JP2007530498A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007530498A5 JP2007530498A5 JP2007504378A JP2007504378A JP2007530498A5 JP 2007530498 A5 JP2007530498 A5 JP 2007530498A5 JP 2007504378 A JP2007504378 A JP 2007504378A JP 2007504378 A JP2007504378 A JP 2007504378A JP 2007530498 A5 JP2007530498 A5 JP 2007530498A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pharmaceutical composition
- hydroxy tamoxifen
- composition according
- isomer form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (12)
- 約４５％〜５５％、約４６％〜５４％、約４７％〜５３％、約４８％〜５２％、約４９％〜５１％または約５０％の４−ヒドロキシタモキシフェンがＺ異性体の形態で存在し、残りの４−ヒドロキシタモキシフェンがＥ異性体の形態で存在する、４−ヒドロキシタモキシフェンを含む、平衡状態の医薬組成物。
- 経皮投与用に製剤されている請求項１に記載の医薬組成物。
- アルコールおよび／または浸透促進剤をさらに含む請求項２に記載の医薬組成物。
- 前記４−ヒドロキシタモキシフェンが、水性アルコールゲル、水性アルコール溶液、貼付剤、軟膏、クリーム、乳濁液（ローション）、散剤またはオイルに製剤されている請求項２に記載の医薬組成物。
- 前記４−ヒドロキシタモキシフェンが、水性アルコールゲルに製剤されている請求項４に記載の医薬組成物。
- 前記水性アルコールゲルが、エタノール、ミリスチン酸イソプロピル、およびヒドロキシプロピルセルロースを含む請求項５に記載の医薬組成物。
- この医薬組成物が、
ａ）約０．０１重量％〜０．２重量％の４−ヒドロキシタモキシフェン、
ｂ）約０．５重量％〜２重量％のミリスチン酸イソプロピル、
ｃ）約６０重量％〜７５重量％の無水アルコール、
ｄ）約２５重量％〜４０重量％の水系媒体、
ｅ）約０．５重量％〜５重量％のゲル化剤
を含み；
成分の前記パーセントが、前記組成物の重量に対する重量である請求項２に記載の医薬組成物。 - 単位用量小袋内または計量ポンプ付きの複数用量容器内に入れられている請求項７に記載の医薬組成物。
- （ｉ）所定量の４−ヒドロキシタモキシフェンを準備する工程と、
（ｉｉ）少なくとも１種の賦形剤を準備する工程と、
（ｉｉｉ）前記４−ヒドロキシタモキシフェンと前記少なくとも１種の賦形剤とを組み合わせることにより、医薬組成物を形成する工程と、
（ｉｖ）前記医薬組成物を、約４５％〜５５％、約４６％〜５４％、約４７％〜５３％、約４８％〜５２％、約４９％〜５１％または約５０％の４−ヒドロキシタモキシフェンがＺ異性体の形態で存在し、残りの４−ヒドロキシタモキシフェンがＥ異性体の形態で存在する平衡状態にする工程と
を有する医薬組成物を製造する方法。 - 前記医薬組成物が経皮投与用のものである請求項９に記載の方法。
- 前記医薬組成物が、
ａ）約０．０１重量％〜０．２重量％の４−ヒドロキシタモキシフェン、
ｂ）約０．５重量％〜２重量％のミリスチン酸イソプロピル、
ｃ）約６０重量％〜７５重量％の無水アルコール、
ｄ）約２５重量％〜４０重量％の水系媒体、
ｅ）約０．５重量％〜５重量％のゲル化剤
を含み；
成分の前記パーセントが、前記組成物の重量に対する重量である請求項９に記載の方法。 - 請求項９〜１１のいずれかに記載の方法で得られる医薬組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/805,530 US20050208139A1 (en) | 2004-03-22 | 2004-03-22 | Chemically stable compositions of 4-hydroxy tamoxifen |
| EP04290762A EP1579857A1 (en) | 2004-03-22 | 2004-03-22 | Chemically stable compositions of 4-hydroxy tamoxifen |
| US10/805,530 | 2004-03-22 | ||
| EP04290762.6 | 2004-03-22 | ||
| PCT/EP2005/003455 WO2005092310A2 (en) | 2004-03-22 | 2005-03-18 | Chemically stable compositions of 4-hydroxy tamoxifen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007530498A JP2007530498A (ja) | 2007-11-01 |
| JP2007530498A5 true JP2007530498A5 (ja) | 2008-05-08 |
| JP5489407B2 JP5489407B2 (ja) | 2014-05-14 |
Family
ID=34854723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504378A Active JP5489407B2 (ja) | 2004-03-22 | 2005-03-18 | ４−ヒドロキシタモキシフェンの化学的に安定な組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20050208139A1 (ja) |
| EP (4) | EP1579857A1 (ja) |
| JP (1) | JP5489407B2 (ja) |
| CN (1) | CN101080222B (ja) |
| AR (1) | AR048587A1 (ja) |
| AT (1) | ATE453387T1 (ja) |
| AU (1) | AU2005227073B2 (ja) |
| CA (1) | CA2557806C (ja) |
| DE (1) | DE602005018613D1 (ja) |
| DK (1) | DK1727532T3 (ja) |
| ES (3) | ES2337069T3 (ja) |
| HK (2) | HK1098674A1 (ja) |
| IL (2) | IL177778A (ja) |
| MX (1) | MXPA06010928A (ja) |
| NO (1) | NO337298B1 (ja) |
| NZ (1) | NZ549664A (ja) |
| PL (1) | PL1727532T3 (ja) |
| PT (1) | PT1727532E (ja) |
| RU (1) | RU2389483C2 (ja) |
| TW (1) | TWI401078B (ja) |
| WO (1) | WO2005092310A2 (ja) |
| ZA (1) | ZA200607291B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4938237B2 (ja) * | 2002-12-18 | 2012-05-23 | ラボラトワール ブザン アンテルナスィヨナル | ４−ヒドロキシタモキシフェンによる乳房痛の治療 |
| EP1952809B1 (en) * | 2002-12-18 | 2017-08-02 | Besins Healthcare Luxembourg SARL | Formulations for the reduction of breast density with 4-Hydroxy Tamoxifen |
| JP5490346B2 (ja) * | 2003-04-01 | 2014-05-14 | ブザン ヘルスケア ルクセンブルグ エスアーエールエル | ４−ヒドロキシタモキシフェンによる乳癌の予防および治療 |
| DE602004013439T2 (de) * | 2003-06-09 | 2009-06-04 | Ascend Therapeutics, Inc. | Behandlung und prävention von übermässiger narbenbildung mit 4-hydroxy tamoxifen |
| US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| DK1799201T3 (da) * | 2004-10-14 | 2009-03-30 | Besins Int Lab | 4-Hydroxy-tamoxifen gelformuleringer |
| EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
| US8785501B2 (en) | 2009-10-13 | 2014-07-22 | Duquesne University Of The Holy Spirit | Anti-cancer tamoxifen-melatonin hybrid ligand |
| CN103945832B (zh) * | 2011-07-14 | 2017-03-29 | 能脑有限责任公司 | 用于脑能量分子延迟释放和持续释放的组合物，装置及方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2558373B1 (fr) * | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee |
| US5475851A (en) * | 1986-04-14 | 1995-12-12 | National Instruments Corporation | Method and apparatus for improved local and global variable capabilities in a graphical data flow program |
| US5002938A (en) * | 1988-03-21 | 1991-03-26 | Bristol-Myers Squibb Company | Antifungal gel formulations |
| CA2032695A1 (en) | 1989-12-20 | 1991-06-21 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
| DE4407742C1 (de) * | 1994-03-08 | 1995-06-22 | Hexal Pharma Gmbh | Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat |
| US6160549A (en) * | 1994-07-29 | 2000-12-12 | Oracle Corporation | Method and apparatus for generating reports using declarative tools |
| DE4435784C2 (de) * | 1994-10-06 | 1998-10-29 | Heraeus Electro Nite Int | Elektrisch beheizbarer Starterkat |
| US5777621A (en) * | 1994-12-22 | 1998-07-07 | Apple Computer, Inc. | Quality control mechanism for three-dimensional graphics rendering |
| WO1997026234A1 (en) * | 1996-01-20 | 1997-07-24 | Bradford University | Tamoxifen and analogues thereof |
| WO1997036570A1 (de) * | 1996-03-29 | 1997-10-09 | S.W. Patentverwertungs Ges. M.B.H. Edelsbacher U. Partner | Kosmetikum bzw. kosmetikzusammensetzung zur glättung und straffung der haut bei gestörtem unterhaut-binde-fettgewebe, insbesondere bei der 'cellulite' |
| US6083996A (en) * | 1997-11-05 | 2000-07-04 | Nexmed Holdings, Inc. | Topical compositions for NSAI drug delivery |
| WO1999033451A2 (en) * | 1997-12-23 | 1999-07-08 | Hexal Ag | Mixture and pharmaceutical composition comprising z-4-hydroxytamoxifen and cyclodextrin |
| JP2000038335A (ja) * | 1998-07-22 | 2000-02-08 | Kanebo Ltd | 皮膚化粧料 |
| AU6890800A (en) | 1999-08-23 | 2001-03-19 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
| DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| AU2002340120A1 (en) * | 2001-10-04 | 2003-04-14 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
| DE60139625D1 (de) * | 2001-12-07 | 2009-10-01 | Besins Int Belgique | Gel oder Lösung enthaltend Dihydrotestosterone, deren Herstellungsverfahren und Verwendung |
| US6695171B2 (en) * | 2002-02-12 | 2004-02-24 | Seaquistperfect Dispensing Foreign, Inc. | Pump dispenser |
| JP4938237B2 (ja) * | 2002-12-18 | 2012-05-23 | ラボラトワール ブザン アンテルナスィヨナル | ４−ヒドロキシタモキシフェンによる乳房痛の治療 |
| EP1952809B1 (en) * | 2002-12-18 | 2017-08-02 | Besins Healthcare Luxembourg SARL | Formulations for the reduction of breast density with 4-Hydroxy Tamoxifen |
| JP5490346B2 (ja) * | 2003-04-01 | 2014-05-14 | ブザン ヘルスケア ルクセンブルグ エスアーエールエル | ４−ヒドロキシタモキシフェンによる乳癌の予防および治療 |
| DE602004013439T2 (de) * | 2003-06-09 | 2009-06-04 | Ascend Therapeutics, Inc. | Behandlung und prävention von übermässiger narbenbildung mit 4-hydroxy tamoxifen |
| JP5069469B2 (ja) * | 2003-12-15 | 2012-11-07 | ラボラトワール ブザン アンテルナスィヨナル | 女性化乳房治療用の薬剤を製造する際の４−ヒドロキシタモキシフェンの使用 |
| US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
-
2004
- 2004-03-22 US US10/805,530 patent/US20050208139A1/en not_active Abandoned
- 2004-03-22 EP EP04290762A patent/EP1579857A1/en not_active Withdrawn
-
2005
- 2005-03-18 ES ES05735277T patent/ES2337069T3/es active Active
- 2005-03-18 AU AU2005227073A patent/AU2005227073B2/en active Active
- 2005-03-18 EP EP10180921A patent/EP2269599B1/en active Active
- 2005-03-18 NZ NZ549664A patent/NZ549664A/en unknown
- 2005-03-18 RU RU2006137282/15A patent/RU2389483C2/ru active
- 2005-03-18 DK DK05735277.5T patent/DK1727532T3/da active
- 2005-03-18 PT PT05735277T patent/PT1727532E/pt unknown
- 2005-03-18 EP EP09175781.5A patent/EP2147670B1/en active Active
- 2005-03-18 WO PCT/EP2005/003455 patent/WO2005092310A2/en active Search and Examination
- 2005-03-18 ES ES09175781.5T patent/ES2517894T3/es active Active
- 2005-03-18 CA CA2557806A patent/CA2557806C/en active Active
- 2005-03-18 PL PL05735277T patent/PL1727532T3/pl unknown
- 2005-03-18 EP EP05735277A patent/EP1727532B1/en active Active
- 2005-03-18 JP JP2007504378A patent/JP5489407B2/ja active Active
- 2005-03-18 DE DE602005018613T patent/DE602005018613D1/de active Active
- 2005-03-18 ES ES10180921T patent/ES2402921T3/es active Active
- 2005-03-18 AT AT05735277T patent/ATE453387T1/de active
- 2005-03-18 MX MXPA06010928A patent/MXPA06010928A/es active IP Right Grant
- 2005-03-18 CN CN200580009171XA patent/CN101080222B/zh active Active
- 2005-03-21 TW TW094108588A patent/TWI401078B/zh active
- 2005-03-22 AR ARP050101125A patent/AR048587A1/es unknown
-
2006
- 2006-08-30 IL IL177778A patent/IL177778A/en active IP Right Grant
- 2006-08-31 ZA ZA2006/07291A patent/ZA200607291B/en unknown
- 2006-10-20 NO NO20064765A patent/NO337298B1/no unknown
-
2007
- 2007-04-20 HK HK07104159.2A patent/HK1098674A1/xx unknown
-
2010
- 2010-06-23 HK HK10106178.9A patent/HK1139332A1/xx unknown
-
2011
- 2011-10-25 IL IL215897A patent/IL215897A/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007530498A5 (ja) | ||
| JP7187522B2 (ja) | 勃起不全および他の適応症の処置 | |
| Barkin | Topical nonsteroidal anti-inflammatory drugs: the importance of drug, delivery, and therapeutic outcome | |
| Egorova et al. | Cytotoxic activity of salicylic acid-containing drug models with ionic and covalent binding | |
| JP5589130B1 (ja) | 結晶及び該結晶を含有してなる医薬製剤 | |
| KR20190037229A (ko) | 상승효과적 항진균 조성물 및 그의 방법 | |
| CN102770123A (zh) | 用于治疗甲癣的高渗透性特比萘芬制剂 | |
| TW200815045A (en) | Pharmaceutical compositions of ropinirole and methods of use thereof | |
| Liu et al. | Protective effects of quercetin against pyrazinamide induced hepatotoxicity via a cocrystallization strategy of complementary advantages | |
| Jain et al. | Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system | |
| WO2007111993A2 (en) | Polyamine analogs as therapeutic agents for skin diseases | |
| IL215897A (en) | Pharmacological preparation in equilibrium containing 4-hydroxy tamoxifen and a method for its preparation | |
| TW201247613A (en) | Ester derivatives of bimatoprost compositions and methods | |
| BR112014012601A2 (pt) | composição preservativa antimicrobiana, método para a preservação de produto de cuidado pessoal do ataque microbiano que contém uma fase aquosa, e formulação de cuidado pessoal para aplicação tópica | |
| Lather et al. | Proniosomal gel-mediated transdermal delivery of bromocriptine: in vitro and ex vivo evaluation | |
| BRPI0618273A2 (pt) | formulações de dosagem oral de ibuprofeno organolepticamente aceitáveis, métodos de produção e uso das mesmas | |
| JP2006527234A5 (ja) | ||
| JP2019526631A5 (ja) | ||
| TWI789448B (zh) | 灰指甲治療用之外用製劑 | |
| JP5608331B2 (ja) | 熱産生タンパク質発現促進剤 | |
| CN102988276B (zh) | 一种盐酸特比萘芬乳膏处方及其制备工艺 | |
| JP2005047906A (ja) | 外用消炎鎮痛剤組成物 | |
| GB2614741A (en) | A liquid pharmaceutical formulation of clonidine hydrochloride | |
| JP6503626B2 (ja) | 医薬組成物 | |
| JP2007535505A5 (ja) |