JP2007524709A5 - - Google Patents
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- Publication number
- JP2007524709A5 JP2007524709A5 JP2007500294A JP2007500294A JP2007524709A5 JP 2007524709 A5 JP2007524709 A5 JP 2007524709A5 JP 2007500294 A JP2007500294 A JP 2007500294A JP 2007500294 A JP2007500294 A JP 2007500294A JP 2007524709 A5 JP2007524709 A5 JP 2007524709A5
- Authority
- JP
- Japan
- Prior art keywords
- species
- scutellaria
- weight
- standardized
- crude drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims 21
- 241000207929 Scutellaria Species 0.000 claims 10
- 241000196324 Embryophyta Species 0.000 claims 9
- 239000002245 particle Substances 0.000 claims 8
- 241000894007 species Species 0.000 claims 7
- 229940088679 drug related substance Drugs 0.000 claims 6
- 239000000284 extract Substances 0.000 claims 6
- 241000555712 Forsythia Species 0.000 claims 5
- 241000245240 Lonicera Species 0.000 claims 5
- 239000002994 raw material Substances 0.000 claims 5
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 claims 4
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims 4
- UDFLTIRFTXWNJO-UHFFFAOYSA-N baicalein Chemical compound O1C2=CC(=O)C(O)=C(O)C2=C(O)C=C1C1=CC=CC=C1 UDFLTIRFTXWNJO-UHFFFAOYSA-N 0.000 claims 4
- 229940015301 baicalein Drugs 0.000 claims 4
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims 4
- 229960003321 baicalin Drugs 0.000 claims 4
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 4
- 241000315672 SARS coronavirus Species 0.000 claims 3
- 230000000840 anti-viral effect Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims 2
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 235000004883 caffeic acid Nutrition 0.000 claims 2
- 229940074360 caffeic acid Drugs 0.000 claims 2
- 229940074393 chlorogenic acid Drugs 0.000 claims 2
- 235000001368 chlorogenic acid Nutrition 0.000 claims 2
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims 2
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims 2
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 229930003935 flavonoid Natural products 0.000 claims 2
- 150000002215 flavonoids Chemical class 0.000 claims 2
- 235000017173 flavonoids Nutrition 0.000 claims 2
- 239000003349 gelling agent Substances 0.000 claims 2
- 241000411851 herbal medicine Species 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- 239000000080 wetting agent Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- DTOUWTJYUCZJQD-UJERWXFOSA-N Forsythiaside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H](O)[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O1 DTOUWTJYUCZJQD-UJERWXFOSA-N 0.000 claims 1
- DTOUWTJYUCZJQD-QJDQKFITSA-N Forsythiaside Natural products C[C@@H]1O[C@H](OC[C@H]2O[C@@H](OCCc3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O DTOUWTJYUCZJQD-QJDQKFITSA-N 0.000 claims 1
- 235000017396 Menta cendrata Nutrition 0.000 claims 1
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 235000010672 Monarda didyma Nutrition 0.000 claims 1
- 241001062991 Pycnanthemum Species 0.000 claims 1
- 208000009341 RNA Virus Infections Diseases 0.000 claims 1
- 241000006814 Scutellaria amoena Species 0.000 claims 1
- 240000004534 Scutellaria baicalensis Species 0.000 claims 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims 1
- 241000915604 Scutellaria barbata Species 0.000 claims 1
- 240000000672 Scutellaria discolor Species 0.000 claims 1
- 241001373465 Scutellaria likiangensis Species 0.000 claims 1
- 241001574584 Scutellaria orthocalyx Species 0.000 claims 1
- 241000717669 Scutellaria rehderiana Species 0.000 claims 1
- 241000674965 Scutellaria viscidula Species 0.000 claims 1
- 241000681542 Spiraea hypericifolia Species 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000000469 ethanolic extract Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0404327A GB2411354B (en) | 2004-02-27 | 2004-02-27 | Use of Scutellaria for the treatment of viral infections |
| PCT/GB2005/000714 WO2005082388A1 (en) | 2004-02-27 | 2005-02-25 | Extracts of scutellaria for the treatment of sars |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007524709A JP2007524709A (ja) | 2007-08-30 |
| JP2007524709A5 true JP2007524709A5 (enExample) | 2008-04-10 |
Family
ID=32050939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500294A Withdrawn JP2007524709A (ja) | 2004-02-27 | 2005-02-25 | Ｓａｒｓを治療するためのスクテラリア抽出物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080038382A1 (enExample) |
| EP (1) | EP1734976A1 (enExample) |
| JP (1) | JP2007524709A (enExample) |
| CN (1) | CN1925863A (enExample) |
| AU (1) | AU2005216697A1 (enExample) |
| GB (2) | GB2411354B (enExample) |
| WO (1) | WO2005082388A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006100710A1 (ja) * | 2005-03-18 | 2008-08-28 | 太陽化学株式会社 | 重症急性呼吸器症候群の予防および治療用組成物 |
| CN101701245B (zh) * | 2009-10-21 | 2013-06-19 | 中国科学院生物物理研究所 | 从中药中筛选sars冠状病毒主蛋白酶抑制剂的方法 |
| CN103720650A (zh) * | 2014-01-17 | 2014-04-16 | 中国药科大学 | 一种具有抗流感病毒作用的黄芩苷注射剂 |
| CN104800318A (zh) * | 2014-01-26 | 2015-07-29 | 天津嘉创生物科技有限公司 | 治疗畜禽上呼吸道感染的中药组合物及其制备方法 |
| CN105372377B (zh) * | 2014-08-07 | 2017-09-29 | 富力 | 一种原料药连翘苷的质量检测方法 |
| CN104356185B (zh) * | 2014-09-26 | 2017-05-17 | 山西大学 | 一种提取黄芩苷的方法 |
| CN105168807B (zh) * | 2015-10-16 | 2019-04-19 | 大连民族大学 | 治疗猪蓝耳病的中药组合物及其制备方法 |
| CN113209164B (zh) * | 2020-02-06 | 2023-01-20 | 中国科学院上海药物研究所 | 黄芩、连翘、金银花主要成分及其组合物在抗冠状病毒中的应用 |
| CN113244211B (zh) * | 2020-02-07 | 2023-04-07 | 中国科学院上海药物研究所 | 黄芩素、黄芩苷用于制备冠状病毒SARS-CoV-2的3CL蛋白酶的抑制剂的用途 |
| CN113244212B (zh) * | 2020-02-10 | 2023-05-05 | 中国医学科学院药物研究所 | 黄芩素在制备预防和/或治疗新型冠状病毒感染疾病的药物中的应用 |
| CN113368121A (zh) * | 2020-03-09 | 2021-09-10 | 吉林亚泰制药股份有限公司 | 抗冠状病毒的连翘苷和连翘脂素组合物 |
| WO2021188614A1 (en) * | 2020-03-18 | 2021-09-23 | Dejia Harmony Llc | Composition, methods of making and using for treating a viral infection, including coronavirus infection |
| AU2021281159B2 (en) * | 2020-05-29 | 2024-09-19 | Vedicinals India Private Limited | A composition for management of COVID-19 and associated disorders |
| RU2741714C1 (ru) * | 2020-08-13 | 2021-01-28 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Ингибитор репликации коронавируса SARS-CoV-2 на основе водного экстракта гриба Inonotus obliquus |
| US20220054575A1 (en) * | 2020-08-19 | 2022-02-24 | Natreon, Inc. | Protection against coronavirus infection by extracts and extract components |
| RU2747018C1 (ru) * | 2020-10-14 | 2021-04-23 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере зашиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Ингибитор репликации коронавируса SARS-CoV-2 на основе меланина из гриба Inonotus obliquus |
| RU2752872C1 (ru) * | 2020-11-03 | 2021-08-11 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Ингибитор репликации коронавируса SARS-CoV-2 на основе гуминовых веществ |
| CN113813271B (zh) * | 2020-11-09 | 2023-12-12 | 首都医科大学 | 连翘酯苷f在制备抗冠状病毒产品中的应用 |
| CN118477064B (zh) * | 2024-05-14 | 2024-12-20 | 南阳师范学院 | 黄芩素在抗大口黑鲈弹状病毒方面的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411733A (en) * | 1992-04-27 | 1995-05-02 | Hozumi; Toyoharu | Antiviral agent containing crude drug |
| US6083921A (en) * | 1998-01-12 | 2000-07-04 | Xu; Kai Jian | Pharmaceutical compositions and method of using same |
| CN1309399C (zh) * | 2000-10-25 | 2007-04-11 | 国家中药制药工程技术研究中心 | 复方双黄连制剂及制备方法 |
| CN1470262A (zh) * | 2002-07-23 | 2004-01-28 | 北京大学安康药物研究院 | 一种双黄连制剂及其制备方法 |
| CN1449813A (zh) * | 2003-04-29 | 2003-10-22 | 兰金初 | 治疗非典型肺炎的药物 |
| CN1159060C (zh) * | 2003-05-06 | 2004-07-28 | 哈药集团中药二厂 | 注射用双黄连在制备用于治疗严重急性呼吸道综合症的药物中的应用 |
| CN1454665A (zh) * | 2003-06-02 | 2003-11-12 | 丁润泉 | 一种防治sars病毒的中药 |
| CN1164267C (zh) * | 2003-06-02 | 2004-09-01 | 中国科学院上海药物研究所 | 绿原酸的医学用途及它的制剂 |
| CN1238037C (zh) * | 2003-06-09 | 2006-01-25 | 方文理 | 治疗肺炎和非典型肺炎的药物 |
| CN1135111C (zh) * | 2003-06-13 | 2004-01-21 | 胡馨元 | 抗非典型性肺炎汤 |
| CN1476886A (zh) * | 2003-07-01 | 2004-02-25 | 陈淀炜 | 抗癌抗sars保健茶 |
-
2004
- 2004-02-27 GB GB0404327A patent/GB2411354B/en not_active Expired - Fee Related
- 2004-02-27 GB GB0608398A patent/GB2425476A/en not_active Withdrawn
-
2005
- 2005-02-25 EP EP05717795A patent/EP1734976A1/en not_active Withdrawn
- 2005-02-25 WO PCT/GB2005/000714 patent/WO2005082388A1/en not_active Ceased
- 2005-02-25 AU AU2005216697A patent/AU2005216697A1/en not_active Abandoned
- 2005-02-25 US US10/590,287 patent/US20080038382A1/en not_active Abandoned
- 2005-02-25 CN CNA2005800060853A patent/CN1925863A/zh active Pending
- 2005-02-25 JP JP2007500294A patent/JP2007524709A/ja not_active Withdrawn
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