JP2007527240A5 - - Google Patents
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- JP2007527240A5 JP2007527240A5 JP2007501881A JP2007501881A JP2007527240A5 JP 2007527240 A5 JP2007527240 A5 JP 2007527240A5 JP 2007501881 A JP2007501881 A JP 2007501881A JP 2007501881 A JP2007501881 A JP 2007501881A JP 2007527240 A5 JP2007527240 A5 JP 2007527240A5
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- sirna
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- protein
- ige
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- 239000000203 mixture Substances 0.000 claims 105
- 108091030071 RNAI Proteins 0.000 claims 46
- 230000009368 gene silencing by RNA Effects 0.000 claims 46
- 108020004459 Small interfering RNA Proteins 0.000 claims 43
- 108091027967 Small hairpin RNA Proteins 0.000 claims 40
- 239000004055 small Interfering RNA Substances 0.000 claims 40
- 108090000623 proteins and genes Proteins 0.000 claims 34
- 102000004169 proteins and genes Human genes 0.000 claims 34
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- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 7
- 101000763579 Homo sapiens Toll-like receptor 1 Proteins 0.000 claims 7
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- 102100038006 High affinity immunoglobulin epsilon receptor subunit alpha Human genes 0.000 claims 4
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- 239000004475 Arginine Substances 0.000 claims 2
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
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- 239000003937 drug carrier Substances 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
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- 229920001661 Chitosan Polymers 0.000 claims 1
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- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 102000014450 RNA Polymerase III Human genes 0.000 claims 1
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- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
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- 108700009124 Transcription Initiation Site Proteins 0.000 claims 1
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- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
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- 208000037891 myocardial injury Diseases 0.000 claims 1
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- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
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- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54907004P | 2004-03-01 | 2004-03-01 | |
| PCT/US2005/006445 WO2005085443A2 (en) | 2004-03-01 | 2005-03-01 | Rnai-based therapeutics for allergic rhinitis and asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527240A JP2007527240A (ja) | 2007-09-27 |
| JP2007527240A5 true JP2007527240A5 (enExample) | 2008-03-21 |
Family
ID=34919432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501881A Pending JP2007527240A (ja) | 2004-03-01 | 2005-03-01 | アレルギー性鼻炎および喘息のためのＲＮＡｉベースの治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060058255A1 (enExample) |
| EP (1) | EP1737956A2 (enExample) |
| JP (1) | JP2007527240A (enExample) |
| CA (1) | CA2558262A1 (enExample) |
| WO (1) | WO2005085443A2 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2531069A1 (en) * | 2003-07-03 | 2005-01-27 | The Trustees Of The University Of Pennsylvania | Inhibition of syk kinase expression |
| DE102004010547A1 (de) * | 2004-03-03 | 2005-11-17 | Beiersdorf Ag | Oligoribonukleotide zur Behandlung von irritativen und/oder entzündlichen Hauterscheinungen durch RNA-Interferenz |
| TW200808360A (en) | 2006-04-13 | 2008-02-16 | Alcon Mfg Ltd | RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions |
| US7825101B2 (en) * | 2006-08-30 | 2010-11-02 | The Board Of Trustees Of The University Of Illinois | Modulation of MLCK-L expression and uses thereof |
| EP2074225B1 (en) | 2006-10-10 | 2014-12-03 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations |
| DE102006050655A1 (de) * | 2006-10-24 | 2008-04-30 | Halmon Beheer B.V. | Pharmazeutische Zusammensetzung zur Behandlung allergischer Erkrankungen |
| WO2008091680A2 (en) * | 2007-01-25 | 2008-07-31 | The General Hospital Corporation | Methods for controlling stem cell differentiation |
| EP1953228A1 (en) * | 2007-02-05 | 2008-08-06 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Method to diminish cd83 expression in monocyte-derived dendritic cells, t-cells and b-cells by RNAi |
| WO2008109558A2 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting tlr gene expression and uses thereof |
| JP2010527914A (ja) * | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | 呼吸器系への抑制性核酸分子の治療的送達 |
| WO2008147956A2 (en) * | 2007-05-25 | 2008-12-04 | Centocor, Inc. | Toll-like receptor 3 modulators and uses thereof |
| US20100326218A1 (en) * | 2007-09-27 | 2010-12-30 | Michael Boeckh | Identifying a subject with an increased risk of invasive mold infection |
| WO2009137505A2 (en) * | 2008-05-05 | 2009-11-12 | University Of Louisville Research Foundation, Inc. | Anti-inflammatory mirnas and uses therefor |
| US20100047188A1 (en) * | 2008-08-04 | 2010-02-25 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 8 expression by antisense oligonucleotides |
| US8035016B2 (en) * | 2008-09-05 | 2011-10-11 | The Research Foundation Of State University Of New York | Method of using gold nanorods-siRNA complexes |
| EP2340309A2 (en) | 2008-09-22 | 2011-07-06 | Rxi Pharmaceuticals Corporation | Neutral nanotransporters |
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| MX2011004677A (es) * | 2008-11-04 | 2011-05-25 | Idera Pharmaceuticals Inc | Modulacion de la expresion del receptor 5 tipo larga distancia por oligonucleotidos antisentido. |
| US8435961B2 (en) * | 2009-06-26 | 2013-05-07 | Massachusetts Institute Of Technology | Methods and compositions for increasing the activity of inhibitory RNA |
| US20110097329A1 (en) | 2009-06-26 | 2011-04-28 | Massachusetts Institute Of Technology | Compositions and methods for treating cancer and modulating stress granule formation |
| US8268550B2 (en) * | 2009-06-26 | 2012-09-18 | Massachusetts Institute Of Technology | Compositions and methods for identification of PARP function, inhibitors, and activators |
| KR20120082906A (ko) | 2009-09-30 | 2012-07-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 자가포식현상-향상 유전자 생성물의 조절을 통한 자가포식현상의 조절 방법 |
| CA2793663C (en) * | 2010-03-19 | 2019-03-19 | The Administrators Of The Tulane Educational Fund | Polyplex gene delivery vectors |
| BR112012024049A2 (pt) | 2010-03-24 | 2017-03-01 | Rxi Pharmaceuticals Corp | interferência de rna em indicações dérmicas e fibróticas |
| WO2012112245A1 (en) | 2011-02-14 | 2012-08-23 | Beth Israel Deaconess Medical Center, Inc. | Modulation of phosphatidylinositol-5-phosphate-4-kinase activity |
| EP2681314B1 (en) | 2011-03-03 | 2017-11-01 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating lung disease and injury |
| US9796979B2 (en) | 2011-03-03 | 2017-10-24 | Quark Pharmaceuticals Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| WO2012118911A1 (en) * | 2011-03-03 | 2012-09-07 | Quark Pharmaceuticals, Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| US10119135B2 (en) * | 2012-05-22 | 2018-11-06 | Ruprecht-Karls-Universität Heidelberg | Therapeutic micro RNA targets in chronic pulmonary diseases |
| WO2016134422A1 (en) * | 2015-02-26 | 2016-09-01 | Prince Henry's Institute Of Medical Research Trading As The Hudson Institute Of Medical Research | A method of treatment |
| WO2017007994A1 (en) | 2015-07-08 | 2017-01-12 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| CN111569090A (zh) | 2016-01-15 | 2020-08-25 | 美国基因技术国际有限公司 | 用于活化γ-δ T细胞的方法和组合物 |
| WO2017136435A1 (en) | 2016-02-01 | 2017-08-10 | The Usa, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer National Institute Of Health | Compounds for modulating fc-epsilon-ri-beta expression and uses thereof |
| JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖワクチン接種および免疫療法 |
| ES2911448T3 (es) * | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| US11976292B2 (en) | 2016-06-08 | 2024-05-07 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| EP3481418A4 (en) | 2016-07-08 | 2020-03-11 | American Gene Technologies International Inc. | PRE-IMMUNIZATION AND IMMUNOTHERAPY OF HIV |
| US11583562B2 (en) | 2016-07-21 | 2023-02-21 | American Gene Technologies International Inc. | Viral vectors for treating Parkinson's disease |
| WO2018170765A1 (zh) * | 2017-03-22 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | Imd16基因的rna干涉载体及其应用 |
| WO2018170763A1 (zh) * | 2017-03-22 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | ILA 基因的 RNAi 表达载体及其构建方法和应用 |
| JP2020512815A (ja) | 2017-04-03 | 2020-04-30 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | フェニルケトン尿症を処置するための組成物および方法 |
| WO2018232359A1 (en) | 2017-06-16 | 2018-12-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| US11497752B2 (en) | 2018-01-30 | 2022-11-15 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2020081588A1 (en) | 2018-10-17 | 2020-04-23 | Dana-Farber Cancer Institute, Inc. | Swi/snf family chromatin remodeling complexes and uses thereof |
| US11352646B2 (en) | 2018-11-05 | 2022-06-07 | American Gene Technologies International Inc. | Vector system for expressing regulatory RNA |
| WO2020117706A1 (en) | 2018-12-03 | 2020-06-11 | Triplet Therapeutics, Inc. | Methods for the treatment of trinucleotide repeat expansion disorders associated with mlh3 activity |
| CN113631709A (zh) | 2018-12-20 | 2021-11-09 | 普拉克西斯精密药物股份有限公司 | 用于治疗kcnt1相关病症的组合物和方法 |
| WO2020160100A1 (en) | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2020160196A1 (en) | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| BR112022015004A2 (pt) | 2020-01-29 | 2022-09-20 | Foghorn Therapeutics Inc | Composto, composição farmacêutica, métodos para diminuir a atividade de um complexo baf, induzir apoptose, reduzir o crescimento tumoral, suprimir a progressão e a colonização metastática do câncer e reduzir o nível e/ou a atividade de brg1 e/ou brm em um câncer e métodos de tratamento e de inibição de brm e brg1 |
| WO2021231679A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2) |
| EP4150088A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1) |
| WO2021231691A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi) |
| WO2021231692A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of otoferlin (otof) |
| WO2021231680A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2) |
| EP4150077A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1) |
| WO2021231673A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2) |
| WO2021231698A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl) |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| US11408000B2 (en) | 2020-06-03 | 2022-08-09 | Triplet Therapeutics, Inc. | Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity |
| IL299771A (en) | 2020-07-10 | 2023-03-01 | Inst Nat Sante Rech Med | Methods and compounds for the treatment of epilepsy |
| JP2024509268A (ja) | 2021-03-09 | 2024-02-29 | フォグホーン セラピューティクス インコーポレイテッド | 結晶形、それらを含有する組成物、及びそれらの使用方法 |
| EP4341405A1 (en) | 2021-05-20 | 2024-03-27 | Korro Bio, Inc. | Methods and compositions for adar-mediated editing |
| WO2022256283A2 (en) | 2021-06-01 | 2022-12-08 | Korro Bio, Inc. | Methods for restoring protein function using adar |
| US20250034564A1 (en) | 2021-06-29 | 2025-01-30 | Korro Bio, Inc. | Methods and Compositions for ADAR-Mediated Editing |
| US20230194709A9 (en) | 2021-06-29 | 2023-06-22 | Seagate Technology Llc | Range information detection using coherent pulse sets with selected waveform characteristics |
| KR102767089B1 (ko) * | 2021-09-07 | 2025-02-17 | 렉스소프트 주식회사 | 호흡기 질환 진단용 마커 및 이의 용도 |
| AU2022370009A1 (en) | 2021-10-22 | 2024-05-16 | Korro Bio, Inc. | Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing |
| KR20240126870A (ko) | 2021-12-22 | 2024-08-21 | 캠프4 테라퓨틱스 코포레이션 | 조절 rna들을 표적으로 하는 안티센스 올리고뉴클레오티드를 사용한 유전자 전사의 조절 |
| AU2023283551A1 (en) | 2022-06-10 | 2024-12-19 | Camp4 Therapeutics Corporation | Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas |
| TW202426644A (zh) * | 2022-10-19 | 2024-07-01 | 美商亞羅生物治療公司 | Ｆｎ３域－ｓｉｒｎａ結合物及其用途 |
| JP2025540101A (ja) | 2022-12-01 | 2025-12-11 | キャンプ４ セラピューティクス コーポレイション | 調節ｒｎａを標的とするアンチセンスオリゴヌクレオチドを用いたｓｙｎｇａｐ１遺伝子転写の調節 |
| WO2025015338A1 (en) | 2023-07-13 | 2025-01-16 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| AU2024287308A1 (en) | 2023-07-13 | 2025-12-18 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2025080993A1 (en) * | 2023-10-13 | 2025-04-17 | Sri International | Altered immune mast cell therapy as a pre-exposure treatment of an allergic response |
| WO2025096809A1 (en) | 2023-10-31 | 2025-05-08 | Korro Bio, Inc. | Oligonucleotides comprising phosphoramidate internucleotide linkages |
| WO2025128799A1 (en) | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Double-stranded rna-editing oligonucleotides and uses thereof |
| WO2025255388A1 (en) | 2024-06-05 | 2025-12-11 | Camp4 Therapeutics Corporation | Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas |
| WO2026050243A1 (en) | 2024-08-26 | 2026-03-05 | Korro Bio, Inc. | Galnac conjugated oligonucleotides for rna editing |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6005087A (en) * | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US6399754B1 (en) * | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5596091A (en) * | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| FR2722506B1 (fr) * | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| GB9510718D0 (en) * | 1995-05-26 | 1995-07-19 | Sod Conseils Rech Applic | Antisense oligonucleotides |
| US6013516A (en) * | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5922695A (en) * | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| US6127533A (en) * | 1997-02-14 | 2000-10-03 | Isis Pharmaceuticals, Inc. | 2'-O-aminooxy-modified oligonucleotides |
| JP2002515513A (ja) * | 1998-05-21 | 2002-05-28 | アイシス・ファーマシューティカルス・インコーポレーテッド | 核酸の肺送達のための組成物および方法 |
| US6403779B1 (en) * | 1999-01-08 | 2002-06-11 | Isis Pharmaceuticals, Inc. | Regioselective synthesis of 2′-O-modified nucleosides |
| AU6755300A (en) * | 1999-08-09 | 2001-03-05 | Genaissance Pharmaceuticals, Inc. | Drug target isogenes: polymorphisms in the immunoglobulin e receptor i alpha subunit gene |
| AU3041701A (en) * | 1999-12-23 | 2001-07-09 | Exiqon A/S | Therapeutic uses of lna-modified oligonucleotides |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| AU2002314881A1 (en) * | 2001-06-07 | 2002-12-23 | Rigel Pharmaceuticals, Inc. | Cd43:modulators of mast cell degranulation |
| ES2386775T3 (es) * | 2001-07-23 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos |
| AU2002368202B2 (en) * | 2001-11-02 | 2008-06-05 | Insert Therapeutics, Inc | Methods and compositions for therapeutic use of RNA interference |
| US20030166018A1 (en) * | 2002-03-01 | 2003-09-04 | Matthias Wabl | Methods for identifying agents that modulate mast cell degranulation |
| US6974672B2 (en) * | 2002-03-19 | 2005-12-13 | Amgen Inc. | Gene amplification in cancer |
| WO2003099298A1 (en) * | 2002-05-24 | 2003-12-04 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference mediating small rna molecules |
| US20040127395A1 (en) * | 2002-09-06 | 2004-07-01 | Desai Pragnya J. | Use of histamine H4 receptor modulators for the treatment of allergy and asthma |
| JP2006507841A (ja) * | 2002-11-14 | 2006-03-09 | ダーマコン， インコーポレイテッド | 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ |
| WO2005080410A1 (en) * | 2004-02-20 | 2005-09-01 | Genesis Research And Development Corporation Limited | Targeted delivery of rna interference molecules for the treatment of ige-mediated disorders |
-
2005
- 2005-03-01 US US11/069,611 patent/US20060058255A1/en not_active Abandoned
- 2005-03-01 JP JP2007501881A patent/JP2007527240A/ja active Pending
- 2005-03-01 CA CA002558262A patent/CA2558262A1/en not_active Abandoned
- 2005-03-01 WO PCT/US2005/006445 patent/WO2005085443A2/en not_active Ceased
- 2005-03-01 EP EP05724064A patent/EP1737956A2/en not_active Withdrawn
-
2010
- 2010-09-27 US US12/891,626 patent/US20110112169A1/en not_active Abandoned
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