JP2007517895A5 - - Google Patents
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- Publication number
- JP2007517895A5 JP2007517895A5 JP2006549475A JP2006549475A JP2007517895A5 JP 2007517895 A5 JP2007517895 A5 JP 2007517895A5 JP 2006549475 A JP2006549475 A JP 2006549475A JP 2006549475 A JP2006549475 A JP 2006549475A JP 2007517895 A5 JP2007517895 A5 JP 2007517895A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- membered
- heteroaryl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCN(CC)CCC* Chemical compound CCN(CC)CCC* 0.000 description 15
- CCSKCDULCFGGTP-UHFFFAOYSA-N CCN(CCc1ccccn1)S(C)=O Chemical compound CCN(CCc1ccccn1)S(C)=O CCSKCDULCFGGTP-UHFFFAOYSA-N 0.000 description 1
- ODHMYZBQXOCZDJ-UHFFFAOYSA-N CCN(Cc1ncccc1)S(C)(=O)=O Chemical compound CCN(Cc1ncccc1)S(C)(=O)=O ODHMYZBQXOCZDJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53489804P | 2004-01-08 | 2004-01-08 | |
| PCT/US2005/000663 WO2005066139A2 (en) | 2004-01-08 | 2005-01-10 | 2-(amino-substituted)-4-aryl pyramidines and related compounds useful for treating inflammatory diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517895A JP2007517895A (ja) | 2007-07-05 |
| JP2007517895A5 true JP2007517895A5 (https=) | 2008-01-24 |
Family
ID=34749013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549475A Pending JP2007517895A (ja) | 2004-01-08 | 2005-01-10 | 炎症疾患を処置するのに有用な２−（アミノ置換）−４−アリールピリミジンおよび関連化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7732444B2 (https=) |
| EP (2) | EP1701944B1 (https=) |
| JP (1) | JP2007517895A (https=) |
| AR (1) | AR047185A1 (https=) |
| AT (1) | ATE437861T1 (https=) |
| AU (1) | AU2005204060A1 (https=) |
| CA (1) | CA2559888A1 (https=) |
| CY (1) | CY1109529T1 (https=) |
| DE (1) | DE602005015677D1 (https=) |
| DK (1) | DK1701944T3 (https=) |
| ES (1) | ES2330863T3 (https=) |
| HR (1) | HRP20090572T1 (https=) |
| PL (1) | PL1701944T3 (https=) |
| PT (1) | PT1701944E (https=) |
| RS (1) | RS51091B (https=) |
| SI (1) | SI1701944T1 (https=) |
| TW (1) | TW200533357A (https=) |
| WO (1) | WO2005066139A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| JP2009521488A (ja) * | 2005-12-21 | 2009-06-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｋｃ−シータのインヒビターとして有益なピリミジン誘導体 |
| US8232298B2 (en) * | 2006-03-22 | 2012-07-31 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between MDM2 and P53 |
| WO2008124092A2 (en) * | 2007-04-03 | 2008-10-16 | E. I. Du Pont De Nemours And Company | Substituted benzene fungicides |
| ES2533266T5 (es) | 2007-10-30 | 2018-04-18 | Genentech, Inc. | Purificación de anticuerpos mediante cromatografía de intercambio catiónico |
| WO2009107391A1 (ja) | 2008-02-27 | 2009-09-03 | 武田薬品工業株式会社 | ６員芳香環含有化合物 |
| WO2010036062A2 (en) | 2008-09-25 | 2010-04-01 | Lg Electronics Inc. | A method and an apparatus for processing a signal |
| EP2523677A2 (en) * | 2010-01-11 | 2012-11-21 | Healor Ltd. | Method for treatment of inflammatory disease and disorder |
| AU2011274369A1 (en) * | 2010-07-02 | 2012-12-06 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| EP2681215B1 (en) | 2011-02-28 | 2015-04-22 | Array Biopharma, Inc. | Serine/threonine kinase inhibitors |
| US9187462B2 (en) | 2011-08-04 | 2015-11-17 | Array Biopharma Inc. | Substituted quinazolines as serine/threonine kinase inhibitors |
| DK2820009T3 (en) | 2012-03-01 | 2018-04-16 | Array Biopharma Inc | Serine / threonine kinase inhibitors |
| MX371331B (es) | 2012-04-24 | 2020-01-27 | Vertex Pharma | Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico(adn-pk). |
| TW201408658A (zh) | 2012-08-27 | 2014-03-01 | Array Biopharma Inc | 絲胺酸／酥胺酸激酶抑制劑 |
| ME03336B (me) | 2013-03-12 | 2019-10-20 | Vertex Pharma | Inhibitori dnk-pk |
| ES2851724T3 (es) | 2013-09-18 | 2021-09-08 | Epiaxis Therapeutics Pty Ltd | Modulación de células madre |
| JP6408569B2 (ja) | 2013-10-17 | 2018-10-17 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｄｎａ−ｐｋ阻害剤としての（ｓ）−ｎ−メチル−８−（１−（（２’−メチル−［４，５’−ビピリミジン］−６−イル）アミノ）プロパン−２−イル）キノリン−４−カルボキサミドおよびその重水素化誘導体の共結晶 |
| CA2958704A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
| EP3518931A4 (en) | 2016-09-27 | 2020-05-13 | Vertex Pharmaceuticals Incorporated | METHOD FOR TREATING CANCER WITH A COMBINATION OF DNA-DAMAGING SUBSTANCES AND DNA-PK INHIBITORS |
| US20250144253A1 (en) | 2021-12-06 | 2025-05-08 | Helmholtz-Zentrum Dresden-Rossendorf E.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698697A (en) | 1995-07-19 | 1997-12-16 | Mitsubishi Chemical Corporation | 2-cyanopiperazine and method of producing the same |
| AU1924699A (en) * | 1997-12-19 | 1999-07-12 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses |
| EA200000840A1 (ru) * | 1998-02-17 | 2001-02-26 | Туларик, Инк. | Антивирусные производные пиримидина |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| WO1999065897A1 (en) * | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| CA2358047A1 (en) | 1998-12-24 | 2000-07-06 | Francis A. Volz | Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds |
| US6492516B1 (en) | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| EP1194152A4 (en) | 1999-06-30 | 2002-11-06 | Merck & Co Inc | Links to SRC kinase inhibition |
| BR0013551A (pt) | 1999-08-13 | 2003-06-17 | Vertex Pharma | Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas |
| GB0003224D0 (en) * | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
| US6869956B2 (en) | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
| PL360944A1 (en) | 2000-10-12 | 2004-09-20 | Merck & Co, Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| CA2441733A1 (en) * | 2001-03-29 | 2002-10-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| AU2002338642A1 (en) * | 2001-04-13 | 2002-10-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| GB0112803D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
| WO2003040131A1 (en) | 2001-11-07 | 2003-05-15 | F. Hoffmann-La Roche Ag | Aminopyrimidines and pyridines |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| CA2489458A1 (en) | 2002-06-14 | 2003-12-24 | Altana Pharma Ag | Substituted diaminopyrimidines |
| TW200510311A (en) | 2002-12-23 | 2005-03-16 | Millennium Pharm Inc | CCr8 inhibitors |
| US20040242613A1 (en) | 2003-01-30 | 2004-12-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of PKC-theta |
| US8178570B2 (en) | 2003-04-09 | 2012-05-15 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| US7459460B2 (en) | 2003-05-28 | 2008-12-02 | Bristol-Myers Squibb Company | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators |
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| US20060234205A1 (en) * | 2004-03-05 | 2006-10-19 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| CA2564355C (en) | 2004-05-07 | 2012-07-03 | Amgen Inc. | Protein kinase modulators and method of use |
| RU2401265C2 (ru) | 2004-06-10 | 2010-10-10 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
| US7767680B2 (en) * | 2004-11-03 | 2010-08-03 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| TWI359810B (en) | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| EP1831207B1 (en) | 2004-12-17 | 2012-11-14 | Amgen Inc. | Aminopyrimidine compounds as plk inhibitors |
| US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| DE102005034821A1 (de) * | 2005-07-26 | 2007-02-08 | Fleissner Gmbh | Voluminöse Faserlaminate und ihre Herstellung |
| TWM293131U (en) * | 2006-01-10 | 2006-07-01 | Shuen Tai Prec Entpr Co Ltd | Handheld power hammer |
-
2005
- 2005-01-07 TW TW094100533A patent/TW200533357A/zh unknown
- 2005-01-10 AU AU2005204060A patent/AU2005204060A1/en not_active Abandoned
- 2005-01-10 AR ARP050100080A patent/AR047185A1/es unknown
- 2005-01-10 PT PT05726205T patent/PT1701944E/pt unknown
- 2005-01-10 DK DK05726205T patent/DK1701944T3/da active
- 2005-01-10 JP JP2006549475A patent/JP2007517895A/ja active Pending
- 2005-01-10 EP EP05726205A patent/EP1701944B1/en not_active Expired - Lifetime
- 2005-01-10 WO PCT/US2005/000663 patent/WO2005066139A2/en not_active Ceased
- 2005-01-10 EP EP09009692A patent/EP2123647A1/en not_active Withdrawn
- 2005-01-10 ES ES05726205T patent/ES2330863T3/es not_active Expired - Lifetime
- 2005-01-10 SI SI200530816T patent/SI1701944T1/sl unknown
- 2005-01-10 CA CA002559888A patent/CA2559888A1/en not_active Abandoned
- 2005-01-10 HR HR20090572T patent/HRP20090572T1/hr unknown
- 2005-01-10 AT AT05726205T patent/ATE437861T1/de active
- 2005-01-10 RS RSP-2009/0466A patent/RS51091B/sr unknown
- 2005-01-10 DE DE602005015677T patent/DE602005015677D1/de not_active Expired - Lifetime
- 2005-01-10 US US11/032,299 patent/US7732444B2/en not_active Expired - Fee Related
- 2005-01-10 PL PL05726205T patent/PL1701944T3/pl unknown
-
2009
- 2009-10-27 CY CY20091101118T patent/CY1109529T1/el unknown
-
2010
- 2010-04-26 US US12/767,139 patent/US8268822B2/en not_active Expired - Fee Related
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