28 在20位与整联蛋白拮抗剂缀合的7－叔丁氧基亚氨基甲基喜树碱 Pending CN101065150A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2004A000242 2004-05-13
IT000242A ITRM20040242A1 (it) 2004-05-13 2004-05-13 "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.

Publications (1)

Publication Number Publication Date
CN101065150A true CN101065150A (zh) 2007-10-31

Family

ID=35124315

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800152130A Pending CN101065150A (zh) 2004-05-13 2005-04-28 在20位与整联蛋白拮抗剂缀合的7－叔丁氧基亚氨基甲基喜树碱

Country Status (12)

Country Link
US (1) US7589099B2 (enExample)
EP (1) EP1747020A2 (enExample)
JP (1) JP2007537243A (enExample)
CN (1) CN101065150A (enExample)
AR (1) AR049337A1 (enExample)
AU (1) AU2005243883A1 (enExample)
BR (1) BRPI0511077A (enExample)
CA (1) CA2562569A1 (enExample)
IT (1) ITRM20040242A1 (enExample)
MX (1) MXPA06012885A (enExample)
TW (1) TW200538123A (enExample)
WO (1) WO2005110486A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040239A1 (it) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti Derivati ciclopeptidici ad attivita' antintegrine.
WO2011086553A1 (en) * 2010-01-13 2011-07-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Cyclic peptides, compositions comprising them and uses thereof as nucleases of nucleotidic macromolecules
CN103275094B (zh) * 2013-05-08 2015-07-08 中国农业科学院植物保护研究所 (20s)-喜树碱的衍生物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.

Also Published As

Publication number Publication date
WO2005110486A3 (en) 2007-03-08
US7589099B2 (en) 2009-09-15
WO2005110486A2 (en) 2005-11-24
BRPI0511077A (pt) 2007-12-26
EP1747020A2 (en) 2007-01-31
AU2005243883A1 (en) 2005-11-24
AR049337A1 (es) 2006-07-19
ITRM20040242A1 (it) 2004-08-13
TW200538123A (en) 2005-12-01
US20070225311A1 (en) 2007-09-27
CA2562569A1 (en) 2005-11-24
JP2007537243A (ja) 2007-12-20
MXPA06012885A (es) 2007-08-14

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