JP2013529627A5 - - Google Patents
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- Publication number
- JP2013529627A5 JP2013529627A5 JP2013516021A JP2013516021A JP2013529627A5 JP 2013529627 A5 JP2013529627 A5 JP 2013529627A5 JP 2013516021 A JP2013516021 A JP 2013516021A JP 2013516021 A JP2013516021 A JP 2013516021A JP 2013529627 A5 JP2013529627 A5 JP 2013529627A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- hydroxychloroquine
- acceptable salt
- hcv
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 16
- 229960004171 hydroxychloroquine Drugs 0.000 claims 15
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000003443 antiviral agent Substances 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960000329 ribavirin Drugs 0.000 claims 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- ZAVJTSLIGAGALR-UHFFFAOYSA-N 2-(2,2,2-trifluoroacetyl)cyclooctan-1-one Chemical group FC(F)(F)C(=O)C1CCCCCCC1=O ZAVJTSLIGAGALR-UHFFFAOYSA-N 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 1
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 1
- 101800001020 Non-structural protein 4A Proteins 0.000 claims 1
- 101800001014 Non-structural protein 5A Proteins 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002927 hydroxychloroquine sulfate Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35801410P | 2010-06-24 | 2010-06-24 | |
| US61/358,014 | 2010-06-24 | ||
| PCT/IB2011/052762 WO2011161644A1 (en) | 2010-06-24 | 2011-06-23 | Treatment of hepatitis c virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013529627A JP2013529627A (ja) | 2013-07-22 |
| JP2013529627A5 true JP2013529627A5 (https=) | 2014-08-07 |
Family
ID=44630083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516021A Pending JP2013529627A (ja) | 2010-06-24 | 2011-06-23 | ヒドロキシクロロキンまたはヒドロキシクロロキンおよび抗ウイルス剤の組合せを使用するｃ型肝炎ウイルス関連疾患の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8987302B2 (https=) |
| EP (1) | EP2585065A1 (https=) |
| JP (1) | JP2013529627A (https=) |
| CN (1) | CN103096891A (https=) |
| AU (1) | AU2011268498A1 (https=) |
| BR (1) | BR112012033022A2 (https=) |
| CA (1) | CA2803093A1 (https=) |
| IN (1) | IN2012MN02896A (https=) |
| MX (1) | MX2013000242A (https=) |
| WO (1) | WO2011161644A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013529627A (ja) | 2010-06-24 | 2013-07-22 | パンメド リミテッド | ヒドロキシクロロキンまたはヒドロキシクロロキンおよび抗ウイルス剤の組合せを使用するｃ型肝炎ウイルス関連疾患の処置 |
| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
| WO2014122537A2 (en) | 2013-02-05 | 2014-08-14 | Genoscience Sa | Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin |
| CN103145811B (zh) * | 2013-03-15 | 2014-05-07 | 深圳翰宇药业股份有限公司 | 一种合成阿拉泊韦的方法 |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| US20230139565A1 (en) * | 2020-04-20 | 2023-05-04 | Glanis Pharmaceuticals, Inc. | Oral delivery system comprising hydroxychloroquine and/or chloroquine |
| US20230149515A1 (en) * | 2020-04-29 | 2023-05-18 | The Regents Of The University Of Michigan | Inhibition of sars-cov-2 viral entry through oral administration of lactoferrin and uses thereof |
| JP7477152B2 (ja) | 2020-05-12 | 2024-05-01 | 国立大学法人 宮崎大学 | Ｈｔｌｖ－１関連疾患の発症予防、進展抑制または治療のための剤 |
| JP2024504728A (ja) | 2021-01-26 | 2024-02-01 | サイトケアズ （シャンハイ） インコーポレイテッド | キメラ抗原受容体（ｃａｒ）構築物およびｃａｒ構築物を発現するｎｋ細胞 |
| CN114796126B (zh) * | 2022-04-02 | 2023-04-18 | 复旦大学附属中山医院青浦分院(上海市青浦区中心医院) | 关节腔注射用硫酸羟氯喹缓释微球及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2546658A (en) | 1949-07-23 | 1951-03-27 | Sterling Drug Inc | 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| JP2514950B2 (ja) | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質，その製造法および中間体 |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5314894A (en) | 1992-09-15 | 1994-05-24 | Sterling Winthrop Inc. | (S)-(+)-hydroxychloroquine |
| ATE214940T1 (de) | 1993-11-10 | 2002-04-15 | Enzon Inc | Verbesserte interferon-polymerkonjugate |
| US5624938A (en) * | 1994-07-18 | 1997-04-29 | The Trustees Of Columbia University In The City Of New York | Use of chloroquine to treat multiple sclerosis |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| US6849254B1 (en) | 1999-04-19 | 2005-02-01 | Schering Corporation | HCV combination therapy |
| US6924270B2 (en) | 2000-04-20 | 2005-08-02 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| WO2005003296A2 (en) | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ITBO20020416A1 (it) * | 2002-06-28 | 2003-12-29 | Valpharma Sa | Uso della clorochina, idrossi-clorochina e derivati 4 amino-chinolinici per l'ottenimento di un farmaco per la terapia anti retrovirale atti |
| CA2676567A1 (en) | 2003-02-21 | 2005-03-31 | Jarrow Formulas, Inc. | Methods for treatment of hiv or malaria using combinations of chloroquine and protease inhibitors |
| WO2005049065A2 (en) | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
| US7671017B2 (en) | 2004-07-14 | 2010-03-02 | Novartis Ag | Use of a combination of cyclosporine and pegylated interferon for treating hepatitis C (HCV) |
| WO2006109196A2 (en) | 2005-02-04 | 2006-10-19 | Tripep Ab | Transgenic mouse models of hepatitis c virus (hcv) and identification of hcv therapeutics |
| AU2006242475B2 (en) | 2005-05-02 | 2011-07-07 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| TWI387603B (zh) | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Ｈｃｖ ｎｓ３蛋白酶抑制劑 |
| BRPI0614205A2 (pt) | 2005-08-01 | 2016-11-22 | Merck & Co Inc | composto, composição farmacêutica, e, uso de composto |
| WO2010101649A2 (en) * | 2009-03-05 | 2010-09-10 | Pablo Gastaminza | Sigma 1 receptor inhibition as a novel therapeutical approach against hepatitis c virus infection |
| AU2011209051B2 (en) | 2010-01-27 | 2015-01-15 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as HCV inhibitors |
| JP2013529627A (ja) | 2010-06-24 | 2013-07-22 | パンメド リミテッド | ヒドロキシクロロキンまたはヒドロキシクロロキンおよび抗ウイルス剤の組合せを使用するｃ型肝炎ウイルス関連疾患の処置 |
| MX2013004906A (es) | 2010-11-01 | 2013-12-06 | Genoscience Pharma | Nuevos inhibidores especificos de la proteasa ns3 de hcv. |
| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
-
2011
- 2011-06-23 JP JP2013516021A patent/JP2013529627A/ja active Pending
- 2011-06-23 CA CA2803093A patent/CA2803093A1/en not_active Abandoned
- 2011-06-23 BR BR112012033022A patent/BR112012033022A2/pt not_active IP Right Cessation
- 2011-06-23 WO PCT/IB2011/052762 patent/WO2011161644A1/en not_active Ceased
- 2011-06-23 EP EP11743355.7A patent/EP2585065A1/en not_active Withdrawn
- 2011-06-23 CN CN2011800411855A patent/CN103096891A/zh active Pending
- 2011-06-23 IN IN2896MUN2012 patent/IN2012MN02896A/en unknown
- 2011-06-23 AU AU2011268498A patent/AU2011268498A1/en not_active Abandoned
- 2011-06-23 MX MX2013000242A patent/MX2013000242A/es not_active Application Discontinuation
-
2012
- 2012-12-26 US US13/726,783 patent/US8987302B2/en not_active Expired - Fee Related
-
2013
- 2013-03-15 US US13/836,397 patent/US8575195B2/en not_active Expired - Fee Related
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