CA2558552C - Novel sulphonylpyrroles - Google Patents

Novel sulphonylpyrroles Download PDF

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Publication number
CA2558552C
CA2558552C CA2558552A CA2558552A CA2558552C CA 2558552 C CA2558552 C CA 2558552C CA 2558552 A CA2558552 A CA 2558552A CA 2558552 A CA2558552 A CA 2558552A CA 2558552 C CA2558552 C CA 2558552C
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Prior art keywords
phenyl
alkyl
hydrogen
compounds
pyrrol
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Expired - Lifetime
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CA2558552A
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English (en)
French (fr)
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CA2558552A1 (en
Inventor
Thomas Maier
Thomas Beckers
Thomas Baer
Petra Gimmnich
Frank Dullweber
Matthias Vennemann
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4SC AG
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4SC AG
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
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CA2558552A 2004-03-11 2005-03-10 Novel sulphonylpyrroles Expired - Lifetime CA2558552C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101003.4 2004-03-11
EP04101003 2004-03-11
PCT/EP2005/051086 WO2005087724A2 (en) 2004-03-11 2005-03-10 Sulphonylpyrroles as hdac inhibitors

Publications (2)

Publication Number Publication Date
CA2558552A1 CA2558552A1 (en) 2005-09-22
CA2558552C true CA2558552C (en) 2015-06-02

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CA2558552A Expired - Lifetime CA2558552C (en) 2004-03-11 2005-03-10 Novel sulphonylpyrroles

Country Status (25)

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US (5) US7842820B2 (OSRAM)
EP (2) EP1725528B1 (OSRAM)
JP (1) JP4856623B2 (OSRAM)
KR (1) KR101130556B1 (OSRAM)
CN (1) CN1926103B (OSRAM)
AR (1) AR048427A1 (OSRAM)
AU (1) AU2005221834B2 (OSRAM)
BR (1) BRPI0508464B8 (OSRAM)
CA (1) CA2558552C (OSRAM)
CY (1) CY1114284T1 (OSRAM)
DK (1) DK1725528T3 (OSRAM)
EA (1) EA012451B1 (OSRAM)
ES (1) ES2430371T3 (OSRAM)
HR (1) HRP20130810T1 (OSRAM)
IL (1) IL177168A (OSRAM)
ME (1) ME02122B (OSRAM)
NO (1) NO337457B1 (OSRAM)
NZ (1) NZ549251A (OSRAM)
PL (1) PL1725528T3 (OSRAM)
PT (1) PT1725528E (OSRAM)
RS (1) RS52937B (OSRAM)
SI (1) SI1725528T1 (OSRAM)
TW (1) TWI353977B (OSRAM)
WO (1) WO2005087724A2 (OSRAM)
ZA (1) ZA200606315B (OSRAM)

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TW201912183A (zh) 2017-08-31 2019-04-01 德商４Ｓｃ製藥公司 Hdac抑制劑與抗代謝藥劑組合用於癌症治療
TW202011959A (zh) 2018-04-14 2020-04-01 美商戴納瓦克斯技術公司 用於治療癌症之包括CpG-C 型寡核苷酸及組蛋白去乙醯酶抑制劑之組合
KR20200143452A (ko) 2018-04-17 2020-12-23 4에스체 악티엔게젤샤프트 암 치료를 위한 hdac 억제제, lag-3 억제제 및 pd-1 억제제 또는 pd-l1 억제제를 포함하는 배합물
TW202114659A (zh) 2019-10-02 2021-04-16 德商４Ｓｃ製藥公司 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合

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