JP2006528947A5 - - Google Patents
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- Publication number
- JP2006528947A5 JP2006528947A5 JP2006529793A JP2006529793A JP2006528947A5 JP 2006528947 A5 JP2006528947 A5 JP 2006528947A5 JP 2006529793 A JP2006529793 A JP 2006529793A JP 2006529793 A JP2006529793 A JP 2006529793A JP 2006528947 A5 JP2006528947 A5 JP 2006528947A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- hydrogen
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 59
- 229910052739 hydrogen Inorganic materials 0.000 claims 39
- 239000001257 hydrogen Substances 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 28
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000000623 heterocyclic group Chemical group 0.000 claims 19
- -1 cyano, phenyl Chemical group 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 229960004099 azithromycin Drugs 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 5
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 5
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 150000001540 azides Chemical class 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 229960002626 clarithromycin Drugs 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229960003276 erythromycin Drugs 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0310984.0A GB0310984D0 (en) | 2003-05-13 | 2003-05-13 | Novel compounds |
| PCT/EP2004/005081 WO2004101585A1 (en) | 2003-05-13 | 2004-05-11 | Macrolides substituded at the 4'-position |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528947A JP2006528947A (ja) | 2006-12-28 |
| JP2006528947A5 true JP2006528947A5 (https=) | 2007-06-28 |
Family
ID=9957982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006529793A Pending JP2006528947A (ja) | 2003-05-13 | 2004-05-11 | ４”−置換マクロライド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070213283A1 (https=) |
| EP (1) | EP1625137A1 (https=) |
| JP (1) | JP2006528947A (https=) |
| CN (1) | CN1820017A (https=) |
| AR (1) | AR044308A1 (https=) |
| CA (1) | CA2525449A1 (https=) |
| CL (1) | CL2004001007A1 (https=) |
| GB (1) | GB0310984D0 (https=) |
| WO (1) | WO2004101585A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0510328A (pt) * | 2004-05-06 | 2007-10-23 | Glaxosmithkline Zagreb | macrolìdeos ligados a éster úteis para o tratamento de infecções microbianas |
| GB0424961D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| GB0424958D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| JP2008540503A (ja) | 2005-05-10 | 2008-11-20 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 細菌感染症の処置に有用なエーテル結合マクロライド |
| WO2009007988A1 (en) * | 2007-07-11 | 2009-01-15 | Alembic Limited | Process for the preparation of 6-o-methylerythromycin a 9-oxime |
| GB201520419D0 (en) * | 2015-11-19 | 2016-01-06 | Epi Endo Pharmaceuticals Ehf | Compounds |
| AU2020259997B2 (en) * | 2019-04-18 | 2025-08-07 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180654A (en) * | 1978-01-03 | 1979-12-25 | Pfizer Inc. | 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate |
| US4512982A (en) * | 1984-04-13 | 1985-04-23 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method |
| US4686207A (en) * | 1985-11-12 | 1987-08-11 | Abbott Laboratories | Erythromycin A 11,12-carbonates and method of use |
| WO1990011288A1 (en) * | 1989-03-28 | 1990-10-04 | Abbott Laboratories | Erythromycin derivatives |
| AU3710695A (en) * | 1995-04-27 | 1996-11-18 | Laboratorios Aranda, S.A. De C.V. | Quinolonylcarboxyerythromycin derivatives and pharmaceutical compositions containing them |
| JP2002502366A (ja) * | 1996-05-07 | 2002-01-22 | アボット・ラボラトリーズ | ３―デスクラジノース―２，３―無水エリスロマイシン誘導体 |
| EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
| GB0025688D0 (en) * | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
| JP4311203B2 (ja) * | 2001-08-08 | 2009-08-12 | 大正製薬株式会社 | １１ａ−アザライド化合物及びその製造方法 |
| GB0127349D0 (en) * | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| GB0225384D0 (en) * | 2002-10-31 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
-
2003
- 2003-05-13 GB GBGB0310984.0A patent/GB0310984D0/en not_active Ceased
-
2004
- 2004-05-11 CN CNA2004800196558A patent/CN1820017A/zh active Pending
- 2004-05-11 US US10/556,381 patent/US20070213283A1/en not_active Abandoned
- 2004-05-11 CL CL200401007A patent/CL2004001007A1/es unknown
- 2004-05-11 JP JP2006529793A patent/JP2006528947A/ja active Pending
- 2004-05-11 CA CA002525449A patent/CA2525449A1/en not_active Abandoned
- 2004-05-11 AR ARP040101613A patent/AR044308A1/es not_active Application Discontinuation
- 2004-05-11 EP EP04732089A patent/EP1625137A1/en not_active Withdrawn
- 2004-05-11 WO PCT/EP2004/005081 patent/WO2004101585A1/en not_active Ceased
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