CN1949977B - 抗冠状病毒化合物 - Google Patents

抗冠状病毒化合物 Download PDF

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Publication number
CN1949977B
CN1949977B CN2005800143095A CN200580014309A CN1949977B CN 1949977 B CN1949977 B CN 1949977B CN 2005800143095 A CN2005800143095 A CN 2005800143095A CN 200580014309 A CN200580014309 A CN 200580014309A CN 1949977 B CN1949977 B CN 1949977B
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CN
China
Prior art keywords
alkyl
compound
aryl
independently respectively
heterocyclylalkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2005800143095A
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English (en)
Chinese (zh)
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CN1949977A (zh
Inventor
翁启惠
吴宗益
詹家琮
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Publication of CN1949977A publication Critical patent/CN1949977A/zh
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Publication of CN1949977B publication Critical patent/CN1949977B/zh
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Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2005800143095A 2004-05-04 2005-05-03 抗冠状病毒化合物 Expired - Fee Related CN1949977B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56808004P 2004-05-04 2004-05-04
US60/568,080 2004-05-04
PCT/US2005/015227 WO2006073456A2 (en) 2004-05-04 2005-05-03 Anti-coronavirus compounds

Publications (2)

Publication Number Publication Date
CN1949977A CN1949977A (zh) 2007-04-18
CN1949977B true CN1949977B (zh) 2010-09-29

Family

ID=36647910

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800143095A Expired - Fee Related CN1949977B (zh) 2004-05-04 2005-05-03 抗冠状病毒化合物

Country Status (7)

Country Link
US (1) US8481571B2 (enExample)
JP (1) JP2007536240A (enExample)
CN (1) CN1949977B (enExample)
AU (1) AU2005323435A1 (enExample)
NZ (1) NZ550945A (enExample)
TW (1) TWI372048B (enExample)
WO (1) WO2006073456A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2856708C (en) * 2011-11-25 2022-01-11 Bayer Intellectual Property Gmbh Antibacterial tylosin derivatives and methods for their preparation
CA2875975A1 (en) * 2012-06-06 2013-12-12 Unither Virology, Llc Novel iminosugars and their applications
WO2017059118A1 (en) * 2015-09-29 2017-04-06 Duke University Compositions and methods for identifying and treating dystonia disorders
US20190282558A1 (en) * 2016-05-16 2019-09-19 Emergent Virology Llc Methods of Treating Zika Virus Infection
CN107595906B (zh) * 2017-11-10 2020-10-30 中国药科大学 常春藤皂苷元及其糖苷在制备抗病毒的药物中的应用
AU2020289560A1 (en) 2019-06-05 2021-12-23 Emory University Peptidomimetics for the treatment of coronavirus and picornavirus infections
IL297069A (en) * 2020-04-10 2022-12-01 Cocrystal Pharma Inc Replication inhibitors of norovirus and corona virus
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
CN117402204A (zh) * 2022-07-07 2024-01-16 北京大学 三萜类化合物及其抗病毒用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
JPH0778021B2 (ja) * 1988-04-13 1995-08-23 太陽化学株式会社 下痢症ウイルス感染阻害剤
US5156973A (en) * 1988-11-23 1992-10-20 Edward Shanbrom Antiviral blood sampling process and apparatus
JPH07502970A (ja) 1990-06-01 1995-03-30 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー １，４―ジアミノ―２，３―ジヒドロキシブタン類
JPH04297475A (ja) * 1991-03-26 1992-10-21 Yamanouchi Pharmaceut Co Ltd 抗ウイルス剤
US6803466B1 (en) 1997-12-08 2004-10-12 The Scripps Research Institute HIV/FIV protease inhibitors having a small P3 residue

Also Published As

Publication number Publication date
CN1949977A (zh) 2007-04-18
US20060160866A1 (en) 2006-07-20
WO2006073456A3 (en) 2006-09-14
TW200600084A (en) 2006-01-01
US8481571B2 (en) 2013-07-09
TWI372048B (en) 2012-09-11
JP2007536240A (ja) 2007-12-13
NZ550945A (en) 2010-04-30
WO2006073456A2 (en) 2006-07-13
AU2005323435A1 (en) 2006-07-13

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Granted publication date: 20100929

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CF01 Termination of patent right due to non-payment of annual fee