JP2007536371A - 微生物感染症の治療に有用なエステル結合マクロライド - Google Patents

Info

Publication number

JP2007536371A

JP2007536371A JP2007512549A JP2007512549A JP2007536371A JP 2007536371 A JP2007536371 A JP 2007536371A JP 2007512549 A JP2007512549 A JP 2007512549A JP 2007512549 A JP2007512549 A JP 2007512549A JP 2007536371 A JP2007536371 A JP 2007536371A

Authority

JP

Japan

Prior art keywords

ethoxy

oxo

dihydro

propionyl

quinolin

Prior art date

2004-05-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 208000015181 infectious disease Diseases 0.000 title claims abstract description 9
• 230000000813 microbial effect Effects 0.000 title claims abstract description 8
• 239000003120 macrolide antibiotic agent Substances 0.000 title abstract description 10
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• 238000000034 method Methods 0.000 claims abstract description 149
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• 150000001875 compounds Chemical class 0.000 claims description 291
• -1 3- {4- [3- (3-Ethoxycarbonyl-1-ethyl-4-oxo-1,4-dihydro-quinolin-6-yl) -prop-2-ynyl] -piperazine- 1-yl} -propionyl Chemical group 0.000 claims description 268
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• 239000001257 hydrogen Substances 0.000 claims description 60
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 36
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 36
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• 125000003118 aryl group Chemical group 0.000 claims description 22
• 150000002431 hydrogen Chemical class 0.000 claims description 18
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 18
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
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• 125000004001 thioalkyl group Chemical group 0.000 claims description 2
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• 239000002904 solvent Substances 0.000 description 43
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