JP2007523166A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007523166A5 JP2007523166A5 JP2006554129A JP2006554129A JP2007523166A5 JP 2007523166 A5 JP2007523166 A5 JP 2007523166A5 JP 2006554129 A JP2006554129 A JP 2006554129A JP 2006554129 A JP2006554129 A JP 2006554129A JP 2007523166 A5 JP2007523166 A5 JP 2007523166A5
- Authority
- JP
- Japan
- Prior art keywords
- contain
- substituted
- branched
- combination
- heteroatoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000005842 heteroatom Chemical group 0.000 claims 60
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims 18
- 101001035752 Homo sapiens Hydroxycarboxylic acid receptor 3 Proteins 0.000 claims 13
- 102100039356 Hydroxycarboxylic acid receptor 3 Human genes 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 12
- 239000000556 agonist Substances 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 229940125425 inverse agonist Drugs 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 4
- 230000007781 signaling event Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54601104P | 2004-02-20 | 2004-02-20 | |
| PCT/US2005/004108 WO2005082350A1 (en) | 2004-02-20 | 2005-02-10 | Furosemide derivatives as modulators of hm74 and their use for the treatment of inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523166A JP2007523166A (ja) | 2007-08-16 |
| JP2007523166A5 true JP2007523166A5 (https=) | 2008-01-17 |
Family
ID=34910746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554129A Pending JP2007523166A (ja) | 2004-02-20 | 2005-02-10 | Ｈｍ７４の調節剤としてのフロセミド誘導体および炎症を処置するためのそれらの使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7232811B2 (https=) |
| EP (1) | EP1718292A1 (https=) |
| JP (1) | JP2007523166A (https=) |
| KR (1) | KR20060127141A (https=) |
| CN (1) | CN1921845A (https=) |
| AR (1) | AR047747A1 (https=) |
| AU (1) | AU2005216879B2 (https=) |
| BR (1) | BRPI0506792A (https=) |
| CA (1) | CA2557444A1 (https=) |
| CR (1) | CR8528A (https=) |
| EC (1) | ECSP066777A (https=) |
| IL (1) | IL177086A (https=) |
| MA (1) | MA28373A1 (https=) |
| ME (1) | MEP21108A (https=) |
| MX (1) | MXPA06008612A (https=) |
| NO (1) | NO20064237L (https=) |
| NZ (1) | NZ548830A (https=) |
| RS (1) | RS20060473A (https=) |
| RU (1) | RU2006133540A (https=) |
| SG (1) | SG164305A1 (https=) |
| TN (1) | TNSN06234A1 (https=) |
| TW (1) | TW200538109A (https=) |
| WO (1) | WO2005082350A1 (https=) |
| ZA (1) | ZA200606679B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008283B2 (en) | 1998-12-23 | 2011-08-30 | Neurotherapeutics Pharma, Inc. | Methods and compositions for the treatment of neuropsychiatric disorders |
| WO2004083388A2 (en) | 2003-03-14 | 2004-09-30 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| CN101115726A (zh) | 2004-12-03 | 2008-01-30 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| WO2007079470A2 (en) * | 2006-01-03 | 2007-07-12 | Algebra, Inc. | Therapeutic amine-arylsulfonamide conjugate compounds |
| AR059021A1 (es) * | 2006-01-18 | 2008-03-05 | Schering Corp | Moduladores de receptores cannabinoides |
| JP2010508300A (ja) * | 2006-10-26 | 2010-03-18 | フライン、ギャリー・エー． | アクアポリン修飾因子並びに浮腫および体液平衡異常の治療のためのそれらの使用方法 |
| US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| US8623873B2 (en) * | 2007-06-28 | 2014-01-07 | Intervet Inc. | Substituted piperazines as CB1 antagonists |
| US20100286160A1 (en) * | 2007-06-28 | 2010-11-11 | Intervet Inc. | Substituted piperazines as cb1 antagonists |
| LT6401B (lt) | 2015-07-28 | 2017-06-12 | Vilniaus Universitetas | Karboanhidrazės selektyvūs inhibitoriai |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1260155A (en) * | 1969-04-29 | 1972-01-12 | Leo Pharm Prod Ltd | Sulphonamido anthranilic acid derivatives |
| US3875150A (en) | 1969-04-29 | 1975-04-01 | Leo Pharm Prod Ltd | New sulfamyl-anthranilic acids |
| DE2206424A1 (de) * | 1971-02-15 | 1972-08-24 | Dumex Ltd As | Verfahren zur Herstellung von N-substituierten Anthranilsäurederivaten |
| DE2247828A1 (de) * | 1972-09-29 | 1974-04-04 | Hoechst Ag | Sulfamoyl-anthranilsaeuren und verfahren zu ihrer herstellung |
| DE2406972C3 (de) * | 1974-02-14 | 1979-07-19 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von 5-Sulfamoylanthranilsäuren |
| DE2718871C3 (de) * | 1977-04-28 | 1980-07-17 | Hoechst Ag, 6000 Frankfurt | N-(2-Furylmethyl)-5-sulfamoylorthanilsäuren und deren physiologisch verträgliche Salze und Verfahren zu ihrer Herstellung und ihre Verwendung bei der Bekämpfung von Oedemkrankheiten und Bluthochdruck |
| US4406896A (en) * | 1979-12-20 | 1983-09-27 | Merck & Co., Inc. | Adjuvants for rectal delivery of drug substances |
| DE3006686A1 (de) * | 1980-02-22 | 1981-08-27 | Hoechst Ag, 6000 Frankfurt | 5-sulfamoyl-orthanilsaeuren, verfahren zu ihrer herstellung und ihre verwendung als heilmittel |
| DE3041812A1 (de) * | 1980-11-06 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Basisch substituierte 5-phenyltetrazole, verfahren zu ihrer herstellung und ihre verwendung als heilmittel |
| DE3101960A1 (de) * | 1981-01-22 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "basisch substituierte anthranilsaeuren, verfahren zu ihrer herstellung und ihre verwendung" |
| US5256687A (en) * | 1985-09-09 | 1993-10-26 | Hoechst Aktiengesellschaft | Pharmaceutical composition for the treatment of high blood pressure |
| JPH0720862B2 (ja) * | 1989-01-27 | 1995-03-08 | ヘキスト・アクチエンゲゼルシヤフト | 吸入用喘息治療剤 |
| EP1007563A4 (en) * | 1997-06-12 | 2003-04-16 | Smithkline Beecham Corp | HM74A RECEPTOR |
| GB0021484D0 (en) * | 2000-09-01 | 2000-10-18 | Boehringer Ingelheim Pharma | Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases |
| DE10060809A1 (de) * | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Substituierte Anthranilsäuren, ihre Verwendung als Medikament oder Diagnostikum, sowie sie enthaltendes Medikament, sowie ein pharmazeutisches Kombinationspräparat mit einem Natrium/Wasserstoff-Austausch (NHE)-Blocker |
| US20030109673A1 (en) * | 2002-10-04 | 2003-06-12 | Xiao Yonghong | Regulation of human hm74-like g protein coupled receptor |
-
2005
- 2005-02-10 BR BRPI0506792-8A patent/BRPI0506792A/pt not_active IP Right Cessation
- 2005-02-10 JP JP2006554129A patent/JP2007523166A/ja active Pending
- 2005-02-10 CA CA002557444A patent/CA2557444A1/en not_active Abandoned
- 2005-02-10 WO PCT/US2005/004108 patent/WO2005082350A1/en not_active Ceased
- 2005-02-10 MX MXPA06008612A patent/MXPA06008612A/es active IP Right Grant
- 2005-02-10 EP EP05713210A patent/EP1718292A1/en not_active Withdrawn
- 2005-02-10 SG SG200901539-7A patent/SG164305A1/en unknown
- 2005-02-10 RS RSP-2006/0473A patent/RS20060473A/sr unknown
- 2005-02-10 AU AU2005216879A patent/AU2005216879B2/en not_active Ceased
- 2005-02-10 NZ NZ548830A patent/NZ548830A/en unknown
- 2005-02-10 RU RU2006133540/04A patent/RU2006133540A/ru not_active Application Discontinuation
- 2005-02-10 ME MEP-211/08A patent/MEP21108A/xx unknown
- 2005-02-10 CN CNA2005800054570A patent/CN1921845A/zh active Pending
- 2005-02-10 KR KR1020067016657A patent/KR20060127141A/ko not_active Withdrawn
- 2005-02-14 US US11/057,587 patent/US7232811B2/en not_active Expired - Fee Related
- 2005-02-18 TW TW094104731A patent/TW200538109A/zh unknown
- 2005-02-18 AR ARP050100596A patent/AR047747A1/es not_active Application Discontinuation
-
2006
- 2006-07-24 CR CR8528A patent/CR8528A/es not_active Application Discontinuation
- 2006-07-25 IL IL177086A patent/IL177086A/en not_active IP Right Cessation
- 2006-07-28 TN TNP2006000234A patent/TNSN06234A1/en unknown
- 2006-08-11 ZA ZA200606679A patent/ZA200606679B/xx unknown
- 2006-08-18 EC EC2006006777A patent/ECSP066777A/es unknown
- 2006-08-29 MA MA29295A patent/MA28373A1/fr unknown
- 2006-09-19 NO NO20064237A patent/NO20064237L/no not_active Application Discontinuation
-
2007
- 2007-05-07 US US11/745,131 patent/US7556931B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007523166A5 (https=) | ||
| PE20120635A1 (es) | Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas | |
| CL2008003529A1 (es) | Compuestos derivados de acido-[(4,5-disustituido)-4h-1,2,4-triazol-3-il o (2,4-disustituido)-1,3-imidazol-2-il]carboxilico, moduladores de los niveles de acido urico sanguineos, utiles para el tratamiento de la gota. | |
| CO6261382A2 (es) | Compuestos de imidazotiazol como moduladores de sirtuina | |
| EA201390877A1 (ru) | Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение | |
| BRPI0515850A (pt) | agentes de transportes derivados de cupredoxina e métodos de uso dos mesmos | |
| NO20090910L (no) | Sulfonamid-derivater som adrenerge agonister og muskariniske antagonister | |
| DE602004012858D1 (de) | 2-aminobenzothiazole als cb1 rezeptor inverse agonisten | |
| EA201390916A1 (ru) | Новые ферроценовые метки для электрохимического анализа и их применение в аналитических способах | |
| PE20090709A1 (es) | Compuestos heterociclico de 5 miembros | |
| JP2020504754A5 (https=) | ||
| JP2018531987A5 (https=) | ||
| DE602004011348D1 (de) | Indanderivate als muscarinrezeptoragonisten | |
| RU2017102513A (ru) | Соль гетероциклического соединения, замещенного галогеном | |
| CY1109694T1 (el) | Παραγωγα πυρρολιδινης ως ανταγωνιστες υποδοχεα η3 ισταμινης | |
| PE20040929A1 (es) | Amidas de acido 5-aminometil-1h-pirrol-2-carboxilico substituidas | |
| RU2006113941A (ru) | Лечение невропатической боли агонистами рецептора 2 нейропептида ff | |
| RU2006133540A (ru) | Фуросемидные модуляторы нм74 | |
| FI20031455A0 (fi) | Sulfonyyliamino-peptidomimeettejä, jotka ovat aktiivisia somatostatiinireseptorialatyyppien 4 (SSTR4) ja 1 (SSTR1) suhteen | |
| FI20031454A0 (fi) | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja | |
| WO2005103713A3 (en) | Methods, compositions and compound assays for inhibiting amyloid-beta protein production | |
| ATE493110T1 (de) | Kosmetische zusammensetzung zur stimulierung der synthese der proteine der basalmembran | |
| PE20090851A1 (es) | Derivados de piperidina como moduladores de los receptores de quimoquinas | |
| BRPI0513912A (pt) | derivados de amida de ácido cinurênico como antagonistas do receptor nr2b | |
| JP2007526917A5 (https=) |