JP2007522237A5 - - Google Patents
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- JP2007522237A5 JP2007522237A5 JP2006553282A JP2006553282A JP2007522237A5 JP 2007522237 A5 JP2007522237 A5 JP 2007522237A5 JP 2006553282 A JP2006553282 A JP 2006553282A JP 2006553282 A JP2006553282 A JP 2006553282A JP 2007522237 A5 JP2007522237 A5 JP 2007522237A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- effective amount
- therapeutically effective
- interferon
- compound
- Prior art date
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- 239000000203 mixture Substances 0.000 claims 7
- 208000036142 Viral infection Diseases 0.000 claims 5
- 230000029812 viral genome replication Effects 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims 3
- 102000006992 Interferon-alpha Human genes 0.000 claims 3
- 108010047761 Interferon-alpha Proteins 0.000 claims 3
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229960000329 ribavirin Drugs 0.000 claims 3
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229940121740 Inosine monophosphate dehydrogenase inhibitor Drugs 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 101710144111 Non-structural protein 3 Proteins 0.000 claims 1
- 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
- 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
- 108010078233 Thymalfasin Proteins 0.000 claims 1
- 102400000800 Thymosin alpha-1 Human genes 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002348 inosinate dehydrogenase inhibitor Substances 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 239000003001 serine protease inhibitor Substances 0.000 claims 1
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 1
- 229950006081 taribavirin Drugs 0.000 claims 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims 1
- 229960004231 thymalfasin Drugs 0.000 claims 1
- UUWJNBOCAPUTBK-UHFFFAOYSA-N C[n]1c(N=C(N)NC2=O)c2nc1 Chemical compound C[n]1c(N=C(N)NC2=O)c2nc1 UUWJNBOCAPUTBK-UHFFFAOYSA-N 0.000 description 1
- 0 C[n]1c(nc(N)nc2*)c2nc1 Chemical compound C[n]1c(nc(N)nc2*)c2nc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54474304P | 2004-02-13 | 2004-02-13 | |
| US10/903,215 US20050182252A1 (en) | 2004-02-13 | 2004-07-29 | Novel 2'-C-methyl nucleoside derivatives |
| PCT/US2005/004447 WO2005084192A2 (en) | 2004-02-13 | 2005-02-14 | Novel 2’-c-methyl nucleoside derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007522237A JP2007522237A (ja) | 2007-08-09 |
| JP2007522237A5 true JP2007522237A5 (https=) | 2008-08-21 |
Family
ID=34841195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553282A Pending JP2007522237A (ja) | 2004-02-13 | 2005-02-14 | 新規２’−ｃ−メチルヌクレオシド誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20050182252A1 (https=) |
| EP (1) | EP1720556A4 (https=) |
| JP (1) | JP2007522237A (https=) |
| BR (1) | BRPI0507675A (https=) |
| WO (1) | WO2005084192A2 (https=) |
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| TW201004632A (en) * | 2008-07-02 | 2010-02-01 | Idenix Pharmaceuticals Inc | Compounds and pharmaceutical compositions for the treatment of viral infections |
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| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
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| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
| EP3773753A4 (en) | 2018-04-10 | 2021-12-22 | ATEA Pharmaceuticals, Inc. | TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| IL308921A (en) | 2021-06-17 | 2024-01-01 | Atea Pharmaceuticals Inc | Combination anti-HCV therapy is beneficial |
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| US7144868B2 (en) * | 2003-10-27 | 2006-12-05 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| CA2542776A1 (en) * | 2003-10-27 | 2005-05-12 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
-
2004
- 2004-07-29 US US10/903,215 patent/US20050182252A1/en not_active Abandoned
-
2005
- 2005-02-14 JP JP2006553282A patent/JP2007522237A/ja active Pending
- 2005-02-14 BR BRPI0507675-7A patent/BRPI0507675A/pt not_active IP Right Cessation
- 2005-02-14 WO PCT/US2005/004447 patent/WO2005084192A2/en not_active Ceased
- 2005-02-14 EP EP05750052A patent/EP1720556A4/en not_active Withdrawn
- 2005-07-29 US US11/572,785 patent/US20090131370A1/en not_active Abandoned
-
2006
- 2006-10-30 US US11/589,363 patent/US7666855B2/en not_active Expired - Lifetime
- 2006-11-06 US US11/593,381 patent/US20070179114A1/en not_active Abandoned
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