JP2007535928A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007535928A5 JP2007535928A5 JP2007511389A JP2007511389A JP2007535928A5 JP 2007535928 A5 JP2007535928 A5 JP 2007535928A5 JP 2007511389 A JP2007511389 A JP 2007511389A JP 2007511389 A JP2007511389 A JP 2007511389A JP 2007535928 A5 JP2007535928 A5 JP 2007535928A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- ratio
- microarray
- primer
- pcr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004414 DNA Proteins 0.000 claims 18
- 210000000349 chromosome Anatomy 0.000 claims 12
- 239000013615 primer Substances 0.000 claims 11
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 238000002493 microarray Methods 0.000 claims 9
- 238000003752 polymerase chain reaction Methods 0.000 claims 9
- 239000000047 product Substances 0.000 claims 7
- 108091034117 Oligonucleotide Proteins 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 6
- 206010008805 Chromosomal abnormalities Diseases 0.000 claims 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 101710181853 C-factor Proteins 0.000 claims 3
- 238000012408 PCR amplification Methods 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 2
- 108020001019 DNA Primers Proteins 0.000 claims 2
- 239000003155 DNA primer Substances 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000002751 oligonucleotide probe Substances 0.000 claims 2
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 claims 1
- 238000012935 Averaging Methods 0.000 claims 1
- 206010011385 Cri-du-chat syndrome Diseases 0.000 claims 1
- 238000007900 DNA-DNA hybridization Methods 0.000 claims 1
- 208000000398 DiGeorge Syndrome Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 201000006360 Edwards syndrome Diseases 0.000 claims 1
- 108060002716 Exonuclease Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 201000009928 Patau syndrome Diseases 0.000 claims 1
- 108091081021 Sense strand Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 206010044686 Trisomy 13 Diseases 0.000 claims 1
- 208000006284 Trisomy 13 Syndrome Diseases 0.000 claims 1
- 208000007159 Trisomy 18 Syndrome Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 208000036878 aneuploidy Diseases 0.000 claims 1
- 231100001075 aneuploidy Toxicity 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000013611 chromosomal DNA Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 102000013165 exonuclease Human genes 0.000 claims 1
- 238000010363 gene targeting Methods 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000012264 purified product Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 206010053884 trisomy 18 Diseases 0.000 claims 1
- 208000026485 trisomy X Diseases 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/840,208 US7468249B2 (en) | 2004-05-05 | 2004-05-05 | Detection of chromosomal disorders |
| US10/840,208 | 2004-05-05 | ||
| PCT/US2005/013070 WO2005111237A1 (en) | 2004-05-05 | 2005-04-18 | Detection of chromosomal disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007535928A JP2007535928A (ja) | 2007-12-13 |
| JP2007535928A5 true JP2007535928A5 (enExample) | 2008-05-29 |
| JP5032304B2 JP5032304B2 (ja) | 2012-09-26 |
Family
ID=34967157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511389A Expired - Fee Related JP5032304B2 (ja) | 2004-05-05 | 2005-04-18 | 染色体異常の検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7468249B2 (enExample) |
| EP (1) | EP1759011B1 (enExample) |
| JP (1) | JP5032304B2 (enExample) |
| KR (1) | KR101176091B1 (enExample) |
| CN (1) | CN1981052A (enExample) |
| AT (1) | ATE503024T1 (enExample) |
| DE (1) | DE602005027067D1 (enExample) |
| WO (1) | WO2005111237A1 (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
| ES2375724T3 (es) | 2002-09-27 | 2012-03-05 | The General Hospital Corporation | Dispositivo microflu�?dico para seperación de células y sus usos. |
| US8024128B2 (en) * | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| EP2477029A1 (en) | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US20070178501A1 (en) * | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
| US20070027636A1 (en) * | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
| US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US8515679B2 (en) * | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| WO2007080583A2 (en) * | 2006-01-10 | 2007-07-19 | Applied Spectral Imaging Ltd. | Methods and systems for analyzing biological samples |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| WO2007147018A1 (en) * | 2006-06-14 | 2007-12-21 | Cellpoint Diagnostics, Inc. | Analysis of rare cell-enriched samples |
| US20080090237A1 (en) * | 2006-10-13 | 2008-04-17 | Zohar Yakhini | Methods and compositions for comparing chromosomal copy number between genomic samples |
| KR100920134B1 (ko) | 2007-06-29 | 2009-10-08 | 차의과학대학교 산학협력단 | Ｙ 염색체 미세결실 검출용 마이크로어레이 및 이를이용한 검출방법 |
| US8709726B2 (en) | 2008-03-11 | 2014-04-29 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| CN104732118B (zh) | 2008-08-04 | 2017-08-22 | 纳特拉公司 | 等位基因调用和倍性调用的方法 |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| SMT201700149T1 (it) | 2008-09-20 | 2017-05-08 | Univ Leland Stanford Junior | Diagnosi non invasiva di aneuploidia fetale mediante sequenziamento |
| US20100151473A1 (en) * | 2008-12-10 | 2010-06-17 | Yeakley Joanne M | Methods and compositions for hybridizing nucleic acids |
| WO2011027218A1 (en) * | 2009-09-04 | 2011-03-10 | Progenika Biopharma, S.A. | High throughput detection of genomic copy number variations |
| ES2640776T3 (es) | 2009-09-30 | 2017-11-06 | Natera, Inc. | Métodos para denominar de forma no invasiva ploidía prenatal |
| US9926593B2 (en) | 2009-12-22 | 2018-03-27 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10179937B2 (en) | 2014-04-21 | 2019-01-15 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011255641A1 (en) | 2010-05-18 | 2012-12-06 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| CN102465123B (zh) * | 2010-11-04 | 2013-06-12 | 北京金菩嘉医疗科技有限公司 | 一种核酸探针、含有该核酸探针的组合物及其用途 |
| CA2821906C (en) | 2010-12-22 | 2020-08-25 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| CA2834218C (en) | 2011-04-29 | 2021-02-16 | Sequenom, Inc. | Quantification of a minority nucleic acid species using inhibitory oligonucleotides |
| CN102703578B (zh) * | 2011-07-06 | 2013-12-04 | 郭奇伟 | Y染色体微缺失多重实时荧光pcr检测试剂盒 |
| CN102559872B (zh) * | 2011-12-09 | 2014-01-15 | 上海交通大学 | 检测Angelman综合征的基因芯片及使用方法、试剂盒 |
| EP2820129A1 (en) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| JP2015519900A (ja) | 2012-05-21 | 2015-07-16 | フリューダイム・コーポレイション | 粒子集団の単粒子解析方法及び単粒子単離方法 |
| US20150154352A1 (en) * | 2012-06-21 | 2015-06-04 | Gigagen, Inc. | System and Methods for Genetic Analysis of Mixed Cell Populations |
| WO2014011928A1 (en) | 2012-07-13 | 2014-01-16 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| EP2971100A1 (en) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primers for dna methylation analysis |
| WO2015045741A1 (ja) * | 2013-09-26 | 2015-04-02 | 東洋鋼鈑株式会社 | ハイブリダイゼーション用バッファー組成物及びハイブリダイゼーション方法 |
| WO2015048535A1 (en) | 2013-09-27 | 2015-04-02 | Natera, Inc. | Prenatal diagnostic resting standards |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| CA3017945A1 (en) * | 2016-04-26 | 2017-11-02 | Ultivue, Inc. | Super-resolution immunofluorescence with diffraction-limited preview |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| EP3585889A1 (en) | 2017-02-21 | 2020-01-01 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| WO2019028462A1 (en) * | 2017-08-04 | 2019-02-07 | Billiontoone, Inc. | TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS |
| CA3085933A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| WO2019161244A1 (en) | 2018-02-15 | 2019-08-22 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| EP3781714B1 (en) | 2018-04-14 | 2026-01-07 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020191365A1 (en) | 2019-03-21 | 2020-09-24 | Gigamune, Inc. | Engineered cells expressing anti-viral t cell receptors and methods of use thereof |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5213961A (en) | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| WO1994003638A1 (en) | 1992-07-30 | 1994-02-17 | Applied Biosystems, Inc. | Method of detecting aneuploidy by amplified short tandem repeats |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5643765A (en) | 1993-04-06 | 1997-07-01 | University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| JPH0723800A (ja) | 1993-07-08 | 1995-01-27 | Tanabe Seiyaku Co Ltd | 核酸の検出方法 |
| US5716784A (en) | 1996-02-05 | 1998-02-10 | The Perkin-Elmer Corporation | Fluorescence detection assay for homogeneous PCR hybridization systems |
| US5888740A (en) * | 1997-09-19 | 1999-03-30 | Genaco Biomedical Products, Inc. | Detection of aneuploidy and gene deletion by PCR-based gene- dose co-amplification of chromosome specific sequences with synthetic sequences with synthetic internal controls |
| GB9815799D0 (en) | 1998-07-21 | 1998-09-16 | Pharmagene Lab Limited | Quantitative analysis of gene expression |
| US6268147B1 (en) | 1998-11-02 | 2001-07-31 | Kenneth Loren Beattie | Nucleic acid analysis using sequence-targeted tandem hybridization |
| US6251601B1 (en) * | 1999-02-02 | 2001-06-26 | Vysis, Inc. | Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays |
| US6319674B1 (en) * | 1999-09-16 | 2001-11-20 | Agilent Technologies, Inc. | Methods for attaching substances to surfaces |
| WO2003000919A2 (en) * | 2001-06-22 | 2003-01-03 | University Of Geneva | Method for detecting diseases caused by chromosomal imbalances |
| EP1329517A1 (en) * | 2002-01-22 | 2003-07-23 | Wolfgang Prof. Holzgreve | Method for the non-invasive prenatal diagnosis of chromosomal and/or genetic abnormalities |
| US20050191636A1 (en) * | 2004-03-01 | 2005-09-01 | Biocept, Inc. | Detection of STRP, such as fragile X syndrome |
-
2004
- 2004-05-05 US US10/840,208 patent/US7468249B2/en not_active Expired - Fee Related
-
2005
- 2005-04-18 CN CNA2005800205301A patent/CN1981052A/zh active Pending
- 2005-04-18 JP JP2007511389A patent/JP5032304B2/ja not_active Expired - Fee Related
- 2005-04-18 DE DE602005027067T patent/DE602005027067D1/de not_active Expired - Lifetime
- 2005-04-18 EP EP05740284A patent/EP1759011B1/en not_active Expired - Lifetime
- 2005-04-18 KR KR1020067025434A patent/KR101176091B1/ko not_active Expired - Fee Related
- 2005-04-18 WO PCT/US2005/013070 patent/WO2005111237A1/en not_active Ceased
- 2005-04-18 AT AT05740284T patent/ATE503024T1/de active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007535928A5 (enExample) | ||
| Goo et al. | Rolling circle amplification as isothermal gene amplification in molecular diagnostics | |
| JP5032304B2 (ja) | 染色体異常の検出 | |
| JP2007525998A5 (enExample) | ||
| JP2019528726A (ja) | マルチプレックスリアルタイムｐｃｒを実施する方法 | |
| US9970050B2 (en) | Hydrolysis probes | |
| JP6638122B2 (ja) | 標的核酸の検出方法及びキット | |
| JP6144623B2 (ja) | 核酸測定用の核酸プローブ | |
| JP2013540449A5 (enExample) | ||
| IL255714A (en) | The discovery of nucleic acids are intended for their variants | |
| US20090181375A1 (en) | Method for detection of nucleic acid barcodes | |
| KR20160097193A (ko) | 다중 프로브 | |
| US20180356345A1 (en) | Method for detecting specific nucleic acid sequences | |
| JP7618208B2 (ja) | 単一標的遺伝子の遺伝的変異のリアルタイム検出用の一本鎖核酸及びこれを用いた検出方法 | |
| JP5613160B2 (ja) | ゲノムｄｎａ中の標的配列の検出又は解析方法 | |
| JP5165936B2 (ja) | 標的核酸中の変異の検出方法及びアレイ | |
| JP2009232778A (ja) | 標的核酸中の変異の検出方法及びアレイ | |
| WO2007046158A1 (ja) | 核酸分析方法 | |
| JPWO2022090521A5 (enExample) | ||
| US7101673B2 (en) | Method for detecting a nucleic acid comprising asymmetrical amplification | |
| Wu et al. | Detection DNA point mutation with rolling-circle amplification chip | |
| KR20180033911A (ko) | 표적 핵산 또는 유전적 변이를 다중 검출하는 방법 | |
| KR101513276B1 (ko) | 변형 ｍｌｐａ 를 이용한 카피 수 다형성의 다중 분석 방법 | |
| US20220127665A1 (en) | Elimination probe-based method for detecting numerical chromosomal abnormalities, and nucleic acid composition for detecting numerical chromosomal abnormalities | |
| WO2007092033A3 (en) | Rapid identification of the varieties and genotypes of cryptococcus neoformans species complex using a high-throughput flow cytometer |