JP2007526917A5 - - Google Patents
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- Publication number
- JP2007526917A5 JP2007526917A5 JP2006554127A JP2006554127A JP2007526917A5 JP 2007526917 A5 JP2007526917 A5 JP 2007526917A5 JP 2006554127 A JP2006554127 A JP 2006554127A JP 2006554127 A JP2006554127 A JP 2006554127A JP 2007526917 A5 JP2007526917 A5 JP 2007526917A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- combination
- contain
- branched
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000005842 heteroatom Chemical group 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- -1 enol ester Chemical class 0.000 claims description 11
- 239000002262 Schiff base Substances 0.000 claims description 10
- 150000004753 Schiff bases Chemical class 0.000 claims description 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
- 150000002923 oximes Chemical class 0.000 claims description 10
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 9
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims description 9
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 claims description 9
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 9
- 125000000304 alkynyl group Chemical group 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 9
- 101001035752 Homo sapiens Hydroxycarboxylic acid receptor 3 Proteins 0.000 claims 13
- 102100039356 Hydroxycarboxylic acid receptor 3 Human genes 0.000 claims 13
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 7
- 239000000556 agonist Substances 0.000 claims 7
- 229940125425 inverse agonist Drugs 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 230000007781 signaling event Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 150000001241 acetals Chemical class 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 4
- 0 **C1OC(CC(*)CC2*)=C2C(*)C1 Chemical compound **C1OC(CC(*)CC2*)=C2C(*)C1 0.000 description 3
- 238000001212 derivatisation Methods 0.000 description 1
- 150000002917 oxazolidines Chemical class 0.000 description 1
- 150000003548 thiazolidines Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54601204P | 2004-02-20 | 2004-02-20 | |
| PCT/US2005/004095 WO2005082352A1 (en) | 2004-02-20 | 2005-02-10 | Oxydecahydronaphthalene modulators of hm74 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007526917A JP2007526917A (ja) | 2007-09-20 |
| JP2007526917A5 true JP2007526917A5 (https=) | 2008-03-21 |
Family
ID=34910747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554127A Pending JP2007526917A (ja) | 2004-02-20 | 2005-02-10 | Ｈｍ７４のオキシデカヒドロナフタレンモジュレーター |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7264937B2 (https=) |
| EP (1) | EP1718293A1 (https=) |
| JP (1) | JP2007526917A (https=) |
| KR (1) | KR101145693B1 (https=) |
| CN (1) | CN1929833A (https=) |
| AR (1) | AR047708A1 (https=) |
| AU (1) | AU2005216878B2 (https=) |
| BR (1) | BRPI0507916A (https=) |
| CA (1) | CA2556757C (https=) |
| CR (1) | CR8537A (https=) |
| EC (1) | ECSP066776A (https=) |
| IL (1) | IL177106A (https=) |
| MA (1) | MA28368A1 (https=) |
| ME (2) | MEP17008A (https=) |
| NO (1) | NO20064214L (https=) |
| RS (1) | RS20060472A (https=) |
| RU (1) | RU2006133539A (https=) |
| TN (1) | TNSN06235A1 (https=) |
| TW (1) | TWI354552B (https=) |
| WO (1) | WO2005082352A1 (https=) |
| ZA (1) | ZA200606687B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004083388A2 (en) * | 2003-03-14 | 2004-09-30 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| CN101115726A (zh) | 2004-12-03 | 2008-01-30 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| AR059021A1 (es) * | 2006-01-18 | 2008-03-05 | Schering Corp | Moduladores de receptores cannabinoides |
| US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| US8623873B2 (en) * | 2007-06-28 | 2014-01-07 | Intervet Inc. | Substituted piperazines as CB1 antagonists |
| US20100286160A1 (en) * | 2007-06-28 | 2010-11-11 | Intervet Inc. | Substituted piperazines as cb1 antagonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5674908A (en) * | 1993-12-20 | 1997-10-07 | Life Technologies, Inc. | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
| DE19624154A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ringannelierte Dihydropyrane, Verfahren zur Herstellung sowie deren Verwendung |
| US6555339B1 (en) | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| EP1007563A4 (en) * | 1997-06-12 | 2003-04-16 | Smithkline Beecham Corp | HM74A RECEPTOR |
| GB0021484D0 (en) * | 2000-09-01 | 2000-10-18 | Boehringer Ingelheim Pharma | Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases |
-
2005
- 2005-02-10 EP EP05713199A patent/EP1718293A1/en not_active Withdrawn
- 2005-02-10 CA CA2556757A patent/CA2556757C/en not_active Expired - Fee Related
- 2005-02-10 ME MEP-170/08A patent/MEP17008A/xx unknown
- 2005-02-10 ME MEP-2008-170A patent/ME00059B/me unknown
- 2005-02-10 JP JP2006554127A patent/JP2007526917A/ja active Pending
- 2005-02-10 RU RU2006133539/04A patent/RU2006133539A/ru not_active Application Discontinuation
- 2005-02-10 RS RSP-2006/0472A patent/RS20060472A/sr unknown
- 2005-02-10 KR KR1020067016693A patent/KR101145693B1/ko not_active Expired - Fee Related
- 2005-02-10 BR BRPI0507916-0A patent/BRPI0507916A/pt active Search and Examination
- 2005-02-10 AU AU2005216878A patent/AU2005216878B2/en not_active Ceased
- 2005-02-10 CN CNA2005800075098A patent/CN1929833A/zh active Pending
- 2005-02-10 WO PCT/US2005/004095 patent/WO2005082352A1/en not_active Ceased
- 2005-02-14 US US11/057,263 patent/US7264937B2/en not_active Expired - Lifetime
- 2005-02-18 TW TW094104732A patent/TWI354552B/zh not_active IP Right Cessation
- 2005-02-18 AR ARP050100595A patent/AR047708A1/es unknown
-
2006
- 2006-07-26 IL IL177106A patent/IL177106A/en not_active IP Right Cessation
- 2006-07-26 CR CR8537A patent/CR8537A/es not_active Application Discontinuation
- 2006-07-28 TN TNP2006000235A patent/TNSN06235A1/en unknown
- 2006-08-11 ZA ZA200606687A patent/ZA200606687B/xx unknown
- 2006-08-18 EC EC2006006776A patent/ECSP066776A/es unknown
- 2006-08-24 MA MA29288A patent/MA28368A1/fr unknown
- 2006-09-18 NO NO20064214A patent/NO20064214L/no not_active Application Discontinuation
-
2007
- 2007-08-30 US US11/847,370 patent/US20080045586A1/en not_active Abandoned
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