JP2007521807A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007521807A5 JP2007521807A5 JP2006549613A JP2006549613A JP2007521807A5 JP 2007521807 A5 JP2007521807 A5 JP 2007521807A5 JP 2006549613 A JP2006549613 A JP 2006549613A JP 2006549613 A JP2006549613 A JP 2006549613A JP 2007521807 A5 JP2007521807 A5 JP 2007521807A5
- Authority
- JP
- Japan
- Prior art keywords
- hyp
- biologically active
- fusion protein
- glycoprotein
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108020001507 fusion proteins Proteins 0.000 claims 35
- 102000037865 fusion proteins Human genes 0.000 claims 35
- 102000003886 Glycoproteins Human genes 0.000 claims 29
- 108090000288 Glycoproteins Proteins 0.000 claims 29
- 238000000034 method Methods 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 12
- 239000000854 Human Growth Hormone Substances 0.000 claims 11
- 230000013595 glycosylation Effects 0.000 claims 11
- 238000006206 glycosylation reaction Methods 0.000 claims 11
- 108010000521 Human Growth Hormone Proteins 0.000 claims 10
- 102000002265 Human Growth Hormone Human genes 0.000 claims 10
- 150000001720 carbohydrates Chemical class 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 238000009472 formulation Methods 0.000 claims 8
- 102000018997 Growth Hormone Human genes 0.000 claims 7
- 108010051696 Growth Hormone Proteins 0.000 claims 7
- 235000014633 carbohydrates Nutrition 0.000 claims 7
- 239000000122 growth hormone Substances 0.000 claims 7
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 7
- 229940122853 Growth hormone antagonist Drugs 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- DNDWZFHLZVYOGF-KKUMJFAQSA-N Leu-Leu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O DNDWZFHLZVYOGF-KKUMJFAQSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 108010049589 leucyl-leucyl-leucine Proteins 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- 101800001586 Ghrelin Proteins 0.000 claims 2
- 102400000442 Ghrelin-28 Human genes 0.000 claims 2
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 claims 2
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims 2
- 206010056438 Growth hormone deficiency Diseases 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 108010057464 Prolactin Proteins 0.000 claims 2
- 102100024819 Prolactin Human genes 0.000 claims 2
- 101710142969 Somatoliberin Proteins 0.000 claims 2
- 102000005157 Somatostatin Human genes 0.000 claims 2
- 108010056088 Somatostatin Proteins 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000008176 lyophilized powder Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940097325 prolactin Drugs 0.000 claims 2
- 229960000553 somatostatin Drugs 0.000 claims 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 2
- 102100021809 Chorionic somatomammotropin hormone 1 Human genes 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 102000003968 Fibroblast growth factor 6 Human genes 0.000 claims 1
- 108090000382 Fibroblast growth factor 6 Proteins 0.000 claims 1
- 108090000368 Fibroblast growth factor 8 Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 claims 1
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 1
- 108010078049 Interferon alpha-2 Proteins 0.000 claims 1
- 102100039350 Interferon alpha-7 Human genes 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102100021592 Interleukin-7 Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 108010092277 Leptin Proteins 0.000 claims 1
- 102000016267 Leptin Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108010003044 Placental Lactogen Proteins 0.000 claims 1
- 239000000381 Placental Lactogen Substances 0.000 claims 1
- 102100039277 Pleiotrophin Human genes 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 108700004813 glycosylated insulin Proteins 0.000 claims 1
- 108700004708 glycosylated somatotropin Proteins 0.000 claims 1
- 239000005090 green fluorescent protein Substances 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 108010045648 interferon omega 1 Proteins 0.000 claims 1
- 229940076144 interleukin-10 Drugs 0.000 claims 1
- 229940100994 interleukin-7 Drugs 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 229940039781 leptin Drugs 0.000 claims 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53648604P | 2004-01-14 | 2004-01-14 | |
| US58202704P | 2004-06-22 | 2004-06-22 | |
| US60256204P | 2004-08-18 | 2004-08-18 | |
| PCT/US2005/001160 WO2005069845A2 (en) | 2004-01-14 | 2005-01-14 | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013065541A Division JP2013208114A (ja) | 2004-01-14 | 2013-03-27 | 植物においてペプチド／タンパク質を産生する方法およびそれにより産生されたペプチド／タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007521807A JP2007521807A (ja) | 2007-08-09 |
| JP2007521807A5 true JP2007521807A5 (https=) | 2008-03-06 |
Family
ID=34812077
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549613A Withdrawn JP2007521807A (ja) | 2004-01-14 | 2005-01-14 | 植物においてペプチド／タンパク質を産生する方法およびそれにより産生されたペプチド／タンパク質 |
| JP2013065541A Pending JP2013208114A (ja) | 2004-01-14 | 2013-03-27 | 植物においてペプチド／タンパク質を産生する方法およびそれにより産生されたペプチド／タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013065541A Pending JP2013208114A (ja) | 2004-01-14 | 2013-03-27 | 植物においてペプチド／タンパク質を産生する方法およびそれにより産生されたペプチド／タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US20060026719A1 (https=) |
| EP (2) | EP1711533B1 (https=) |
| JP (2) | JP2007521807A (https=) |
| AU (1) | AU2005206885B2 (https=) |
| CA (1) | CA2553257A1 (https=) |
| IL (1) | IL176781A0 (https=) |
| MX (1) | MXPA06008126A (https=) |
| NZ (1) | NZ548513A (https=) |
| WO (1) | WO2005069845A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6570062B1 (en) * | 1997-07-21 | 2003-05-27 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US7378506B2 (en) * | 1997-07-21 | 2008-05-27 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US6639050B1 (en) | 1997-07-21 | 2003-10-28 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US20060252120A1 (en) * | 2003-05-09 | 2006-11-09 | Kieliszewski Marcia J | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| EP1711533B1 (en) * | 2004-01-14 | 2013-12-11 | Ohio University | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
| CA2573918A1 (en) | 2004-04-19 | 2005-11-24 | Ohio University | Cross-linkable glycoproteins and methods of making the same |
| US20080242834A1 (en) * | 2005-07-08 | 2008-10-02 | Ohio University | Methods of Predicting Hyp-Glycosylation Sites For Proteins Expressed and Secreted in Plant Cells, and Related Methods and Products |
| US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| EP1929073A4 (en) * | 2005-09-27 | 2010-03-10 | Amunix Inc | PROTEIN MEDICAMENT AND ITS USE |
| US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
| TWI321052B (en) * | 2005-11-08 | 2010-03-01 | Univ Kaohsiung Medical | Composition for treating cancer cells and preparation method thereof |
| DK1984344T3 (da) | 2005-12-29 | 2013-01-14 | Lexicon Pharmaceuticals Inc | Multicykliske aminosyrederivater og fremgangsmåder til anvendelse heraf |
| US20070258941A1 (en) * | 2006-05-02 | 2007-11-08 | Pfister Brian E | Methods and compositions for remediation of disc herniation by modifying structure |
| EP2084285A4 (en) * | 2006-07-10 | 2010-01-13 | Univ Ohio | COEXPRESSION OF PROLIN HYDROXYLASES TO FACILITATE HYP-GLYCOSYLATION OF PROTEINS EXPRESSED AND SEPARATED IN PLANT CELLS |
| US8933197B2 (en) * | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
| CN101883784B (zh) | 2007-10-01 | 2014-10-15 | 药华医药股份有限公司 | N-端修饰的干扰素-α |
| US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| CA2748314C (en) | 2009-02-03 | 2018-10-02 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
| JP5839597B2 (ja) | 2009-06-08 | 2016-01-06 | アムニクス オペレーティング インコーポレイテッド | グルコース調節ポリペプチド並びにその作成及び使用方法 |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| AU2010290131C1 (en) * | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| US20110105735A1 (en) * | 2009-10-29 | 2011-05-05 | Heather Desaire | Methods of producing and purifying proteins |
| EP2325194A1 (en) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Process for the purification of glycoproteins |
| WO2011123830A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| BR112014020694A2 (pt) | 2012-02-15 | 2018-05-08 | Amunix Operating Inc. | proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a |
| CN117462693A (zh) | 2012-02-27 | 2024-01-30 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| WO2015130963A2 (en) * | 2014-02-27 | 2015-09-03 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| KR101652953B1 (ko) * | 2016-01-15 | 2016-08-31 | (주)넥스젠바이오텍 | 열 안정성이 증가한 인간성장호르몬 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선 및 탄력 유지용 화장료 조성물 |
| IL319473A (en) | 2016-12-02 | 2025-05-01 | Bioverativ Therapeutics Inc | Methods for treating hemophilic arthritis using chimeric blood clotting factors |
| CN112040968B (zh) * | 2018-04-30 | 2024-01-30 | 欧莱雅 | 对人肌肉烟碱性乙酰胆碱受体具有高结合亲和力的生物活性肽 |
| US20210230608A1 (en) * | 2018-05-09 | 2021-07-29 | Gat Biosciences, S.L. | Gycomodule motifs and uses thereof |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
| CN112399851A (zh) | 2018-07-11 | 2021-02-23 | 俄亥俄大学 | 基于肽的生长激素作用抑制剂及其使用方法 |
| CN111802241B (zh) * | 2020-07-24 | 2022-11-08 | 海南广陵高科实业有限公司 | 一种高抗性水稻的育种方法 |
| CA3196814A1 (en) | 2020-09-25 | 2022-03-31 | Proabtech Inc. | Uricase-albumin conjugate, preparation method therefor, and use thereof |
| EP4218825A4 (en) * | 2020-09-25 | 2025-03-19 | Proabtech Inc. | Conjugate of functional polypeptide variant, and use thereof |
| KR20250162537A (ko) | 2023-03-24 | 2025-11-18 | 가트 바이오사이언시스, 에스.엘. | 변형된 항체 및 이의 용도 |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3664925A (en) * | 1970-02-20 | 1972-05-23 | Martin Sonenberg | Clinically active bovine growth hormone fraction |
| US4056520A (en) * | 1972-03-31 | 1977-11-01 | Research Corporation | Clinically active bovine growth hormone fraction |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US5034322A (en) * | 1983-01-17 | 1991-07-23 | Monsanto Company | Chimeric genes suitable for expression in plant cells |
| US5352605A (en) * | 1983-01-17 | 1994-10-04 | Monsanto Company | Chimeric genes for transforming plant cells using viral promoters |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| US4478827A (en) * | 1983-05-09 | 1984-10-23 | The General Hospital Corporation | Renin inhibitors |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
| US6774283B1 (en) * | 1985-07-29 | 2004-08-10 | Calgene Llc | Molecular farming |
| US6018030A (en) * | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| IL90146A (en) * | 1988-05-20 | 1994-10-07 | Genentech Inc | Glycosylation derivatives of tissue plasminogen activator |
| US6680426B2 (en) * | 1991-01-07 | 2004-01-20 | Auburn University | Genetic engineering of plant chloroplasts |
| US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| EP0397834B1 (en) | 1988-10-28 | 2000-02-02 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| US5501967A (en) | 1989-07-26 | 1996-03-26 | Mogen International, N.V./Rijksuniversiteit Te Leiden | Process for the site-directed integration of DNA into the genome of plants |
| NL8901932A (nl) * | 1989-07-26 | 1991-02-18 | Mogen Int | Produktie van heterologe eiwitten in planten of plantecellen. |
| US6787336B1 (en) * | 1989-10-12 | 2004-09-07 | Ohio University/Edison Biotechnology Institute | DNA encoding growth hormone antagonists |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5958879A (en) | 1989-10-12 | 1999-09-28 | Ohio University/Edison Biotechnology Institute | Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal |
| US6583115B1 (en) * | 1989-10-12 | 2003-06-24 | Ohio University/Edison Biotechnology Institute | Methods for treating acromegaly and giantism with growth hormone antagonists |
| US5989894A (en) * | 1990-04-20 | 1999-11-23 | University Of Wyoming | Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA |
| CA2087267A1 (en) | 1990-08-17 | 1992-02-18 | Steven H. Bass | Metal ion mediated receptor binding of polypeptide hormones |
| US5780279A (en) * | 1990-12-03 | 1998-07-14 | Genentech, Inc. | Method of selection of proteolytic cleavage sites by directed evolution and phagemid display |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| JP3417558B2 (ja) | 1991-05-10 | 2003-06-16 | ジェネンテク，インコーポレイテッド | 配位子作用薬および拮抗薬の選択 |
| WO1992020713A1 (en) | 1991-05-15 | 1992-11-26 | The University Of Melbourne | Proline rich protein from nicotiana alata |
| WO1993000109A1 (en) | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
| US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5474925A (en) * | 1991-12-19 | 1995-12-12 | Agracetus, Inc. | Immobilized proteins in cotton fiber |
| US6225080B1 (en) * | 1992-03-23 | 2001-05-01 | George R. Uhl | Mu-subtype opioid receptor |
| US5352596A (en) * | 1992-09-11 | 1994-10-04 | The United States Of America As Represented By The Secretary Of Agriculture | Pseudorabies virus deletion mutants involving the EPO and LLT genes |
| WO1994017087A1 (en) * | 1993-01-28 | 1994-08-04 | The Regents Of The University Of California | Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use |
| JPH0762038B2 (ja) * | 1993-08-19 | 1995-07-05 | ユニヴァーシティー オブ ユータ | グリコシル化インシュリン及びそれを含む糖尿病治療剤 |
| US5646029A (en) * | 1993-12-03 | 1997-07-08 | Cooperative Research Centre For Industrial Plant Biopolymers | Plant arabinogalactan protein (AGP) genes |
| CA2158733C (en) | 1994-01-21 | 2007-01-16 | Dennis E. Mccabe | Gas driven gene delivery instrument |
| US5733771A (en) * | 1994-03-14 | 1998-03-31 | University Of Wyoming | cDNAs encoding minor ampullate spider silk proteins |
| US6080560A (en) * | 1994-07-25 | 2000-06-27 | Monsanto Company | Method for producing antibodies in plant cells |
| US5695971A (en) * | 1995-04-07 | 1997-12-09 | Amresco | Phage-cosmid hybrid vector, open cos DNA fragments, their method of use, and process of production |
| US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
| AU6504796A (en) * | 1995-07-20 | 1997-02-18 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
| CA2230492C (en) * | 1995-09-21 | 2009-05-26 | Genentech, Inc. | Human growth hormone variants |
| AR006928A1 (es) * | 1996-05-01 | 1999-09-29 | Pioneer Hi Bred Int | Una molecula de adn aislada que codifica una proteina fluorescente verde como marcador rastreable para la transformacion de plantas, un metodo para laproduccion de plantas transgenicas, un vector de expresion, una planta transgenica y celulas de dichas plantas. |
| US5821089A (en) * | 1996-06-03 | 1998-10-13 | Gruskin; Elliott A. | Amino acid modified polypeptides |
| US6639050B1 (en) * | 1997-07-21 | 2003-10-28 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US7378506B2 (en) * | 1997-07-21 | 2008-05-27 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US6548642B1 (en) | 1997-07-21 | 2003-04-15 | Ohio University | Synthetic genes for plant gums |
| US6570062B1 (en) * | 1997-07-21 | 2003-05-27 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US20030204864A1 (en) * | 2001-02-28 | 2003-10-30 | Henry Daniell | Pharmaceutical proteins, human therapeutics, human serum albumin, insulin, native cholera toxic b submitted on transgenic plastids |
| US5994099A (en) * | 1997-12-31 | 1999-11-30 | The University Of Wyoming | Extremely elastic spider silk protein and DNA coding therefor |
| US6037456A (en) * | 1998-03-10 | 2000-03-14 | Biosource Technologies, Inc. | Process for isolating and purifying viruses, soluble proteins and peptides from plant sources |
| US20030167531A1 (en) * | 1998-07-10 | 2003-09-04 | Russell Douglas A. | Expression and purification of bioactive, authentic polypeptides from plants |
| DE69936351T2 (de) | 1998-10-30 | 2008-02-21 | Novozymes A/S | Glykosylierte proteine mit reduzierter allergenität |
| ES2558160T3 (es) * | 1998-12-09 | 2016-02-02 | Phyton Holdings, Llc | Glicoproteínas que tienen glicosilación de tipo humano |
| US6210950B1 (en) * | 1999-05-25 | 2001-04-03 | University Of Medicine And Dentistry Of New Jersey | Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors |
| AU6678200A (en) * | 1999-08-27 | 2001-03-26 | University Of Guelph | Use of arabinogalactan protein fusion constructs in a method of expressing proteins and peptides in plants |
| AU2352201A (en) | 1999-12-30 | 2001-07-16 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| US20020127652A1 (en) * | 2000-02-11 | 2002-09-12 | Schambye Hans Thalsgard | Follicle stimulating hormones |
| US20020162135A1 (en) * | 2001-04-18 | 2002-10-31 | Henry Daniell | Expression of antimicrobial peptide via the plastid genome to control phytopathogenic bacteria |
| US20020174453A1 (en) * | 2001-04-18 | 2002-11-21 | Henry Daniell | Production of antibodies in transgenic plastids |
| US20030041353A1 (en) * | 2001-04-18 | 2003-02-27 | Henry Daniell | Mutiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants |
| EP1272649A2 (en) | 2000-04-03 | 2003-01-08 | Monsanto Technology LLC | Method for producing authentic cytokines in plants |
| EP1156060B1 (en) | 2000-05-12 | 2007-06-27 | GPC Biotech AG | Human peptides/proteins causing or leading to the killing of cells including lymphoid tumor cells |
| US20030036181A1 (en) * | 2000-06-30 | 2003-02-20 | Okkels Jens Sigurd | Peptide extended glycosylated polypeptides |
| WO2002037313A2 (en) | 2000-11-06 | 2002-05-10 | Thrasos, Inc. | Computer method and apparatus for classifying objects |
| US6987172B2 (en) * | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
| US7173113B2 (en) * | 2002-01-31 | 2007-02-06 | The Trustees Of Columbia University In The City Of New York | Long-acting hormone and growth factor compositions and uses thereof |
| US20060252120A1 (en) * | 2003-05-09 | 2006-11-09 | Kieliszewski Marcia J | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| AU2004240553A1 (en) * | 2003-05-09 | 2004-12-02 | Neose Technologies, Inc. | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
| JP2005087172A (ja) * | 2003-09-19 | 2005-04-07 | Institute Of Physical & Chemical Research | アラビノガラクタン様ｏ−結合型糖鎖付加モチーフ |
| EP1711533B1 (en) * | 2004-01-14 | 2013-12-11 | Ohio University | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
| CA2573918A1 (en) * | 2004-04-19 | 2005-11-24 | Ohio University | Cross-linkable glycoproteins and methods of making the same |
| DE602005023332D1 (de) | 2004-09-29 | 2010-10-14 | Collplant Ltd | Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung |
| US20080242834A1 (en) * | 2005-07-08 | 2008-10-02 | Ohio University | Methods of Predicting Hyp-Glycosylation Sites For Proteins Expressed and Secreted in Plant Cells, and Related Methods and Products |
| EP2084285A4 (en) | 2006-07-10 | 2010-01-13 | Univ Ohio | COEXPRESSION OF PROLIN HYDROXYLASES TO FACILITATE HYP-GLYCOSYLATION OF PROTEINS EXPRESSED AND SEPARATED IN PLANT CELLS |
-
2005
- 2005-01-14 EP EP05726258.6A patent/EP1711533B1/en not_active Expired - Lifetime
- 2005-01-14 JP JP2006549613A patent/JP2007521807A/ja not_active Withdrawn
- 2005-01-14 EP EP09004742.4A patent/EP2133427B1/en not_active Expired - Lifetime
- 2005-01-14 WO PCT/US2005/001160 patent/WO2005069845A2/en not_active Ceased
- 2005-01-14 CA CA002553257A patent/CA2553257A1/en not_active Abandoned
- 2005-01-14 NZ NZ548513A patent/NZ548513A/en not_active IP Right Cessation
- 2005-01-14 US US11/036,256 patent/US20060026719A1/en not_active Abandoned
- 2005-01-14 US US11/036,257 patent/US20060148680A1/en not_active Abandoned
- 2005-01-14 MX MXPA06008126A patent/MXPA06008126A/es unknown
- 2005-01-14 AU AU2005206885A patent/AU2005206885B2/en not_active Ceased
-
2006
- 2006-07-11 IL IL176781A patent/IL176781A0/en unknown
-
2008
- 2008-05-08 US US12/117,692 patent/US20100029548A1/en not_active Abandoned
- 2008-05-16 US US12/122,606 patent/US20100028993A1/en not_active Abandoned
-
2011
- 2011-01-13 US US13/005,715 patent/US20110230404A1/en not_active Abandoned
- 2011-02-02 US US13/019,819 patent/US9006410B2/en not_active Expired - Fee Related
-
2013
- 2013-03-27 JP JP2013065541A patent/JP2013208114A/ja active Pending
- 2013-04-03 US US13/855,946 patent/US8962811B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007521807A5 (https=) | ||
| US12599652B2 (en) | Serum albumin-binding fibronectin type III domains | |
| JP6983075B2 (ja) | 極性の組換え延長部を有するインスリン | |
| JP6101638B2 (ja) | 多価ヘテロマルチマー足場設計及び構築物 | |
| CN104211800B (zh) | 组织损伤修复中的基质细胞衍生因子1的蛋白酶抗性突变体 | |
| ES2318418T3 (es) | Proteinas de fusion recombinantes de la hormona de crecimiento y la albumina de suero. | |
| US9956264B2 (en) | MIC-1 fusion proteins and uses thereof | |
| US8084021B2 (en) | Recombinant human albumin-interleukin-11 fusion protein with long-lasting biological effects | |
| EP2502939B1 (en) | Nonnatural collagen-like protein and use thereof | |
| CN105121459A (zh) | 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法 | |
| WO2021136303A1 (zh) | 长效glp-1化合物 | |
| JP2013535467A (ja) | 組換えにより発現されたインスリンポリペプチドおよびその使用 | |
| WO2014165093A2 (en) | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto | |
| CN104768571A (zh) | 多价异多聚体支架设计和构建体 | |
| CN102939304A (zh) | 白蛋白衍生物和变体 | |
| CA2871145A1 (en) | Fibroblast growth factor 21 proteins | |
| US20210284690A1 (en) | Fusion protein with half-life extending polypeptide | |
| TW202342089A (zh) | 長效顆粒球巨噬細胞群落刺激因子 | |
| JP2008543304A (ja) | ヒト顆粒球コロニー刺激因子イソ型（ＨｕｍａｎＧｒａｎｕｌｏｃｙｔｅ−ＣｏｌｏｎｙＳｔｉｍｕｌａｔｉｎｇＦａｃｔｏｒＩｓｏｆｏｒｍｓ） | |
| US10968267B2 (en) | Serum albumin-20K growth hormone fusion protein | |
| Binder et al. | Current strategies for pharmacokinetic optimization | |
| JP2008538501A5 (https=) | ||
| CN115960246B (zh) | 一种重组环状人生长激素-Fc融合蛋白及其应用 | |
| RU2515913C1 (ru) | ГИБРИДНЫЙ БЕЛОК, ОБЛАДАЮЩИЙ ПРОЛОНГИРОВАННЫМ ДЕЙСТВИЕМ, НА ОСНОВЕ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА АЛЬФА-2 ЧЕЛОВЕКА (ВАРИАНТЫ), СПОСОБ ЕГО ПОЛУЧЕНИЯ И ШТАММ Saccharomyces cerevisiae ДЛЯ ОСУЩЕСТВЛЕНИЯ ЭТОГО СПОСОБА (ВАРИАНТЫ) | |
| HK40006036B (en) | Serum albumin-binding fibronectin type iii domains |