ATE453387T1 - Chemisch stabile zusammensetzungen von 4-hydroxy- tamoxifen - Google Patents

Chemisch stabile zusammensetzungen von 4-hydroxy- tamoxifen

Info

Publication number
ATE453387T1
ATE453387T1 AT05735277T AT05735277T ATE453387T1 AT E453387 T1 ATE453387 T1 AT E453387T1 AT 05735277 T AT05735277 T AT 05735277T AT 05735277 T AT05735277 T AT 05735277T AT E453387 T1 ATE453387 T1 AT E453387T1
Authority
AT
Austria
Prior art keywords
tamoxifen
hydroxy
chemically stable
stable compositions
compositions
Prior art date
Application number
AT05735277T
Other languages
English (en)
Inventor
Dana C Hilt
Valerie Masini-Eteve
Richard Fedynec
Brigitte Taravella
Original Assignee
Besins Int Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Besins Int Lab filed Critical Besins Int Lab
Application granted granted Critical
Publication of ATE453387T1 publication Critical patent/ATE453387T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05735277T 2004-03-22 2005-03-18 Chemisch stabile zusammensetzungen von 4-hydroxy- tamoxifen ATE453387T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04290762A EP1579857A1 (de) 2004-03-22 2004-03-22 Stabile Zusammensetzungen enthaltend 4-hydroxy Tamoxifen
US10/805,530 US20050208139A1 (en) 2004-03-22 2004-03-22 Chemically stable compositions of 4-hydroxy tamoxifen
PCT/EP2005/003455 WO2005092310A2 (en) 2004-03-22 2005-03-18 Chemically stable compositions of 4-hydroxy tamoxifen

Publications (1)

Publication Number Publication Date
ATE453387T1 true ATE453387T1 (de) 2010-01-15

Family

ID=34854723

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05735277T ATE453387T1 (de) 2004-03-22 2005-03-18 Chemisch stabile zusammensetzungen von 4-hydroxy- tamoxifen

Country Status (22)

Country Link
US (1) US20050208139A1 (de)
EP (4) EP1579857A1 (de)
JP (1) JP5489407B2 (de)
CN (1) CN101080222B (de)
AR (1) AR048587A1 (de)
AT (1) ATE453387T1 (de)
AU (1) AU2005227073B2 (de)
CA (1) CA2557806C (de)
DE (1) DE602005018613D1 (de)
DK (1) DK1727532T3 (de)
ES (3) ES2402921T3 (de)
HK (2) HK1098674A1 (de)
IL (2) IL177778A (de)
MX (1) MXPA06010928A (de)
NO (1) NO337298B1 (de)
NZ (1) NZ549664A (de)
PL (1) PL1727532T3 (de)
PT (1) PT1727532E (de)
RU (1) RU2389483C2 (de)
TW (1) TWI401078B (de)
WO (1) WO2005092310A2 (de)
ZA (1) ZA200607291B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2050443B1 (de) * 2002-12-18 2017-05-24 Besins Healthcare Luxembourg SARL Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen
EP1572178B1 (de) * 2002-12-18 2006-05-03 Laboratoires Besins International Behandlung von mastalgie mit4-hydroxy-tamoxifen
US7704516B2 (en) 2003-04-01 2010-04-27 Laboratories Besins International Sa Percutaneous composition comprising 4-hydroxy tamoxifen
AU2004246812B8 (en) * 2003-06-09 2010-01-14 Besins Healthcare Luxembourg Sarl Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
DE602005011314D1 (de) * 2004-10-14 2009-01-08 Besins Int Lab 4-hydroxytamoxifengel-formulierungen
EP1647271A1 (de) * 2004-10-14 2006-04-19 Laboratoires Besins International Gelzubereitung enthaltend 4-Hydroxy tamoxifen.
CA2775266C (en) 2009-10-13 2013-12-31 Duquesne University Of The Holy Spirit, A Nonprofit Corporation Organized Under The Laws Of The Commonwealth Of Pennsylvania Anti-cancer tamoxifen-melatonin hybrid ligand
WO2013010137A2 (en) * 2011-07-14 2013-01-17 Jacks Health Technologies Llc A composition, device and method for delayed and sustained release of brain energy molecules

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558373B1 (fr) * 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
US5475851A (en) * 1986-04-14 1995-12-12 National Instruments Corporation Method and apparatus for improved local and global variable capabilities in a graphical data flow program
US5002938A (en) * 1988-03-21 1991-03-26 Bristol-Myers Squibb Company Antifungal gel formulations
CA2032695A1 (en) 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US6160549A (en) * 1994-07-29 2000-12-12 Oracle Corporation Method and apparatus for generating reports using declarative tools
DE4435784C2 (de) * 1994-10-06 1998-10-29 Heraeus Electro Nite Int Elektrisch beheizbarer Starterkat
US5777621A (en) * 1994-12-22 1998-07-07 Apple Computer, Inc. Quality control mechanism for three-dimensional graphics rendering
AU725286B2 (en) * 1996-01-20 2000-10-12 Bradford University Tamoxifen and analogues thereof
JP2001500841A (ja) * 1996-03-29 2001-01-23 エス ヴェー パテントフェアヴェアツングス ゲゼルシャフト ミット ベシュレンクテル ハフツンク 障害された皮下結合脂肪組織、とりわけ脂肪性浮腫の場合における皮膚を引きしめ滑らかにするための化粧品および化粧用組成物
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
EP1043986B1 (de) * 1997-12-23 2003-04-16 Hexal Ag Gemisch und pharmazeutische zubereitung enthaltend z-4-hydroxytamoxifen und cyclodextrin
JP2000038335A (ja) * 1998-07-22 2000-02-08 Kanebo Ltd 皮膚化粧料
EP1212325A2 (de) 1999-08-23 2002-06-12 Eli Lilly And Company Neue kristalline form von disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic säuresalz und verfahren hierfür
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
AU2002340120A1 (en) * 2001-10-04 2003-04-14 Cellegy Pharmaceuticals, Inc. Semisolid topical hormonal compositions and methods for treatment
EP1317921B1 (de) * 2001-12-07 2009-08-19 Besins International Belgique Gel oder Lösung enthaltend Dihydrotestosterone, deren Herstellungsverfahren und Verwendung
US6695171B2 (en) * 2002-02-12 2004-02-24 Seaquistperfect Dispensing Foreign, Inc. Pump dispenser
EP1572178B1 (de) * 2002-12-18 2006-05-03 Laboratoires Besins International Behandlung von mastalgie mit4-hydroxy-tamoxifen
EP2050443B1 (de) * 2002-12-18 2017-05-24 Besins Healthcare Luxembourg SARL Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen
US7704516B2 (en) * 2003-04-01 2010-04-27 Laboratories Besins International Sa Percutaneous composition comprising 4-hydroxy tamoxifen
AU2004246812B8 (en) * 2003-06-09 2010-01-14 Besins Healthcare Luxembourg Sarl Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
ATE401067T1 (de) * 2003-12-15 2008-08-15 Besins Int Lab Verwendung von 4-hydroxytamoxifen zur herstellung eines medikaments zur behandlung von gynäkomastie
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
EP1647271A1 (de) * 2004-10-14 2006-04-19 Laboratoires Besins International Gelzubereitung enthaltend 4-Hydroxy tamoxifen.

Also Published As

Publication number Publication date
TW200533334A (en) 2005-10-16
EP1727532B1 (de) 2009-12-30
IL215897A0 (en) 2011-12-29
NO20064765L (no) 2006-10-20
WO2005092310A3 (en) 2005-12-01
AU2005227073B2 (en) 2011-06-23
HK1139332A1 (en) 2010-09-17
NO337298B1 (no) 2016-03-07
MXPA06010928A (es) 2006-12-15
ZA200607291B (en) 2008-04-30
CA2557806C (en) 2011-08-30
ES2337069T3 (es) 2010-04-20
EP2147670B1 (de) 2014-10-01
EP2269599A1 (de) 2011-01-05
RU2006137282A (ru) 2008-04-27
CA2557806A1 (en) 2005-10-06
HK1098674A1 (en) 2007-07-27
ES2402921T3 (es) 2013-05-10
PL1727532T3 (pl) 2010-06-30
EP2269599B1 (de) 2013-02-20
EP2147670A1 (de) 2010-01-27
CN101080222A (zh) 2007-11-28
WO2005092310A2 (en) 2005-10-06
IL215897A (en) 2014-09-30
EP1727532A2 (de) 2006-12-06
JP2007530498A (ja) 2007-11-01
TWI401078B (zh) 2013-07-11
IL177778A (en) 2011-12-29
AU2005227073A1 (en) 2005-10-06
CN101080222B (zh) 2013-08-07
AR048587A1 (es) 2006-05-10
US20050208139A1 (en) 2005-09-22
IL177778A0 (en) 2006-12-31
DK1727532T3 (da) 2010-05-03
EP1579857A1 (de) 2005-09-28
RU2389483C2 (ru) 2010-05-20
NZ549664A (en) 2011-01-28
JP5489407B2 (ja) 2014-05-14
DE602005018613D1 (de) 2010-02-11
PT1727532E (pt) 2010-03-30
ES2517894T3 (es) 2014-11-04

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