JP2007523633A5 - - Google Patents
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- Publication number
- JP2007523633A5 JP2007523633A5 JP2006544119A JP2006544119A JP2007523633A5 JP 2007523633 A5 JP2007523633 A5 JP 2007523633A5 JP 2006544119 A JP2006544119 A JP 2006544119A JP 2006544119 A JP2006544119 A JP 2006544119A JP 2007523633 A5 JP2007523633 A5 JP 2007523633A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- immune response
- pharmaceutical composition
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 23
- 102000039446 nucleic acids Human genes 0.000 claims 23
- 229920001184 polypeptide Polymers 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108010008707 Mucin-1 Proteins 0.000 claims 9
- 102100034256 Mucin-1 Human genes 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 239000000556 agonist Substances 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 230000028993 immune response Effects 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 6
- 230000024932 T cell mediated immunity Effects 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 claims 1
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010063954 Mucins Proteins 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52932903P | 2003-12-12 | 2003-12-12 | |
| US60/529,329 | 2003-12-12 | ||
| PCT/US2004/041921 WO2005058937A2 (en) | 2003-12-12 | 2004-12-10 | A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007523633A JP2007523633A (ja) | 2007-08-23 |
| JP2007523633A5 true JP2007523633A5 (https=) | 2008-02-07 |
| JP5060134B2 JP5060134B2 (ja) | 2012-10-31 |
Family
ID=34699963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544119A Expired - Lifetime JP5060134B2 (ja) | 2003-12-12 | 2004-12-10 | ヒト細胞傷害性Ｔリンパ球のエピトープ及びそのＭＵＣ−１の非ＶＮＴＲ（ｎｏｎ−ｖａｒｉａｂｌｅｎｕｍｂｅｒｏｆｔａｎｄｅｍｒｅｐｅａｔｓｅｑｕｅｎｃｅ）由来のアゴニストエピトープ |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7999071B2 (https=) |
| EP (1) | EP1697399B1 (https=) |
| JP (1) | JP5060134B2 (https=) |
| AU (1) | AU2004299457B2 (https=) |
| CA (1) | CA2547635C (https=) |
| DK (1) | DK1697399T3 (https=) |
| ES (1) | ES2616337T3 (https=) |
| WO (1) | WO2005058937A2 (https=) |
Families Citing this family (41)
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| US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US20090317414A1 (en) * | 2006-07-25 | 2009-12-24 | 4G Vaccines Pty Ltd | Cancer vaccine comprising a mucin 1 (muc1) t cell epitope-derived peptide |
| WO2008035350A1 (en) * | 2006-09-21 | 2008-03-27 | Vaxil Biotherapeutics Ltd. | Antigen specific multi epitope vaccines |
| DK2170384T3 (en) | 2007-07-02 | 2016-07-25 | Etubics Corp | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination |
| US8569244B2 (en) * | 2007-08-20 | 2013-10-29 | Oncotherapy Science, Inc. | FOXM1 peptide and medicinal agent comprising the same |
| CA3069082C (en) | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Ｆｏｘｍ１胜肽以及含此胜肽之疫苗 |
| US9346998B2 (en) | 2009-04-23 | 2016-05-24 | The University Of Chicago | Materials and methods for the preparation of nanocomposites |
| SG10201607663YA (en) * | 2011-08-17 | 2016-11-29 | Globeimmune Inc | Yeast-muc1 immunotherapeutic compositions and uses thereof |
| EP2800762B1 (en) * | 2012-01-03 | 2018-01-03 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Native and agonist ctl epitopes of the muc1 tumor antigen |
| CN103570821A (zh) * | 2012-07-27 | 2014-02-12 | 北京智飞绿竹生物制药有限公司 | 粘蛋白-1抗原性多肽及其作为肿瘤疫苗的用途 |
| US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| WO2015061416A2 (en) | 2013-10-23 | 2015-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| AU2016205208A1 (en) | 2015-01-09 | 2017-07-06 | Etubics Corporation | Methods and compositions for ebola virus vaccination |
| CN107406857B (zh) * | 2015-01-09 | 2021-06-29 | 埃图比克斯公司 | 用于联合免疫治疗的方法和组合物 |
| US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US20190183870A1 (en) | 2016-01-05 | 2019-06-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Combination of histone deacetylase inhibitor and immunotherapy |
| WO2017136342A1 (en) | 2016-02-02 | 2017-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells |
| CN110198733B (zh) * | 2016-09-28 | 2024-04-30 | 巴法里安诺迪克有限公司 | 用于增强痘病毒中转基因的稳定性的组合物和方法 |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
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| IT1164225B (it) | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4844893A (en) | 1986-10-07 | 1989-07-04 | Scripps Clinic And Research Foundation | EX vivo effector cell activation for target cell killing |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5108910A (en) | 1989-08-22 | 1992-04-28 | Immunex Corporation | DNA sequences encoding fusion proteins comprising GM-CSF and IL-3 |
| US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| DK0423980T3 (da) | 1989-10-16 | 2000-10-09 | Amgen Inc | Stamcellefaktor |
| FR2668064B1 (fr) * | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| EP0666923A1 (en) | 1991-09-05 | 1995-08-16 | The University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| ES2180539T3 (es) | 1991-10-23 | 2003-02-16 | Nexell Therapeutics Inc | Metodos para expandir selectivamente celulas madre. |
| DK1621554T4 (da) * | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| HU219767B (hu) | 1993-01-26 | 2001-07-30 | Leslie R. Coney | Készítmények és eljárások genetikai anyag sejtbe történő beviteléhez |
| US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
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| US5405772A (en) | 1993-06-18 | 1995-04-11 | Amgen Inc. | Medium for long-term proliferation and development of cells |
| US5744144A (en) * | 1993-07-30 | 1998-04-28 | University Of Pittsburgh University Patent Committee Policy And Procedures | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
| EP0745134A1 (en) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
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| JP5165175B2 (ja) * | 2000-09-11 | 2013-03-21 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｕｃ１細胞外ドメインおよびそれから得られた癌治療組成物 |
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-
2004
- 2004-12-10 EP EP04814140.2A patent/EP1697399B1/en not_active Expired - Lifetime
- 2004-12-10 AU AU2004299457A patent/AU2004299457B2/en not_active Expired
- 2004-12-10 WO PCT/US2004/041921 patent/WO2005058937A2/en not_active Ceased
- 2004-12-10 US US10/582,702 patent/US7999071B2/en active Active
- 2004-12-10 ES ES04814140.2T patent/ES2616337T3/es not_active Expired - Lifetime
- 2004-12-10 JP JP2006544119A patent/JP5060134B2/ja not_active Expired - Lifetime
- 2004-12-10 CA CA2547635A patent/CA2547635C/en not_active Expired - Lifetime
- 2004-12-10 DK DK04814140.2T patent/DK1697399T3/en active
-
2011
- 2011-07-05 US US13/176,341 patent/US8957192B2/en not_active Expired - Lifetime
-
2013
- 2013-07-15 US US13/941,705 patent/US9370559B2/en not_active Expired - Lifetime
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