JP2007527902A5 - - Google Patents

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Publication number
JP2007527902A5
JP2007527902A5 JP2007502348A JP2007502348A JP2007527902A5 JP 2007527902 A5 JP2007527902 A5 JP 2007527902A5 JP 2007502348 A JP2007502348 A JP 2007502348A JP 2007502348 A JP2007502348 A JP 2007502348A JP 2007527902 A5 JP2007527902 A5 JP 2007527902A5
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JP
Japan
Prior art keywords
alkyl
phenyl
hydrogen
group
hydroxy
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JP2007502348A
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English (en)
Japanese (ja)
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JP2007527902A (ja
JP4856623B2 (ja
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Priority claimed from PCT/EP2005/051086 external-priority patent/WO2005087724A2/en
Publication of JP2007527902A publication Critical patent/JP2007527902A/ja
Publication of JP2007527902A5 publication Critical patent/JP2007527902A5/ja
Application granted granted Critical
Publication of JP4856623B2 publication Critical patent/JP4856623B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007502348A 2004-03-11 2005-03-10 新規のｎ−スルホニルピロール誘導体 Expired - Lifetime JP4856623B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101003 2004-03-11
EP04101003.4 2004-03-11
PCT/EP2005/051086 WO2005087724A2 (en) 2004-03-11 2005-03-10 Sulphonylpyrroles as hdac inhibitors

Publications (3)

Publication Number Publication Date
JP2007527902A JP2007527902A (ja) 2007-10-04
JP2007527902A5 true JP2007527902A5 (enExample) 2008-04-10
JP4856623B2 JP4856623B2 (ja) 2012-01-18

Family

ID=34928899

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007502348A Expired - Lifetime JP4856623B2 (ja) 2004-03-11 2005-03-10 新規のｎ−スルホニルピロール誘導体

Country Status (25)

Country Link
US (5) US7842820B2 (enExample)
EP (2) EP1725528B1 (enExample)
JP (1) JP4856623B2 (enExample)
KR (1) KR101130556B1 (enExample)
CN (1) CN1926103B (enExample)
AR (1) AR048427A1 (enExample)
AU (1) AU2005221834B2 (enExample)
BR (1) BRPI0508464B8 (enExample)
CA (1) CA2558552C (enExample)
CY (1) CY1114284T1 (enExample)
DK (1) DK1725528T3 (enExample)
EA (1) EA012451B1 (enExample)
ES (1) ES2430371T3 (enExample)
HR (1) HRP20130810T1 (enExample)
IL (1) IL177168A (enExample)
ME (1) ME02122B (enExample)
NO (1) NO337457B1 (enExample)
NZ (1) NZ549251A (enExample)
PL (1) PL1725528T3 (enExample)
PT (1) PT1725528E (enExample)
RS (1) RS52937B (enExample)
SI (1) SI1725528T1 (enExample)
TW (1) TWI353977B (enExample)
WO (1) WO2005087724A2 (enExample)
ZA (1) ZA200606315B (enExample)

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DK1725528T3 (da) 2004-03-11 2013-09-02 4Sc Ag Sulfonylpyrroler som hdac-inhibitorer
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
ES2552338T3 (es) * 2005-01-21 2015-11-27 Astex Therapeutics Limited Compuestos farmacéuticos
ES2327269T3 (es) 2005-03-15 2009-10-27 4Sc Ag N-sulfonilpirroles y su utilizacion como inhibidores de la histona desacetilasa.
US20090117074A1 (en) * 2005-04-07 2009-05-07 Nycomed Gmbh Sulfonylpyrroles as Histone Deacetylase Inhibitors
NZ541788A (en) * 2005-08-11 2007-12-21 Auckland Uniservices Ltd Conducting polymers and their use in oligonucleotide (ODN) probes
NZ566073A (en) 2005-09-21 2011-08-26 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
US8232297B2 (en) 2005-09-21 2012-07-31 4Sc Ag Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles
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US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
WO2012118782A1 (en) 2011-02-28 2012-09-07 Repligen Corporation Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
BR112015023399A8 (pt) 2013-03-15 2019-12-03 Biomarin Pharm Inc inibidores de hdac, seu uso e composição farmacêutica
AU2014337102B2 (en) * 2013-10-18 2019-02-28 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
CN105801464B (zh) * 2014-12-29 2019-05-28 成都先导药物开发有限公司 吡咯酰胺类化合物及其制备方法与用途
WO2017178577A1 (en) 2016-04-14 2017-10-19 4Sc Ag Medical application of resminostat in asian patients
TW201912183A (zh) 2017-08-31 2019-04-01 德商４Ｓｃ製藥公司 Hdac抑制劑與抗代謝藥劑組合用於癌症治療
WO2019200238A1 (en) 2018-04-14 2019-10-17 Dynavax Technologies Corporation Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer
TW202002968A (zh) 2018-04-17 2020-01-16 德商４Ｓｃ製藥公司 用於癌症治療的包含hdac 抑制劑、lag-3 抑制劑和pd-1 抑制劑或pd-l1抑制劑之組合
TW202114659A (zh) 2019-10-02 2021-04-16 德商４Ｓｃ製藥公司 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合

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US20090117074A1 (en) * 2005-04-07 2009-05-07 Nycomed Gmbh Sulfonylpyrroles as Histone Deacetylase Inhibitors
US8232297B2 (en) 2005-09-21 2012-07-31 4Sc Ag Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles
NZ566073A (en) * 2005-09-21 2011-08-26 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
EP2060565A1 (en) * 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
EP2100882A1 (en) * 2008-03-12 2009-09-16 4Sc Ag (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts

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