JP2007527902A5 - - Google Patents
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- Publication number
- JP2007527902A5 JP2007527902A5 JP2007502348A JP2007502348A JP2007527902A5 JP 2007527902 A5 JP2007527902 A5 JP 2007527902A5 JP 2007502348 A JP2007502348 A JP 2007502348A JP 2007502348 A JP2007502348 A JP 2007502348A JP 2007527902 A5 JP2007527902 A5 JP 2007527902A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- group
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04101003 | 2004-03-11 | ||
| EP04101003.4 | 2004-03-11 | ||
| PCT/EP2005/051086 WO2005087724A2 (en) | 2004-03-11 | 2005-03-10 | Sulphonylpyrroles as hdac inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007527902A JP2007527902A (ja) | 2007-10-04 |
| JP2007527902A5 true JP2007527902A5 (OSRAM) | 2008-04-10 |
| JP4856623B2 JP4856623B2 (ja) | 2012-01-18 |
Family
ID=34928899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007502348A Expired - Lifetime JP4856623B2 (ja) | 2004-03-11 | 2005-03-10 | 新規のｎ−スルホニルピロール誘導体 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US7842820B2 (OSRAM) |
| EP (2) | EP1725528B1 (OSRAM) |
| JP (1) | JP4856623B2 (OSRAM) |
| KR (1) | KR101130556B1 (OSRAM) |
| CN (1) | CN1926103B (OSRAM) |
| AR (1) | AR048427A1 (OSRAM) |
| AU (1) | AU2005221834B2 (OSRAM) |
| BR (1) | BRPI0508464B8 (OSRAM) |
| CA (1) | CA2558552C (OSRAM) |
| CY (1) | CY1114284T1 (OSRAM) |
| DK (1) | DK1725528T3 (OSRAM) |
| EA (1) | EA012451B1 (OSRAM) |
| ES (1) | ES2430371T3 (OSRAM) |
| HR (1) | HRP20130810T1 (OSRAM) |
| IL (1) | IL177168A (OSRAM) |
| ME (1) | ME02122B (OSRAM) |
| NO (1) | NO337457B1 (OSRAM) |
| NZ (1) | NZ549251A (OSRAM) |
| PL (1) | PL1725528T3 (OSRAM) |
| PT (1) | PT1725528E (OSRAM) |
| RS (1) | RS52937B (OSRAM) |
| SI (1) | SI1725528T1 (OSRAM) |
| TW (1) | TWI353977B (OSRAM) |
| WO (1) | WO2005087724A2 (OSRAM) |
| ZA (1) | ZA200606315B (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0412259B1 (pt) | 2003-07-22 | 2019-08-20 | Astex Therapeutics Limited | Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica |
| EP1725528B1 (en) * | 2004-03-11 | 2013-05-29 | 4Sc Ag | Sulphonylpyrroles as hdac inhibitors |
| CA2594477C (en) * | 2005-01-21 | 2016-07-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| EA201100689A1 (ru) * | 2005-03-15 | 2011-10-31 | 4Сц Аг | N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы |
| US20090117074A1 (en) * | 2005-04-07 | 2009-05-07 | Nycomed Gmbh | Sulfonylpyrroles as Histone Deacetylase Inhibitors |
| NZ541788A (en) * | 2005-08-11 | 2007-12-21 | Auckland Uniservices Ltd | Conducting polymers and their use in oligonucleotide (ODN) probes |
| KR101314158B1 (ko) * | 2005-09-21 | 2013-10-04 | 4에스체 악티엔게젤샤프트 | 히스톤 탈아세틸 효소 억제제로서의 설포닐피롤 염산염 |
| PL1928872T3 (pl) | 2005-09-21 | 2012-08-31 | 4Sc Ag | Nowe sulfonylopirole jako inhibitory HDAC |
| PL1975158T3 (pl) * | 2005-12-27 | 2011-12-30 | Univ Del Pais Vasco Euskal Herriko Unibersitatea | Nowe pochodne pirolu o aktywności inhibitującej deacylazę histonową |
| EP2100878A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | Novel method for the production of sulphonylpyrroles as HDAC inhibitors |
| EP2100882A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts |
| EP2306836B1 (en) * | 2008-07-01 | 2016-09-07 | PTC Therapeutics, Inc. | Bmi-1 protein expression modulators |
| CA2735593C (en) | 2008-09-03 | 2017-08-15 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| CN101941948A (zh) * | 2009-07-10 | 2011-01-12 | 南开大学 | 点击化学合成具有分支结构的组蛋白去乙酰酶抑制剂 |
| EP2680694B1 (en) | 2011-02-28 | 2019-01-02 | BioMarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| MX370142B (es) | 2013-03-15 | 2019-12-03 | Biomarin Pharm Inc | Inhibidores de hdac. |
| EP3062783B1 (en) | 2013-10-18 | 2020-08-12 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| CN105801464B (zh) * | 2014-12-29 | 2019-05-28 | 成都先导药物开发有限公司 | 吡咯酰胺类化合物及其制备方法与用途 |
| JP2019511544A (ja) | 2016-04-14 | 2019-04-25 | ４エスツェー アクチェンゲゼルシャフト | アジア人患者におけるレスミノスタットの医薬用途 |
| TW201912183A (zh) | 2017-08-31 | 2019-04-01 | 德商４Ｓｃ製藥公司 | Hdac抑制劑與抗代謝藥劑組合用於癌症治療 |
| WO2019200238A1 (en) | 2018-04-14 | 2019-10-17 | Dynavax Technologies Corporation | Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer |
| CN112055589A (zh) | 2018-04-17 | 2020-12-08 | 4Sc股份公司 | 用于癌症治疗的包含hdac抑制剂、lag-3抑制剂和pd-1抑制剂或pd-l1抑制剂的组合 |
| TW202114659A (zh) | 2019-10-02 | 2021-04-16 | 德商４Ｓｃ製藥公司 | 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960787A (en) | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
| KR100236806B1 (ko) | 1991-12-10 | 2000-01-15 | 시오노 요시히코 | 방향족 설폰아미드계 하이드록삼산 유도체 |
| WO1996038418A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| KR20070053362A (ko) * | 1999-11-23 | 2007-05-23 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
| EP1259506A1 (en) | 1999-11-23 | 2002-11-27 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| RU2315746C2 (ru) | 2001-08-09 | 2008-01-27 | Оно Фармасьютикал Ко., Лтд. | Производные карбоновых кислот и фармацевтическое средство, содержащее их в качестве активного ингредиента |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| CN1578663B (zh) | 2001-09-14 | 2011-05-25 | 梅特希尔基因公司 | 组蛋白脱乙酰化酶抑制剂 |
| OA12792A (en) * | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | Sulfonyl-derivatives as novel inhibitors of histone deacetylase. |
| JP2006512306A (ja) | 2002-08-29 | 2006-04-13 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | アリール及びヘテロアリールプロペンアミド、それらの誘導体並びにそれらの治療用途 |
| GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| AU2004268621C1 (en) | 2003-08-29 | 2011-08-18 | Exelixis, Inc. | c-Kit modulators and methods of use |
| EP1709007A1 (en) | 2004-01-22 | 2006-10-11 | Altana Pharma AG | N-4-(6-(heteo)aryl-pyrimidin-4-ylaminophenyl)-benzenesulfonamides as kinase inhibitors |
| US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| EP1725528B1 (en) * | 2004-03-11 | 2013-05-29 | 4Sc Ag | Sulphonylpyrroles as hdac inhibitors |
| US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| GB2415703A (en) | 2004-07-02 | 2006-01-04 | Hewlett Packard Development Co | Liquid crystal display device |
| UA87884C2 (uk) | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| US7432808B2 (en) | 2004-12-15 | 2008-10-07 | Intel Corporation | Wireless module enabled component carrier for parts inventory and tracking |
| EP1831173B1 (en) | 2004-12-17 | 2011-01-26 | Janssen Pharmaceutica NV | Tetrahydroisoquinoline compounds for treatment of cns disorders |
| EA201100689A1 (ru) | 2005-03-15 | 2011-10-31 | 4Сц Аг | N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы |
| US20090117074A1 (en) | 2005-04-07 | 2009-05-07 | Nycomed Gmbh | Sulfonylpyrroles as Histone Deacetylase Inhibitors |
| PL1928872T3 (pl) | 2005-09-21 | 2012-08-31 | 4Sc Ag | Nowe sulfonylopirole jako inhibitory HDAC |
| KR101314158B1 (ko) * | 2005-09-21 | 2013-10-04 | 4에스체 악티엔게젤샤프트 | 히스톤 탈아세틸 효소 억제제로서의 설포닐피롤 염산염 |
| EP2060565A1 (en) * | 2007-11-16 | 2009-05-20 | 4Sc Ag | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases |
| EP2100882A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts |
-
2005
- 2005-03-10 EP EP05716989.8A patent/EP1725528B1/en not_active Expired - Lifetime
- 2005-03-10 AU AU2005221834A patent/AU2005221834B2/en not_active Expired
- 2005-03-10 JP JP2007502348A patent/JP4856623B2/ja not_active Expired - Lifetime
- 2005-03-10 HR HRP20130810TT patent/HRP20130810T1/hr unknown
- 2005-03-10 CA CA2558552A patent/CA2558552C/en not_active Expired - Lifetime
- 2005-03-10 WO PCT/EP2005/051086 patent/WO2005087724A2/en not_active Ceased
- 2005-03-10 KR KR1020067020031A patent/KR101130556B1/ko not_active Expired - Lifetime
- 2005-03-10 ES ES05716989T patent/ES2430371T3/es not_active Expired - Lifetime
- 2005-03-10 RS RS20130367A patent/RS52937B/sr unknown
- 2005-03-10 PT PT57169898T patent/PT1725528E/pt unknown
- 2005-03-10 US US10/591,477 patent/US7842820B2/en active Active
- 2005-03-10 ME MEP-2013-367A patent/ME02122B/me unknown
- 2005-03-10 PL PL05716989T patent/PL1725528T3/pl unknown
- 2005-03-10 CN CN2005800065927A patent/CN1926103B/zh not_active Expired - Lifetime
- 2005-03-10 EA EA200601587A patent/EA012451B1/ru not_active IP Right Cessation
- 2005-03-10 SI SI200531768T patent/SI1725528T1/sl unknown
- 2005-03-10 BR BRPI0508464A patent/BRPI0508464B8/pt active IP Right Grant
- 2005-03-10 DK DK05716989.8T patent/DK1725528T3/da active
- 2005-03-10 EP EP10185834A patent/EP2272827A1/en not_active Withdrawn
- 2005-03-10 AR ARP050100915A patent/AR048427A1/es active IP Right Grant
- 2005-03-10 NZ NZ549251A patent/NZ549251A/en not_active IP Right Cessation
- 2005-03-11 TW TW094107605A patent/TWI353977B/zh not_active IP Right Cessation
-
2006
- 2006-07-31 IL IL177168A patent/IL177168A/en active IP Right Grant
- 2006-07-31 ZA ZA200606315A patent/ZA200606315B/xx unknown
- 2006-09-29 NO NO20064418A patent/NO337457B1/no unknown
-
2010
- 2010-06-24 US US12/822,641 patent/US8067615B2/en active Active
- 2010-06-24 US US12/822,606 patent/US8399505B2/en not_active Expired - Lifetime
-
2011
- 2011-03-14 US US13/046,936 patent/US20110166140A1/en not_active Abandoned
-
2012
- 2012-11-20 US US13/682,060 patent/US8969401B2/en not_active Expired - Lifetime
-
2013
- 2013-08-28 CY CY20131100737T patent/CY1114284T1/el unknown
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