JP2008508319A5 - - Google Patents

Info

Publication number

JP2008508319A5

JP2008508319A5 JP2007523879A JP2007523879A JP2008508319A5 JP 2008508319 A5 JP2008508319 A5 JP 2008508319A5 JP 2007523879 A JP2007523879 A JP 2007523879A JP 2007523879 A JP2007523879 A JP 2007523879A JP 2008508319 A5 JP2008508319 A5 JP 2008508319A5

Authority

JP

Japan

Prior art keywords

group

alkyl

independently selected

substituted

hcv

Prior art date

2005-07-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 4
• 125000001424 substituent group Chemical group 0.000 claims 4
• 208000036142 Viral infection Diseases 0.000 claims 3
• 230000029812 viral genome replication Effects 0.000 claims 3
• 230000009385 viral infection Effects 0.000 claims 3
• IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims 2
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 125000002541 furyl group Chemical group 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 229960000329 ribavirin Drugs 0.000 claims 2
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
• 125000001544 thienyl group Chemical group 0.000 claims 2
• 101710088194 Dehydrogenase Proteins 0.000 claims 1
• HAEJPQIATWHALX-KQYNXXCUSA-N ITP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 HAEJPQIATWHALX-KQYNXXCUSA-N 0.000 claims 1
• 102000006992 Interferon-alpha Human genes 0.000 claims 1
• 108010047761 Interferon-alpha Proteins 0.000 claims 1
• 102000003996 Interferon-beta Human genes 0.000 claims 1
• 108090000467 Interferon-beta Proteins 0.000 claims 1
• 102000014150 Interferons Human genes 0.000 claims 1
• 108010050904 Interferons Proteins 0.000 claims 1
• 102000012479 Serine Proteases Human genes 0.000 claims 1
• 108010022999 Serine Proteases Proteins 0.000 claims 1
• 108010078233 Thymalfasin Proteins 0.000 claims 1
• 102400000800 Thymosin alpha-1 Human genes 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 229940079322 interferon Drugs 0.000 claims 1
• 229960001388 interferon-beta Drugs 0.000 claims 1
• 230000010076 replication Effects 0.000 claims 1
• NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 1
• 229950006081 taribavirin Drugs 0.000 claims 1
• NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims 1
• 229960004231 thymalfasin Drugs 0.000 claims 1