KR20070001259A - 심장 부정맥 치료에 유용한 벤조푸라닐 유도체 - Google Patents

심장 부정맥 치료에 유용한 벤조푸라닐 유도체 Download PDF

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Publication number
KR20070001259A
KR20070001259A KR1020067022953A KR20067022953A KR20070001259A KR 20070001259 A KR20070001259 A KR 20070001259A KR 1020067022953 A KR1020067022953 A KR 1020067022953A KR 20067022953 A KR20067022953 A KR 20067022953A KR 20070001259 A KR20070001259 A KR 20070001259A
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KR
South Korea
Prior art keywords
compound
compounds
diiodo
benzofuran
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020067022953A
Other languages
English (en)
Korean (ko)
Inventor
파스칼 드루즈갈라
Original Assignee
아릭스 테라퓨틱스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아릭스 테라퓨틱스 filed Critical 아릭스 테라퓨틱스
Publication of KR20070001259A publication Critical patent/KR20070001259A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020067022953A 2004-04-09 2005-04-08 심장 부정맥 치료에 유용한 벤조푸라닐 유도체 Ceased KR20070001259A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56091704P 2004-04-09 2004-04-09
US60/560,917 2004-04-09

Publications (1)

Publication Number Publication Date
KR20070001259A true KR20070001259A (ko) 2007-01-03

Family

ID=34965215

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067022953A Ceased KR20070001259A (ko) 2004-04-09 2005-04-08 심장 부정맥 치료에 유용한 벤조푸라닐 유도체

Country Status (14)

Country Link
US (3) US7105568B2 (enExample)
EP (1) EP1732537A1 (enExample)
JP (1) JP2007532576A (enExample)
KR (1) KR20070001259A (enExample)
CN (1) CN1950080A (enExample)
AU (1) AU2005232701A1 (enExample)
BR (1) BRPI0509740A (enExample)
CA (1) CA2560336A1 (enExample)
IL (1) IL178127A0 (enExample)
MX (1) MXPA06011647A (enExample)
NO (1) NO20065156L (enExample)
RU (1) RU2373199C2 (enExample)
WO (1) WO2005099684A1 (enExample)
ZA (1) ZA200607666B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1732537A1 (en) * 2004-04-09 2006-12-20 Aryx Therapeutics Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia
RU2446143C2 (ru) * 2010-05-19 2012-03-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ЯГТУ) Способ получения эфиров замещенных 5,6-дицианобензофуран-2-карбоновых кислот
CN108396016B (zh) * 2018-02-05 2021-05-25 中国科学院南海海洋研究所 一种酯酶phe21及其编码基因和在手性乙酸仲丁酯制备中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550091B1 (fr) * 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
US5175187A (en) * 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6309823B1 (en) * 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US6121278A (en) * 1997-09-03 2000-09-19 Guilford Pharmaceuticals, Inc. Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
RU2138492C1 (ru) * 1997-12-23 1999-09-27 Пятигорская государственная фармацевтическая академия Способ синтеза производных 3-(5-метилфур-2-ил)-бензофурана, обладающих гипотензивной, антиангинальной и антиаритмической активностями
DE60035888T2 (de) * 1999-10-15 2007-12-06 Aryx Therapeutics, Fremont Enantiomere verbindungen zur behandlung von herzrythmusstörungen und verfahren zu ihrer anwendung
EP1451169A1 (en) * 2001-12-10 2004-09-01 ARYx Therapeutics Novel compounds for the treatment of cardiac arrhythmia, synthesis, and methods of use
US7015568B2 (en) * 2003-08-21 2006-03-21 Texas Instruments Incorporated System for ultraviolet atmospheric seed layer remediation
EP1732537A1 (en) * 2004-04-09 2006-12-20 Aryx Therapeutics Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia

Also Published As

Publication number Publication date
IL178127A0 (en) 2006-12-31
NO20065156L (no) 2006-11-09
RU2373199C2 (ru) 2009-11-20
US7105568B2 (en) 2006-09-12
US20080114059A1 (en) 2008-05-15
CN1950080A (zh) 2007-04-18
BRPI0509740A (pt) 2007-09-25
MXPA06011647A (es) 2007-04-13
RU2006139649A (ru) 2008-05-20
ZA200607666B (en) 2008-03-26
CA2560336A1 (en) 2005-10-27
JP2007532576A (ja) 2007-11-15
EP1732537A1 (en) 2006-12-20
WO2005099684A1 (en) 2005-10-27
US7351842B2 (en) 2008-04-01
AU2005232701A1 (en) 2005-10-27
US20060276535A1 (en) 2006-12-07
US20050228045A1 (en) 2005-10-13

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PA0105 International application

Patent event date: 20061101

Patent event code: PA01051R01D

Comment text: International Patent Application

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Patent event code: PA02012R01D

Patent event date: 20100405

Comment text: Request for Examination of Application

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Patent event date: 20111219

Patent event code: PE09021S01D

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PE0601 Decision on rejection of patent

Patent event date: 20120628

Comment text: Decision to Refuse Application

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Patent event date: 20111219

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I