JP2007517895A5 - - Google Patents
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- Publication number
- JP2007517895A5 JP2007517895A5 JP2006549475A JP2006549475A JP2007517895A5 JP 2007517895 A5 JP2007517895 A5 JP 2007517895A5 JP 2006549475 A JP2006549475 A JP 2006549475A JP 2006549475 A JP2006549475 A JP 2006549475A JP 2007517895 A5 JP2007517895 A5 JP 2007517895A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- membered
- heteroaryl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCN(CC)CCC* Chemical compound CCN(CC)CCC* 0.000 description 15
- CCSKCDULCFGGTP-UHFFFAOYSA-N CCN(CCc1ccccn1)S(C)=O Chemical compound CCN(CCc1ccccn1)S(C)=O CCSKCDULCFGGTP-UHFFFAOYSA-N 0.000 description 1
- ODHMYZBQXOCZDJ-UHFFFAOYSA-N CCN(Cc1ncccc1)S(C)(=O)=O Chemical compound CCN(Cc1ncccc1)S(C)(=O)=O ODHMYZBQXOCZDJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53489804P | 2004-01-08 | 2004-01-08 | |
| PCT/US2005/000663 WO2005066139A2 (en) | 2004-01-08 | 2005-01-10 | 2-(amino-substituted)-4-aryl pyramidines and related compounds useful for treating inflammatory diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517895A JP2007517895A (ja) | 2007-07-05 |
| JP2007517895A5 true JP2007517895A5 (https=) | 2008-01-24 |
Family
ID=34749013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549475A Pending JP2007517895A (ja) | 2004-01-08 | 2005-01-10 | 炎症疾患を処置するのに有用な２−（アミノ置換）−４−アリールピリミジンおよび関連化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7732444B2 (https=) |
| EP (2) | EP2123647A1 (https=) |
| JP (1) | JP2007517895A (https=) |
| AR (1) | AR047185A1 (https=) |
| AT (1) | ATE437861T1 (https=) |
| AU (1) | AU2005204060A1 (https=) |
| CA (1) | CA2559888A1 (https=) |
| CY (1) | CY1109529T1 (https=) |
| DE (1) | DE602005015677D1 (https=) |
| DK (1) | DK1701944T3 (https=) |
| ES (1) | ES2330863T3 (https=) |
| HR (1) | HRP20090572T1 (https=) |
| PL (1) | PL1701944T3 (https=) |
| PT (1) | PT1701944E (https=) |
| RS (1) | RS51091B (https=) |
| SI (1) | SI1701944T1 (https=) |
| TW (1) | TW200533357A (https=) |
| WO (1) | WO2005066139A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| MXPA06010520A (es) * | 2004-03-30 | 2007-03-26 | Chiron Corp | Derivados de tiofeno sustituidos como agentes anticancerosos. |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| CA2633992A1 (en) * | 2005-12-21 | 2007-07-05 | Boehringer Ingelheim International Gmbh | Pyrimidine derivatives useful as inhibitors of pkc-theta |
| JP5385125B2 (ja) * | 2006-03-22 | 2014-01-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ＭＤＭ２とｐ５３の間の相互作用の阻害剤 |
| WO2008124092A2 (en) * | 2007-04-03 | 2008-10-16 | E. I. Du Pont De Nemours And Company | Substituted benzene fungicides |
| CN101889025B (zh) | 2007-10-30 | 2013-11-13 | 健泰科生物技术公司 | 通过阳离子交换层析进行的抗体纯化 |
| US20110009421A1 (en) | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| WO2010036062A2 (en) | 2008-09-25 | 2010-04-01 | Lg Electronics Inc. | A method and an apparatus for processing a signal |
| JP2013516500A (ja) * | 2010-01-11 | 2013-05-13 | ヒールオア・リミテッド | 炎症性疾患および障害を治療するための方法 |
| WO2012003476A2 (en) * | 2010-07-02 | 2012-01-05 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| CN103635472B (zh) | 2011-02-28 | 2018-01-12 | 阵列生物制药公司 | 丝氨酸/苏氨酸激酶抑制剂 |
| JP6097289B2 (ja) | 2011-08-04 | 2017-03-15 | アレイ バイオファーマ、インコーポレイテッド | セリン／スレオニンキナーゼインヒビターとしてのキナゾリン化合物 |
| HUE053994T2 (hu) | 2012-03-01 | 2021-08-30 | Array Biopharma Inc | Szerin/treonin kináz inhibitorok |
| JP6378171B2 (ja) | 2012-04-24 | 2018-08-22 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｄｎａ−ｐｋ阻害剤 |
| AR092253A1 (es) | 2012-08-27 | 2015-04-08 | Array Biopharma Inc | Inhibidores de serina/treonina cinasa |
| SI3527563T1 (sl) | 2013-03-12 | 2022-01-31 | Vertex Pharmaceuticals Incorporated | Inhibitorji DNA-PK |
| EP3046560B1 (en) | 2013-09-18 | 2021-01-06 | EpiAxis Therapeutics Pty Ltd | Stem cell modulation ii |
| RU2675270C2 (ru) | 2013-10-17 | 2018-12-18 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
| CA2958704A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
| RU2758669C2 (ru) | 2016-09-27 | 2021-11-01 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк |
| WO2023104744A1 (en) | 2021-12-06 | 2023-06-15 | Helmholtz-Zentrum Dresden-Rossendorf E.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698697A (en) | 1995-07-19 | 1997-12-16 | Mitsubishi Chemical Corporation | 2-cyanopiperazine and method of producing the same |
| WO1999032121A1 (en) * | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
| BR9908004A (pt) | 1998-02-17 | 2001-12-18 | Tularik Inc | Composto, composição e método para prevençãoou supressão de uma infecção viral |
| KR100581199B1 (ko) * | 1998-06-19 | 2006-05-17 | 카이론 코포레이션 | 글리코겐 신타제 키나제 3의 억제제 |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| KR20010086461A (ko) * | 1998-12-24 | 2001-09-12 | 오흘러 로스 제이. | 인자 ｘａ 억제제로서의 치환된 (아미노이미노메틸 또는아미노메틸)벤조헤테로아릴 화합물 |
| US6492516B1 (en) * | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| WO2001000214A1 (en) | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| MXPA02001565A (es) * | 1999-08-13 | 2005-07-14 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas. |
| GB0003224D0 (en) * | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
| US6869956B2 (en) | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
| CA2425440C (en) | 2000-10-12 | 2010-04-13 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| EP1373257B9 (en) * | 2001-03-29 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| MXPA03009378A (es) * | 2001-04-13 | 2004-01-29 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminales (jnk) y otras proteinas cinasas. |
| GB0112803D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
| WO2003040131A1 (en) * | 2001-11-07 | 2003-05-15 | F. Hoffmann-La Roche Ag | Aminopyrimidines and pyridines |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| AU2003236720A1 (en) * | 2002-06-14 | 2003-12-31 | Altana Pharma Ag | Substituted diaminopyrimidines |
| TW200510311A (en) | 2002-12-23 | 2005-03-16 | Millennium Pharm Inc | CCr8 inhibitors |
| ATE440087T1 (de) | 2003-01-30 | 2009-09-15 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
| WO2004091480A2 (en) * | 2003-04-09 | 2004-10-28 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| US7459460B2 (en) * | 2003-05-28 | 2008-12-02 | Bristol-Myers Squibb Company | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators |
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| BRPI0508470A (pt) * | 2004-03-05 | 2007-07-31 | Chiron Corp | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
| MXPA06010520A (es) * | 2004-03-30 | 2007-03-26 | Chiron Corp | Derivados de tiofeno sustituidos como agentes anticancerosos. |
| EP1751136B1 (en) * | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| JP4688876B2 (ja) * | 2004-06-10 | 2011-05-25 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
| US7767680B2 (en) * | 2004-11-03 | 2010-08-03 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| TWI359810B (en) | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| US7786132B2 (en) * | 2004-12-17 | 2010-08-31 | Amgen Inc. | Aminopyrimidine compounds and methods of use |
| US20060178388A1 (en) * | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| DE102005034821A1 (de) * | 2005-07-26 | 2007-02-08 | Fleissner Gmbh | Voluminöse Faserlaminate und ihre Herstellung |
| TWM293131U (en) * | 2006-01-10 | 2006-07-01 | Shuen Tai Prec Entpr Co Ltd | Handheld power hammer |
-
2005
- 2005-01-07 TW TW094100533A patent/TW200533357A/zh unknown
- 2005-01-10 PL PL05726205T patent/PL1701944T3/pl unknown
- 2005-01-10 EP EP09009692A patent/EP2123647A1/en not_active Withdrawn
- 2005-01-10 CA CA002559888A patent/CA2559888A1/en not_active Abandoned
- 2005-01-10 ES ES05726205T patent/ES2330863T3/es not_active Expired - Lifetime
- 2005-01-10 EP EP05726205A patent/EP1701944B1/en not_active Expired - Lifetime
- 2005-01-10 US US11/032,299 patent/US7732444B2/en not_active Expired - Fee Related
- 2005-01-10 AR ARP050100080A patent/AR047185A1/es unknown
- 2005-01-10 PT PT05726205T patent/PT1701944E/pt unknown
- 2005-01-10 RS RSP-2009/0466A patent/RS51091B/sr unknown
- 2005-01-10 AT AT05726205T patent/ATE437861T1/de active
- 2005-01-10 HR HR20090572T patent/HRP20090572T1/hr unknown
- 2005-01-10 JP JP2006549475A patent/JP2007517895A/ja active Pending
- 2005-01-10 DK DK05726205T patent/DK1701944T3/da active
- 2005-01-10 DE DE602005015677T patent/DE602005015677D1/de not_active Expired - Lifetime
- 2005-01-10 WO PCT/US2005/000663 patent/WO2005066139A2/en not_active Ceased
- 2005-01-10 SI SI200530816T patent/SI1701944T1/sl unknown
- 2005-01-10 AU AU2005204060A patent/AU2005204060A1/en not_active Abandoned
-
2009
- 2009-10-27 CY CY20091101118T patent/CY1109529T1/el unknown
-
2010
- 2010-04-26 US US12/767,139 patent/US8268822B2/en not_active Expired - Fee Related
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