JP2008531704A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008531704A5 JP2008531704A5 JP2007558142A JP2007558142A JP2008531704A5 JP 2008531704 A5 JP2008531704 A5 JP 2008531704A5 JP 2007558142 A JP2007558142 A JP 2007558142A JP 2007558142 A JP2007558142 A JP 2007558142A JP 2008531704 A5 JP2008531704 A5 JP 2008531704A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- ribofuranosyl
- benzo
- dihydro
- tetraaza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 27
- -1 amino, aminocarbonyl Chemical group 0.000 claims 21
- 125000005843 halogen group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 10
- 125000004442 acylamino group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 150000002431 hydrogen Chemical group 0.000 claims 9
- 150000001540 azides Chemical class 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000000033 alkoxyamino group Chemical group 0.000 claims 6
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 6
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 241000710781 Flaviviridae Species 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 2
- 229950006081 taribavirin Drugs 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- ICMNAHWBYQOWJO-NZQZLILVSA-N (2R,3R,4R,5R)-2-(11-fluoro-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-3-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NCC(F)=C3)=C2C3=C1 ICMNAHWBYQOWJO-NZQZLILVSA-N 0.000 claims 1
- NSEYHMDNGSNOBQ-NZQZLILVSA-N (2R,3R,4R,5R)-2-(12-fluoro-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-3-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NCC=C3F)=C2C3=C1 NSEYHMDNGSNOBQ-NZQZLILVSA-N 0.000 claims 1
- BLURITVAGFDMPS-NHULRPGXSA-N (2R,3R,4R,5R)-2-(3,5,7,9,10,12-hexazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-3-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NNC=N3)=C2C3=C1 BLURITVAGFDMPS-NHULRPGXSA-N 0.000 claims 1
- IXXVTGLQEGPRLV-KNJXUWEQSA-N (2R,3R,4R,5R)-5-(hydroxymethyl)-3-methyl-2-(3,5,7,9,10-pentazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-3-yl)oxolane-3,4-diol Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NNC=C3)=C2C3=C1 IXXVTGLQEGPRLV-KNJXUWEQSA-N 0.000 claims 1
- IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims 1
- OESHHJVQXYGCKW-FTTKWNSESA-N 11-amino-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C(N)=C3)=C2C3=C1 OESHHJVQXYGCKW-FTTKWNSESA-N 0.000 claims 1
- KYDZVISIOSNRMR-KXOWALFDSA-N 12-amino-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-11-fluoro-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C(F)=C3N)=C2C3=C1 KYDZVISIOSNRMR-KXOWALFDSA-N 0.000 claims 1
- GLOQJXCSHIAUSF-ZCLWBALQSA-N 12-amino-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaene-10-thione Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=S)C=C3N)=C2C3=C1 GLOQJXCSHIAUSF-ZCLWBALQSA-N 0.000 claims 1
- RJFIQUNBXWRVTA-PMXXHBEXSA-N 12-amino-3-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C=C3N)=C2C3=C1 RJFIQUNBXWRVTA-PMXXHBEXSA-N 0.000 claims 1
- ZKGVSTUMOHZOEQ-FRJWGUMJSA-N 12-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C1=C(C2=3)C(N)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O ZKGVSTUMOHZOEQ-FRJWGUMJSA-N 0.000 claims 1
- GRMYVLYSBJYKBE-ZCLWBALQSA-N 12-chloro-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C=C3Cl)=C2C3=C1 GRMYVLYSBJYKBE-ZCLWBALQSA-N 0.000 claims 1
- SFQUTMMHSCDERR-YTUKDDMISA-N 2-(2'-methyl-β-d-ribofuranosyl)-2,9-dihydro-6h-2,3,5,6,9-pentaaza-benzo[cd]azulene-7,8-dione Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1N=C(C=NNC2=O)C3=C2C(=O)NC3=C1 SFQUTMMHSCDERR-YTUKDDMISA-N 0.000 claims 1
- CFLGNWHWVWVTMA-JEGMJTAISA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaene-11-carbonitrile Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C(C#N)=C3)=C2C3=C1 CFLGNWHWVWVTMA-JEGMJTAISA-N 0.000 claims 1
- TUOWVHKWPGTSGL-ZVTMDSFCSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaene-11-carboxamide Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C(C(N)=O)=C3)=C2C3=C1 TUOWVHKWPGTSGL-ZVTMDSFCSA-N 0.000 claims 1
- IWPWLRDURFXKNV-KXOWALFDSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-11,12-difluoro-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C(F)=C3F)=C2C3=C1 IWPWLRDURFXKNV-KXOWALFDSA-N 0.000 claims 1
- ZKJIVMQMKMMFHI-FTTKWNSESA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-11-fluoro-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C(F)=C3)=C2C3=C1 ZKJIVMQMKMMFHI-FTTKWNSESA-N 0.000 claims 1
- OAHNQJQLXDEFCL-ZCLWBALQSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-12-(hydroxyamino)-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C=C3NO)=C2C3=C1 OAHNQJQLXDEFCL-ZCLWBALQSA-N 0.000 claims 1
- GVOOKYOKQRCJFT-KHTZZEJVSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-12-(methoxyamino)-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C1=C(C2=3)C(NOC)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O GVOOKYOKQRCJFT-KHTZZEJVSA-N 0.000 claims 1
- IQDRYMACQDAPTL-KHTZZEJVSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-12-(methylamino)-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C1=C(C2=3)C(NC)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O IQDRYMACQDAPTL-KHTZZEJVSA-N 0.000 claims 1
- RZZYLGRBIREDSW-ZQEXUDESSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-12-fluoro-3,5,7,9,11-pentazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)N=C3F)=C2C3=C1 RZZYLGRBIREDSW-ZQEXUDESSA-N 0.000 claims 1
- WEBPMOZRCPJYAW-ZCLWBALQSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-12-fluoro-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C=C3F)=C2C3=C1 WEBPMOZRCPJYAW-ZCLWBALQSA-N 0.000 claims 1
- XEQDJLRBBKBFBE-ZCLWBALQSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-12-hydrazinyl-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)C=C3NN)=C2C3=C1 XEQDJLRBBKBFBE-ZCLWBALQSA-N 0.000 claims 1
- SPHINGCEMHXYKE-VHQAPHLWSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9,10,12-hexazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-11-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NNC(=O)N3)=C2C3=C1 SPHINGCEMHXYKE-VHQAPHLWSA-N 0.000 claims 1
- ODPUUCQVEIOVPK-AMJCQUEASA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9,11-pentazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-10-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)N=C3)=C2C3=C1 ODPUUCQVEIOVPK-AMJCQUEASA-N 0.000 claims 1
- XFYUUODDJHDVFN-ZQEXUDESSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9,11-pentazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8-tetraene-10,12-dione Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)NC3=O)=C2C3=C1 XFYUUODDJHDVFN-ZQEXUDESSA-N 0.000 claims 1
- NIAJWNYWHQCZHB-YTUKDDMISA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9,12-pentazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-11-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NCC(=O)N3)=C2C3=C1 NIAJWNYWHQCZHB-YTUKDDMISA-N 0.000 claims 1
- XUJHVFLLGKRHTE-ZCLWBALQSA-N 3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraene-10,12-dione Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CN=C2NC(=O)CC3=O)=C2C3=C1 XUJHVFLLGKRHTE-ZCLWBALQSA-N 0.000 claims 1
- IQTNLLIVXRSHGW-YTUKDDMISA-N 9-amino-2-(2'-methyl-β-d-ribofuranosyl)-2,6-dihydro-2,3,5,6,8-pentaaza-benzo[cd]azulen-7-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1N=C(C=NNC2=O)C3=C2N=C(N)C3=C1 IQTNLLIVXRSHGW-YTUKDDMISA-N 0.000 claims 1
- YDTPSIYKHMTGKX-PZTHBURQSA-N 9-amino-2-(2'-methyl-β-d-ribofuranosyl)-2,6-dihydro-2,3,5,6-tetraaza-benzo[cd]azulen-7-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1N=C(C=NNC2=O)C3=C2C=C(N)C3=C1 YDTPSIYKHMTGKX-PZTHBURQSA-N 0.000 claims 1
- YCXPYXMDZXJQKB-QTDMDRALSA-N 9-carbamoyl-2-(2'-methyl-β-d-ribofuranosyl)-2,6-dihydro-2,3,5,6-tetraaza-benzo[cd]azulen-7-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1N=C(C=NNC2=O)C3=C2C=C(C(N)=O)C3=C1 YCXPYXMDZXJQKB-QTDMDRALSA-N 0.000 claims 1
- JKGHPHSYUAVDSB-UIBBOPPKSA-N 9-cyano-2-(2'-methyl-β-d-ribofuranosyl)-2,6-dihydro-2,3,5,6-tetraaza-benzo[cd]azulen-7-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1N=C(C=NNC2=O)C3=C2C=C(C#N)C3=C1 JKGHPHSYUAVDSB-UIBBOPPKSA-N 0.000 claims 1
- CDWPLWQNOLTUNM-PZTHBURQSA-N 9-iodo-2-(2'-methyl-β-d-ribofuranosyl)-2,6-dihydro-2,3,5,6-tetraaza-benzo[cd]azulen-7-one Chemical compound C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1N=C(C=NNC2=O)C3=C2C=C(I)C3=C1 CDWPLWQNOLTUNM-PZTHBURQSA-N 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 claims 1
- 102000016600 Inosine-5'-monophosphate dehydrogenases Human genes 0.000 claims 1
- 108050006182 Inosine-5'-monophosphate dehydrogenases Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- JIPYIHALDIWXLT-FPOOMLEOSA-N N-[3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-12-yl]acetamide Chemical compound C1=C(C2=3)C(NC(=O)C)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O JIPYIHALDIWXLT-FPOOMLEOSA-N 0.000 claims 1
- 101800001019 Non-structural protein 4B Proteins 0.000 claims 1
- 101800001014 Non-structural protein 5A Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 108010078233 Thymalfasin Proteins 0.000 claims 1
- 102400000800 Thymosin alpha-1 Human genes 0.000 claims 1
- UVUFIBDXCNFICN-YTUKDDMISA-N [[(2R,3R,4R,5R)-3,4-dihydroxy-4-methyl-5-(11-oxo-3,5,7,9,12-pentazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-3-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NCC(=O)N3)=C2C3=C1 UVUFIBDXCNFICN-YTUKDDMISA-N 0.000 claims 1
- WKKGEQIYVHERTA-ZCLWBALQSA-N [[(2R,3R,4R,5R)-3,4-dihydroxy-5-(12-iodo-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3I)=C2C3=C1 WKKGEQIYVHERTA-ZCLWBALQSA-N 0.000 claims 1
- UGTQFAADSJDRSS-ZCLWBALQSA-N [[(2R,3R,4R,5R)-3,4-dihydroxy-5-[12-(hydroxyamino)-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl]-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3NO)=C2C3=C1 UGTQFAADSJDRSS-ZCLWBALQSA-N 0.000 claims 1
- LNEZPAJWCWZSLR-KHTZZEJVSA-N [[(2R,3R,4R,5R)-3,4-dihydroxy-5-[12-(methoxyamino)-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl]-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C1=C(C2=3)C(NOC)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@@]1(C)O LNEZPAJWCWZSLR-KHTZZEJVSA-N 0.000 claims 1
- IRPWNCKXLZNAOT-FTTKWNSESA-N [[(2R,3R,4R,5R)-5-(11-fluoro-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C(F)=C3)=C2C3=C1 IRPWNCKXLZNAOT-FTTKWNSESA-N 0.000 claims 1
- UGTXDEGAFZVXOG-FPOOMLEOSA-N [[(2R,3R,4R,5R)-5-(12-acetamido-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C1=C(C2=3)C(NC(=O)C)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@@]1(C)O UGTXDEGAFZVXOG-FPOOMLEOSA-N 0.000 claims 1
- MRLRXQNXOVYHCI-ZQEXUDESSA-N [[(2R,3R,4R,5R)-5-(12-amino-10-oxo-3,5,7,9,11-pentazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)N=C3N)=C2C3=C1 MRLRXQNXOVYHCI-ZQEXUDESSA-N 0.000 claims 1
- ZVWWKBRKHNYVPZ-ZCLWBALQSA-N [[(2R,3R,4R,5R)-5-(12-amino-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3N)=C2C3=C1 ZVWWKBRKHNYVPZ-ZCLWBALQSA-N 0.000 claims 1
- CVWCOPFFHJDDJX-PMXXHBEXSA-N [[(2R,3R,4R,5R)-5-(12-amino-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3N)=C2C3=C1 CVWCOPFFHJDDJX-PMXXHBEXSA-N 0.000 claims 1
- JSWXEAGVIBIQKU-ZCLWBALQSA-N [[(2R,3R,4R,5R)-5-(12-chloro-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3Cl)=C2C3=C1 JSWXEAGVIBIQKU-ZCLWBALQSA-N 0.000 claims 1
- NSZGCCIJGZZVIO-ZCLWBALQSA-N [[(2R,3R,4R,5R)-5-(12-fluoro-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3F)=C2C3=C1 NSZGCCIJGZZVIO-ZCLWBALQSA-N 0.000 claims 1
- LCFFBOATQVXWEL-ZCLWBALQSA-N [[(2R,3R,4R,5R)-5-(12-hydrazinyl-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CN=C2NC(=O)C=C3NN)=C2C3=C1 LCFFBOATQVXWEL-ZCLWBALQSA-N 0.000 claims 1
- FFCDTAKRDPJRLR-FRJWGUMJSA-N [[(2R,3S,4R,5R)-5-(12-amino-10-oxo-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4(13),5,8,11-pentaen-3-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C1=C(C2=3)C(N)=CC(=O)NC2=NC=NC=3N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O FFCDTAKRDPJRLR-FRJWGUMJSA-N 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 235000013902 inosinic acid Nutrition 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims 1
- 229960004231 thymalfasin Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65746305P | 2005-02-28 | 2005-02-28 | |
| PCT/US2006/007132 WO2006093987A1 (en) | 2005-02-28 | 2006-02-28 | Tricyclic-nucleoside compounds for treating viral infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008531704A JP2008531704A (ja) | 2008-08-14 |
| JP2008531704A5 true JP2008531704A5 (https=) | 2009-04-09 |
Family
ID=36570903
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558142A Withdrawn JP2008531704A (ja) | 2005-02-28 | 2006-02-28 | ウイルス感染症の治療のための三環式ヌクレオシド化合物 |
| JP2007558141A Withdrawn JP2008531703A (ja) | 2005-02-28 | 2006-02-28 | ウイルス感染症の治療のための三環式ヌクレオシドプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558141A Withdrawn JP2008531703A (ja) | 2005-02-28 | 2006-02-28 | ウイルス感染症の治療のための三環式ヌクレオシドプロドラッグ |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7524825B2 (https=) |
| EP (2) | EP1853618A1 (https=) |
| JP (2) | JP2008531704A (https=) |
| KR (2) | KR20070106767A (https=) |
| CN (2) | CN101142226A (https=) |
| AP (2) | AP2007004128A0 (https=) |
| AR (1) | AR058419A1 (https=) |
| AU (2) | AU2006218705A1 (https=) |
| BR (2) | BRPI0607770A2 (https=) |
| CA (2) | CA2597685A1 (https=) |
| EA (2) | EA200701849A1 (https=) |
| HR (2) | HRP20070436A2 (https=) |
| IL (2) | IL184954A0 (https=) |
| MX (2) | MX2007010460A (https=) |
| NO (2) | NO20074613L (https=) |
| TW (1) | TW200640474A (https=) |
| WO (2) | WO2006093986A1 (https=) |
| ZA (1) | ZA200707410B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1863813B (zh) | 2003-08-27 | 2011-03-30 | 生物区科学管理控股有限公司 | 作为治疗剂的三环核苷或核苷酸 |
| HRP20070436A2 (hr) * | 2005-02-28 | 2008-02-29 | Genelabs Technologies | Triciklički nukleozidni predlijekovi za liječenjevirusnih infekcija |
| AR056327A1 (es) * | 2005-04-25 | 2007-10-03 | Genelabs Tech Inc | Compuestos de nucleosidos para el tratamiento de infecciones virales |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| PT2144604E (pt) | 2007-02-28 | 2011-10-19 | Conatus Pharmaceuticals Inc | Métodos para o tratamento da hepatite c viral crónica utilizando ro-113-0830 |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| WO2009029729A1 (en) * | 2007-08-31 | 2009-03-05 | Genelabs Technologies, Inc. | Amino tricyclic-nucleoside compounds, compositions, and methods of use |
| GB0718575D0 (en) * | 2007-09-24 | 2007-10-31 | Angeletti P Ist Richerche Bio | Nucleoside derivatives as inhibitors of viral polymerases |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| GB2471806B (en) * | 2008-04-03 | 2012-12-19 | Spring Bank Pharmaceuticals Inc | Compositions and methods for treating viral infections |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| KR20110098849A (ko) | 2008-12-23 | 2011-09-01 | 파마셋 인코포레이티드 | 뉴클레오시드 유사체 |
| PT2376088T (pt) | 2008-12-23 | 2017-05-02 | Gilead Pharmasset Llc | Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída |
| SG194404A1 (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| GB0900914D0 (en) * | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| TW201102390A (en) * | 2009-03-31 | 2011-01-16 | Arqule Inc | Substituted pyrazolo-pyrimidine compounds |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| PT2609923T (pt) | 2010-03-31 | 2017-08-30 | Gilead Pharmasset Llc | Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| UY33312A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidato de nucleosido de purina |
| MX2012011222A (es) | 2010-04-01 | 2013-01-18 | Centre Nat Rech Scient | Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales. |
| AU2011336632B2 (en) | 2010-11-30 | 2015-09-03 | Gilead Pharmasset Llc | Compounds |
| EP2691409B1 (en) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| KR20140064765A (ko) | 2011-06-30 | 2014-05-28 | 스텔라 에이피에스 | Hcv 조합 치료 |
| WO2013033093A1 (en) * | 2011-08-29 | 2013-03-07 | Biocryst Pharmaceuticals, Inc. | Heterocyclic compounds as janus kinase inhibitors |
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| PL2709613T5 (pl) | 2011-09-16 | 2020-12-14 | Gilead Pharmasset Llc | Metody leczenia hcv |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| EP2639238A1 (en) * | 2012-03-15 | 2013-09-18 | Universität Bern | Tricyclic nucleosides and oligomeric compounds prepared therefrom |
| AR090699A1 (es) * | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
| US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| CA2873315A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharamaceuticals, Inc. | D-amino acid compounds for liver disease |
| SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| KR102001280B1 (ko) | 2012-10-08 | 2019-07-17 | 아이데닉스 파마슈티칼스 엘엘씨 | Hcv 감염에 대한 2'-클로로 뉴클레오시드 유사체 |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| PT2950786T (pt) | 2013-01-31 | 2020-03-03 | Gilead Pharmasset Llc | Formulação de combinação de dois compostos antivirais |
| US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| ATE270326T1 (de) | 1990-04-04 | 2004-07-15 | Chiron Corp | Protease von hepatitis-c-virus |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| DE69434931T2 (de) | 1993-04-02 | 2007-11-22 | Rigel Pharmaceuticals, Inc., South San Francisco | Methode zur selektiven inaktivierung der viralen replication |
| IT1272179B (it) | 1994-02-23 | 1997-06-16 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv. |
| US5861267A (en) * | 1995-05-01 | 1999-01-19 | Vertex Pharmaceuticals Incorporated | Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity |
| EP0859833B1 (en) | 1995-09-27 | 2006-03-01 | Emory University | Recombinant hepatitis c virus rna replicase |
| US5759795A (en) * | 1996-03-08 | 1998-06-02 | Schering Corporation | Assay for determining inhibitors of ATPase |
| JP2001514508A (ja) | 1997-03-05 | 2001-09-11 | ユニバーシティー オブ ワシントン | Ｃ型肝炎ウイルスの複製を選択的に抑制する薬剤を同定するための新規なスクリーニング法 |
| EP0973788A1 (en) | 1997-04-02 | 2000-01-26 | Amersham Pharmacia Biotech UK Limited | Tricyclic base analogues |
| US6228576B1 (en) * | 1997-12-11 | 2001-05-08 | Smithkline Beecham Corporation | Hepatitis C virus NS5B truncated protein and methods thereof to identify antiviral compounds |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| WO2002057425A2 (en) * | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2003061385A1 (en) * | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents |
| WO2004014852A2 (en) | 2002-08-12 | 2004-02-19 | Bristol-Myers Squibb Company | Iminothiazolidinones as inhibitors of hcv replication |
| EP2345657A1 (en) | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| CN1863813B (zh) * | 2003-08-27 | 2011-03-30 | 生物区科学管理控股有限公司 | 作为治疗剂的三环核苷或核苷酸 |
| US7144868B2 (en) * | 2003-10-27 | 2006-12-05 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| JP2007509939A (ja) * | 2003-10-27 | 2007-04-19 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染を治療するためのヌクレオシド化合物 |
| US7202223B2 (en) | 2003-10-27 | 2007-04-10 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| HRP20070436A2 (hr) | 2005-02-28 | 2008-02-29 | Genelabs Technologies | Triciklički nukleozidni predlijekovi za liječenjevirusnih infekcija |
-
2006
- 2006-02-28 HR HR20070436A patent/HRP20070436A2/xx not_active Application Discontinuation
- 2006-02-28 CA CA002597685A patent/CA2597685A1/en not_active Abandoned
- 2006-02-28 MX MX2007010460A patent/MX2007010460A/es not_active Application Discontinuation
- 2006-02-28 BR BRPI0607770-6A patent/BRPI0607770A2/pt not_active IP Right Cessation
- 2006-02-28 AP AP2007004128A patent/AP2007004128A0/xx unknown
- 2006-02-28 CN CNA2006800063894A patent/CN101142226A/zh active Pending
- 2006-02-28 JP JP2007558142A patent/JP2008531704A/ja not_active Withdrawn
- 2006-02-28 ZA ZA200707410A patent/ZA200707410B/xx unknown
- 2006-02-28 EP EP06736451A patent/EP1853618A1/en not_active Withdrawn
- 2006-02-28 KR KR1020077020680A patent/KR20070106767A/ko not_active Withdrawn
- 2006-02-28 AP AP2007004118A patent/AP2007004118A0/xx unknown
- 2006-02-28 EA EA200701849A patent/EA200701849A1/ru unknown
- 2006-02-28 US US11/365,321 patent/US7524825B2/en not_active Expired - Fee Related
- 2006-02-28 MX MX2007010463A patent/MX2007010463A/es not_active Application Discontinuation
- 2006-02-28 AR ARP060100751A patent/AR058419A1/es unknown
- 2006-02-28 CN CNA2006800063907A patent/CN101128474A/zh active Pending
- 2006-02-28 EA EA200701850A patent/EA200701850A1/ru unknown
- 2006-02-28 WO PCT/US2006/007131 patent/WO2006093986A1/en not_active Ceased
- 2006-02-28 EP EP06736450A patent/EP1853617A1/en not_active Withdrawn
- 2006-02-28 KR KR1020077021265A patent/KR20070106781A/ko not_active Withdrawn
- 2006-02-28 AU AU2006218705A patent/AU2006218705A1/en not_active Abandoned
- 2006-02-28 AU AU2006218704A patent/AU2006218704A1/en not_active Abandoned
- 2006-02-28 US US11/365,170 patent/US7534771B2/en not_active Expired - Fee Related
- 2006-02-28 CA CA002597683A patent/CA2597683A1/en not_active Abandoned
- 2006-02-28 BR BRPI0607769-2A patent/BRPI0607769A2/pt not_active IP Right Cessation
- 2006-02-28 WO PCT/US2006/007132 patent/WO2006093987A1/en not_active Ceased
- 2006-02-28 JP JP2007558141A patent/JP2008531703A/ja not_active Withdrawn
- 2006-02-28 HR HR20070435A patent/HRP20070435A9/xx not_active Application Discontinuation
- 2006-03-01 TW TW095106861A patent/TW200640474A/zh unknown
-
2007
- 2007-07-31 IL IL184954A patent/IL184954A0/en unknown
- 2007-07-31 IL IL184955A patent/IL184955A0/en unknown
- 2007-09-11 NO NO20074613A patent/NO20074613L/no not_active Application Discontinuation
- 2007-09-27 NO NO20074915A patent/NO20074915L/no not_active Application Discontinuation
-
2009
- 2009-03-31 US US12/415,286 patent/US20090208457A1/en not_active Abandoned
- 2009-03-31 US US12/415,335 patent/US20090253648A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008531704A5 (https=) | ||
| AU2009293493B2 (en) | Combination of HCV NS3 protease inhibitor with interferon and ribavirin | |
| JP5891241B2 (ja) | Ｈｃｖを処置するための組合せ | |
| RU2011139180A (ru) | Комбинация нуклеозидного ингибитора полимеразы и макроциклического ингибитора протеазы и ее применение для лечения гепатита с, фиброза печени и нарушенной печеночной функции | |
| JP2013521279A5 (https=) | ||
| JP2012519181A5 (https=) | ||
| JP2016503800A5 (https=) | ||
| JP2015525220A5 (https=) | ||
| JP2008518943A5 (https=) | ||
| RU2006124594A (ru) | Ингибиторы сериновой протеазы ns3/ns4а вируса гепатита с | |
| EP2341065A3 (en) | Inhibitors of serine proteases, particularly HCV NS3-NS4a protease | |
| JP2012512169A5 (https=) | ||
| KR20060096415A (ko) | Ｃ형 간염 바이러스에 의한 감염증을 치료하기 위해투여하는 ｔｌｒ７ 리간드 및 이의 전구약물 | |
| WO2004002422A3 (en) | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections | |
| JP2015512860A5 (https=) | ||
| JP2012504126A5 (https=) | ||
| WO2005077969A3 (en) | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease | |
| TR201906767T4 (tr) | Modifiye florlanmış nükleosit analogları. | |
| TW200500373A (en) | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections | |
| TW200510391A (en) | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | |
| AR021876A1 (es) | Terapia de combinacion para vhc por induccion de ribavirina - interferon alfa pegilado | |
| WO2005037860A3 (en) | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease | |
| RU2008152171A (ru) | Новые ингибиторы вирусной репликации гепатита с | |
| JP2012513479A5 (https=) | ||
| JP2002539204A5 (https=) |