JP2007532696A5 - - Google Patents

Download PDF

Info

Publication number
JP2007532696A5
JP2007532696A5 JP2007509552A JP2007509552A JP2007532696A5 JP 2007532696 A5 JP2007532696 A5 JP 2007532696A5 JP 2007509552 A JP2007509552 A JP 2007509552A JP 2007509552 A JP2007509552 A JP 2007509552A JP 2007532696 A5 JP2007532696 A5 JP 2007532696A5
Authority
JP
Japan
Prior art keywords
delivery vehicle
agent
medical condition
delivery
vehicle according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007509552A
Other languages
English (en)
Japanese (ja)
Other versions
JP5630942B2 (ja
JP2007532696A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/013228 external-priority patent/WO2005102282A1/en
Publication of JP2007532696A publication Critical patent/JP2007532696A/ja
Publication of JP2007532696A5 publication Critical patent/JP2007532696A5/ja
Application granted granted Critical
Publication of JP5630942B2 publication Critical patent/JP5630942B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007509552A 2004-04-19 2005-04-19 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 Expired - Lifetime JP5630942B2 (ja)

Applications Claiming Priority (51)

Application Number Priority Date Filing Date Title
US56356904P 2004-04-19 2004-04-19
US56356504P 2004-04-19 2004-04-19
US56356004P 2004-04-19 2004-04-19
US56357404P 2004-04-19 2004-04-19
US56356604P 2004-04-19 2004-04-19
US56356104P 2004-04-19 2004-04-19
US56355304P 2004-04-19 2004-04-19
US56355104P 2004-04-19 2004-04-19
US56356304P 2004-04-19 2004-04-19
US56357004P 2004-04-19 2004-04-19
US56355404P 2004-04-19 2004-04-19
US56355704P 2004-04-19 2004-04-19
US56357504P 2004-04-19 2004-04-19
US56355204P 2004-04-19 2004-04-19
US56355604P 2004-04-19 2004-04-19
US56357204P 2004-04-19 2004-04-19
US56357304P 2004-04-19 2004-04-19
US56356704P 2004-04-19 2004-04-19
US56355504P 2004-04-19 2004-04-19
US56356404P 2004-04-19 2004-04-19
US56355904P 2004-04-19 2004-04-19
US56356204P 2004-04-19 2004-04-19
US56357104P 2004-04-19 2004-04-19
US56355804P 2004-04-19 2004-04-19
US56357604P 2004-04-19 2004-04-19
US60/563,558 2004-04-19
US60/563,554 2004-04-19
US60/563,565 2004-04-19
US60/563,576 2004-04-19
US60/563,553 2004-04-19
US60/563,557 2004-04-19
US60/563,562 2004-04-19
US60/563,556 2004-04-19
US60/563,560 2004-04-19
US60/563,572 2004-04-19
US60/563,555 2004-04-19
US60/563,551 2004-04-19
US60/563,573 2004-04-19
US60/563,571 2004-04-19
US60/563,563 2004-04-19
US60/563,566 2004-04-19
US60/563,570 2004-04-19
US60/563,559 2004-04-19
US60/563,552 2004-04-19
US60/563,575 2004-04-19
US60/563,561 2004-04-19
US60/563,564 2004-04-19
US60/563,567 2004-04-19
US60/563,569 2004-04-19
US60/563,574 2004-04-19
PCT/US2005/013228 WO2005102282A1 (en) 2004-04-19 2005-04-19 Transdermal delivery of beneficial substances effected by a hostile biophysical environment

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011283904A Division JP2012062328A (ja) 2004-04-19 2011-12-26 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2012172904A Division JP2012211201A (ja) 2004-04-19 2012-08-03 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達

Publications (3)

Publication Number Publication Date
JP2007532696A JP2007532696A (ja) 2007-11-15
JP2007532696A5 true JP2007532696A5 (enExample) 2008-06-05
JP5630942B2 JP5630942B2 (ja) 2014-11-26

Family

ID=35196712

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2007509552A Expired - Lifetime JP5630942B2 (ja) 2004-04-19 2005-04-19 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2007509553A Withdrawn JP2007532697A (ja) 2004-04-19 2005-04-19 局所的血流増大の有益な効果
JP2011093358A Pending JP2011140525A (ja) 2004-04-19 2011-04-19 局所的血流増大の有益な効果
JP2011273409A Withdrawn JP2012056964A (ja) 2004-04-19 2011-12-14 局所的血流増大の有益な効果
JP2011283904A Pending JP2012062328A (ja) 2004-04-19 2011-12-26 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2012172904A Withdrawn JP2012211201A (ja) 2004-04-19 2012-08-03 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2015088079A Withdrawn JP2015164932A (ja) 2004-04-19 2015-04-23 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2015088080A Pending JP2015131861A (ja) 2004-04-19 2015-04-23 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2007509553A Withdrawn JP2007532697A (ja) 2004-04-19 2005-04-19 局所的血流増大の有益な効果
JP2011093358A Pending JP2011140525A (ja) 2004-04-19 2011-04-19 局所的血流増大の有益な効果
JP2011273409A Withdrawn JP2012056964A (ja) 2004-04-19 2011-12-14 局所的血流増大の有益な効果
JP2011283904A Pending JP2012062328A (ja) 2004-04-19 2011-12-26 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2012172904A Withdrawn JP2012211201A (ja) 2004-04-19 2012-08-03 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2015088079A Withdrawn JP2015164932A (ja) 2004-04-19 2015-04-23 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
JP2015088080A Pending JP2015131861A (ja) 2004-04-19 2015-04-23 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達

Country Status (7)

Country Link
US (10) US9050365B2 (enExample)
EP (2) EP1737441A4 (enExample)
JP (8) JP5630942B2 (enExample)
AU (2) AU2005235308B2 (enExample)
CA (2) CA2563670C (enExample)
ES (1) ES2429443T3 (enExample)
WO (2) WO2005102307A2 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629384B2 (en) * 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US20060140984A1 (en) 2002-10-25 2006-06-29 Foamix Ltd. Cosmetic and pharmaceutical foam
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
WO2005081964A2 (en) * 2004-02-23 2005-09-09 Strategic Science & Technologies, Llc Topical delivery of a nitric oxide donor to improve body and skin appearance
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
CA2563670C (en) * 2004-04-19 2014-09-16 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
US20110028548A1 (en) * 2004-04-19 2011-02-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
HUP0401422A2 (en) * 2004-07-15 2006-04-28 G Laszlo Meszaros Use of l-arginine as vasoaktive ingredient absorbing through skin for external application
CA2606565C (en) 2005-05-27 2016-05-10 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
WO2009090495A2 (en) 2007-12-07 2009-07-23 Foamix Ltd. Oil and liquid silicone foamable carriers and formulations
WO2009090558A2 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
WO2009152372A1 (en) 2008-06-11 2009-12-17 Biochemics, Inc. Control of blood vessel physiology to treat skin disorders
BRPI0918142A2 (pt) 2008-09-10 2015-12-01 Biochemics Inc composição farmaclógica tópica, seu método de preparação, bem como uso da forma de ácido livre de ácido 2-(4-isobutifilfenil)prpiônico
BRPI0914192A2 (pt) 2008-09-22 2015-11-03 Biochemics Inc distribuição transdérmica de fármaco usando um osmólito e agente vasoativo
CN102209627B (zh) * 2008-10-02 2013-11-06 迈兰公司 多层粘合剂层压制品的制造方法
US9278233B2 (en) 2008-12-04 2016-03-08 Biochemics, Inc. Methods and compositions for tattoo removal
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
CN104069060A (zh) * 2009-06-24 2014-10-01 战略科学技术有限公司 含有布洛芬的表面组合物
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
AU2015203547B2 (en) * 2009-06-24 2017-05-18 Strategic Science & Technologies, Llc Topical composition containing ibuprofen
US8604081B2 (en) * 2009-06-24 2013-12-10 Strategic Science & Technologies, Llc Topical composition containing ibuprofen
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US9072659B2 (en) 2009-06-24 2015-07-07 Strategic Science & Technologies, Llc Topical composition containing naproxen
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CN102711729B (zh) 2009-08-21 2015-04-01 诺万公司 局部用凝胶
BR112012003804B1 (pt) 2009-08-21 2019-02-19 Novan, Inc. Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
AU2010302350B2 (en) 2009-10-02 2015-06-18 Journey Medical Corporation Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
CA2784824A1 (en) * 2009-12-18 2011-06-23 Achelios Therapeutics Llc Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
EP2658554A4 (en) * 2010-12-29 2015-01-07 Strategic Science & Tech Llc SYSTEMS AND METHOD FOR THE TREATMENT OF ALLERGIES AND OTHER INDICATIONS
CN105879035A (zh) * 2010-12-29 2016-08-24 战略科学与技术有限责任公司 治疗偏头痛和其它适应症的方法和系统
EP2658551B1 (en) 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
EP2658552A4 (en) * 2010-12-29 2015-01-07 Strategic Science & Tech Llc TRANSDERMAL TREATMENT ADMINISTRATION FOR FUNGAL INFECTIONS OTHER INDICATIONS
CN103442722A (zh) * 2010-12-29 2013-12-11 战略科学与技术有限责任公司 Cox-2抑制剂和相关的化合物、及其递送系统和方法
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
EP2968130A1 (en) 2013-03-15 2016-01-20 Strategic Science & Technologies, LLC Transdermal delivery of sildenafil and other phosphodiesterase type 5 inhibitors
JP2016513686A (ja) 2013-03-15 2016-05-16 ストラテジック サイエンス アンド テクノロジーズ, エルエルシー フルチカゾンの経皮製剤
JP6513667B2 (ja) 2013-08-08 2019-05-15 ノヴァン,インコーポレイテッド 局所用組成物およびそれを使用する方法
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
EP3226972A4 (en) 2014-12-01 2018-08-08 Achelios Therapeutics, Inc. Methods and compositions for treating migraine and conditions associated with pain
WO2016112201A1 (en) 2015-01-07 2016-07-14 Strategic Science & Technologies, Llc Techniques and systems for transdermal delivery involving treatment of psoriasis, skin cancer, and other indications
AR102172A1 (es) * 2015-10-05 2017-02-08 Química Luar S R L Una composición farmacéutica bactericida y virucida
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
RU2651767C1 (ru) * 2017-07-11 2018-04-23 федеральное государственное бюджетное образовательное учреждение высшего образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РостГМУ Минздрава России) Способ лечения невралгии тройничного нерва

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5799M (enExample) * 1966-03-22 1968-03-25
FR5940M (enExample) 1966-10-18 1968-04-08
FR1553063A (enExample) 1967-11-28 1969-01-10
US3960782A (en) * 1974-09-27 1976-06-01 The Procter & Gamble Company Shampoo compositions which impart high luster and manageability to hair
US4185100A (en) * 1976-05-13 1980-01-22 Johnson & Johnson Topical anti-inflammatory drug therapy
JPS5753404A (en) 1980-09-17 1982-03-30 Kao Corp External preparation for skin obtained by blending plant extract
GB2094142B (en) * 1981-03-06 1984-09-26 Lab For Applied Biology Ltd Injectable solution containing theophylline and a basic amino acid
GB2126868B (en) 1982-09-20 1986-03-19 Ralston Purina Co Method of improving the shelf life of processed meat products
DE3327840C1 (de) * 1983-08-02 1984-09-20 Blendax Werke Schneider Co Hautpflegemittel
FR2557452B1 (fr) 1983-12-28 1986-08-14 Roussel Uclaf Nouvelles compositions pour les soins de la peau renfermant de l'huile d'onagre et des traits tissulaires de rate
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
JPS60252412A (ja) 1984-05-29 1985-12-13 Nichiban Co Ltd 貼布治療製剤
US4722837A (en) * 1984-05-29 1988-02-02 Derma-Cure, Inc. Medicated shampoo composition
US4692462A (en) * 1985-03-18 1987-09-08 Menley & James Laboratories, Ltd. Compositions and method of controlling transdermal penetration of topical and systemic agents
US4732892A (en) 1985-07-12 1988-03-22 American Home Products Corporation L-α-amino acids as transdermal penetration enhancers
ES2038122T3 (es) * 1985-11-18 1993-07-16 Beecham Group Plc Un procedimiento para la preparacion de una composicion veterinaria2.
GB8606368D0 (en) 1986-03-14 1986-04-23 Unilever Plc Skin treatment composition
FR2602678B1 (fr) 1986-08-13 1992-06-05 Drouault Guy Composition pharmaceutique aqueuse a base de sels de magnesium, sodium et potassium pour la regulation des circulations locales
US4940456A (en) * 1987-02-10 1990-07-10 Dan Sibalis Electrolytic transdermal delivery of proteins
US4885157A (en) 1987-02-13 1989-12-05 Fiaschetti Mary G Dermal cosmetic composition and applications therefor
DE3715576A1 (de) 1987-05-09 1988-11-24 Wella Ag Neue makromolekulare, oberflaechenaktive, quaternaere n-substituierte chitosanderivate sowie kosmetisches mittel auf der basis dieser neuen chitosanderivate
KR900004875Y1 (ko) 1987-10-02 1990-05-31 삼성전자 주식회사 Pip의 수평 윈도우 신호발생 회로
US5925372A (en) 1987-12-16 1999-07-20 Novartis Corporation Mixed solvent mutually enhanced transdermal therapeutic system
JPH045231Y2 (enExample) 1987-12-16 1992-02-14
US4871718A (en) 1987-12-29 1989-10-03 Raymond A. Roncari Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
GB2217595B (en) 1988-04-21 1991-11-20 American Cyanamid Co Antiinflammatory gel
DE3827362A1 (de) * 1988-08-12 1990-02-15 Basf Ag Pulvrige, hydrophile theophyllinformulierung und verfahren zur ihrer herstellung
WO1990003178A1 (en) 1988-09-30 1990-04-05 Kazuo Watanabe Anti-inflammatory and analgesic compounds, related compositions and methods for preparation and use thereof
US4945901A (en) * 1989-03-22 1990-08-07 Burcke Jr Harry J Hand therapy apparatus and method therefor
US5158761A (en) * 1989-04-05 1992-10-27 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
US5476852A (en) 1989-05-03 1995-12-19 Janssen Pharmaceutica N.V. Method of topically treating acne vulgaris, hyperkeratotic dermatoses, and photo-aging of the skin
US5028435A (en) 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
JP2761939B2 (ja) 1989-09-04 1998-06-04 株式会社コーセー 水中油型乳化化粧料
DK0424028T3 (da) 1989-10-17 1996-01-29 Merck & Co Inc S(+)-ibuprofen-L-aminosyre og S(+)-ibuprofen-D-aminosyre som et forbedret smertestillende middel med fremskyndet indtrædelse
US5576351A (en) * 1989-12-29 1996-11-19 Mcgaw, Inc. Use of arginine as an immunostimulator
EP0441119A3 (en) * 1990-01-09 1992-10-14 Richard D. Levere The use of l-arginine in the treatment of hypertension and other vascular disorders
US5332758A (en) 1990-07-13 1994-07-26 Kanebo, Ltd. Collagen metabolism ameliorant and its use
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
ES2070513T3 (es) 1990-11-14 1995-06-01 Upjohn Co Compuestos de 5-fluoro-2,4,6-pirimidintriamina para prevenir la caida del pelo.
DE4100975A1 (de) 1991-01-15 1992-07-16 Weuffen Wolfgang Kosmetische oder pharmazeutische zubereitungen zur verbesserung der haarqualitaet und foerderung des haarwachstums
US5210099A (en) * 1991-02-11 1993-05-11 American Home Products Corporation Analgesic compositions
EP0531495B1 (en) 1991-03-01 1997-08-20 Atherton Investments, Ltd. Therapeutic and cosmetic compositions for treatment of skin
BR9205713A (pt) 1991-03-01 1994-06-07 Atherton Investments Ltd Ingrediente ativo de secreçao de gastrópode, processo para sua preparaçao, e composiçao de ingrediente ativo
US5498420A (en) * 1991-04-12 1996-03-12 Merz & Co. Gmbh & Co. Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions
EP0515982B1 (en) * 1991-05-27 1995-04-19 Fujisawa Pharmaceutical Co., Ltd. Normal-pentadecyl nicotinate N-oxide and hair restorer comprising the same
JP2636118B2 (ja) * 1991-09-10 1997-07-30 三省製薬株式会社 育毛剤
US5254331A (en) * 1991-09-12 1993-10-19 Chanel, Inc. Skin cream composition
US5215759A (en) * 1991-10-01 1993-06-01 Chanel, Inc. Cosmetic composition
US5217652A (en) * 1991-10-04 1993-06-08 The Gillette Company Conditioning shampoo
EP0552879B1 (en) * 1992-01-21 1998-08-19 Macrochem Corporation Improved iontophoretic administration of drugs
JP3302995B2 (ja) * 1992-04-01 2002-07-15 株式会社ダイゾー エアゾール組成物
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5464954A (en) * 1992-08-31 1995-11-07 Idec Izumi Corporation Safety switch assembly
DK169121B1 (da) * 1992-09-09 1994-08-22 Gea Farmaceutisk Fabrik As Antiviralt virksom farmaceutisk olie-i-vand-emulsion indeholdende 9-[(2-hydroxyethoxy)methyl]guanin (acyclovir) eller et salt eller en ester deraf
GB9222772D0 (en) 1992-10-30 1992-12-09 Unilever Plc Cosmetic composition
US5573776A (en) * 1992-12-02 1996-11-12 Alza Corporation Oral osmotic device with hydrogel driving member
JP3191833B2 (ja) 1993-02-24 2001-07-23 三菱東京製薬株式会社 育毛剤
JPH06287135A (ja) 1993-04-01 1994-10-11 Lion Corp 皮膚外用剤組成物
US5439938A (en) 1993-04-07 1995-08-08 The Johns Hopkins University Treatments for male sexual dysfunction
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5852058A (en) 1993-06-11 1998-12-22 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US5428070A (en) 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
US5891459A (en) * 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
DE4338793A1 (de) 1993-11-12 1995-05-18 Froelich Juergen C L-Arginin und Analoge als Thrombozytenaggregationshemmer
DE4341000A1 (de) 1993-12-02 1995-06-08 Beiersdorf Ag Verwendung von L-Arginin, L-Ornithin oder L-Citrullin und topischen Zubereitungen mit diesen Stoffen
US5714472A (en) 1993-12-23 1998-02-03 Nestec Ltd. Enternal formulation designed for optimized nutrient absorption and wound healing
GB9409281D0 (en) * 1994-05-10 1994-06-29 Svedman Paul Transdermal device
JPH07316075A (ja) 1994-05-26 1995-12-05 Pola Chem Ind Inc 皮膚外用剤
US6190704B1 (en) 1994-09-23 2001-02-20 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US5543430A (en) 1994-10-05 1996-08-06 Kaesemeyer; W. H. Method and formulation of stimulating nitric oxide synthesis
US5505958A (en) * 1994-10-31 1996-04-09 Algos Pharmaceutical Corporation Transdermal drug delivery device and method for its manufacture
BR9509590A (pt) * 1994-11-04 1997-12-23 Polymun Scient Immunbio Forsch Aplicação de sod em liposomas
US5594032A (en) 1994-11-10 1997-01-14 Gonzalez-Cadavid; Nestor F. Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA
US5648101A (en) 1994-11-14 1997-07-15 Tawashi; Rashad Drug delivery of nitric oxide
US5562917A (en) * 1994-12-23 1996-10-08 Pentech Pharmaceuticals, Inc. Transdermal administration of apomorphine
US5853768A (en) 1995-03-01 1998-12-29 Altadonna; James Topical preparation and method for pain relief
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
US5595753A (en) 1995-04-14 1997-01-21 President And Fellows Of Harvard College Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract
US5643586A (en) * 1995-04-27 1997-07-01 Perricone; Nicholas V. Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds
US5698738A (en) 1995-05-15 1997-12-16 Board Of Regents, The University Of Texas System N-nitroso-N-substituted hydroxylamines as nitric oxide donors
US5762963A (en) * 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US5645859A (en) * 1995-10-02 1997-07-08 Isp Investments Inc. Process for producing an alpha or beta-hydroxy acid-vinylpyrrolidone polymer, copolymer or graft polymer complex in the form of free-flowing powders having a high acid loading
US5605685A (en) * 1995-09-13 1997-02-25 Isp Investments Inc. Non-irritating skin and hair rejuvenating compostion having a pH between 1 and 6.5
US5734080A (en) 1995-09-22 1998-03-31 Anihealth Corporation Reaction product of arginine and p-aminobenzoic acid, cosmetic, and human and animal health compositions thereof
US6036977A (en) * 1995-09-29 2000-03-14 L.A.M. Pharmaceutical Corp. Drug preparations for treating sexual dysfunction
FR2740339B1 (fr) 1995-10-26 1997-12-05 Oreal Utilisation d'au moins un inhibiteur de no-synthase dans le traitement des peaux sensibles
FR2740453B1 (fr) 1995-10-27 1998-01-16 Bieurope Melanges peptidiques, leur preparation et compositions cosmetiques les contenant
JP2681881B2 (ja) 1995-11-24 1997-11-26 ナショナル サイエンス カウンシル 抗ウイルス剤アシクロビルの経皮吸収製剤
US5789442A (en) 1996-01-18 1998-08-04 Schering Aktiengesellschaft Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents
JPH09208460A (ja) 1996-01-31 1997-08-12 Lion Corp 貼付剤
JP4020989B2 (ja) 1996-03-06 2007-12-12 株式会社ノエビア 血流促進剤及びこれを配合して成る皮膚外用剤
GB9608408D0 (en) 1996-04-23 1996-06-26 Adams Michael A Treatment of erectile dysfunction
US5911980A (en) * 1996-06-27 1999-06-15 Macrochem Corporation Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery system and method of delivering agents to the skin
US5985317A (en) * 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
US20020015713A1 (en) * 1996-10-24 2002-02-07 Murdock Robert W. Methods and transdermal compositions for pain relief
US5891472A (en) * 1996-11-19 1999-04-06 Meri Charmyne Russell Treatment of equine laminitis
JPH10167953A (ja) 1996-12-06 1998-06-23 Daicel Chem Ind Ltd 化粧品組成物
US5807957A (en) * 1996-12-23 1998-09-15 Macrochem Corporation Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
FR2762782B1 (fr) 1997-05-05 1999-06-11 Oreal Composition comprenant un milieu de culture de micro-organisme et utilisation
CA2293501A1 (en) 1997-07-03 1999-01-14 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing amidine-derived diazeniumdiolates, compositions and uses thereof
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
US5922332A (en) * 1997-09-17 1999-07-13 Fossel; Eric T. Topical delivery of arginine to overcome pain
EP2158907B1 (en) * 1997-09-17 2015-08-05 Strategic Science & Technologies, LLC Topical administration of arginine for pain treatment
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US6207713B1 (en) * 1997-09-17 2001-03-27 Eric T. Fossel Topical and oral delivery of arginine to cause beneficial effects
US5895658A (en) 1997-09-17 1999-04-20 Fossel; Eric T. Topical delivery of L-arginine to cause tissue warming
US7629384B2 (en) 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US6096759A (en) 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
US5906822A (en) * 1997-09-25 1999-05-25 Macrochem Corporation Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin
US6037346A (en) * 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6046244A (en) * 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
JP2002516828A (ja) 1998-06-01 2002-06-11 アンソニー・ジェイ・バービスカー 局所経皮治療
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US6117872A (en) 1998-06-23 2000-09-12 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity
AU4972599A (en) * 1998-07-07 2000-01-24 Transdermal Technologies, Inc. Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof
DE19830649C2 (de) * 1998-07-09 2003-04-10 Lohmann Therapie Syst Lts Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
DE19831798A1 (de) 1998-07-15 2000-01-27 Mandorlo Investment Gmbh Luxem Mittel zur Pflege und/oder Behandlung von Haut und Gewebe
AU1231000A (en) * 1998-10-26 2000-05-15 University Of Massachusetts Treatment of skin with adenosine or adenosine analog
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
JP2000186028A (ja) 1998-12-21 2000-07-04 Nobuko Koga 化粧品
FR2787996B1 (fr) 1998-12-30 2002-05-10 Dior Christian Parfums Composition cosmetique ou dermatologique contenant un actif stimulant la synthese de la proteine hsp 32 dans la peau et methode de traitement cosmetique
AU3490300A (en) * 1999-03-12 2000-10-04 Nitromed, Inc. Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
EP1161306B1 (en) 1999-03-12 2006-07-26 Mystic Tan, Inc. Misting apparatus for application of coating materials to skin surface
US6375672B1 (en) 1999-03-22 2002-04-23 Board Of Trustees Of Michigan State University Method for controlling the chemical and heat induced responses of collagenous materials
FR2794974B1 (fr) 1999-06-16 2001-08-17 Exsymol Sa Composition cosmetique pour l'amincissement a base de l-arginine, d'un analogue de l-arginine ou d'un de leurs derives, applicable par voie topique
AU5449699A (en) 1999-09-07 2001-04-10 Kabushiki Kaisha Soken Skin normalizing agents
US6558695B2 (en) * 1999-12-16 2003-05-06 Dermatrends, Inc. Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers
US6602912B2 (en) * 2000-06-30 2003-08-05 Dermatrends, Inc. Transdermal administration of phenylpropanolamine
US6719997B2 (en) * 2000-06-30 2004-04-13 Dermatrends, Inc. Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
US6565879B1 (en) * 1999-12-16 2003-05-20 Dermatrends, Inc. Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers
US6582724B2 (en) 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US6562370B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers
FR2802414B1 (fr) 1999-12-20 2003-06-27 G Pharm Lab Composition, notamment cosmetique ou dermatologique, contenant des oligosaccharides, son procede de preparation et un procede de traitement cosmetique
DE60034791T2 (de) * 2000-01-19 2008-01-17 Mitsubishi Denki K.K. Mikrobauelement und dessen herstellungsverfahren
DE10003767A1 (de) * 2000-01-28 2001-10-04 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika
JP2001288068A (ja) 2000-04-06 2001-10-16 Nof Corp 皮膚化粧料
FR2810540B1 (fr) 2000-06-21 2004-04-30 C3D Nouvelles preparations cosmetiques ou hygieniques sous forme de dispersion
JP2002003373A (ja) 2000-06-27 2002-01-09 Shiseido Co Ltd 皮膚外用剤
US6538033B2 (en) 2000-08-29 2003-03-25 Huntington Medical Research Institutes Nitric oxide donor compounds
US20020168325A1 (en) * 2001-01-25 2002-11-14 Ethan Lerner NOS inhibitors for treatment of wrinkles
WO2002087700A1 (en) 2001-04-26 2002-11-07 The Procter & Gamble Company Method, kit and device for the treatment of cosmetic skin conditions
DE10128910A1 (de) 2001-06-15 2002-12-19 Beiersdorf Ag Verwendung von Wirkstoffkombinationen aus Arginin und Ascorbinsäure zur Hautstraffung
WO2003049593A2 (en) 2001-12-06 2003-06-19 Duke University Prevention of flap necrosis in plastic surgery
US20030157185A1 (en) * 2002-02-08 2003-08-21 Lou Paradise Topical treatment of neuropathy
JP4229842B2 (ja) 2002-02-22 2009-02-25 ルバンス セラピュティックス インク. L−アルギニンオリゴマーを含む化粧品処方
US20030219494A1 (en) 2002-03-20 2003-11-27 Smith Maree Therese Compositions and methods of using them
MXPA04009135A (es) 2002-03-22 2004-12-07 Applied Research Systems Uso de inhibidores de il-18 para el tratamiento y/o prevencion de enfermedades vasculares perifericas.
JP2003286129A (ja) 2002-03-27 2003-10-07 Hakugen:Kk 痩身シート材
WO2003086282A2 (en) * 2002-04-05 2003-10-23 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
RU2229286C2 (ru) 2002-05-27 2004-05-27 Пятигорская государственная фармацевтическая академия Мазь ибупрофена, приготовленная на полиэтиленоксидной основе, обладающая противовоспалительным действием
JP4419368B2 (ja) 2002-07-25 2010-02-24 小野薬品工業株式会社 プロスタグランジン誘導体およびその誘導体を有効成分として含有する薬剤
US20020168424A1 (en) 2002-07-31 2002-11-14 Dr. Mohsen Shahinpoor Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for glaucoma
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US7241456B2 (en) * 2002-10-25 2007-07-10 Australian Importers Ltd. Formulations for topical delivery of bioactive substances and methods for their use
KR100673044B1 (ko) * 2003-05-16 2007-01-22 로터스 파마세티컬 리미티드 컴퍼니 경피 투여용 국소 조성물
AU2003903037A0 (en) * 2003-06-17 2003-07-03 Institute Of Nutraceutical Research Connective tissue derived polypeptides
CA2529528A1 (en) * 2003-06-20 2004-12-29 Ronald Aung-Din Topical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
US20050069590A1 (en) * 2003-09-30 2005-03-31 Buehler Gail K. Stable suspensions for medicinal dosages
JP2005200370A (ja) 2004-01-16 2005-07-28 Nikko Chemical Co Ltd 一酸化窒素産生促進剤およびその利用
WO2005081964A2 (en) 2004-02-23 2005-09-09 Strategic Science & Technologies, Llc Topical delivery of a nitric oxide donor to improve body and skin appearance
US20050196418A1 (en) 2004-03-04 2005-09-08 Yu Ruey J. Bioavailability and improved delivery of alkaline pharmaceutical drugs
US9205062B2 (en) 2004-03-09 2015-12-08 Mylan Pharmaceuticals, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
US20110028548A1 (en) * 2004-04-19 2011-02-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
US9226909B2 (en) * 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
CA2563670C (en) 2004-04-19 2014-09-16 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
US20090105336A1 (en) * 2004-04-19 2009-04-23 Strategic Science & Technologies, Llc Beneficial Effects of Increasing Local Blood Flow
ITMI20041492A1 (it) 2004-07-23 2004-10-23 Italiano Biochimico Far Maceut Nuovo dispositivo per il rilascio di principi attivi
US20070087977A1 (en) * 2004-11-16 2007-04-19 Wendye Robbins Methods and compositions for treating pain
WO2006096360A1 (en) 2005-03-03 2006-09-14 Isw Group, Inc. Topical gels compositions
US7442690B2 (en) * 2005-03-14 2008-10-28 P & L Enterprise Llc Topical treatment for psoriasis
EP1770086A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2007072923A1 (ja) 2005-12-22 2007-06-28 Kowa Company, Ltd. ステロイドの経時的安定性が改善された外用製剤
AU2007283277A1 (en) 2006-08-11 2008-02-14 The University Of Warwick Osmium compounds
US20100015184A1 (en) 2006-12-13 2010-01-21 Tuel Stephen M Methods of Making Pharmaceutical Components for Customized Drug Products
AU2008228764B2 (en) * 2007-03-22 2014-05-08 Berg Llc Topical formulations having enhanced bioavailability
US8686040B2 (en) * 2008-03-31 2014-04-01 Rdd Pharma Ltd. Method for treating anal pruritis and other perianal disorders
US8842076B2 (en) * 2008-07-07 2014-09-23 Rockstar Consortium Us Lp Multi-touch touchscreen incorporating pen tracking
US8969081B2 (en) * 2008-12-10 2015-03-03 The Trustees Of Columbia University In The City Of New York Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid
KR20110136825A (ko) * 2009-03-09 2011-12-21 바이오아트라, 엘엘씨 미락 단백질
US9072659B2 (en) * 2009-06-24 2015-07-07 Strategic Science & Technologies, Llc Topical composition containing naproxen
US8604081B2 (en) * 2009-06-24 2013-12-10 Strategic Science & Technologies, Llc Topical composition containing ibuprofen
EP2658552A4 (en) * 2010-12-29 2015-01-07 Strategic Science & Tech Llc TRANSDERMAL TREATMENT ADMINISTRATION FOR FUNGAL INFECTIONS OTHER INDICATIONS
EP2658551B1 (en) * 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
CN105879035A (zh) * 2010-12-29 2016-08-24 战略科学与技术有限责任公司 治疗偏头痛和其它适应症的方法和系统
EP2658554A4 (en) 2010-12-29 2015-01-07 Strategic Science & Tech Llc SYSTEMS AND METHOD FOR THE TREATMENT OF ALLERGIES AND OTHER INDICATIONS
CN103442722A (zh) * 2010-12-29 2013-12-11 战略科学与技术有限责任公司 Cox-2抑制剂和相关的化合物、及其递送系统和方法
CA2810334C (en) * 2011-02-18 2014-01-07 Precision Biologic Inc. Methods and compositions relating to coagulation assays
JP5727258B2 (ja) * 2011-02-25 2015-06-03 ウイングアーク1st株式会社 分散型データベースシステム

Similar Documents

Publication Publication Date Title
JP2007532696A5 (enExample)
JP5630942B2 (ja) 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達
CN102481275B (zh) 含有布洛芬的表面组合物
JP2012062328A5 (enExample)
US20110028548A1 (en) Beneficial effects of increasing local blood flow
US20090105336A1 (en) Beneficial Effects of Increasing Local Blood Flow
JP2007532697A5 (enExample)
US20130289059A1 (en) Beneficial effects of increasing local blood flow
RU2182006C2 (ru) Способ лечения ревматоидного артрита
CA2835840C (en) Beneficial effects of increasing local blood flow
US20040234620A1 (en) Aluminum-zirconium compound-based treatment for herpes simplex virus lesions
HK1188943A (en) Transdermal delivery of beneficial substances effected by a hostile biophysical environment
AU2015202451A1 (en) Transdermal delivery of beneficial substances effected by a hostile biophysical environment
AU2013203814A1 (en) Transdermal delivery of beneficial substances effected by a hostile biophysical environment transdermal delivery of beneficial substances effected by a hostile biophysical environment