JP2007536240A5 - - Google Patents
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- Publication number
- JP2007536240A5 JP2007536240A5 JP2007511484A JP2007511484A JP2007536240A5 JP 2007536240 A5 JP2007536240 A5 JP 2007536240A5 JP 2007511484 A JP2007511484 A JP 2007511484A JP 2007511484 A JP2007511484 A JP 2007511484A JP 2007536240 A5 JP2007536240 A5 JP 2007536240A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alkyl
- aryl
- heterocycloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 55
- 125000000217 alkyl group Chemical group 0.000 claims 45
- 125000003118 aryl group Chemical group 0.000 claims 33
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 29
- 125000000753 cycloalkyl group Chemical group 0.000 claims 27
- 241000711573 Coronaviridae Species 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 241000315672 SARS coronavirus Species 0.000 claims 6
- 208000001528 Coronaviridae Infections Diseases 0.000 claims 5
- 229940125782 compound 2 Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 241000725303 Human immunodeficiency virus Species 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 241000713800 Feline immunodeficiency virus Species 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 101900225426 Feline immunodeficiency virus Protease Proteins 0.000 claims 1
- 229940125810 compound 20 Drugs 0.000 claims 1
- JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 0 CC*C(*)(C(*)(*)C(*)(*)NC(*)=O)C(*)(*)NC(C(*)(*)NC(*)=O)=O Chemical compound CC*C(*)(C(*)(*)C(*)(*)NC(*)=O)C(*)(*)NC(C(*)(*)NC(*)=O)=O 0.000 description 9
- RPPKGGKXORNOHP-QXCLCYAZSA-N CC(C)(C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(/C=C/C(C=C1)=CCC1OC)=O Chemical compound CC(C)(C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(/C=C/C(C=C1)=CCC1OC)=O RPPKGGKXORNOHP-QXCLCYAZSA-N 0.000 description 1
- OPSAIBJIKRLERT-NIHKGPPOSA-N CC(C)C(C1)[C@@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(CSc1ncccc1)=O Chemical compound CC(C)C(C1)[C@@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(CSc1ncccc1)=O OPSAIBJIKRLERT-NIHKGPPOSA-N 0.000 description 1
- QSHAKYBQPNPOMV-PZZSAPDUSA-N CC(C)[C@@H](C1)C1(C(CCCC(C)[C@@H](Cc1ccccc1)[C@H](C[C@H](Cc1ccccc1)NC(COc1c(C)cccc1C)=O)O)=O)NC(c1ccc(C(F)(F)F)cc1)=O Chemical compound CC(C)[C@@H](C1)C1(C(CCCC(C)[C@@H](Cc1ccccc1)[C@H](C[C@H](Cc1ccccc1)NC(COc1c(C)cccc1C)=O)O)=O)NC(c1ccc(C(F)(F)F)cc1)=O QSHAKYBQPNPOMV-PZZSAPDUSA-N 0.000 description 1
- KJAGBIDBURADDL-MRLUAOGESA-N CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2=C(C)CCC=C2C)=O)CC1)=O)NC(CCNC(OC(C)(C)C)=O)O Chemical compound CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2=C(C)CCC=C2C)=O)CC1)=O)NC(CCNC(OC(C)(C)C)=O)O KJAGBIDBURADDL-MRLUAOGESA-N 0.000 description 1
- TXXBJSQQOGOAOJ-AFUXAMQGSA-N CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2C(C)=CC=CC2C)=O)CC1)=O)NC(C1=CC2C=CC=CC2N1)=O Chemical compound CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2C(C)=CC=CC2C)=O)CC1)=O)NC(C1=CC2C=CC=CC2N1)=O TXXBJSQQOGOAOJ-AFUXAMQGSA-N 0.000 description 1
- UXTIVPMTVLXBMR-KPEXPGEQSA-N CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(COc1cc2ccccc2cc1)=O Chemical compound CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(COc1cc2ccccc2cc1)=O UXTIVPMTVLXBMR-KPEXPGEQSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56808004P | 2004-05-04 | 2004-05-04 | |
| PCT/US2005/015227 WO2006073456A2 (en) | 2004-05-04 | 2005-05-03 | Anti-coronavirus compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007536240A JP2007536240A (ja) | 2007-12-13 |
| JP2007536240A5 true JP2007536240A5 (enExample) | 2008-03-27 |
Family
ID=36647910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511484A Pending JP2007536240A (ja) | 2004-05-04 | 2005-05-03 | 抗コロナウイルス化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8481571B2 (enExample) |
| JP (1) | JP2007536240A (enExample) |
| CN (1) | CN1949977B (enExample) |
| AU (1) | AU2005323435A1 (enExample) |
| NZ (1) | NZ550945A (enExample) |
| TW (1) | TWI372048B (enExample) |
| WO (1) | WO2006073456A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2856708C (en) * | 2011-11-25 | 2022-01-11 | Bayer Intellectual Property Gmbh | Antibacterial tylosin derivatives and methods for their preparation |
| CA2875975A1 (en) * | 2012-06-06 | 2013-12-12 | Unither Virology, Llc | Novel iminosugars and their applications |
| WO2017059118A1 (en) * | 2015-09-29 | 2017-04-06 | Duke University | Compositions and methods for identifying and treating dystonia disorders |
| US20190282558A1 (en) * | 2016-05-16 | 2019-09-19 | Emergent Virology Llc | Methods of Treating Zika Virus Infection |
| CN107595906B (zh) * | 2017-11-10 | 2020-10-30 | 中国药科大学 | 常春藤皂苷元及其糖苷在制备抗病毒的药物中的应用 |
| AU2020289560A1 (en) | 2019-06-05 | 2021-12-23 | Emory University | Peptidomimetics for the treatment of coronavirus and picornavirus infections |
| IL297069A (en) * | 2020-04-10 | 2022-12-01 | Cocrystal Pharma Inc | Replication inhibitors of norovirus and corona virus |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| CN117402204A (zh) * | 2022-07-07 | 2024-01-16 | 北京大学 | 三萜类化合物及其抗病毒用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| JPH0778021B2 (ja) * | 1988-04-13 | 1995-08-23 | 太陽化学株式会社 | 下痢症ウイルス感染阻害剤 |
| US5156973A (en) * | 1988-11-23 | 1992-10-20 | Edward Shanbrom | Antiviral blood sampling process and apparatus |
| JPH07502970A (ja) | 1990-06-01 | 1995-03-30 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | １，４―ジアミノ―２，３―ジヒドロキシブタン類 |
| JPH04297475A (ja) * | 1991-03-26 | 1992-10-21 | Yamanouchi Pharmaceut Co Ltd | 抗ウイルス剤 |
| US6803466B1 (en) | 1997-12-08 | 2004-10-12 | The Scripps Research Institute | HIV/FIV protease inhibitors having a small P3 residue |
-
2005
- 2005-05-03 JP JP2007511484A patent/JP2007536240A/ja active Pending
- 2005-05-03 NZ NZ550945A patent/NZ550945A/en not_active IP Right Cessation
- 2005-05-03 CN CN2005800143095A patent/CN1949977B/zh not_active Expired - Fee Related
- 2005-05-03 US US11/121,314 patent/US8481571B2/en not_active Expired - Fee Related
- 2005-05-03 WO PCT/US2005/015227 patent/WO2006073456A2/en not_active Ceased
- 2005-05-03 AU AU2005323435A patent/AU2005323435A1/en not_active Abandoned
- 2005-05-04 TW TW094114468A patent/TWI372048B/zh not_active IP Right Cessation
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