JP2007525213A5 - - Google Patents

Info

Publication number

JP2007525213A5

JP2007525213A5 JP2006550367A JP2006550367A JP2007525213A5 JP 2007525213 A5 JP2007525213 A5 JP 2007525213A5 JP 2006550367 A JP2006550367 A JP 2006550367A JP 2006550367 A JP2006550367 A JP 2006550367A JP 2007525213 A5 JP2007525213 A5 JP 2007525213A5

Authority

JP

Japan

Prior art keywords

acid sequence

polypeptide

seq

nucleic acid

amino acid

Prior art date

2005-01-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001184 polypeptide Polymers 0.000 claims 32
• 108090000765 processed proteins & peptides Proteins 0.000 claims 32
• 102000004196 processed proteins & peptides Human genes 0.000 claims 32
• 125000003275 alpha amino acid group Chemical group 0.000 claims 22
• 150000007523 nucleic acids Chemical group 0.000 claims 20
• 108091033319 polynucleotide Proteins 0.000 claims 20
• 102000040430 polynucleotide Human genes 0.000 claims 20
• 239000002157 polynucleotide Substances 0.000 claims 20
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 19
• 150000001413 amino acids Chemical class 0.000 claims 15
• 238000000034 method Methods 0.000 claims 11
• 208000020446 Cardiac disease Diseases 0.000 claims 5
• 208000019622 heart disease Diseases 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 4
• 208000010125 myocardial infarction Diseases 0.000 claims 4
• 101800000407 Brain natriuretic peptide 32 Proteins 0.000 claims 3
• 102400000667 Brain natriuretic peptide 32 Human genes 0.000 claims 3
• 101800002247 Brain natriuretic peptide 45 Proteins 0.000 claims 3
• 206010019280 Heart failures Diseases 0.000 claims 3
• 238000001514 detection method Methods 0.000 claims 3
• 238000003018 immunoassay Methods 0.000 claims 3
• HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 claims 3
• 208000024891 symptom Diseases 0.000 claims 3
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
• 238000003556 assay Methods 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 238000003748 differential diagnosis Methods 0.000 claims 2
• 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 210000000056 organ Anatomy 0.000 claims 2
• 238000003127 radioimmunoassay Methods 0.000 claims 2
• 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
• 108091093088 Amplicon Proteins 0.000 claims 1
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• 208000031229 Cardiomyopathies Diseases 0.000 claims 1
• 208000000059 Dyspnea Diseases 0.000 claims 1
• 206010013975 Dyspnoeas Diseases 0.000 claims 1
• 238000002965 ELISA Methods 0.000 claims 1
• 206010061216 Infarction Diseases 0.000 claims 1
• 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 1
• 208000009525 Myocarditis Diseases 0.000 claims 1
• 206010036790 Productive cough Diseases 0.000 claims 1
• 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 230000003683 cardiac damage Effects 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 230000005713 exacerbation Effects 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
• 210000003709 heart valve Anatomy 0.000 claims 1
• 238000003384 imaging method Methods 0.000 claims 1
• 230000002055 immunohistochemical effect Effects 0.000 claims 1
• 230000007574 infarction Effects 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 210000002751 lymph Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000004080 milk Anatomy 0.000 claims 1
• 239000008267 milk Substances 0.000 claims 1
• 235000013336 milk Nutrition 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 210000000944 nerve tissue Anatomy 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 230000002980 postoperative effect Effects 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 210000003802 sputum Anatomy 0.000 claims 1
• 208000024794 sputum Diseases 0.000 claims 1
• 210000001138 tear Anatomy 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1
• 238000001262 western blot Methods 0.000 claims 1