ECSP066776A - Moduladores de hm74 de oxidecahidronaftaleno - Google Patents

Moduladores de hm74 de oxidecahidronaftaleno

Info

Publication number
ECSP066776A
ECSP066776A EC2006006776A ECSP066776A ECSP066776A EC SP066776 A ECSP066776 A EC SP066776A EC 2006006776 A EC2006006776 A EC 2006006776A EC SP066776 A ECSP066776 A EC SP066776A EC SP066776 A ECSP066776 A EC SP066776A
Authority
EC
Ecuador
Prior art keywords
oxidecahydronaftalene
modulators
oxidecalin
molecules
host cells
Prior art date
Application number
EC2006006776A
Other languages
English (en)
Inventor
Anne Minnich
Theresa Kuntzweiler
Haifeng Eishingdrelo
Michael Angelastro
Stephan Henke
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of ECSP066776A publication Critical patent/ECSP066776A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se usaron células hospedantes que expresan HM74 para obtener moléculas de tipo oxidecalina con actividad agonista, que tienen la siguiente fórmula estructural:
EC2006006776A 2004-02-20 2006-08-18 Moduladores de hm74 de oxidecahidronaftaleno ECSP066776A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54601204P 2004-02-20 2004-02-20

Publications (1)

Publication Number Publication Date
ECSP066776A true ECSP066776A (es) 2006-11-16

Family

ID=34910747

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006776A ECSP066776A (es) 2004-02-20 2006-08-18 Moduladores de hm74 de oxidecahidronaftaleno

Country Status (21)

Country Link
US (2) US7264937B2 (es)
EP (1) EP1718293A1 (es)
JP (1) JP2007526917A (es)
KR (1) KR101145693B1 (es)
CN (1) CN1929833A (es)
AR (1) AR047708A1 (es)
AU (1) AU2005216878B2 (es)
BR (1) BRPI0507916A (es)
CA (1) CA2556757C (es)
CR (1) CR8537A (es)
EC (1) ECSP066776A (es)
IL (1) IL177106A (es)
MA (1) MA28368A1 (es)
ME (2) MEP17008A (es)
NO (1) NO20064214L (es)
RS (1) RS20060472A (es)
RU (1) RU2006133539A (es)
TN (1) TNSN06235A1 (es)
TW (1) TWI354552B (es)
WO (1) WO2005082352A1 (es)
ZA (1) ZA200606687B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004083388A2 (en) * 2003-03-14 2004-09-30 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74
CA2589483C (en) 2004-12-03 2013-10-29 Schering Corporation Substituted piperazines as cb1 antagonists
BRPI0706623A2 (pt) * 2006-01-18 2011-04-12 Schering Corp moduladores de receptor canabinóide
WO2008130616A2 (en) * 2007-04-19 2008-10-30 Schering Corporation Diaryl morpholines as cb1 modulators
MX2010000334A (es) * 2007-06-28 2010-04-22 Intervet Int Bv Piperazinas sustituidas como antagonistas de cannabinoides 1.
CN101790521A (zh) * 2007-06-28 2010-07-28 英特维特国际股份有限公司 作为cb1拮抗剂的取代哌嗪

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5674908A (en) * 1993-12-20 1997-10-07 Life Technologies, Inc. Highly packed polycationic ammonium, sulfonium and phosphonium lipids
DE19624154A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Ringannelierte Dihydropyrane, Verfahren zur Herstellung sowie deren Verwendung
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
AU7966098A (en) * 1997-06-12 1998-12-30 Smithkline Beecham Corporation Hm74a receptor
GB0021484D0 (en) * 2000-09-01 2000-10-18 Boehringer Ingelheim Pharma Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases

Also Published As

Publication number Publication date
CR8537A (es) 2007-03-05
BRPI0507916A (pt) 2007-07-10
NO20064214L (no) 2006-09-18
RS20060472A (en) 2008-11-28
ZA200606687B (en) 2008-02-27
ME00059B (me) 2010-06-10
IL177106A (en) 2012-03-29
CA2556757A1 (en) 2005-09-09
AU2005216878B2 (en) 2010-06-17
CN1929833A (zh) 2007-03-14
IL177106A0 (en) 2006-12-10
US20080045586A1 (en) 2008-02-21
AR047708A1 (es) 2006-02-08
AU2005216878A1 (en) 2005-09-09
EP1718293A1 (en) 2006-11-08
WO2005082352A1 (en) 2005-09-09
KR20060127982A (ko) 2006-12-13
US20050187263A1 (en) 2005-08-25
TW200539864A (en) 2005-12-16
US7264937B2 (en) 2007-09-04
CA2556757C (en) 2011-05-03
RU2006133539A (ru) 2008-03-27
JP2007526917A (ja) 2007-09-20
MEP17008A (en) 2010-06-10
KR101145693B1 (ko) 2012-05-25
TWI354552B (en) 2011-12-21
MA28368A1 (fr) 2006-12-01
TNSN06235A1 (en) 2007-12-03

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