CN1926103B - 磺酰基吡咯作为hdac抑制剂 - Google Patents

磺酰基吡咯作为hdac抑制剂 Download PDF

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Publication number
CN1926103B
CN1926103B CN2005800065927A CN200580006592A CN1926103B CN 1926103 B CN1926103 B CN 1926103B CN 2005800065927 A CN2005800065927 A CN 2005800065927A CN 200580006592 A CN200580006592 A CN 200580006592A CN 1926103 B CN1926103 B CN 1926103B
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phenyl
hydrogen
alkyl
methyl
compound
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Chinese (zh)
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CN1926103A (zh
Inventor
T·迈尔
T·贝克尔斯
T·贝尔
P·吉姆尼希
F·杜尔韦伯
M·文内曼
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4sc Corp
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4sc Corp
Altana Pharma AG
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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CN2005800065927A 2004-03-11 2005-03-10 磺酰基吡咯作为hdac抑制剂 Expired - Lifetime CN1926103B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101003 2004-03-11
EP04101003.4 2004-03-11
PCT/EP2005/051086 WO2005087724A2 (en) 2004-03-11 2005-03-10 Sulphonylpyrroles as hdac inhibitors

Publications (2)

Publication Number Publication Date
CN1926103A CN1926103A (zh) 2007-03-07
CN1926103B true CN1926103B (zh) 2012-12-19

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US (5) US7842820B2 (OSRAM)
EP (2) EP1725528B1 (OSRAM)
JP (1) JP4856623B2 (OSRAM)
KR (1) KR101130556B1 (OSRAM)
CN (1) CN1926103B (OSRAM)
AR (1) AR048427A1 (OSRAM)
AU (1) AU2005221834B2 (OSRAM)
BR (1) BRPI0508464B8 (OSRAM)
CA (1) CA2558552C (OSRAM)
CY (1) CY1114284T1 (OSRAM)
DK (1) DK1725528T3 (OSRAM)
EA (1) EA012451B1 (OSRAM)
ES (1) ES2430371T3 (OSRAM)
HR (1) HRP20130810T1 (OSRAM)
IL (1) IL177168A (OSRAM)
ME (1) ME02122B (OSRAM)
NO (1) NO337457B1 (OSRAM)
NZ (1) NZ549251A (OSRAM)
PL (1) PL1725528T3 (OSRAM)
PT (1) PT1725528E (OSRAM)
RS (1) RS52937B (OSRAM)
SI (1) SI1725528T1 (OSRAM)
TW (1) TWI353977B (OSRAM)
WO (1) WO2005087724A2 (OSRAM)
ZA (1) ZA200606315B (OSRAM)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0412259B1 (pt) 2003-07-22 2019-08-20 Astex Therapeutics Limited Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica
EP1725528B1 (en) * 2004-03-11 2013-05-29 4Sc Ag Sulphonylpyrroles as hdac inhibitors
CA2594477C (en) * 2005-01-21 2016-07-12 Astex Therapeutics Limited Pharmaceutical compounds
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
EA201100689A1 (ru) * 2005-03-15 2011-10-31 4Сц Аг N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы
US20090117074A1 (en) * 2005-04-07 2009-05-07 Nycomed Gmbh Sulfonylpyrroles as Histone Deacetylase Inhibitors
NZ541788A (en) * 2005-08-11 2007-12-21 Auckland Uniservices Ltd Conducting polymers and their use in oligonucleotide (ODN) probes
KR101314158B1 (ko) * 2005-09-21 2013-10-04 4에스체 악티엔게젤샤프트 히스톤 탈아세틸 효소 억제제로서의 설포닐피롤 염산염
PL1928872T3 (pl) 2005-09-21 2012-08-31 4Sc Ag Nowe sulfonylopirole jako inhibitory HDAC
PL1975158T3 (pl) * 2005-12-27 2011-12-30 Univ Del Pais Vasco Euskal Herriko Unibersitatea Nowe pochodne pirolu o aktywności inhibitującej deacylazę histonową
EP2100878A1 (en) * 2008-03-12 2009-09-16 4Sc Ag Novel method for the production of sulphonylpyrroles as HDAC inhibitors
EP2100882A1 (en) * 2008-03-12 2009-09-16 4Sc Ag (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts
EP2306836B1 (en) * 2008-07-01 2016-09-07 PTC Therapeutics, Inc. Bmi-1 protein expression modulators
CA2735593C (en) 2008-09-03 2017-08-15 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
CN101941948A (zh) * 2009-07-10 2011-01-12 南开大学 点击化学合成具有分支结构的组蛋白去乙酰酶抑制剂
EP2680694B1 (en) 2011-02-28 2019-01-02 BioMarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
MX370142B (es) 2013-03-15 2019-12-03 Biomarin Pharm Inc Inhibidores de hdac.
EP3062783B1 (en) 2013-10-18 2020-08-12 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
CN105801464B (zh) * 2014-12-29 2019-05-28 成都先导药物开发有限公司 吡咯酰胺类化合物及其制备方法与用途
JP2019511544A (ja) 2016-04-14 2019-04-25 ４エスツェー アクチェンゲゼルシャフト アジア人患者におけるレスミノスタットの医薬用途
TW201912183A (zh) 2017-08-31 2019-04-01 德商４Ｓｃ製藥公司 Hdac抑制劑與抗代謝藥劑組合用於癌症治療
WO2019200238A1 (en) 2018-04-14 2019-10-17 Dynavax Technologies Corporation Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer
CN112055589A (zh) 2018-04-17 2020-12-08 4Sc股份公司 用于癌症治疗的包含hdac抑制剂、lag-3抑制剂和pd-1抑制剂或pd-l1抑制剂的组合
TW202114659A (zh) 2019-10-02 2021-04-16 德商４Ｓｃ製藥公司 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960787A (en) 1989-02-06 1990-10-02 Ciba-Geigy Corporation Certain pyrrolyl-substituted hydroxamic acid derivatives
KR100236806B1 (ko) 1991-12-10 2000-01-15 시오노 요시히코 방향족 설폰아미드계 하이드록삼산 유도체
WO1996038418A1 (en) 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
KR20070053362A (ko) * 1999-11-23 2007-05-23 메틸진, 인크. 히스톤 디아세틸라제의 억제제
EP1259506A1 (en) 1999-11-23 2002-11-27 Merck & Co., Inc. Pyrazinone thrombin inhibitors
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
RU2315746C2 (ru) 2001-08-09 2008-01-27 Оно Фармасьютикал Ко., Лтд. Производные карбоновых кислот и фармацевтическое средство, содержащее их в качестве активного ингредиента
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
CN1578663B (zh) 2001-09-14 2011-05-25 梅特希尔基因公司 组蛋白脱乙酰化酶抑制剂
OA12792A (en) * 2002-03-13 2006-07-10 Janssen Pharmaceutica Nv Sulfonyl-derivatives as novel inhibitors of histone deacetylase.
JP2006512306A (ja) 2002-08-29 2006-04-13 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション アリール及びヘテロアリールプロペンアミド、それらの誘導体並びにそれらの治療用途
GB0226855D0 (en) 2002-11-18 2002-12-24 Queen Mary & Westfield College Histone deacetylase inhibitors
AU2004268621C1 (en) 2003-08-29 2011-08-18 Exelixis, Inc. c-Kit modulators and methods of use
EP1709007A1 (en) 2004-01-22 2006-10-11 Altana Pharma AG N-4-(6-(heteo)aryl-pyrimidin-4-ylaminophenyl)-benzenesulfonamides as kinase inhibitors
US20050197336A1 (en) 2004-03-08 2005-09-08 Miikana Therapeutics Corporation Inhibitors of histone deacetylase
EP1725528B1 (en) * 2004-03-11 2013-05-29 4Sc Ag Sulphonylpyrroles as hdac inhibitors
US7345043B2 (en) 2004-04-01 2008-03-18 Miikana Therapeutics Inhibitors of histone deacetylase
GB2415703A (en) 2004-07-02 2006-01-04 Hewlett Packard Development Co Liquid crystal display device
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US7432808B2 (en) 2004-12-15 2008-10-07 Intel Corporation Wireless module enabled component carrier for parts inventory and tracking
EP1831173B1 (en) 2004-12-17 2011-01-26 Janssen Pharmaceutica NV Tetrahydroisoquinoline compounds for treatment of cns disorders
EA201100689A1 (ru) 2005-03-15 2011-10-31 4Сц Аг N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы
US20090117074A1 (en) 2005-04-07 2009-05-07 Nycomed Gmbh Sulfonylpyrroles as Histone Deacetylase Inhibitors
PL1928872T3 (pl) 2005-09-21 2012-08-31 4Sc Ag Nowe sulfonylopirole jako inhibitory HDAC
KR101314158B1 (ko) * 2005-09-21 2013-10-04 4에스체 악티엔게젤샤프트 히스톤 탈아세틸 효소 억제제로서의 설포닐피롤 염산염
EP2060565A1 (en) * 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
EP2100882A1 (en) * 2008-03-12 2009-09-16 4Sc Ag (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOUCHAIN CILIANE ET AL.Journal of medicinal chemistry46 5.2003,46(5),820-830.
BOUCHAIN CILIANE ET AL.Journal of medicinal chemistry46 5.2003,46(5),820-830. *
MAI ANTONELLO ET AL.Journal of medicinal chemistry46 4.2003,46(4),512-524.
MAI ANTONELLO ET AL.Journal of medicinal chemistry46 4.2003,46(4),512-524. *
MILLER THOMAS A ET AL.Histone deacetylase inhibitors.Journal of medicinal chemistry46 24.2003,46(24),5097-5116.
MILLER THOMAS A ET AL.Histone deacetylase inhibitors.Journal of medicinal chemistry46 24.2003,46(24),5097-5116. *

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