JP2007536371A5 - - Google Patents
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- Publication number
- JP2007536371A5 JP2007536371A5 JP2007512549A JP2007512549A JP2007536371A5 JP 2007536371 A5 JP2007536371 A5 JP 2007536371A5 JP 2007512549 A JP2007512549 A JP 2007512549A JP 2007512549 A JP2007512549 A JP 2007512549A JP 2007536371 A5 JP2007536371 A5 JP 2007536371A5
- Authority
- JP
- Japan
- Prior art keywords
- ethoxy
- dihydro
- oxo
- propionyl
- quinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 3- {4- [3- (3-Ethoxycarbonyl-1-ethyl-4-oxo-1,4-dihydro-quinolin-6-yl) -prop-2-ynyl] -piperazine- 1-yl} -propionyl Chemical group 0.000 claims 65
- 125000000217 alkyl group Chemical group 0.000 claims 38
- 229960004099 azithromycin Drugs 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 229960002626 clarithromycin Drugs 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 229960003276 erythromycin Drugs 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 3
- 229930006677 Erythromycin A Natural products 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229960005224 roxithromycin Drugs 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
- 0 C[C@@](*1)C(C)(C)OC1=O Chemical compound C[C@@](*1)C(C)(C)OC1=O 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56940204P | 2004-05-06 | 2004-05-06 | |
| US58111804P | 2004-06-18 | 2004-06-18 | |
| PCT/IB2005/001186 WO2005108412A1 (en) | 2004-05-06 | 2005-05-02 | Ester linked macrolides useful for the treatment of microbial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007536371A JP2007536371A (ja) | 2007-12-13 |
| JP2007536371A5 true JP2007536371A5 (https=) | 2008-06-19 |
Family
ID=34967616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007512549A Withdrawn JP2007536371A (ja) | 2004-05-06 | 2005-05-02 | 微生物感染症の治療に有用なエステル結合マクロライド |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080255060A1 (https=) |
| EP (1) | EP1756135B1 (https=) |
| JP (1) | JP2007536371A (https=) |
| AR (1) | AR049269A1 (https=) |
| AT (1) | ATE439367T1 (https=) |
| AU (1) | AU2005240849B2 (https=) |
| BR (1) | BRPI0510328A (https=) |
| CA (1) | CA2566085A1 (https=) |
| DE (1) | DE602005015963D1 (https=) |
| ES (1) | ES2331739T3 (https=) |
| IL (1) | IL178876A0 (https=) |
| MA (1) | MA28640B1 (https=) |
| MX (1) | MXPA06012923A (https=) |
| NO (1) | NO20065662L (https=) |
| RU (1) | RU2006143051A (https=) |
| WO (1) | WO2005108412A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2552682T3 (es) | 2003-03-10 | 2015-12-01 | Merck Sharp & Dohme Corp. | Agentes antibacterianos novedosos |
| JP2008540503A (ja) | 2005-05-10 | 2008-11-20 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 細菌感染症の処置に有用なエーテル結合マクロライド |
| KR101120483B1 (ko) * | 2006-12-05 | 2012-02-29 | 브리스톨-마이어즈 스퀴브 컴페니 | 모틸라이드 다형체 |
| CN105732745A (zh) | 2007-10-25 | 2016-07-06 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
| AU2009308182B2 (en) | 2008-10-24 | 2016-05-19 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| CN105198944B (zh) | 2010-05-20 | 2018-06-01 | 森普拉制药公司 | 制备大环内酯和酮内酯及其中间体的方法 |
| EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES |
| MX2014011537A (es) | 2012-03-27 | 2015-02-10 | Cempra Pharmaceuticals Inc | Formulaciones parenterales para la administracion de antibioticos macrolidos. |
| HK1217665A1 (zh) | 2013-03-14 | 2017-01-20 | 森普拉制药公司 | 用於治療呼吸道疾病的方法及其製劑 |
| RU2015138797A (ru) | 2013-03-15 | 2017-04-24 | Семпра Фармасьютикалс, Инк. | Конвергентные способы получения макролидных антибактериальных агентов |
| GB201608236D0 (en) | 2016-05-11 | 2016-06-22 | Fidelta D O O | Seco macrolide compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0127349D0 (en) * | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| GB0225384D0 (en) * | 2002-10-31 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| GB0310984D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| SI1628989T1 (sl) * | 2003-05-13 | 2007-06-30 | Glaxo Group Ltd | Nove cikliäśne spojine s 14 in 15 obroäśnimi äśleni |
| GB0310979D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| JP2008540503A (ja) * | 2005-05-10 | 2008-11-20 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 細菌感染症の処置に有用なエーテル結合マクロライド |
-
2005
- 2005-05-02 BR BRPI0510328-2A patent/BRPI0510328A/pt not_active IP Right Cessation
- 2005-05-02 ES ES05739739T patent/ES2331739T3/es not_active Expired - Lifetime
- 2005-05-02 WO PCT/IB2005/001186 patent/WO2005108412A1/en not_active Ceased
- 2005-05-02 AU AU2005240849A patent/AU2005240849B2/en not_active Ceased
- 2005-05-02 AT AT05739739T patent/ATE439367T1/de not_active IP Right Cessation
- 2005-05-02 CA CA002566085A patent/CA2566085A1/en not_active Abandoned
- 2005-05-02 MX MXPA06012923A patent/MXPA06012923A/es unknown
- 2005-05-02 EP EP05739739A patent/EP1756135B1/en not_active Expired - Lifetime
- 2005-05-02 US US11/568,562 patent/US20080255060A1/en not_active Abandoned
- 2005-05-02 RU RU2006143051/04A patent/RU2006143051A/ru not_active Application Discontinuation
- 2005-05-02 JP JP2007512549A patent/JP2007536371A/ja not_active Withdrawn
- 2005-05-02 DE DE602005015963T patent/DE602005015963D1/de not_active Expired - Lifetime
- 2005-05-04 AR ARP050101810A patent/AR049269A1/es not_active Application Discontinuation
-
2006
- 2006-10-26 IL IL178876A patent/IL178876A0/en unknown
- 2006-12-01 MA MA29498A patent/MA28640B1/fr unknown
- 2006-12-06 NO NO20065662A patent/NO20065662L/no not_active Application Discontinuation
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