JP2007537244A5 - - Google Patents
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- Publication number
- JP2007537244A5 JP2007537244A5 JP2007512735A JP2007512735A JP2007537244A5 JP 2007537244 A5 JP2007537244 A5 JP 2007537244A5 JP 2007512735 A JP2007512735 A JP 2007512735A JP 2007512735 A JP2007512735 A JP 2007512735A JP 2007537244 A5 JP2007537244 A5 JP 2007537244A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- branched
- linear
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000013256 coordination polymer Substances 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- -1 4- carboxybenzyl Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 101710183280 Topoisomerase Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000241A ITRM20040241A1 (it) | 2004-05-13 | 2004-05-13 | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
| PCT/IT2005/000261 WO2005110487A2 (en) | 2004-05-13 | 2005-05-04 | Camptothecin derivatives conjugated in position 20 with integrin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007537244A JP2007537244A (ja) | 2007-12-20 |
| JP2007537244A5 true JP2007537244A5 (enExample) | 2008-06-26 |
Family
ID=35124307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007512735A Withdrawn JP2007537244A (ja) | 2004-05-13 | 2005-05-04 | ２０位にてインテグリンアンタゴニストと接合したカンプトテシン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070232639A1 (enExample) |
| EP (1) | EP1747019A2 (enExample) |
| JP (1) | JP2007537244A (enExample) |
| CN (1) | CN101010103A (enExample) |
| AR (1) | AR049275A1 (enExample) |
| AU (1) | AU2005243834A1 (enExample) |
| BR (1) | BRPI0511037A (enExample) |
| CA (1) | CA2562572A1 (enExample) |
| IT (1) | ITRM20040241A1 (enExample) |
| MX (1) | MXPA06012886A (enExample) |
| TW (1) | TW200538125A (enExample) |
| WO (1) | WO2005110487A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2606911A1 (en) * | 2007-02-16 | 2013-06-26 | KTB Tumorforschungsgesellschaft mbH | Receptor And Antigen Targeted Prodrug |
| MX2014008373A (es) * | 2012-01-27 | 2014-09-26 | Hoffmann La Roche | Conjugados antagonistas de integrina para suministro dirigido a celulas que expresan alfa-v-beta-3. |
| CN105399757A (zh) * | 2015-12-29 | 2016-03-16 | 遵义医学院 | 酸敏感型喜树碱-20位去甲斑蝥酸酯衍生物及其抗肿瘤应用 |
| CN111068068A (zh) * | 2019-12-04 | 2020-04-28 | 云南民族大学 | 一种rgd多肽-喜树碱多肽药物偶联物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19815812A1 (de) * | 1998-04-08 | 1999-10-14 | Bayer Ag | Modifizierte Cytostatika |
| ATE216998T1 (de) * | 1999-03-09 | 2002-05-15 | Sigma Tau Ind Farmaceuti | Camptothecin-derivate mit antitumor-wirkung |
| US6207832B1 (en) * | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| HUP0203899A3 (en) * | 1999-09-08 | 2004-09-28 | Bayer Ag | Conjugates containing alphavbetha3 or alphavbetha5 integrin antagonist and cytostatic, process for their preparation and pharmaceutical compositions containing the same |
-
2004
- 2004-05-13 IT IT000241A patent/ITRM20040241A1/it unknown
-
2005
- 2005-05-04 BR BRPI0511037-8A patent/BRPI0511037A/pt not_active IP Right Cessation
- 2005-05-04 EP EP05743015A patent/EP1747019A2/en not_active Withdrawn
- 2005-05-04 TW TW094114403A patent/TW200538125A/zh unknown
- 2005-05-04 WO PCT/IT2005/000261 patent/WO2005110487A2/en not_active Ceased
- 2005-05-04 CN CNA2005800152323A patent/CN101010103A/zh active Pending
- 2005-05-04 CA CA002562572A patent/CA2562572A1/en not_active Abandoned
- 2005-05-04 JP JP2007512735A patent/JP2007537244A/ja not_active Withdrawn
- 2005-05-04 MX MXPA06012886A patent/MXPA06012886A/es not_active Application Discontinuation
- 2005-05-04 US US11/596,189 patent/US20070232639A1/en not_active Abandoned
- 2005-05-04 AU AU2005243834A patent/AU2005243834A1/en not_active Abandoned
- 2005-05-12 AR ARP050101933A patent/AR049275A1/es unknown
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