JP2007527240A - アレルギー性鼻炎および喘息のためのRNAiベースの治療 - Google Patents
アレルギー性鼻炎および喘息のためのRNAiベースの治療 Download PDFInfo
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- JP2007527240A JP2007527240A JP2007501881A JP2007501881A JP2007527240A JP 2007527240 A JP2007527240 A JP 2007527240A JP 2007501881 A JP2007501881 A JP 2007501881A JP 2007501881 A JP2007501881 A JP 2007501881A JP 2007527240 A JP2007527240 A JP 2007527240A
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2320/32—Special delivery means, e.g. tissue-specific
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54907004P | 2004-03-01 | 2004-03-01 | |
| PCT/US2005/006445 WO2005085443A2 (en) | 2004-03-01 | 2005-03-01 | Rnai-based therapeutics for allergic rhinitis and asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527240A true JP2007527240A (ja) | 2007-09-27 |
| JP2007527240A5 JP2007527240A5 (enExample) | 2008-03-21 |
Family
ID=34919432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501881A Pending JP2007527240A (ja) | 2004-03-01 | 2005-03-01 | アレルギー性鼻炎および喘息のためのRNAiベースの治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060058255A1 (enExample) |
| EP (1) | EP1737956A2 (enExample) |
| JP (1) | JP2007527240A (enExample) |
| CA (1) | CA2558262A1 (enExample) |
| WO (1) | WO2005085443A2 (enExample) |
Cited By (14)
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| JP2014508161A (ja) * | 2011-03-03 | 2014-04-03 | クォーク ファーマシューティカルズ インコーポレーティッド | 肺疾患および損傷を治療するための組成物および方法 |
| JP2019508045A (ja) * | 2016-03-09 | 2019-03-28 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | がんを処置するための組み合わせベクターおよび方法 |
| JP2019071881A (ja) * | 2010-03-24 | 2019-05-16 | フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. | 皮膚および線維症適用におけるrna干渉 |
| US10815485B2 (en) | 2008-09-22 | 2020-10-27 | Phio Pharmaceuticals Corp. | RNA interference in skin indications |
| US11007209B2 (en) | 2008-10-17 | 2021-05-18 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| US11090379B2 (en) | 2016-07-08 | 2021-08-17 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| US11352646B2 (en) | 2018-11-05 | 2022-06-07 | American Gene Technologies International Inc. | Vector system for expressing regulatory RNA |
| US11519006B2 (en) | 2016-01-15 | 2022-12-06 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
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| US11976292B2 (en) | 2016-06-08 | 2024-05-07 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| US11980663B2 (en) | 2015-07-08 | 2024-05-14 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| US12090200B2 (en) | 2016-02-08 | 2024-09-17 | American Gene Technologies International Inc. | Methods of producing cells resistant to HIV infection |
| US12403155B2 (en) | 2016-01-15 | 2025-09-02 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
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| EP2371835A1 (en) * | 2003-07-03 | 2011-10-05 | The Trustees Of The University Of Pennsylvania | Inhibition of syk kinase expression |
| DE102004010547A1 (de) * | 2004-03-03 | 2005-11-17 | Beiersdorf Ag | Oligoribonukleotide zur Behandlung von irritativen und/oder entzündlichen Hauterscheinungen durch RNA-Interferenz |
| TW200808360A (en) * | 2006-04-13 | 2008-02-16 | Alcon Mfg Ltd | RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions |
| WO2008028085A2 (en) * | 2006-08-30 | 2008-03-06 | The Board Of Trustees Of The University Of Illinois | Modulation of mlck-l expression and uses thereof |
| EP2074225B1 (en) | 2006-10-10 | 2014-12-03 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892023A (en) * | 1995-05-26 | 1999-04-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Anti sense oligonucleotides for blocking IgE receptor synthesis |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| JP2003524637A (ja) * | 1999-12-23 | 2003-08-19 | エクシコン エ/エス | Lna修飾オリゴヌクレオチドの治療上の使用 |
| WO2003099298A1 (en) * | 2002-05-24 | 2003-12-04 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference mediating small rna molecules |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399754B1 (en) * | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
| US6005087A (en) * | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5596091A (en) * | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| FR2722506B1 (fr) * | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| US6013516A (en) * | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5922695A (en) * | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| US6127533A (en) * | 1997-02-14 | 2000-10-03 | Isis Pharmaceuticals, Inc. | 2'-O-aminooxy-modified oligonucleotides |
| JP2002515513A (ja) * | 1998-05-21 | 2002-05-28 | アイシス・ファーマシューティカルス・インコーポレーテッド | 核酸の肺送達のための組成物および方法 |
| US6403779B1 (en) * | 1999-01-08 | 2002-06-11 | Isis Pharmaceuticals, Inc. | Regioselective synthesis of 2′-O-modified nucleosides |
| JP2003506074A (ja) * | 1999-08-09 | 2003-02-18 | ジェネッサンス ファーマシューティカルズ,インコーポレイティド | 薬剤標的同質遺伝子:免疫グロブリンe受容体ialphaサブユニット遺伝子における多型 |
| WO2002101071A2 (en) * | 2001-06-07 | 2002-12-19 | Rigel Pharmaceuticals, Inc. | Cd43:modulators of mast cell degranulation |
| CA2454183C (en) * | 2001-07-23 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| AU2002368202B2 (en) * | 2001-11-02 | 2008-06-05 | Insert Therapeutics, Inc | Methods and compositions for therapeutic use of RNA interference |
| US20030166018A1 (en) * | 2002-03-01 | 2003-09-04 | Matthias Wabl | Methods for identifying agents that modulate mast cell degranulation |
| AU2003220387A1 (en) * | 2002-03-19 | 2003-10-08 | Tularik Inc. | Gene amplification in cancer |
| US20040127395A1 (en) * | 2002-09-06 | 2004-07-01 | Desai Pragnya J. | Use of histamine H4 receptor modulators for the treatment of allergy and asthma |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| WO2005080410A1 (en) * | 2004-02-20 | 2005-09-01 | Genesis Research And Development Corporation Limited | Targeted delivery of rna interference molecules for the treatment of ige-mediated disorders |
-
2005
- 2005-03-01 WO PCT/US2005/006445 patent/WO2005085443A2/en not_active Ceased
- 2005-03-01 JP JP2007501881A patent/JP2007527240A/ja active Pending
- 2005-03-01 US US11/069,611 patent/US20060058255A1/en not_active Abandoned
- 2005-03-01 CA CA002558262A patent/CA2558262A1/en not_active Abandoned
- 2005-03-01 EP EP05724064A patent/EP1737956A2/en not_active Withdrawn
-
2010
- 2010-09-27 US US12/891,626 patent/US20110112169A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892023A (en) * | 1995-05-26 | 1999-04-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Anti sense oligonucleotides for blocking IgE receptor synthesis |
| JP2003524637A (ja) * | 1999-12-23 | 2003-08-19 | エクシコン エ/エス | Lna修飾オリゴヌクレオチドの治療上の使用 |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| WO2003099298A1 (en) * | 2002-05-24 | 2003-12-04 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference mediating small rna molecules |
Non-Patent Citations (1)
| Title |
|---|
| JPN6010057412, J. Biol. Chem., 2003, Vol.278, No.7, p.4725−4729 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20060058255A1 (en) | 2006-03-16 |
| WO2005085443A2 (en) | 2005-09-15 |
| EP1737956A2 (en) | 2007-01-03 |
| CA2558262A1 (en) | 2005-09-15 |
| WO2005085443A3 (en) | 2006-03-16 |
| US20110112169A1 (en) | 2011-05-12 |
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