JP2007527240A5 - - Google Patents
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- JP2007527240A5 JP2007527240A5 JP2007501881A JP2007501881A JP2007527240A5 JP 2007527240 A5 JP2007527240 A5 JP 2007527240A5 JP 2007501881 A JP2007501881 A JP 2007501881A JP 2007501881 A JP2007501881 A JP 2007501881A JP 2007527240 A5 JP2007527240 A5 JP 2007527240A5
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- sirna
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- protein
- ige
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- 108091030071 RNAI Proteins 0.000 claims 46
- 230000009368 gene silencing by RNA Effects 0.000 claims 46
- 108020004459 Small interfering RNA Proteins 0.000 claims 43
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- 102000004169 proteins and genes Human genes 0.000 claims 34
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- 239000004475 Arginine Substances 0.000 claims 2
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- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
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- 239000003937 drug carrier Substances 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
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- 229920001661 Chitosan Polymers 0.000 claims 1
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- 206010037660 Pyrexia Diseases 0.000 claims 1
- 102000014450 RNA Polymerase III Human genes 0.000 claims 1
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- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
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- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
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- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54907004P | 2004-03-01 | 2004-03-01 | |
| PCT/US2005/006445 WO2005085443A2 (en) | 2004-03-01 | 2005-03-01 | Rnai-based therapeutics for allergic rhinitis and asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527240A JP2007527240A (ja) | 2007-09-27 |
| JP2007527240A5 true JP2007527240A5 (enExample) | 2008-03-21 |
Family
ID=34919432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501881A Pending JP2007527240A (ja) | 2004-03-01 | 2005-03-01 | アレルギー性鼻炎および喘息のためのＲＮＡｉベースの治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060058255A1 (enExample) |
| EP (1) | EP1737956A2 (enExample) |
| JP (1) | JP2007527240A (enExample) |
| CA (1) | CA2558262A1 (enExample) |
| WO (1) | WO2005085443A2 (enExample) |
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| EP1692153A4 (en) * | 2003-07-03 | 2007-03-21 | Univ Pennsylvania | INHIBITION OF EXPRESSION OF SYK-KINASE |
| DE102004010547A1 (de) * | 2004-03-03 | 2005-11-17 | Beiersdorf Ag | Oligoribonukleotide zur Behandlung von irritativen und/oder entzündlichen Hauterscheinungen durch RNA-Interferenz |
| TW201336514A (zh) * | 2006-04-13 | 2013-09-16 | Alcon Res Ltd | ＲＮＡ干擾（ＲＮＡｉ）所媒介之與脾酪胺酸激酶相關之發炎症狀的抑制作用（二） |
| US7825101B2 (en) * | 2006-08-30 | 2010-11-02 | The Board Of Trustees Of The University Of Illinois | Modulation of MLCK-L expression and uses thereof |
| CA3018520C (en) | 2006-10-10 | 2022-05-17 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations |
| DE102006050655A1 (de) * | 2006-10-24 | 2008-04-30 | Halmon Beheer B.V. | Pharmazeutische Zusammensetzung zur Behandlung allergischer Erkrankungen |
| US8975068B2 (en) * | 2007-01-25 | 2015-03-10 | The General Hospital Corporation | Isolated stem cell comprising a Xic flanking region transgene |
| EP1953228A1 (en) * | 2007-02-05 | 2008-08-06 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Method to diminish cd83 expression in monocyte-derived dendritic cells, t-cells and b-cells by RNAi |
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Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399754B1 (en) * | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
| US6005087A (en) * | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5596091A (en) * | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| FR2722506B1 (fr) * | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| GB9510718D0 (en) * | 1995-05-26 | 1995-07-19 | Sod Conseils Rech Applic | Antisense oligonucleotides |
| US6013516A (en) * | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5922695A (en) * | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| US6127533A (en) * | 1997-02-14 | 2000-10-03 | Isis Pharmaceuticals, Inc. | 2'-O-aminooxy-modified oligonucleotides |
| WO1999060166A1 (en) * | 1998-05-21 | 1999-11-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for the pulmonary delivery of nucleic acids |
| US6403779B1 (en) * | 1999-01-08 | 2002-06-11 | Isis Pharmaceuticals, Inc. | Regioselective synthesis of 2′-O-modified nucleosides |
| EP1208194A2 (en) * | 1999-08-09 | 2002-05-29 | Genaissance Pharmaceuticals, Inc. | Drug target isogenes: polymorphisms in the immunoglobulin e receptor i alpha subunit gene |
| IL149694A0 (en) * | 1999-12-23 | 2002-11-10 | Exiqon As | Therapeutic uses of lna-modified oligonucleotides |
| EP1386004A4 (en) * | 2001-04-05 | 2005-02-16 | Ribozyme Pharm Inc | MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID |
| WO2002101071A2 (en) * | 2001-06-07 | 2002-12-19 | Rigel Pharmaceuticals, Inc. | Cd43:modulators of mast cell degranulation |
| DK2280070T3 (en) * | 2001-07-23 | 2015-08-24 | Univ Leland Stanford Junior | Methods and compositions for use in RNAi-mediated inhibition of gene expression in mammals |
| US20030157030A1 (en) * | 2001-11-02 | 2003-08-21 | Insert Therapeutics, Inc. | Methods and compositions for therapeutic use of rna interference |
| US20030166018A1 (en) * | 2002-03-01 | 2003-09-04 | Matthias Wabl | Methods for identifying agents that modulate mast cell degranulation |
| EP1497642A2 (en) * | 2002-03-19 | 2005-01-19 | Tularik, Inc. | Gene amplification in cancer |
| AU2003237686A1 (en) * | 2002-05-24 | 2003-12-12 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Rna interference mediating small rna molecules |
| US20040127395A1 (en) * | 2002-09-06 | 2004-07-01 | Desai Pragnya J. | Use of histamine H4 receptor modulators for the treatment of allergy and asthma |
| AU2003295600A1 (en) * | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| WO2005080410A1 (en) * | 2004-02-20 | 2005-09-01 | Genesis Research And Development Corporation Limited | Targeted delivery of rna interference molecules for the treatment of ige-mediated disorders |
-
2005
- 2005-03-01 US US11/069,611 patent/US20060058255A1/en not_active Abandoned
- 2005-03-01 CA CA002558262A patent/CA2558262A1/en not_active Abandoned
- 2005-03-01 WO PCT/US2005/006445 patent/WO2005085443A2/en not_active Ceased
- 2005-03-01 JP JP2007501881A patent/JP2007527240A/ja active Pending
- 2005-03-01 EP EP05724064A patent/EP1737956A2/en not_active Withdrawn
-
2010
- 2010-09-27 US US12/891,626 patent/US20110112169A1/en not_active Abandoned
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