JP2006522813A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006522813A5 JP2006522813A5 JP2006509755A JP2006509755A JP2006522813A5 JP 2006522813 A5 JP2006522813 A5 JP 2006522813A5 JP 2006509755 A JP2006509755 A JP 2006509755A JP 2006509755 A JP2006509755 A JP 2006509755A JP 2006522813 A5 JP2006522813 A5 JP 2006522813A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- heterocyclyl
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1=N*C(IC)=N1 Chemical compound CC1=N*C(IC)=N1 0.000 description 2
- FLCDVLNNMVKCLZ-UHFFFAOYSA-N C[IH]c1c[nH]c(I)n1 Chemical compound C[IH]c1c[nH]c(I)n1 FLCDVLNNMVKCLZ-UHFFFAOYSA-N 0.000 description 1
- NFCNEDKYXMWATM-UHFFFAOYSA-N Ic1nc(I)n[nH]1 Chemical compound Ic1nc(I)n[nH]1 NFCNEDKYXMWATM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46147103P | 2003-04-09 | 2003-04-09 | |
| US60/461,471 | 2003-04-09 | ||
| PCT/US2004/010626 WO2004091480A2 (en) | 2003-04-09 | 2004-04-08 | Tie-2 modulators and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522813A JP2006522813A (ja) | 2006-10-05 |
| JP2006522813A5 true JP2006522813A5 (https=) | 2007-06-14 |
| JP4881725B2 JP4881725B2 (ja) | 2012-02-22 |
Family
ID=33299820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509755A Expired - Fee Related JP4881725B2 (ja) | 2003-04-09 | 2004-04-08 | Ｔｉｅ−２モジュレータと使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8178570B2 (https=) |
| EP (1) | EP1611123B8 (https=) |
| JP (1) | JP4881725B2 (https=) |
| AU (1) | AU2004229392A1 (https=) |
| CA (1) | CA2520255C (https=) |
| WO (1) | WO2004091480A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| US20080096848A1 (en) * | 2004-09-29 | 2008-04-24 | Cytovia Inc. | Substituted N-Aryl-9-Oxo-9H-Fluorene-1-Carboxamides and Analogs as Activators of Caspases and Inducers of Apoptosis |
| MX2007004781A (es) | 2004-10-20 | 2007-05-11 | Applied Research Systems | Derivados de 3-arilamino piridina. |
| ES2373912T3 (es) * | 2005-01-28 | 2012-02-10 | Novartis Ag | Uso de pirimidilaminobenzamidas para el tratamiento de enfermedades que responden a la modulación de la actividad de quinasa tie-2. |
| ZA200807263B (en) * | 2006-04-19 | 2009-11-25 | Serono Lab | Novel heteroaryl-substituted arylaminopyrldine derivatives as MEK inhibitors |
| CL2008000986A1 (es) | 2007-04-06 | 2008-10-17 | Neurocrine Biosciences Inc | COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV |
| PE20090044A1 (es) | 2007-04-06 | 2009-01-23 | Neurocrine Biosciences Inc | Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| EP2307456B1 (en) | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| JO3078B1 (ar) | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
| JP2013147428A (ja) * | 2010-04-27 | 2013-08-01 | Dainippon Sumitomo Pharma Co Ltd | 新規２−ヘテロアリール単環ピリミジン誘導体 |
| EP2708537A4 (en) * | 2011-05-10 | 2014-10-01 | Taisho Pharmaceutical Co Ltd | HETEROAROMATIC RING DERIVATIVE |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| AU2014233363B2 (en) * | 2013-03-15 | 2017-06-29 | EyePoint, Inc. | Compositions, formulations and methods for treating ocular diseases |
| JP2015131783A (ja) * | 2014-01-14 | 2015-07-23 | 株式会社日本ファインケム | アリール−１，２，４−トリアゾール誘導体の製造方法 |
| US9598381B2 (en) * | 2014-07-31 | 2017-03-21 | Abbvie Inc. | SMYD2 inhibitors |
| US11352326B2 (en) | 2016-11-16 | 2022-06-07 | The General Hospital Corporation | Myeloperoxidase imaging agents |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| CN114072205A (zh) * | 2019-04-18 | 2022-02-18 | 视点制药公司 | 用tie-2激活剂治疗高血压的方法 |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
| AU2020364007A1 (en) | 2019-10-11 | 2022-04-28 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC598A1 (fr) * | 1966-02-16 | 1967-03-21 | Mauvernay Roland Yves | Nouveaux composés chimiques et procédé pour leur préparation |
| IL31990A (en) * | 1968-04-26 | 1974-05-16 | Chinoin Gyogyszer Es Vegyeszet | Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same |
| US3978054A (en) * | 1974-11-29 | 1976-08-31 | Merck & Co., Inc. | 1,3,5-Trisubstituted-1,2,4-triazole compounds |
| AR230994A1 (es) | 1981-08-31 | 1984-08-31 | Pfizer | Procedimiento para preparar compuesto de 3'-substituido-5'-(2-amino-4-piridil)-1',2',4'-triazol |
| GB8829296D0 (en) * | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
| JPH0813446B2 (ja) * | 1990-05-30 | 1996-02-14 | 株式会社日立製作所 | スリツプキヤステイング法 |
| JP3217846B2 (ja) * | 1992-03-04 | 2001-10-15 | クミアイ化学工業株式会社 | トリアゾール誘導体及び殺虫剤 |
| WO2002032896A1 (en) | 2000-10-16 | 2002-04-25 | Novo Nordisk A/S | Furazanyl-triazole derivates for the treatment of diseases |
| JP2004532234A (ja) | 2001-04-27 | 2004-10-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | トリアゾール由来キナーゼインヒビターおよびその使用 |
| KR20040004705A (ko) * | 2001-06-08 | 2004-01-13 | 시토비아 인크. | 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도 |
| US20050004186A1 (en) * | 2002-12-20 | 2005-01-06 | Pfizer Inc | MEK inhibiting compounds |
| JP2007223901A (ja) * | 2004-03-24 | 2007-09-06 | Takeda Chem Ind Ltd | 複素環化合物およびその用途 |
-
2004
- 2004-04-08 WO PCT/US2004/010626 patent/WO2004091480A2/en not_active Ceased
- 2004-04-08 EP EP04759191.2A patent/EP1611123B8/en not_active Expired - Lifetime
- 2004-04-08 US US10/552,424 patent/US8178570B2/en not_active Expired - Fee Related
- 2004-04-08 AU AU2004229392A patent/AU2004229392A1/en not_active Abandoned
- 2004-04-08 JP JP2006509755A patent/JP4881725B2/ja not_active Expired - Fee Related
- 2004-04-08 CA CA2520255A patent/CA2520255C/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006522813A5 (https=) | ||
| RU2441869C2 (ru) | Противовирусные соединения | |
| JP2010531345A5 (https=) | ||
| KR20160043118A (ko) | 가속화된 경화반 퇴행을 위한 조성물 및 치료방법 | |
| RU2013108641A (ru) | Способ лечения офтальмологических заболеваний с использованием соединений ингибиторов киназы в пролекарственных формах | |
| RU2018120330A (ru) | Химерные соединения, осуществляющие нацеливание для протеолиза, и способы их получения и применения | |
| JP2009536620A5 (https=) | ||
| EA201070167A1 (ru) | Замещенные производные индазола, активные как ингибиторы киназы | |
| JP2010509356A5 (https=) | ||
| JP2017507122A5 (https=) | ||
| JP2018515570A (ja) | Ｂｒａｆ−ｖ６００関連疾患の治療に使用するためのｐｌｘ−８３９４またはｐｌｘ−７９０４ | |
| JP2002508326A5 (https=) | ||
| RU2018110770A (ru) | Ингибиторы mdm2 и их комбинации | |
| NO20071042L (no) | 5-substituerte 2-fenylaminobenzamider som MEK-inhibitorer | |
| JP2018520352A5 (https=) | ||
| SI3106463T1 (en) | Compounds of substituted pyrazolo (1,5-) pyrimidine as inhibitors of TRK kinase | |
| NO20071138L (no) | Piperazinderivater som er nyttige for behandling av gastrointestinallidelser | |
| JP2015524472A5 (https=) | ||
| JP2014500265A5 (https=) | ||
| JP2006501201A5 (https=) | ||
| JP2010516700A5 (https=) | ||
| JP2014513123A5 (https=) | ||
| RU2008143703A (ru) | ПРИМЕНЕНИЕ ИНГИБИТОРОВ c-Src В КОМБИНАЦИИ С ПИРИМИДИЛАМИНОБЕНЗАМИДОМ ДЛЯ ЛЕЧЕНИЯ ЛЕЙКОЗА | |
| JP2009541387A5 (https=) | ||
| WO2013081154A1 (ja) | キナーゼ阻害剤の副作用低減剤 |