PE20040929A1 - Amidas de acido 5-aminometil-1h-pirrol-2-carboxilico substituidas - Google Patents
Amidas de acido 5-aminometil-1h-pirrol-2-carboxilico substituidasInfo
- Publication number
- PE20040929A1 PE20040929A1 PE2004000008A PE2004000008A PE20040929A1 PE 20040929 A1 PE20040929 A1 PE 20040929A1 PE 2004000008 A PE2004000008 A PE 2004000008A PE 2004000008 A PE2004000008 A PE 2004000008A PE 20040929 A1 PE20040929 A1 PE 20040929A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pyrrol
- cycloalkyl
- carboxyl
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE REFIERE A AMIDAS DE ACIDO 5-AMINOMETIL-1H-PIRROL-2-CARBOXILICO SUBSTITUIDAS DE FORMULA I DONDE R1 ES H, ALQUILO, CICLOALQUILO CON HETEROATOMO COMO MIEMBRO DEL ANILLO, ARILO, HETEROARILO, ENTRE OTROS; R2 ES ALQUILO, CICLOALQUILO CON HETEROATOMO COMO MIEMBRO DEL ANILLO, ARILO, ENTRE OTROS; R1 Y R2 JUNTO CON EL N AL QUE ESTAN UNIDOS FORMAN UN CICLOALQUILO SATURADO O INSATURADO; R3 ES ARILO, HETEROARILO, ENTRE OTROS; R4 Y R5 SON H, ALQUILO, CICLOALQUILO ENTRE OTROS; R4 Y R5 JUNTO A N FORMAN UN RESTO CICLOALQUILO SATURADO O INSATURADO, ENTRE OTROS; R6 ES ALQUILO, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS CICLOHEXILAMIDA DE ACIDO 5-[DIMETILAMINO-(4-FLUORO-FENIL)-METIL]-1-METIL-1H-PIRROL-2-CARBOXILICO, BUTILAMIDA DE ACIDO 5-[DIMETILAMINO(4-FLUORO-FENIL)-METIL]-1-METIL-1H-PIRROL-2-CARBOXILICO, {5-[DIMETILAMINO-(4-FLUORO-FENIL)-METIL]-1-METIL-1H-PIRROL-2-I}-PIRROLIDIN-1-IL-METANONA, CICLOHEXILAMIDA DE ACIDO 5-[DIMETILAMINO-(4-BROMO-FENIL)-METIL]-1-METIL-1H-PIRROL-2-CARBOXILICO, ENTRE OTROS. SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPOSICIONES. LOS COMPUESTOS MENCIONADOS TIENEN ALTA AFINIDAD POR EL RECEPTOR OPIOIDE (ORL-1) Y SON UTILES PARA EL TRATAMIENTO DE DOLORES CRONICOS, AGUDOS, NEUROPATICOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10261131A DE10261131A1 (de) | 2002-12-20 | 2002-12-20 | Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040929A1 true PE20040929A1 (es) | 2005-01-07 |
Family
ID=32404308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000008A PE20040929A1 (es) | 2002-12-20 | 2004-01-05 | Amidas de acido 5-aminometil-1h-pirrol-2-carboxilico substituidas |
Country Status (9)
Country | Link |
---|---|
US (1) | US7229991B2 (es) |
EP (1) | EP1581490B1 (es) |
AR (1) | AR042521A1 (es) |
AT (1) | ATE496887T1 (es) |
AU (1) | AU2003294900A1 (es) |
DE (2) | DE10261131A1 (es) |
ES (1) | ES2356446T3 (es) |
PE (1) | PE20040929A1 (es) |
WO (1) | WO2004058707A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003291342A1 (en) * | 2002-11-05 | 2004-06-07 | Arena Pharmaceuticals, Inc. | Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof |
CN101792417A (zh) | 2003-06-17 | 2010-08-04 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
CN1809545A (zh) * | 2003-06-20 | 2006-07-26 | 艾尼纳制药公司 | N-苯基-哌嗪衍生物和预防或者治疗5HT2c受体相关疾病的方法 |
TWI258478B (en) | 2003-10-31 | 2006-07-21 | Arena Pharm Inc | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
DE102004024772A1 (de) | 2004-05-17 | 2005-12-22 | Grünenthal GmbH | Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide |
SI1833473T1 (sl) * | 2004-12-23 | 2010-01-29 | Arena Pharm Inc | Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe |
EP3034494A1 (en) * | 2007-08-15 | 2016-06-22 | President and Fellows of Harvard College | Heterocyclic inhibitors of necroptosis |
JP5491421B2 (ja) * | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−ht2cアゴニストである(r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ht2c 수용체 아고니스트의 제조 방법 |
MX2013002422A (es) | 2010-09-01 | 2013-05-17 | Arena Pharm Inc | Sales de lorcaserina con acidos opticamente activos. |
CN103189360A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
SG188365A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Administration of lorcaserin to individuals with renal impairment |
EP3485878A1 (en) | 2010-09-01 | 2019-05-22 | Arena Pharmaceuticals, Inc. | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
AU2012392187B2 (en) | 2012-10-09 | 2018-07-12 | Arena Pharmaceuticals, Inc. | Method of weight management |
WO2014145022A1 (en) | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3551571A (en) * | 1967-05-19 | 1970-12-29 | Endo Lab | Methods for reducing pain,reducing fever and alleviating inflammatory syndromes with heteroaromatic pyrrol-3-yl ketones |
AU2001271631A1 (en) * | 2000-06-30 | 2002-01-14 | Ortho-Mcneil Pharmaceutical, Inc. | Useful aroyl aminoacyl pyrrole compounds |
DK1351950T3 (da) * | 2000-12-20 | 2007-12-03 | Ortho Mcneil Pharm Inc | Isoquinolinylaroylpyrrolforbindelser ti behandling af lidelser i centralnervesystemet |
US6849730B2 (en) * | 2001-09-25 | 2005-02-01 | North Carolina State University | Methods of making porphyrins and related compounds with Lewis acids |
-
2002
- 2002-12-20 DE DE10261131A patent/DE10261131A1/de not_active Ceased
-
2003
- 2003-12-18 ES ES03785875T patent/ES2356446T3/es not_active Expired - Lifetime
- 2003-12-18 DE DE50313444T patent/DE50313444D1/de not_active Expired - Lifetime
- 2003-12-18 AR ARP030104698A patent/AR042521A1/es unknown
- 2003-12-18 WO PCT/EP2003/014496 patent/WO2004058707A1/de not_active Application Discontinuation
- 2003-12-18 EP EP03785875A patent/EP1581490B1/de not_active Expired - Lifetime
- 2003-12-18 AT AT03785875T patent/ATE496887T1/de active
- 2003-12-18 AU AU2003294900A patent/AU2003294900A1/en not_active Abandoned
-
2004
- 2004-01-05 PE PE2004000008A patent/PE20040929A1/es not_active Application Discontinuation
-
2005
- 2005-06-20 US US11/155,764 patent/US7229991B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2356446T3 (es) | 2011-04-08 |
ATE496887T1 (de) | 2011-02-15 |
DE10261131A1 (de) | 2004-07-01 |
US20050288342A1 (en) | 2005-12-29 |
US7229991B2 (en) | 2007-06-12 |
AU2003294900A1 (en) | 2004-07-22 |
WO2004058707A1 (de) | 2004-07-15 |
EP1581490A1 (de) | 2005-10-05 |
DE50313444D1 (en) | 2011-03-10 |
EP1581490B1 (de) | 2011-01-26 |
AR042521A1 (es) | 2005-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |