ATE496036T1 - Zwischenprodukte für die herstellung von pramipexol - Google Patents

Zwischenprodukte für die herstellung von pramipexol

Info

Publication number
ATE496036T1
ATE496036T1 AT05728706T AT05728706T ATE496036T1 AT E496036 T1 ATE496036 T1 AT E496036T1 AT 05728706 T AT05728706 T AT 05728706T AT 05728706 T AT05728706 T AT 05728706T AT E496036 T1 ATE496036 T1 AT E496036T1
Authority
AT
Austria
Prior art keywords
pramipexole
production
intermediate products
intermediates
synthesis
Prior art date
Application number
AT05728706T
Other languages
German (de)
English (en)
Inventor
Graziano Castaldi
Alberto Bologna
Pietro Allegrini
Gabriele Razzetti
Vittorio Lucchini
Original Assignee
Dipharma Francis Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20040531 external-priority patent/ITMI20040531A1/it
Priority claimed from ITMI20050126 external-priority patent/ITMI20050126A1/it
Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl
Application granted granted Critical
Publication of ATE496036T1 publication Critical patent/ATE496036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05728706T 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol ATE496036T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20040531 ITMI20040531A1 (it) 2004-03-19 2004-03-19 Intermedi per la preparazione di pramipexolo
ITMI20050126 ITMI20050126A1 (it) 2005-01-28 2005-01-28 Intermedi per la preparazione di pramipexolo
PCT/EP2005/002641 WO2005092871A2 (en) 2004-03-19 2005-03-11 Intermediates for the preparation of pramipexole

Publications (1)

Publication Number Publication Date
ATE496036T1 true ATE496036T1 (de) 2011-02-15

Family

ID=34963371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05728706T ATE496036T1 (de) 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol

Country Status (8)

Country Link
US (2) US7741490B2 (enExample)
EP (2) EP1730129B1 (enExample)
JP (1) JP2007529446A (enExample)
AT (1) ATE496036T1 (enExample)
CA (1) CA2560128A1 (enExample)
DE (1) DE602005025988D1 (enExample)
IL (1) IL178156A0 (enExample)
WO (1) WO2005092871A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CN102160865A (zh) 2006-05-16 2011-08-24 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
DE602006002385D1 (de) * 2006-06-26 2008-10-02 Helm Ag Verfahren zur Herstellung von Pramipexole
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
JP2010521496A (ja) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． キラル精製置換ベンゾチアゾールジアミンの合成
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
GB0721332D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
EP2334185A4 (en) * 2008-08-19 2011-09-21 Knopp Neurosciences Inc COMPOSITIONS AND METHODS FOR USE OF (R) -PRAMIPEXOL
CN101676272A (zh) * 2008-09-17 2010-03-24 北京德众万全药物技术开发有限公司 一种普拉克索的制备方法
WO2011021214A2 (en) * 2009-08-07 2011-02-24 Msn Laboratories Limited Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
CN102442972B (zh) * 2011-10-18 2014-06-25 济南富创医药科技有限公司 一种普拉克索及其二盐酸盐一水合物的工业化制备方法
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CN103183650A (zh) * 2011-12-31 2013-07-03 天津药物研究院 (s)-(-)2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN103183649A (zh) * 2011-12-31 2013-07-03 天津药物研究院 2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
SMT202100119T1 (it) 2013-07-12 2021-05-07 Knopp Biosciences Llc Trattamento dei livelli elevati di eosinofili e/o basofili
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
EP3033081B1 (en) 2013-08-13 2021-05-12 Knopp Biosciences LLC Compositions and methods for treating chronic urticaria
MX2023001140A (es) * 2020-08-05 2023-05-18 Areteia Therapeutics Inc Uso del dexpramipexol para el tratamiento de asma moderado a grave.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3572485D1 (en) 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
DE3447075A1 (de) * 1984-12-22 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
EP0207696A1 (en) 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazoles and oxazoles
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
RU2265597C2 (ru) * 1997-12-22 2005-12-10 Байер Копэрейшн Арил- и гетероарилзамещенные гетероциклические производные мочевины, способ ингибирования киназы raf и фармацевтическая композиция
JP2000119226A (ja) * 1998-10-13 2000-04-25 Banyu Pharmaceut Co Ltd クルチウス転移反応を固相合成に利用した新規な芳香族アミン類又は芳香族複素環アミン類の製造方法
ES2187249B1 (es) 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
JP2002173476A (ja) * 2000-12-07 2002-06-21 Sumitomo Pharmaceut Co Ltd １，４−フェニレンジアミン誘導体及びその製造法
CL2004000553A1 (es) * 2003-03-20 2005-02-04 Actelion Pharmaceuticals Ltd Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
WO2005000825A1 (ja) * 2003-06-27 2005-01-06 Dainippon Sumitomo Pharma Co., Ltd. チアゾールイミン類およびオキサゾールイミン類

Also Published As

Publication number Publication date
US20070191439A1 (en) 2007-08-16
US8203002B2 (en) 2012-06-19
EP1730129B1 (en) 2011-01-19
WO2005092871A2 (en) 2005-10-06
CA2560128A1 (en) 2005-10-06
US7741490B2 (en) 2010-06-22
JP2007529446A (ja) 2007-10-25
EP2289885A1 (en) 2011-03-02
US20100222595A1 (en) 2010-09-02
WO2005092871A3 (en) 2005-12-01
IL178156A0 (en) 2006-12-31
EP1730129A2 (en) 2006-12-13
DE602005025988D1 (de) 2011-03-03

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