JP2007529196A5 - - Google Patents

Info

Publication number

JP2007529196A5

JP2007529196A5 JP2006526599A JP2006526599A JP2007529196A5 JP 2007529196 A5 JP2007529196 A5 JP 2007529196A5 JP 2006526599 A JP2006526599 A JP 2006526599A JP 2006526599 A JP2006526599 A JP 2006526599A JP 2007529196 A5 JP2007529196 A5 JP 2007529196A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

binding molecule

ser

polynucleotide

Prior art date

2004-09-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000013604 expression vector Substances 0.000 claims description 41
• 239000002773 nucleotide Substances 0.000 claims description 41
• 125000003729 nucleotide group Chemical group 0.000 claims description 41
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 14
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 12
• 229920001184 polypeptide Polymers 0.000 claims 33
• 102000004196 processed proteins & peptides Human genes 0.000 claims 33
• 108090000765 processed proteins & peptides Proteins 0.000 claims 33
• 239000002157 polynucleotide Substances 0.000 claims 20
• 102000040430 polynucleotide Human genes 0.000 claims 20
• 108091033319 polynucleotide Proteins 0.000 claims 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims 18
• 230000002265 prevention Effects 0.000 claims 10
• 102000001708 Protein Isoforms Human genes 0.000 claims 5
• 108010029485 Protein Isoforms Proteins 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
• 206010052779 Transplant rejections Diseases 0.000 claims 4
• 208000024908 graft versus host disease Diseases 0.000 claims 4
• 201000004681 Psoriasis Diseases 0.000 claims 3
• 230000013595 glycosylation Effects 0.000 claims 3
• 238000006206 glycosylation reaction Methods 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010020751 Hypersensitivity Diseases 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 230000007815 allergy Effects 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 238000010494 dissociation reaction Methods 0.000 claims 2
• 230000005593 dissociations Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 210000004153 islets of langerhan Anatomy 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• NTQDELBZOMWXRS-IWGUZYHVSA-N Asp-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(O)=O NTQDELBZOMWXRS-IWGUZYHVSA-N 0.000 claims 1
• 201000004624 Dermatitis Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 230000004988 N-glycosylation Effects 0.000 claims 1
• SPLBRAKYXGOFSO-UNQGMJICSA-N Pro-Phe-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]2CCCN2)O SPLBRAKYXGOFSO-UNQGMJICSA-N 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000013612 plasmid Substances 0.000 description 20
• 108010013709 Leukocyte Common Antigens Proteins 0.000 description 2
• 230000004913 activation Effects 0.000 description 2
• 238000005277 cation exchange chromatography Methods 0.000 description 2
• 231100000673 dose–response relationship Toxicity 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 238000004366 reverse phase liquid chromatography Methods 0.000 description 2
• 102000006395 Globulins Human genes 0.000 description 1
• 108010044091 Globulins Proteins 0.000 description 1
• 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 description 1
• 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 description 1
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
• 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
• 230000010799 Receptor Interactions Effects 0.000 description 1
• 230000006044 T cell activation Effects 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 230000000781 anti-lymphocytic effect Effects 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 210000004027 cell Anatomy 0.000 description 1
• 230000020411 cell activation Effects 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 238000001542 size-exclusion chromatography Methods 0.000 description 1
• 102000009076 src-Family Kinases Human genes 0.000 description 1
• 108010087686 src-Family Kinases Proteins 0.000 description 1