JP2007532576A5 - - Google Patents
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- Publication number
- JP2007532576A5 JP2007532576A5 JP2007507557A JP2007507557A JP2007532576A5 JP 2007532576 A5 JP2007532576 A5 JP 2007532576A5 JP 2007507557 A JP2007507557 A JP 2007507557A JP 2007507557 A JP2007507557 A JP 2007507557A JP 2007532576 A5 JP2007532576 A5 JP 2007532576A5
- Authority
- JP
- Japan
- Prior art keywords
- diiodo
- ethoxyl
- benzoyl
- acetic acid
- benzofuran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000003085 diluting agent Substances 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- -1 2-amino-ethoxyl Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- SOVKDXSMTOVVFW-UHFFFAOYSA-N 2-[3-[4-(2-aminoethoxy)-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetic acid Chemical compound C1=C(I)C(OCCN)=C(I)C=C1C(=O)C1=C(CC(O)=O)OC2=CC=CC=C12 SOVKDXSMTOVVFW-UHFFFAOYSA-N 0.000 claims 1
- PFCZBLNPHPEGKS-UHFFFAOYSA-N 2-[3-[4-[2-(ethylamino)ethoxy]-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetic acid Chemical compound C1=C(I)C(OCCNCC)=C(I)C=C1C(=O)C1=C(CC(O)=O)OC2=CC=CC=C12 PFCZBLNPHPEGKS-UHFFFAOYSA-N 0.000 claims 1
- XAEKWMSRRZNFQR-MRXNPFEDSA-N [(2r)-3-methylbutan-2-yl] 2-[3-[4-[2-(ethylamino)ethoxy]-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetate Chemical compound C1=C(I)C(OCCNCC)=C(I)C=C1C(=O)C1=C(CC(=O)O[C@H](C)C(C)C)OC2=CC=CC=C12 XAEKWMSRRZNFQR-MRXNPFEDSA-N 0.000 claims 1
- IWIWNBHRTHUJNF-OAHLLOKOSA-N [(2r)-butan-2-yl] 2-[3-[4-[2-(ethylamino)ethoxy]-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetate Chemical compound C1=C(I)C(OCCNCC)=C(I)C=C1C(=O)C1=C(CC(=O)O[C@H](C)CC)OC2=CC=CC=C12 IWIWNBHRTHUJNF-OAHLLOKOSA-N 0.000 claims 1
- CTJZIVGEPIKKTD-AWEZNQCLSA-N [(2s)-3-methylbutan-2-yl] 2-[3-[4-(2-aminoethoxy)-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetate Chemical compound CC(C)[C@H](C)OC(=O)CC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN)C(I)=C1 CTJZIVGEPIKKTD-AWEZNQCLSA-N 0.000 claims 1
- AXKHDUDENWKNNO-ZDUSSCGKSA-N [(2s)-butan-2-yl] 2-[3-[4-(2-aminoethoxy)-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetate Chemical compound CC[C@H](C)OC(=O)CC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN)C(I)=C1 AXKHDUDENWKNNO-ZDUSSCGKSA-N 0.000 claims 1
- IWIWNBHRTHUJNF-HNNXBMFYSA-N [(2s)-butan-2-yl] 2-[3-[4-[2-(ethylamino)ethoxy]-3,5-diiodobenzoyl]-1-benzofuran-2-yl]acetate Chemical compound C1=C(I)C(OCCNCC)=C(I)C=C1C(=O)C1=C(CC(=O)O[C@@H](C)CC)OC2=CC=CC=C12 IWIWNBHRTHUJNF-HNNXBMFYSA-N 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56091704P | 2004-04-09 | 2004-04-09 | |
| PCT/US2005/012138 WO2005099684A1 (en) | 2004-04-09 | 2005-04-08 | Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532576A JP2007532576A (ja) | 2007-11-15 |
| JP2007532576A5 true JP2007532576A5 (enExample) | 2008-05-15 |
Family
ID=34965215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507557A Abandoned JP2007532576A (ja) | 2004-04-09 | 2005-04-08 | 心不整脈治療のための新化合物およびその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7105568B2 (enExample) |
| EP (1) | EP1732537A1 (enExample) |
| JP (1) | JP2007532576A (enExample) |
| KR (1) | KR20070001259A (enExample) |
| CN (1) | CN1950080A (enExample) |
| AU (1) | AU2005232701A1 (enExample) |
| BR (1) | BRPI0509740A (enExample) |
| CA (1) | CA2560336A1 (enExample) |
| IL (1) | IL178127A0 (enExample) |
| MX (1) | MXPA06011647A (enExample) |
| NO (1) | NO20065156L (enExample) |
| RU (1) | RU2373199C2 (enExample) |
| WO (1) | WO2005099684A1 (enExample) |
| ZA (1) | ZA200607666B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2373199C2 (ru) * | 2004-04-09 | 2009-11-20 | Арикс Терапьютикс | Производные бензофурана, композиции на их основе и способы лечения аритмии сердца |
| RU2446143C2 (ru) * | 2010-05-19 | 2012-03-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ЯГТУ) | Способ получения эфиров замещенных 5,6-дицианобензофуран-2-карбоновых кислот |
| CN108396016B (zh) * | 2018-02-05 | 2021-05-25 | 中国科学院南海海洋研究所 | 一种酯酶phe21及其编码基因和在手性乙酸仲丁酯制备中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2550091B1 (fr) * | 1983-08-02 | 1986-05-23 | Sanofi Sa | Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne |
| US5175187A (en) * | 1989-03-06 | 1992-12-29 | Soorianarain Baligadoo | Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof |
| US5364880A (en) * | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| US6309823B1 (en) * | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
| US6121278A (en) * | 1997-09-03 | 2000-09-19 | Guilford Pharmaceuticals, Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| RU2138492C1 (ru) * | 1997-12-23 | 1999-09-27 | Пятигорская государственная фармацевтическая академия | Способ синтеза производных 3-(5-метилфур-2-ил)-бензофурана, обладающих гипотензивной, антиангинальной и антиаритмической активностями |
| ATE369351T1 (de) * | 1999-10-15 | 2007-08-15 | Aryx Therapeutics | Enantiomere verbindungen zur behandlung von herzrythmusstörungen und verfahren zu ihrer anwendung |
| EP1451169A1 (en) * | 2001-12-10 | 2004-09-01 | ARYx Therapeutics | Novel compounds for the treatment of cardiac arrhythmia, synthesis, and methods of use |
| US7015568B2 (en) * | 2003-08-21 | 2006-03-21 | Texas Instruments Incorporated | System for ultraviolet atmospheric seed layer remediation |
| RU2373199C2 (ru) * | 2004-04-09 | 2009-11-20 | Арикс Терапьютикс | Производные бензофурана, композиции на их основе и способы лечения аритмии сердца |
-
2005
- 2005-04-08 RU RU2006139649/04A patent/RU2373199C2/ru not_active IP Right Cessation
- 2005-04-08 MX MXPA06011647A patent/MXPA06011647A/es active IP Right Grant
- 2005-04-08 KR KR1020067022953A patent/KR20070001259A/ko not_active Ceased
- 2005-04-08 JP JP2007507557A patent/JP2007532576A/ja not_active Abandoned
- 2005-04-08 EP EP05735166A patent/EP1732537A1/en not_active Ceased
- 2005-04-08 AU AU2005232701A patent/AU2005232701A1/en not_active Abandoned
- 2005-04-08 BR BRPI0509740-1A patent/BRPI0509740A/pt not_active IP Right Cessation
- 2005-04-08 CA CA002560336A patent/CA2560336A1/en not_active Abandoned
- 2005-04-08 US US11/101,995 patent/US7105568B2/en not_active Expired - Lifetime
- 2005-04-08 CN CNA200580012140XA patent/CN1950080A/zh active Pending
- 2005-04-08 WO PCT/US2005/012138 patent/WO2005099684A1/en not_active Ceased
-
2006
- 2006-06-12 US US11/423,559 patent/US7351842B2/en not_active Expired - Fee Related
- 2006-09-13 ZA ZA200607666A patent/ZA200607666B/en unknown
- 2006-09-14 IL IL178127A patent/IL178127A0/en unknown
- 2006-11-09 NO NO20065156A patent/NO20065156L/no not_active Application Discontinuation
-
2007
- 2007-11-07 US US11/936,620 patent/US20080114059A1/en not_active Abandoned