JP2019536778A5 - - Google Patents
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- Publication number
- JP2019536778A5 JP2019536778A5 JP2019526008A JP2019526008A JP2019536778A5 JP 2019536778 A5 JP2019536778 A5 JP 2019536778A5 JP 2019526008 A JP2019526008 A JP 2019526008A JP 2019526008 A JP2019526008 A JP 2019526008A JP 2019536778 A5 JP2019536778 A5 JP 2019536778A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 101100019065 Arabidopsis thaliana IRT3 gene Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 0 Cc1ncc(*)c(CN)c1O Chemical compound Cc1ncc(*)c(CN)c1O 0.000 description 5
- OJUQETBTBKEFSO-UHFFFAOYSA-N COC(CC1C(CC(O)=O)N)=CC=C1O Chemical compound COC(CC1C(CC(O)=O)N)=CC=C1O OJUQETBTBKEFSO-UHFFFAOYSA-N 0.000 description 1
- LIDYFNYBHXPTJG-UHFFFAOYSA-N NC(C(O)=O)c(cccc1)c1O Chemical compound NC(C(O)=O)c(cccc1)c1O LIDYFNYBHXPTJG-UHFFFAOYSA-N 0.000 description 1
- RDKQLEOJQPXUQH-UHFFFAOYSA-N NCc(c(O)cnc1I)c1O Chemical compound NCc(c(O)cnc1I)c1O RDKQLEOJQPXUQH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662422486P | 2016-11-15 | 2016-11-15 | |
| US62/422,486 | 2016-11-15 | ||
| PCT/US2017/061854 WO2018093936A1 (en) | 2016-11-15 | 2017-11-15 | Use of 2-hydroxybenzylamine in the treatment and prevention of pulmonary hypertension |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536778A JP2019536778A (ja) | 2019-12-19 |
| JP2019536778A5 true JP2019536778A5 (enExample) | 2020-12-24 |
| JP7383285B2 JP7383285B2 (ja) | 2023-11-20 |
Family
ID=62145792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019526008A Active JP7383285B2 (ja) | 2016-11-15 | 2017-11-15 | 肺高血圧症の治療及び予防における２－ヒドロキシベンジルアミンの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190314302A1 (enExample) |
| EP (2) | EP3541185B1 (enExample) |
| JP (1) | JP7383285B2 (enExample) |
| CN (1) | CN110177463B (enExample) |
| AU (1) | AU2017362328B2 (enExample) |
| ES (1) | ES2981715T3 (enExample) |
| HU (1) | HUE067036T2 (enExample) |
| PL (1) | PL3541185T3 (enExample) |
| WO (1) | WO2018093936A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11400103B2 (en) * | 2015-12-21 | 2022-08-02 | Vanderbilt University | Methods of preventing platelet activation |
| AU2020210888A1 (en) | 2019-01-25 | 2021-08-19 | Vanderbilt University | Mitochondria-targeted isoketal/isolevuglandin scavengers |
| JP2023512225A (ja) * | 2020-01-27 | 2023-03-24 | ヴァンダービルト ユニバーシティー | ミトコンドリア標的イソケタール／イソレブグランジンスカベンジャー及びその使用 |
| WO2022081777A1 (en) * | 2020-10-13 | 2022-04-21 | Vanderbilt University | Method of preventing kidney injury disruption of intestinal lymphatics |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2520422A1 (en) * | 2003-03-27 | 2004-10-07 | Medicure Inc. | Compositions for treating angina |
| US8822542B2 (en) * | 2004-10-20 | 2014-09-02 | Vanderbilt University | Isoketal scavengers and mitigation of disorders involving oxidative injury |
| JP5132109B2 (ja) * | 2006-09-01 | 2013-01-30 | 花王株式会社 | 一剤式染毛剤組成物 |
| CN101677992A (zh) * | 2006-11-13 | 2010-03-24 | M·F·麦卡蒂 | 抑制nadph氧化酶活性的组合物 |
| US8314015B2 (en) * | 2010-07-14 | 2012-11-20 | Sharp Laboratories Of America, Inc. | Silicon surface modification for the electrochemical synthesis of silicon particles in suspension |
| EP2731597B1 (en) * | 2011-07-12 | 2023-12-20 | Vanderbilt University | Methods for treating inflammation and hypertension with gamma-ketoaldehyde skavengers |
| WO2013142303A1 (en) * | 2012-03-19 | 2013-09-26 | Lycera Corporation | Methods and compositions for detecting immune system activation |
| US20170056381A1 (en) * | 2014-02-20 | 2017-03-02 | Nanometics Llc | Pyridoxamine for the treatment of sickle cell disease, thalassemia and related blood diseases |
| US20160199463A1 (en) * | 2014-12-15 | 2016-07-14 | The Johns Hopkins University | Hdac2 defends vascular endothelium from injury |
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2017
- 2017-11-15 EP EP17871457.2A patent/EP3541185B1/en active Active
- 2017-11-15 ES ES17871457T patent/ES2981715T3/es active Active
- 2017-11-15 PL PL17871457.2T patent/PL3541185T3/pl unknown
- 2017-11-15 HU HUE17871457A patent/HUE067036T2/hu unknown
- 2017-11-15 WO PCT/US2017/061854 patent/WO2018093936A1/en not_active Ceased
- 2017-11-15 US US16/347,755 patent/US20190314302A1/en not_active Abandoned
- 2017-11-15 CN CN201780083516.9A patent/CN110177463B/zh active Active
- 2017-11-15 JP JP2019526008A patent/JP7383285B2/ja active Active
- 2017-11-15 EP EP24171414.6A patent/EP4385576A3/en active Pending
- 2017-11-15 AU AU2017362328A patent/AU2017362328B2/en active Active
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2025
- 2025-03-25 US US19/090,325 patent/US20250381155A1/en active Pending