JP2007529446A - プラミペキソールの製造のための中間体 - Google Patents

プラミペキソールの製造のための中間体 Download PDF

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Publication number
JP2007529446A
JP2007529446A JP2007503255A JP2007503255A JP2007529446A JP 2007529446 A JP2007529446 A JP 2007529446A JP 2007503255 A JP2007503255 A JP 2007503255A JP 2007503255 A JP2007503255 A JP 2007503255A JP 2007529446 A JP2007529446 A JP 2007529446A
Authority
JP
Japan
Prior art keywords
formula
compound
tetrahydro
benzothiazole
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007503255A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007529446A5 (enExample
Inventor
グラツィアーノ・カスタルディ
アルベルト・ボローニャ
ピエトロ・アッレリーニ
ガブリエレ・ラッツェッティ
ヴィットリオ・ルッキーニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma SpA
Original Assignee
Dipharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20040531 external-priority patent/ITMI20040531A1/it
Priority claimed from ITMI20050126 external-priority patent/ITMI20050126A1/it
Application filed by Dipharma SpA filed Critical Dipharma SpA
Publication of JP2007529446A publication Critical patent/JP2007529446A/ja
Publication of JP2007529446A5 publication Critical patent/JP2007529446A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007503255A 2004-03-19 2005-03-11 プラミペキソールの製造のための中間体 Pending JP2007529446A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20040531 ITMI20040531A1 (it) 2004-03-19 2004-03-19 Intermedi per la preparazione di pramipexolo
ITMI20050126 ITMI20050126A1 (it) 2005-01-28 2005-01-28 Intermedi per la preparazione di pramipexolo
PCT/EP2005/002641 WO2005092871A2 (en) 2004-03-19 2005-03-11 Intermediates for the preparation of pramipexole

Publications (2)

Publication Number Publication Date
JP2007529446A true JP2007529446A (ja) 2007-10-25
JP2007529446A5 JP2007529446A5 (enExample) 2008-03-27

Family

ID=34963371

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007503255A Pending JP2007529446A (ja) 2004-03-19 2005-03-11 プラミペキソールの製造のための中間体

Country Status (8)

Country Link
US (2) US7741490B2 (enExample)
EP (2) EP1730129B1 (enExample)
JP (1) JP2007529446A (enExample)
AT (1) ATE496036T1 (enExample)
CA (1) CA2560128A1 (enExample)
DE (1) DE602005025988D1 (enExample)
IL (1) IL178156A0 (enExample)
WO (1) WO2005092871A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
KR20090021169A (ko) 2006-05-16 2009-02-27 크놉 뉴로사이언시스 인코포레이티드 Ｒ(+) 및 ｓ(-) 프라미펙솔을 포함하는 조성물 및 이의 사용 방법
EP1878731B1 (en) * 2006-06-26 2008-08-20 Helm AG Process for producing pramipexole
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
EP2137171A4 (en) * 2007-03-14 2010-05-19 Knopp Neurosciences Inc SYNTHESIS OF BENZOTHIAZOLE DIAMINES SUBSTITUTED AND PURIFIED FROM THE CHIRAL PERSPECTIVE
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
GB0721332D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
CN101676272A (zh) * 2008-09-17 2010-03-24 北京德众万全药物技术开发有限公司 一种普拉克索的制备方法
WO2011021214A2 (en) * 2009-08-07 2011-02-24 Msn Laboratories Limited Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
CN102442972B (zh) * 2011-10-18 2014-06-25 济南富创医药科技有限公司 一种普拉克索及其二盐酸盐一水合物的工业化制备方法
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CN103183649A (zh) * 2011-12-31 2013-07-03 天津药物研究院 2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN103183650A (zh) * 2011-12-31 2013-07-03 天津药物研究院 (s)-(-)2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
LT3838271T (lt) 2013-07-12 2025-11-10 Padidėjusio eozinofilų ir (arba) bazofilų kiekio gydymas
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
AU2014306597B2 (en) 2013-08-13 2018-05-17 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP3038467B1 (en) 2013-08-13 2020-07-29 Knopp Biosciences LLC Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
AU2021322255A1 (en) * 2020-08-05 2023-02-23 Areteia Therapeutics, Inc. Use of dexpramipexole for the treatment of moderate to severe asthma

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61155377A (ja) * 1984-12-22 1986-07-15 ドクトル．カール　トーメー　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツンク テトラヒドロ‐ベンズチアゾール化合物およびその製造方法
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
JP2000119226A (ja) * 1998-10-13 2000-04-25 Banyu Pharmaceut Co Ltd クルチウス転移反応を固相合成に利用した新規な芳香族アミン類又は芳香族複素環アミン類の製造方法
JP2001526269A (ja) * 1997-12-22 2001-12-18 バイエル コーポレイション アリール及びヘテロアリール置換複素環式尿素を用いたｒａｆキナーゼの阻害
JP2002173476A (ja) * 2000-12-07 2002-06-21 Sumitomo Pharmaceut Co Ltd １，４−フェニレンジアミン誘導体及びその製造法
WO2005000825A1 (ja) * 2003-06-27 2005-01-06 Dainippon Sumitomo Pharma Co., Ltd. チアゾールイミン類およびオキサゾールイミン類
JP2006520330A (ja) * 2003-03-20 2006-09-07 アクテリオン　ファマシューティカルズ　リミテッド グアニジン誘導体および神経ペプチドｆｆ受容体拮抗物質としてのそれらの使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE45735T1 (de) 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
ZA864626B (en) 1985-06-24 1988-02-24 Lilly Co Eli Dialkylaminotetrahydrobenzothiazoles and oxazoles
ES2187249B1 (es) 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61155377A (ja) * 1984-12-22 1986-07-15 ドクトル．カール　トーメー　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツンク テトラヒドロ‐ベンズチアゾール化合物およびその製造方法
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
JP2001526269A (ja) * 1997-12-22 2001-12-18 バイエル コーポレイション アリール及びヘテロアリール置換複素環式尿素を用いたｒａｆキナーゼの阻害
JP2000119226A (ja) * 1998-10-13 2000-04-25 Banyu Pharmaceut Co Ltd クルチウス転移反応を固相合成に利用した新規な芳香族アミン類又は芳香族複素環アミン類の製造方法
JP2002173476A (ja) * 2000-12-07 2002-06-21 Sumitomo Pharmaceut Co Ltd １，４−フェニレンジアミン誘導体及びその製造法
JP2006520330A (ja) * 2003-03-20 2006-09-07 アクテリオン　ファマシューティカルズ　リミテッド グアニジン誘導体および神経ペプチドｆｆ受容体拮抗物質としてのそれらの使用
WO2005000825A1 (ja) * 2003-06-27 2005-01-06 Dainippon Sumitomo Pharma Co., Ltd. チアゾールイミン類およびオキサゾールイミン類

Also Published As

Publication number Publication date
EP1730129B1 (en) 2011-01-19
ATE496036T1 (de) 2011-02-15
WO2005092871A3 (en) 2005-12-01
EP1730129A2 (en) 2006-12-13
WO2005092871A2 (en) 2005-10-06
CA2560128A1 (en) 2005-10-06
DE602005025988D1 (de) 2011-03-03
US8203002B2 (en) 2012-06-19
US20070191439A1 (en) 2007-08-16
US7741490B2 (en) 2010-06-22
EP2289885A1 (en) 2011-03-02
US20100222595A1 (en) 2010-09-02
IL178156A0 (en) 2006-12-31

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