JP2007535552A5 - - Google Patents
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- JP2007535552A5 JP2007535552A5 JP2007510974A JP2007510974A JP2007535552A5 JP 2007535552 A5 JP2007535552 A5 JP 2007535552A5 JP 2007510974 A JP2007510974 A JP 2007510974A JP 2007510974 A JP2007510974 A JP 2007510974A JP 2007535552 A5 JP2007535552 A5 JP 2007535552A5
- Authority
- JP
- Japan
- Prior art keywords
- implant
- retinal
- disease
- receptor agonist
- adrenergic receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000007943 implant Substances 0.000 claims description 89
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims description 46
- 229920002988 biodegradable polymer Polymers 0.000 claims description 29
- 239000004621 biodegradable polymer Substances 0.000 claims description 29
- 208000017442 Retinal disease Diseases 0.000 claims description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 208000024891 symptom Diseases 0.000 claims description 16
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims description 13
- 230000001154 acute effect Effects 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 13
- 229960003679 brimonidine Drugs 0.000 claims description 12
- 208000002780 macular degeneration Diseases 0.000 claims description 11
- 230000002207 retinal effect Effects 0.000 claims description 11
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 11
- 206010046851 Uveitis Diseases 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 208000011580 syndromic disease Diseases 0.000 claims description 10
- 230000004304 visual acuity Effects 0.000 claims description 10
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 9
- 208000031886 HIV Infections Diseases 0.000 claims description 9
- 208000037357 HIV infectious disease Diseases 0.000 claims description 9
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 9
- 206010038923 Retinopathy Diseases 0.000 claims description 8
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 8
- 208000001344 Macular Edema Diseases 0.000 claims description 7
- 206010025415 Macular oedema Diseases 0.000 claims description 7
- 206010038848 Retinal detachment Diseases 0.000 claims description 7
- 201000010230 macular retinal edema Diseases 0.000 claims description 7
- 210000001927 retinal artery Anatomy 0.000 claims description 7
- 230000004264 retinal detachment Effects 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 208000002367 Retinal Perforations Diseases 0.000 claims description 6
- 201000005485 Toxoplasmosis Diseases 0.000 claims description 6
- 239000000049 pigment Substances 0.000 claims description 6
- 210000001525 retina Anatomy 0.000 claims description 6
- 208000006379 syphilis Diseases 0.000 claims description 6
- 230000002792 vascular Effects 0.000 claims description 6
- 201000007527 Retinal artery occlusion Diseases 0.000 claims description 5
- 208000027129 choroid disease Diseases 0.000 claims description 5
- 230000002062 proliferating effect Effects 0.000 claims description 5
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical group O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims description 4
- 208000009137 Behcet syndrome Diseases 0.000 claims description 4
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 4
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 4
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 4
- 229960001724 brimonidine tartrate Drugs 0.000 claims description 4
- 201000005667 central retinal vein occlusion Diseases 0.000 claims description 4
- 201000011190 diabetic macular edema Diseases 0.000 claims description 4
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims description 4
- 208000019553 vascular disease Diseases 0.000 claims description 4
- 208000004142 Acute Retinal Necrosis Syndrome Diseases 0.000 claims description 3
- 208000014882 Carotid artery disease Diseases 0.000 claims description 3
- 208000016623 Choroid neoplasm Diseases 0.000 claims description 3
- 206010070957 Choroidal haemangioma Diseases 0.000 claims description 3
- 208000002691 Choroiditis Diseases 0.000 claims description 3
- 208000021089 Coats disease Diseases 0.000 claims description 3
- 206010010356 Congenital anomaly Diseases 0.000 claims description 3
- 206010011732 Cyst Diseases 0.000 claims description 3
- 208000001351 Epiretinal Membrane Diseases 0.000 claims description 3
- 208000010412 Glaucoma Diseases 0.000 claims description 3
- 208000002927 Hamartoma Diseases 0.000 claims description 3
- 208000018565 Hemochromatosis Diseases 0.000 claims description 3
- 241000228402 Histoplasma Species 0.000 claims description 3
- 201000002563 Histoplasmosis Diseases 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 206010020880 Hypertrophy Diseases 0.000 claims description 3
- 206010058558 Hypoperfusion Diseases 0.000 claims description 3
- 206010022557 Intermediate uveitis Diseases 0.000 claims description 3
- 208000016604 Lyme disease Diseases 0.000 claims description 3
- 206010027476 Metastases Diseases 0.000 claims description 3
- 208000009857 Microaneurysm Diseases 0.000 claims description 3
- 208000010164 Multifocal Choroiditis Diseases 0.000 claims description 3
- 206010069385 Ocular ischaemic syndrome Diseases 0.000 claims description 3
- 206010065700 Ocular sarcoidosis Diseases 0.000 claims description 3
- 208000034247 Pattern dystrophy Diseases 0.000 claims description 3
- 208000003971 Posterior uveitis Diseases 0.000 claims description 3
- 206010064714 Radiation retinopathy Diseases 0.000 claims description 3
- 208000008709 Retinal Telangiectasis Diseases 0.000 claims description 3
- 206010038897 Retinal tear Diseases 0.000 claims description 3
- 206010038910 Retinitis Diseases 0.000 claims description 3
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims description 3
- 206010038915 Retinitis viral Diseases 0.000 claims description 3
- 201000000582 Retinoblastoma Diseases 0.000 claims description 3
- 206010038935 Retinopathy sickle cell Diseases 0.000 claims description 3
- 206010039705 Scleritis Diseases 0.000 claims description 3
- 206010040925 Skin striae Diseases 0.000 claims description 3
- 208000022758 Sorsby fundus dystrophy Diseases 0.000 claims description 3
- 208000027073 Stargardt disease Diseases 0.000 claims description 3
- 206010042742 Sympathetic ophthalmia Diseases 0.000 claims description 3
- 206010044269 Toxocariasis Diseases 0.000 claims description 3
- 206010047115 Vasculitis Diseases 0.000 claims description 3
- 208000029977 White Dot Syndromes Diseases 0.000 claims description 3
- 210000001766 X chromosome Anatomy 0.000 claims description 3
- 230000002159 abnormal effect Effects 0.000 claims description 3
- 230000004075 alteration Effects 0.000 claims description 3
- 230000009852 coagulant defect Effects 0.000 claims description 3
- 201000008615 cone dystrophy Diseases 0.000 claims description 3
- 208000006623 congenital stationary night blindness Diseases 0.000 claims description 3
- 208000031513 cyst Diseases 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 208000035475 disorder Diseases 0.000 claims description 3
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims description 3
- 210000004177 elastic tissue Anatomy 0.000 claims description 3
- 206010014801 endophthalmitis Diseases 0.000 claims description 3
- 210000000981 epithelium Anatomy 0.000 claims description 3
- 230000001631 hypertensive effect Effects 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 208000019420 lymphoid neoplasm Diseases 0.000 claims description 3
- 208000038015 macular disease Diseases 0.000 claims description 3
- 208000029233 macular holes Diseases 0.000 claims description 3
- 230000009401 metastasis Effects 0.000 claims description 3
- 208000008940 ocular tuberculosis Diseases 0.000 claims description 3
- 208000008798 osteoma Diseases 0.000 claims description 3
- 208000001297 phlebitis Diseases 0.000 claims description 3
- 230000000649 photocoagulation Effects 0.000 claims description 3
- 238000002428 photodynamic therapy Methods 0.000 claims description 3
- 201000004849 posterior scleritis Diseases 0.000 claims description 3
- 201000002267 posterior uveal melanoma Diseases 0.000 claims description 3
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 230000009897 systematic effect Effects 0.000 claims description 3
- 230000001052 transient effect Effects 0.000 claims description 3
- 230000008733 trauma Effects 0.000 claims description 3
- 201000008827 tuberculosis Diseases 0.000 claims description 3
- 201000007790 vitelliform macular dystrophy Diseases 0.000 claims description 3
- 201000007795 Bietti crystalline corneoretinal dystrophy Diseases 0.000 claims description 2
- 208000008319 Bietti crystalline dystrophy Diseases 0.000 claims description 2
- 208000014087 Chorioretinal disease Diseases 0.000 claims description 2
- 206010065119 Necrotising herpetic retinopathy Diseases 0.000 claims description 2
- 208000003435 Optic Neuritis Diseases 0.000 claims description 2
- 206010038899 Retinal telangiectasia Diseases 0.000 claims description 2
- 208000001445 Uveomeningoencephalitic Syndrome Diseases 0.000 claims description 2
- 208000034705 Vogt-Koyanagi-Harada syndrome Diseases 0.000 claims description 2
- 230000001174 ascending effect Effects 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 201000005849 central retinal artery occlusion Diseases 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 230000004377 improving vision Effects 0.000 claims description 2
- 201000002165 neuroretinitis Diseases 0.000 claims description 2
- 239000000790 retinal pigment Substances 0.000 claims description 2
- 201000007714 retinoschisis Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 19
- 239000011159 matrix material Substances 0.000 claims 17
- 239000000825 pharmaceutical preparation Substances 0.000 claims 17
- 229940127557 pharmaceutical product Drugs 0.000 claims 17
- 229940079593 drug Drugs 0.000 claims 14
- 229920000642 polymer Polymers 0.000 claims 13
- 150000003252 quinoxalines Chemical group 0.000 claims 12
- 229920000747 poly(lactic acid) Polymers 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 239000004626 polylactic acid Substances 0.000 claims 4
- 230000004438 eyesight Effects 0.000 claims 3
- 206010059245 Angiopathy Diseases 0.000 claims 2
- 208000037663 Best vitelliform macular dystrophy Diseases 0.000 claims 2
- 208000028506 Familial Exudative Vitreoretinopathies Diseases 0.000 claims 2
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 claims 2
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 2
- 208000036038 Subretinal fibrosis Diseases 0.000 claims 2
- 206010053648 Vascular occlusion Diseases 0.000 claims 2
- 239000000048 adrenergic agonist Substances 0.000 claims 2
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 2
- 201000002588 choroid cancer Diseases 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 2
- 201000006902 exudative vitreoretinopathy Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940126601 medicinal product Drugs 0.000 claims 2
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 230000006785 proliferative vitreoretinopathy Effects 0.000 claims 2
- 230000000717 retained effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000021331 vascular occlusion disease Diseases 0.000 claims 2
- 208000020938 vitelliform macular dystrophy 2 Diseases 0.000 claims 2
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
- 208000033379 Chorioretinopathy Diseases 0.000 claims 1
- 208000019878 Eales disease Diseases 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 208000006123 Myiasis Diseases 0.000 claims 1
- 206010064997 Necrotising retinitis Diseases 0.000 claims 1
- 208000032398 Retinal pigment epitheliopathy Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 206010043189 Telangiectasia Diseases 0.000 claims 1
- 208000021328 arterial occlusion Diseases 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 208000037906 ischaemic injury Diseases 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 208000009056 telangiectasis Diseases 0.000 claims 1
- 210000004127 vitreous body Anatomy 0.000 claims 1
- 239000013543 active substance Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 238000011282 treatment Methods 0.000 description 3
- QZHBYNSSDLTCRG-LREBCSMRSA-N 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine;(2r,3r)-2,3-dihydroxybutanedioic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 QZHBYNSSDLTCRG-LREBCSMRSA-N 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 206010025412 Macular dystrophy congenital Diseases 0.000 description 1
- 208000034461 Progressive cone dystrophy Diseases 0.000 description 1
- 229940003677 alphagan Drugs 0.000 description 1
- 229960002610 apraclonidine Drugs 0.000 description 1
- IEJXVRYNEISIKR-UHFFFAOYSA-N apraclonidine Chemical compound ClC1=CC(N)=CC(Cl)=C1NC1=NCCN1 IEJXVRYNEISIKR-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229960004716 idoxuridine Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000004283 retinal dysfunction Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000001745 uvea Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/836,911 US20050244463A1 (en) | 2004-04-30 | 2004-04-30 | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| PCT/US2005/014607 WO2005110368A1 (en) | 2004-04-30 | 2005-04-26 | Intraocular implants of alpha-2 adrenergic receptor agonists and methods for improving vision |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012228958A Division JP5696121B2 (ja) | 2004-04-30 | 2012-10-16 | α−２アドレナリン受容体アゴニスト含有生分解性眼内インプラント |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007535552A JP2007535552A (ja) | 2007-12-06 |
| JP2007535552A5 true JP2007535552A5 (https=) | 2008-06-19 |
Family
ID=34967610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007510974A Pending JP2007535552A (ja) | 2004-04-30 | 2005-04-26 | α−２アドレナリン受容体アゴニストの眼内インプラントおよび視力の向上方法 |
| JP2012228958A Expired - Fee Related JP5696121B2 (ja) | 2004-04-30 | 2012-10-16 | α−２アドレナリン受容体アゴニスト含有生分解性眼内インプラント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012228958A Expired - Fee Related JP5696121B2 (ja) | 2004-04-30 | 2012-10-16 | α−２アドレナリン受容体アゴニスト含有生分解性眼内インプラント |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US20050244463A1 (https=) |
| EP (2) | EP2305261B1 (https=) |
| JP (2) | JP2007535552A (https=) |
| KR (1) | KR20070064415A (https=) |
| CN (1) | CN1950067A (https=) |
| AT (1) | ATE516033T1 (https=) |
| AU (2) | AU2005244149A1 (https=) |
| BR (1) | BRPI0510504A (https=) |
| CA (1) | CA2565067C (https=) |
| DK (1) | DK1758552T3 (https=) |
| ES (1) | ES2367804T3 (https=) |
| MX (1) | MXPA06012291A (https=) |
| NZ (1) | NZ550009A (https=) |
| WO (1) | WO2005110368A1 (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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-
2004
- 2004-04-30 US US10/836,911 patent/US20050244463A1/en not_active Abandoned
-
2005
- 2005-04-26 AU AU2005244149A patent/AU2005244149A1/en not_active Abandoned
- 2005-04-26 WO PCT/US2005/014607 patent/WO2005110368A1/en not_active Ceased
- 2005-04-26 EP EP10184295.3A patent/EP2305261B1/en not_active Expired - Lifetime
- 2005-04-26 BR BRPI0510504-8A patent/BRPI0510504A/pt not_active Application Discontinuation
- 2005-04-26 NZ NZ550009A patent/NZ550009A/en not_active IP Right Cessation
- 2005-04-26 MX MXPA06012291A patent/MXPA06012291A/es active IP Right Grant
- 2005-04-26 JP JP2007510974A patent/JP2007535552A/ja active Pending
- 2005-04-26 EP EP05741206A patent/EP1758552B1/en not_active Expired - Lifetime
- 2005-04-26 DK DK05741206.6T patent/DK1758552T3/da active
- 2005-04-26 ES ES05741206T patent/ES2367804T3/es not_active Expired - Lifetime
- 2005-04-26 CA CA2565067A patent/CA2565067C/en not_active Expired - Fee Related
- 2005-04-26 AT AT05741206T patent/ATE516033T1/de not_active IP Right Cessation
- 2005-04-26 CN CNA2005800135737A patent/CN1950067A/zh active Pending
- 2005-04-26 KR KR1020067022639A patent/KR20070064415A/ko not_active Abandoned
- 2005-04-29 US US11/119,021 patent/US8293741B2/en active Active
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2008
- 2008-01-31 US US12/024,014 patent/US8506986B2/en not_active Expired - Fee Related
- 2008-01-31 US US12/024,017 patent/US8580292B2/en not_active Expired - Fee Related
- 2008-01-31 US US12/024,010 patent/US9161938B2/en active Active
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2011
- 2011-05-12 AU AU2011202200A patent/AU2011202200B2/en not_active Ceased
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2012
- 2012-10-16 JP JP2012228958A patent/JP5696121B2/ja not_active Expired - Fee Related
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2015
- 2015-10-19 US US14/886,376 patent/US10201641B2/en not_active Expired - Lifetime
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2019
- 2019-02-11 US US16/272,508 patent/US20190167858A1/en not_active Abandoned
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