CN1950080A - 治疗心律失常的新化合物及其使用方法 - Google Patents

治疗心律失常的新化合物及其使用方法 Download PDF

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Publication number
CN1950080A
CN1950080A CNA200580012140XA CN200580012140A CN1950080A CN 1950080 A CN1950080 A CN 1950080A CN A200580012140X A CNA200580012140X A CN A200580012140XA CN 200580012140 A CN200580012140 A CN 200580012140A CN 1950080 A CN1950080 A CN 1950080A
Authority
CN
China
Prior art keywords
compound
compounds
diiodo
benzofuran
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200580012140XA
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English (en)
Chinese (zh)
Inventor
P·德鲁加拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARYx Therapeutics Inc
Original Assignee
ARYx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARYx Therapeutics Inc filed Critical ARYx Therapeutics Inc
Publication of CN1950080A publication Critical patent/CN1950080A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA200580012140XA 2004-04-09 2005-04-08 治疗心律失常的新化合物及其使用方法 Pending CN1950080A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56091704P 2004-04-09 2004-04-09
US60/560,917 2004-04-09

Publications (1)

Publication Number Publication Date
CN1950080A true CN1950080A (zh) 2007-04-18

Family

ID=34965215

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200580012140XA Pending CN1950080A (zh) 2004-04-09 2005-04-08 治疗心律失常的新化合物及其使用方法

Country Status (14)

Country Link
US (3) US7105568B2 (enExample)
EP (1) EP1732537A1 (enExample)
JP (1) JP2007532576A (enExample)
KR (1) KR20070001259A (enExample)
CN (1) CN1950080A (enExample)
AU (1) AU2005232701A1 (enExample)
BR (1) BRPI0509740A (enExample)
CA (1) CA2560336A1 (enExample)
IL (1) IL178127A0 (enExample)
MX (1) MXPA06011647A (enExample)
NO (1) NO20065156L (enExample)
RU (1) RU2373199C2 (enExample)
WO (1) WO2005099684A1 (enExample)
ZA (1) ZA200607666B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108396016A (zh) * 2018-02-05 2018-08-14 中国科学院南海海洋研究所 一种酯酶phe21及其编码基因和在手性乙酸仲丁酯制备中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2373199C2 (ru) * 2004-04-09 2009-11-20 Арикс Терапьютикс Производные бензофурана, композиции на их основе и способы лечения аритмии сердца
RU2446143C2 (ru) * 2010-05-19 2012-03-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ЯГТУ) Способ получения эфиров замещенных 5,6-дицианобензофуран-2-карбоновых кислот

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550091B1 (fr) * 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
US5175187A (en) * 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6309823B1 (en) * 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US6121278A (en) * 1997-09-03 2000-09-19 Guilford Pharmaceuticals, Inc. Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
RU2138492C1 (ru) * 1997-12-23 1999-09-27 Пятигорская государственная фармацевтическая академия Способ синтеза производных 3-(5-метилфур-2-ил)-бензофурана, обладающих гипотензивной, антиангинальной и антиаритмической активностями
ATE369351T1 (de) * 1999-10-15 2007-08-15 Aryx Therapeutics Enantiomere verbindungen zur behandlung von herzrythmusstörungen und verfahren zu ihrer anwendung
EP1451169A1 (en) * 2001-12-10 2004-09-01 ARYx Therapeutics Novel compounds for the treatment of cardiac arrhythmia, synthesis, and methods of use
US7015568B2 (en) * 2003-08-21 2006-03-21 Texas Instruments Incorporated System for ultraviolet atmospheric seed layer remediation
RU2373199C2 (ru) * 2004-04-09 2009-11-20 Арикс Терапьютикс Производные бензофурана, композиции на их основе и способы лечения аритмии сердца

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108396016A (zh) * 2018-02-05 2018-08-14 中国科学院南海海洋研究所 一种酯酶phe21及其编码基因和在手性乙酸仲丁酯制备中的应用

Also Published As

Publication number Publication date
US20060276535A1 (en) 2006-12-07
US20080114059A1 (en) 2008-05-15
CA2560336A1 (en) 2005-10-27
JP2007532576A (ja) 2007-11-15
AU2005232701A1 (en) 2005-10-27
KR20070001259A (ko) 2007-01-03
US20050228045A1 (en) 2005-10-13
EP1732537A1 (en) 2006-12-20
IL178127A0 (en) 2006-12-31
NO20065156L (no) 2006-11-09
US7105568B2 (en) 2006-09-12
WO2005099684A1 (en) 2005-10-27
MXPA06011647A (es) 2007-04-13
RU2373199C2 (ru) 2009-11-20
BRPI0509740A (pt) 2007-09-25
ZA200607666B (en) 2008-03-26
US7351842B2 (en) 2008-04-01
RU2006139649A (ru) 2008-05-20

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