JP2007520466A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007520466A5 JP2007520466A5 JP2006546009A JP2006546009A JP2007520466A5 JP 2007520466 A5 JP2007520466 A5 JP 2007520466A5 JP 2006546009 A JP2006546009 A JP 2006546009A JP 2006546009 A JP2006546009 A JP 2006546009A JP 2007520466 A5 JP2007520466 A5 JP 2007520466A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- amino
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Amide compounds Chemical class 0.000 claims 41
- 125000004432 carbon atom Chemical group C* 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 13
- KZOWNALBTMILAP-JBMRGDGGSA-N ancitabine hydrochloride Chemical compound Cl.N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 KZOWNALBTMILAP-JBMRGDGGSA-N 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000013543 active substance Substances 0.000 claims 10
- 125000004076 pyridyl group Chemical group 0.000 claims 9
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003254 radicals Chemical class 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 1
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 1
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 claims 1
- YHCUZRJTNSWYCY-UHFFFAOYSA-N 2,3,4,7-tetrahydro-1h-azepine Chemical compound C1CNCC=CC1 YHCUZRJTNSWYCY-UHFFFAOYSA-N 0.000 claims 1
- SMOHMDMTVAYPAI-UHFFFAOYSA-N 2,3,6,7-tetrahydro-1h-azepine Chemical compound C1CC=CCCN1 SMOHMDMTVAYPAI-UHFFFAOYSA-N 0.000 claims 1
- OCELZDDEJJBFSU-UHFFFAOYSA-N 2-chloro-5-[3-[4-(5-phenylpentylamino)phenyl]propanoylamino]benzoic acid Chemical compound C1=C(Cl)C(C(=O)O)=CC(NC(=O)CCC=2C=CC(NCCCCCC=3C=CC=CC=3)=CC=2)=C1 OCELZDDEJJBFSU-UHFFFAOYSA-N 0.000 claims 1
- RQCSDMPDPILTRX-UHFFFAOYSA-N 2-methylsulfanyl-5-[3-[4-(octadecylamino)phenyl]propanoylamino]benzoic acid Chemical compound C1=CC(NCCCCCCCCCCCCCCCCCC)=CC=C1CCC(=O)NC1=CC=C(SC)C(C(O)=O)=C1 RQCSDMPDPILTRX-UHFFFAOYSA-N 0.000 claims 1
- NPVONNZNIBNQBN-UHFFFAOYSA-N 3-(4-aminophenyl)-n-(4-hydroxy-3,5-dimethylphenyl)propanamide Chemical compound CC1=C(O)C(C)=CC(NC(=O)CCC=2C=CC(N)=CC=2)=C1 NPVONNZNIBNQBN-UHFFFAOYSA-N 0.000 claims 1
- HOHMNKIRZPSFKU-UHFFFAOYSA-N 3-[2-[2-hydroxy-3-(4-naphthalen-1-ylpiperidin-1-yl)propoxy]phenyl]-n-methyl-n-phenylprop-2-enamide Chemical compound C=1C=CC=C(OCC(O)CN2CCC(CC2)C=2C3=CC=CC=C3C=CC=2)C=1C=CC(=O)N(C)C1=CC=CC=C1 HOHMNKIRZPSFKU-UHFFFAOYSA-N 0.000 claims 1
- GNWONDUZVUZUOQ-UHFFFAOYSA-N 3-[2-[2-hydroxy-3-(4-naphthalen-2-yl-3,6-dihydro-2h-pyridin-1-yl)propoxy]phenyl]-n-methyl-n-phenylprop-2-enamide Chemical compound C=1C=CC=C(OCC(O)CN2CC=C(CC2)C=2C=C3C=CC=CC3=CC=2)C=1C=CC(=O)N(C)C1=CC=CC=C1 GNWONDUZVUZUOQ-UHFFFAOYSA-N 0.000 claims 1
- ZXURMRFAXFYMAD-UHFFFAOYSA-N 3-[2-[2-hydroxy-3-(4-naphthalen-2-ylpiperidin-1-yl)propoxy]phenyl]-n-methyl-n-phenylprop-2-enamide Chemical compound C=1C=CC=C(OCC(O)CN2CCC(CC2)C=2C=C3C=CC=CC3=CC=2)C=1C=CC(=O)N(C)C1=CC=CC=C1 ZXURMRFAXFYMAD-UHFFFAOYSA-N 0.000 claims 1
- TXLCWKXYBRECFJ-UHFFFAOYSA-N 3-[2-[2-hydroxy-3-(4-naphthalen-2-ylpiperidin-1-yl)propoxy]phenyl]-n-phenylprop-2-enamide Chemical compound C1CC(C=2C=C3C=CC=CC3=CC=2)CCN1CC(O)COC1=CC=CC=C1C=CC(=O)NC1=CC=CC=C1 TXLCWKXYBRECFJ-UHFFFAOYSA-N 0.000 claims 1
- OOOPKDWRISJSLD-UHFFFAOYSA-N 3-[4-(dimethylamino)phenyl]-n-(4-hydroxy-3,5-dimethylphenyl)propanamide Chemical compound C1=CC(N(C)C)=CC=C1CCC(=O)NC1=CC(C)=C(O)C(C)=C1 OOOPKDWRISJSLD-UHFFFAOYSA-N 0.000 claims 1
- FTAHXMZRJCZXDL-UHFFFAOYSA-N 3-piperideine Chemical compound C1CC=CCN1 FTAHXMZRJCZXDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- JVQIKJMSUIMUDI-UHFFFAOYSA-N 3-pyrroline Chemical compound C1NCC=C1 JVQIKJMSUIMUDI-UHFFFAOYSA-N 0.000 claims 1
- LSFSTMXFFDNMJQ-UHFFFAOYSA-N 4-[3-[3-(2-anilino-1,3-benzoxazol-6-yl)propanoylamino]phenoxy]butanoic acid Chemical compound OC(=O)CCCOC1=CC=CC(NC(=O)CCC=2C=C3OC(NC=4C=CC=CC=4)=NC3=CC=2)=C1 LSFSTMXFFDNMJQ-UHFFFAOYSA-N 0.000 claims 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000004634 feeding behavior Effects 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 150000002466 imines Chemical group 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 102000006953 melanin-concentrating hormone receptor activity proteins Human genes 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 229940095102 methyl benzoate Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- YAZGADZUKMSMOV-UHFFFAOYSA-N n-piperidin-4-ylidenehydroxylamine Chemical compound ON=C1CCNCC1 YAZGADZUKMSMOV-UHFFFAOYSA-N 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 CN(C)***N(C)* Chemical compound CN(C)***N(C)* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10360745A DE10360745A1 (de) | 2003-12-23 | 2003-12-23 | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| PCT/EP2004/014378 WO2005063239A1 (de) | 2003-12-23 | 2004-12-17 | 3-(4-piperidin-1ylmethyl-phenyl) -propionsäure-phrnylamid-derivate und verwandte verbindungen als mch (melanine concentrating hormone) antagonisten zur behandlung von essstörungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007520466A JP2007520466A (ja) | 2007-07-26 |
| JP2007520466A5 true JP2007520466A5 (https=) | 2008-02-07 |
Family
ID=34706476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546009A Pending JP2007520466A (ja) | 2003-12-23 | 2004-12-17 | 摂食障害を治療するためのｍｃｈアンタゴニスト（メラニン含有ホルモン）の形態で使用される３−（４−ピペリジン−１−イルメチル−フェニル）−プロピオン酸−フェニルアミド誘導体及び関連化合物 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1708698A1 (https=) |
| JP (1) | JP2007520466A (https=) |
| AR (1) | AR048019A1 (https=) |
| CA (1) | CA2550649A1 (https=) |
| DE (1) | DE10360745A1 (https=) |
| PE (1) | PE20050678A1 (https=) |
| TW (1) | TW200530180A (https=) |
| UY (1) | UY28689A1 (https=) |
| WO (1) | WO2005063239A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
| US20060223837A1 (en) * | 2005-03-24 | 2006-10-05 | Ellen Codd | Biaryl derived amide modulators of vanilloid VR1 receptor |
| TW200800220A (en) * | 2005-10-26 | 2008-01-01 | Boehringer Ingelheim Int | New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US7977346B2 (en) * | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
| KR20090047542A (ko) | 2006-08-25 | 2009-05-12 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｍｃｈ 길항 활성을 갖는 신규한 피리돈 유도체 및 당해 화합물을 포함하는 의약 |
| TW200831485A (en) | 2006-12-11 | 2008-08-01 | Boehringer Ingelheim Int | New pyridazine derivatives with MCH antagonistic activity and medicaments comprising these compounds |
| WO2012008549A1 (ja) * | 2010-07-15 | 2012-01-19 | 武田薬品工業株式会社 | 複素環化合物 |
| CN117177744A (zh) | 2021-01-29 | 2023-12-05 | 塞迪拉治疗股份有限公司 | Cdk2抑制剂及其使用方法 |
| MX2023015436A (es) | 2021-06-26 | 2024-02-21 | Cedilla Therapeutics Inc | Inhibidores de cdk2 y metodos de uso de los mismos. |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
| JPH0454118A (ja) * | 1990-06-20 | 1992-02-21 | Tanabe Seiyaku Co Ltd | ５―リポキシゲナーゼ阻害剤 |
| DE69708968T2 (de) * | 1996-05-28 | 2002-04-25 | Pfizer Inc., New York | Arylacrylamidderivate als 5HT1 Agoniste oder Antagoniste |
| AU2160899A (en) * | 1997-12-11 | 1999-06-28 | Janssen Pharmaceutica N.V. | Retinoic acid mimetic anilides |
| JP2000143635A (ja) * | 1998-06-10 | 2000-05-26 | Takeda Chem Ind Ltd | 血管新生阻害剤 |
| JP2000086603A (ja) * | 1998-07-15 | 2000-03-28 | Yoshitomi Pharmaceut Ind Ltd | 桂皮酸アミド誘導体および３―フェニルプロピオン酸アミド誘導体 |
| EP1133484A2 (en) * | 1998-07-23 | 2001-09-19 | AstraZeneca AB | Heterocyclic derivatives and their use as integrin inhibitors |
| EP1153017B1 (en) * | 1999-02-16 | 2006-05-03 | Aventis Pharma Limited | Bicyclic compounds and their use as integrin receptor ligands |
| AU757680B2 (en) * | 1999-07-01 | 2003-02-27 | Taisho Pharmaceutical Co., Ltd. | Aminobenzoic acid derivatives |
| JP2002003370A (ja) * | 1999-09-20 | 2002-01-09 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
| DE10115994A1 (de) * | 2001-03-30 | 2002-10-10 | Wella Ag | (p-Amino-hydroxyphenyl)acrylamid-Derivate und diese Verbindungen enthaltende Färbemittel |
| WO2002092068A1 (en) * | 2001-05-10 | 2002-11-21 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CA2468015A1 (en) * | 2001-11-27 | 2003-06-05 | Merck & Co., Inc. | 2-aminoquinoline compounds |
| AU2002352868A1 (en) * | 2001-11-27 | 2003-06-10 | Merck & Co., Inc. | 4-aminoquinoline compounds |
| MXPA04005427A (es) * | 2001-12-10 | 2005-04-19 | Amgen Inc | Ligandos de receptor vainilloide y su uso en tratamientos. |
| AU2003298567B9 (en) * | 2002-08-29 | 2009-07-23 | Temple University - Of The Commonwealth System Of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
| US20040192728A1 (en) * | 2003-02-03 | 2004-09-30 | Ellen Codd | Quinoline-derived amide modulators of vanilloid VR1 receptor |
| WO2004072018A1 (ja) * | 2003-02-12 | 2004-08-26 | Takeda Pharmaceutical Company Limited | アミン誘導体 |
| JP4630555B2 (ja) * | 2003-02-12 | 2011-02-09 | 武田薬品工業株式会社 | アミン誘導体 |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
2003
- 2003-12-23 DE DE10360745A patent/DE10360745A1/de not_active Withdrawn
-
2004
- 2004-12-17 JP JP2006546009A patent/JP2007520466A/ja active Pending
- 2004-12-17 CA CA002550649A patent/CA2550649A1/en not_active Abandoned
- 2004-12-17 WO PCT/EP2004/014378 patent/WO2005063239A1/de not_active Ceased
- 2004-12-17 EP EP04803987A patent/EP1708698A1/de not_active Withdrawn
- 2004-12-20 UY UY28689A patent/UY28689A1/es not_active Application Discontinuation
- 2004-12-22 TW TW093140144A patent/TW200530180A/zh unknown
- 2004-12-22 AR ARP040104840A patent/AR048019A1/es unknown
-
2005
- 2005-01-03 PE PE2005000007A patent/PE20050678A1/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2606262C (en) | Novel histamine h3-receptor ligands and their therapeutic applications | |
| JP3073238B2 (ja) | １−（１，２−ジ置換ピペリジニル）−４−置換ピペラジン誘導体 | |
| JP2006504761A5 (https=) | ||
| PT823896E (pt) | Oximas hidrazonas e olefinas substituidas como antagonistas de neuroquinina | |
| SK82298A3 (en) | Novel compounds with analgesic effect | |
| US20080096922A1 (en) | Novel Sulfonamide derivative | |
| JP2009539762A (ja) | Ｈ３受容体のテトラリン拮抗薬 | |
| JP2007532596A5 (https=) | ||
| JPWO2004011430A1 (ja) | ナトリウムチャネル阻害剤 | |
| BG107510A (bg) | Карбоксамидни съединения и тяхното използване като антагонисти на човешки 11 cby рецептор | |
| EP0661266A1 (en) | Substituted cyclic amine compounds as 5HT2 antagonists | |
| MX2008016574A (es) | (aza)ciclohexanos carboxilados nuevos como ligandos de receptores de dopamina d3. | |
| US4539322A (en) | Dihydropyridine derivatives and their use in treating heart conditions and hypertension | |
| JP2007520466A5 (https=) | ||
| JP4464280B2 (ja) | エリスロポエチン産生促進剤 | |
| US20040048875A1 (en) | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | |
| JP4353803B2 (ja) | ムスカリン受容体アンタゴニストとしての４−ピペリジニルアルキルアミン誘導体 | |
| KR20090009971A (ko) | 4-[(3-플루오로페녹시)페닐메틸] 피페리딘 메탄술포네이트,그의 사용방법, 합성방법 및 이를 포함하는 약제학적 조성물 | |
| JP2008542365A5 (https=) | ||
| AU616014B2 (en) | Butenoic or propenoic acid derivative | |
| US20160095854A1 (en) | Arylpiperazine opioid receptor antagonists | |
| JP4276070B2 (ja) | 環状アミン化合物 | |
| JP2007532594A5 (https=) | ||
| CA2268866C (en) | Substituted arylalkylamines as neurokinin antagonists | |
| JP2007528884A5 (https=) |